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UniProtKB - Q9ET22 (DPP2_MOUSE)
Protein
Dipeptidyl peptidase 2
Gene
Dpp7
Organism
Mus musculus (Mouse)
Status
Functioni
Plays an important role in the degradation of some oligopeptides.
Catalytic activityi
- Release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides. EC:3.4.14.2
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 172 | Charge relay systemSequence analysis | 1 | |
Active sitei | 428 | Charge relay systemSequence analysis | 1 | |
Active sitei | 453 | Charge relay systemSequence analysis | 1 |
GO - Molecular functioni
- aminopeptidase activity Source: UniProtKB-KW
- dipeptidyl-peptidase activity Source: MGI
- serine-type peptidase activity Source: UniProtKB-KW
GO - Biological processi
- lysosomal protein catabolic process Source: MGI
- proteolysis Source: MGI
Keywordsi
Molecular function | Aminopeptidase, Hydrolase, Protease, Serine protease |
Enzyme and pathway databases
Reactomei | R-MMU-6798695, Neutrophil degranulation |
Protein family/group databases
ESTHERi | mouse-dpp2, Prolylcarboxypeptidase |
MEROPSi | S28.002 |
Names & Taxonomyi
Protein namesi | Recommended name: Dipeptidyl peptidase 2 (EC:3.4.14.2)Alternative name(s): Dipeptidyl aminopeptidase II Dipeptidyl peptidase 7 Dipeptidyl peptidase II Short name: DPP II Quiescent cell proline dipeptidase |
Gene namesi | Name:Dpp7 Synonyms:Dpp2, Qpp |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1933213, Dpp7 |
VEuPathDBi | HostDB:ENSMUSG00000026958 |
Subcellular locationi
Lysosome
- Lysosome By similarity
Extracellular region or secreted
- Secreted By similarity
Other locations
- Cytoplasmic vesicle By similarity
Cytosol
- cytosol Source: MGI
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: MGI
Lysosome
- lysosome Source: MGI
Other locations
- cytoplasmic vesicle Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: MGI
- vesicle Source: MGI
Keywords - Cellular componenti
Cytoplasmic vesicle, Lysosome, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | Sequence analysisAdd BLAST | 33 | |
PropeptideiPRO_0000027316 | 34 – 36 | By similarity | 3 | |
ChainiPRO_0000027317 | 37 – 506 | Dipeptidyl peptidase 2Add BLAST | 470 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 60 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 96 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 325 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 366 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 373 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 438 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, ZymogenProteomic databases
EPDi | Q9ET22 |
jPOSTi | Q9ET22 |
MaxQBi | Q9ET22 |
PaxDbi | Q9ET22 |
PeptideAtlasi | Q9ET22 |
PRIDEi | Q9ET22 |
ProteomicsDBi | 277600 |
PTM databases
GlyConnecti | 2256, 2 N-Linked glycans (2 sites) |
GlyGeni | Q9ET22, 6 sites, 2 N-linked glycans (2 sites) |
iPTMneti | Q9ET22 |
PhosphoSitePlusi | Q9ET22 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000026958, Expressed in epithelium of small intestine and 300 other tissues |
Genevisiblei | Q9ET22, MM |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
BioGRIDi | 219972, 20 interactors |
STRINGi | 10090.ENSMUSP00000028332 |
Miscellaneous databases
RNActi | Q9ET22, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase S28 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG2183, Eukaryota |
GeneTreei | ENSGT00940000159838 |
HOGENOMi | CLU_020959_0_0_1 |
InParanoidi | Q9ET22 |
OMAi | IKGGAHH |
OrthoDBi | 555765at2759 |
PhylomeDBi | Q9ET22 |
TreeFami | TF314414 |
Family and domain databases
Gene3Di | 1.20.120.980, 1 hit 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR008758, Peptidase_S28 IPR042269, Ser_carbopepase_S28_SKS |
