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Protein

Nucleolar protein of 40 kDa

Gene

Zcchc17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri131 – 148CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

  • RNA binding Source: MGI
  • zinc ion binding Source: InterPro

Keywordsi

Molecular functionRibonucleoprotein
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein of 40 kDa
Short name:
pNO40
Alternative name(s):
Putative S1 RNA-binding domain protein
Short name:
PS1D protein
Zinc finger CCHC domain-containing protein 17
Gene namesi
Name:Zcchc17
Synonyms:Ps1d
ORF Names:Ldc4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1919955 Zcchc17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000969041 – 241Nucleolar protein of 40 kDaAdd BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei114PhosphoserineBy similarity1
Modified residuei144N6-acetyllysineCombined sources1
Modified residuei183PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9ESX4
PRIDEiQ9ESX4

PTM databases

iPTMnetiQ9ESX4
PhosphoSitePlusiQ9ESX4

Expressioni

Tissue specificityi

Expressed in liver, brain, heart, kidney testis, stomach, small intestine, skin, thymus, uterus, placenta, spleen, lung and skeletal muscle.2 Publications

Gene expression databases

BgeeiENSMUSG00000028772 Expressed in 269 organ(s), highest expression level in brain
CleanExiMM_ZCCHC17
ExpressionAtlasiQ9ESX4 baseline and differential
GenevisibleiQ9ESX4 MM

Interactioni

Subunit structurei

Interacts with PNN (By similarity). Associates with the 60S ribosomal subunit.By similarity1 Publication

Protein-protein interaction databases

IntActiQ9ESX4, 1 interactor
STRINGi10090.ENSMUSP00000120807

Structurei

3D structure databases

ProteinModelPortaliQ9ESX4
SMRiQ9ESX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 88S1 motifPROSITE-ProRule annotationAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi110 – 113Poly-Arg4
Compositional biasi165 – 240Lys-richAdd BLAST76

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri131 – 148CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410INHE Eukaryota
COG1185 LUCA
GeneTreeiENSGT00510000047363
HOGENOMiHOG000113809
HOVERGENiHBG080343
InParanoidiQ9ESX4
OMAiVWIKVIG
OrthoDBiEOG091G0WQ8
PhylomeDBiQ9ESX4
TreeFamiTF332136

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR037320 pNO40
IPR022967 S1_dom
IPR003029 S1_domain
IPR001878 Znf_CCHC
PANTHERiPTHR15838 PTHR15838, 1 hit
PfamiView protein in Pfam
PF00575 S1, 1 hit
SMARTiView protein in SMART
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS50126 S1, 1 hit
PS50158 ZF_CCHC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9ESX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSGRPETME NLPALYTIFQ GEVAMVTDYG AFIKIPGCRK QGLVHRTHMS
60 70 80 90 100
SCRVDKPSEI VDVGDKVWVK LIGREMKNDR IKVSLSMKVV NQGTGKDLDP
110 120 130 140 150
NNVVIEQEER RRRSFQDYTG QKITLEAVLN TTCKKCGCKG HFAKDCFMQP
160 170 180 190 200
GGTKYSLIPE EEEEKEEAKA EGLEKPDPTK NSSRKRKKEK KKKKHRDRKS
210 220 230 240
SDCDSSDSES DTGKKARHSS KDSKATKKKK KKKKHKKKHK E
Length:241
Mass (Da):27,472
Last modified:March 1, 2001 - v1
Checksum:iC6F6B3B420716167
GO
Isoform 2 (identifier: Q9ESX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.

Note: Less abundant than isoform 1.
Show »
Length:193
Mass (Da):22,110
Checksum:i112260AF299D2156
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0153091 – 48Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272345 mRNA Translation: CAC03718.1
AY253297 mRNA Translation: AAO83392.1
BC018382 mRNA Translation: AAH18382.1
BC049231 mRNA Translation: AAH49231.1
CCDSiCCDS38891.1 [Q9ESX4-1]
RefSeqiNP_694800.1, NM_153160.4 [Q9ESX4-1]
XP_006503322.1, XM_006503259.1
XP_006503323.1, XM_006503260.1
UniGeneiMm.297196

Genome annotation databases

EnsembliENSMUST00000134159; ENSMUSP00000120807; ENSMUSG00000028772 [Q9ESX4-1]
ENSMUST00000205840; ENSMUSP00000146234; ENSMUSG00000108747 [Q9ESX4-1]
GeneIDi619605
KEGGimmu:619605
UCSCiuc008uze.1 mouse [Q9ESX4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272345 mRNA Translation: CAC03718.1
AY253297 mRNA Translation: AAO83392.1
BC018382 mRNA Translation: AAH18382.1
BC049231 mRNA Translation: AAH49231.1
CCDSiCCDS38891.1 [Q9ESX4-1]
RefSeqiNP_694800.1, NM_153160.4 [Q9ESX4-1]
XP_006503322.1, XM_006503259.1
XP_006503323.1, XM_006503260.1
UniGeneiMm.297196

3D structure databases

ProteinModelPortaliQ9ESX4
SMRiQ9ESX4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9ESX4, 1 interactor
STRINGi10090.ENSMUSP00000120807

PTM databases

iPTMnetiQ9ESX4
PhosphoSitePlusiQ9ESX4

Proteomic databases

PaxDbiQ9ESX4
PRIDEiQ9ESX4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000134159; ENSMUSP00000120807; ENSMUSG00000028772 [Q9ESX4-1]
ENSMUST00000205840; ENSMUSP00000146234; ENSMUSG00000108747 [Q9ESX4-1]
GeneIDi619605
KEGGimmu:619605
UCSCiuc008uze.1 mouse [Q9ESX4-1]

Organism-specific databases

CTDi51538
MGIiMGI:1919955 Zcchc17

Phylogenomic databases

eggNOGiENOG410INHE Eukaryota
COG1185 LUCA
GeneTreeiENSGT00510000047363
HOGENOMiHOG000113809
HOVERGENiHBG080343
InParanoidiQ9ESX4
OMAiVWIKVIG
OrthoDBiEOG091G0WQ8
PhylomeDBiQ9ESX4
TreeFamiTF332136

Miscellaneous databases

ChiTaRSiZcchc17 mouse
PROiPR:Q9ESX4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028772 Expressed in 269 organ(s), highest expression level in brain
CleanExiMM_ZCCHC17
ExpressionAtlasiQ9ESX4 baseline and differential
GenevisibleiQ9ESX4 MM

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR037320 pNO40
IPR022967 S1_dom
IPR003029 S1_domain
IPR001878 Znf_CCHC
PANTHERiPTHR15838 PTHR15838, 1 hit
PfamiView protein in Pfam
PF00575 S1, 1 hit
SMARTiView protein in SMART
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS50126 S1, 1 hit
PS50158 ZF_CCHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNO40_MOUSE
AccessioniPrimary (citable) accession number: Q9ESX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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