Pfami | View protein in Pfam PF05577, Peptidase_S28, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9ET22-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNFHPCYPVD HGVPSWILVL LLSLGLCNLQ ARADRVLDPD FHENYFEQYM
60 70 80 90 100
DHFNFESFGN KTFGQRFLVS DKFWKMGEGP IFFYTGNEGD IWSFANNSGF
110 120 130 140 150
MVELAAQQEA LLVFAEHRYY GKSLPFGVQS TQRGYTQLLT VEQALADFAV
160 170 180 190 200
LLQALRQDLG VHDAPTIAFG GSYGGMLSAY MRMKYPHLVA GALAASAPVV
210 220 230 240 250
AVAGLGDSYQ FFRDVTADFY GQSPKCAQAV RDAFQQIKDL FLQGAYDTIS
260 270 280 290 300
QNFGTCQSLS SPKDLTQLFG FARNAFTVLA MMDYPYPTDF LGPLPANPVK
310 320 330 340 350
VGCQRLLNEG QRIMGLRALA GLVYNSSGTE PCYDIYRLYQ SCADPTGCGT
360 370 380 390 400
GSDARAWDYQ ACTEINLTFD SNNVTDMFPE IPFSEELRQQ YCLDTWGVWP
410 420 430 440 450
RQDWLQTSFW GGDLKAASNI IFSNGDLDPW AGGGIQSNLS TSVIAVTIQG
460 470 480 490 500
GAHHLDLRAS NSEDPPSVVE VRKLESTLIR EWVAAARLKQ PAMPRWPGPK
KQHPSR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 497 | P → L in AAG01154 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF285235 mRNA Translation: AAG01154.1 AL732557 Genomic DNA No translation available. CH466542 Genomic DNA Translation: EDL08237.1 BC027205 mRNA Translation: AAH27205.1 |
CCDSi | CCDS15766.1 |
RefSeqi | NP_114031.2, NM_031843.2 |
Genome annotation databases
Ensembli | ENSMUST00000028332; ENSMUSP00000028332; ENSMUSG00000026958 |
GeneIDi | 83768 |
KEGGi | mmu:83768 |
UCSCi | uc008irq.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF285235 mRNA Translation: AAG01154.1 AL732557 Genomic DNA No translation available. CH466542 Genomic DNA Translation: EDL08237.1 BC027205 mRNA Translation: AAH27205.1 |
CCDSi | CCDS15766.1 |
RefSeqi | NP_114031.2, NM_031843.2 |
3D structure databases
SMRi | Q9ET22 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 219972, 20 interactors |
STRINGi | 10090.ENSMUSP00000028332 |
Chemistry databases
ChEMBLi | CHEMBL3259501 |
Protein family/group databases
ESTHERi | mouse-dpp2, Prolylcarboxypeptidase |
MEROPSi | S28.002 |
PTM databases
GlyConnecti | 2256, 2 N-Linked glycans (2 sites) |
GlyGeni | Q9ET22, 6 sites, 2 N-linked glycans (2 sites) |
iPTMneti | Q9ET22 |
PhosphoSitePlusi | Q9ET22 |
Proteomic databases
EPDi | Q9ET22 |
jPOSTi | Q9ET22 |
MaxQBi | Q9ET22 |
PaxDbi | Q9ET22 |
PeptideAtlasi | Q9ET22 |
PRIDEi | Q9ET22 |
ProteomicsDBi | 277600 |
Protocols and materials databases
Antibodypediai | 18905, 298 antibodies from 33 providers |
DNASUi | 83768 |
Genome annotation databases
Ensembli | ENSMUST00000028332; ENSMUSP00000028332; ENSMUSG00000026958 |
GeneIDi | 83768 |
KEGGi | mmu:83768 |
UCSCi | uc008irq.1, mouse |
Organism-specific databases
CTDi | 29952 |
MGIi | MGI:1933213, Dpp7 |
VEuPathDBi | HostDB:ENSMUSG00000026958 |
Phylogenomic databases
eggNOGi | KOG2183, Eukaryota |
GeneTreei | ENSGT00940000159838 |
HOGENOMi | CLU_020959_0_0_1 |
InParanoidi | Q9ET22 |
OMAi | IKGGAHH |
OrthoDBi | 555765at2759 |
PhylomeDBi | Q9ET22 |
TreeFami | TF314414 |
Enzyme and pathway databases
Reactomei | R-MMU-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 83768, 5 hits in 64 CRISPR screens |
ChiTaRSi | Dpp7, mouse |
PROi | PR:Q9ET22 |
RNActi | Q9ET22, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026958, Expressed in epithelium of small intestine and 300 other tissues |
Genevisiblei | Q9ET22, MM |
Family and domain databases
Gene3Di | 1.20.120.980, 1 hit 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR008758, Peptidase_S28 IPR042269, Ser_carbopepase_S28_SKS |
Pfami | View protein in Pfam PF05577, Peptidase_S28, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DPP2_MOUSE | |
Accessioni | Q9ET22Primary (citable) accession number: Q9ET22 Secondary accession number(s): Q8R082 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families