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Protein

Eukaryotic translation initiation factor 4E transporter

Gene

Eif4enif1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism.By similarity

GO - Molecular functioni

  • mRNA binding Source: MGI

GO - Biological processi

  • negative regulation of neuron differentiation Source: MGI
  • negative regulation of translation Source: MGI
  • protein transport Source: UniProtKB-KW
  • stem cell population maintenance Source: MGI

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E transporter
Short name:
4E-T
Short name:
eIF4E transporter
Alternative name(s):
Eukaryotic translation initiation factor 4E nuclear import factor 1
Gene namesi
Name:Eif4enif1
Synonyms:Clast4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1921453 Eif4enif1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643821 – 983Eukaryotic translation initiation factor 4E transporterAdd BLAST983

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei73PhosphoserineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei114PhosphoserineBy similarity1
Modified residuei119PhosphoserineBy similarity1
Modified residuei135PhosphoserineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei300PhosphoserineBy similarity1
Modified residuei344PhosphoserineBy similarity1
Modified residuei352PhosphoserineBy similarity1
Cross-linki409Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei416PhosphoserineBy similarity1
Modified residuei485N6-acetyllysineBy similarity1
Modified residuei563PhosphoserineCombined sources1
Modified residuei586PhosphoserineCombined sources1
Modified residuei692PhosphoserineBy similarity1
Modified residuei919PhosphoserineBy similarity1
Modified residuei949PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9EST3
PaxDbiQ9EST3
PeptideAtlasiQ9EST3
PRIDEiQ9EST3

PTM databases

iPTMnetiQ9EST3
PhosphoSitePlusiQ9EST3

Expressioni

Gene expression databases

BgeeiENSMUSG00000020454 Expressed in 276 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiQ9EST3 baseline and differential
GenevisibleiQ9EST3 MM

Interactioni

Subunit structurei

Interacts with EIF4E. Interacts with importin beta only in the presence of importin alpha, suggesting a direct interaction with importin alpha. Interacts with APOBEC3G in an RNA-dependent manner.By similarity

Protein-protein interaction databases

BioGridi216574, 6 interactors
STRINGi10090.ENSMUSP00000105676

Structurei

3D structure databases

SMRiQ9EST3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 35EIF4E-bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi194 – 210Nuclear localization signalBy similarityAdd BLAST17
Motifi437 – 446Nuclear export signalBy similarity10
Motifi612 – 637Nuclear export signalBy similarityAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi147 – 209Arg-richAdd BLAST63

Phylogenomic databases

eggNOGiENOG410IG0J Eukaryota
ENOG41110MN LUCA
GeneTreeiENSGT00390000012071
HOGENOMiHOG000232370
HOVERGENiHBG023298
InParanoidiQ9EST3
KOiK18728
OMAiYPASGRN
OrthoDBiEOG091G04PY
TreeFamiTF101531

Family and domain databases

InterProiView protein in InterPro
IPR018862 eIF4E-T
PANTHERiPTHR12269 PTHR12269, 1 hit
PfamiView protein in Pfam
PF10477 EIF4E-T, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9EST3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKSVAETEN GDAFLELKKL PTSKSPHRYT KEELLDIKER PYSKQRPSCL
60 70 80 90 100
SEKYDSDGVW DPEKWHASLY PASGRSSPVE SLKKESESDR PSLVRRIADP
110 120 130 140 150
RERVKEDDLD VVLSPQRRSF GGGCHVTAAV SSRRSGSPLE KDSDGLRLLG
160 170 180 190 200
GRRIGSGRII SARAFEKDHR LSDKDLRDLR DRDRERDYKD KRFRREFGDS
210 220 230 240 250
KRVFGERRRN DSYTEEEPEW FSAGPTSQSE TIELTGFDDK ILEEDHKGRK
260 270 280 290 300
RTRRRTASVK EGIVECNGGV AEEDEVEVIL AQEPSADQEV PRDVILPEQS
310 320 330 340 350
PGEFDFNEFF NLDKVPCLAS MIEDVLGEGS VSASRFSRWF SNPSRSGSRS
360 370 380 390 400
SSLGSTPHEE LERLAGLEQA VLSPGQNSGN YFAPIPSEDH AENKVDILEM
410 420 430 440 450
LQKAKVDLKP LLSSLSANKE KLKESSHSGV VLSVEEVEAG LKGLKVDQQM
460 470 480 490 500
KNSTPFMAEH LEETLSAASS NRQLKKDGDM TAFNKLVNTM KASGTLPTQP
510 520 530 540 550
KVSRNVESHL LAPAEIPGQP VSKNILQELL GQPVQRPASS NLLSGLMGSL
560 570 580 590 600
EATASLLSQR APSPPMSQVF RTQAASADYL HPRIPSPIGF PSGPQQLLGD
610 620 630 640 650
PFQGMRKPMS PVSAQMSQLE LQQAALEGLA LPHDLAVQTA PFYQPGFSKP
660 670 680 690 700
QVDRTRDGLR NRQQRMSKSP APMHGGNSSS PAPAASITSM LSPSFTPTSV
710 720 730 740 750
IRKMYESREK TKEEMAPGMV VPGDGKEDTQ KTSEENLLSS NPIPNTDQDS
760 770 780 790 800
STTNPKLSTL QRSSCSTPLS QTSRYTKEQD YRPKTAGRKT PTLASPVPGT
810 820 830 840 850
PFLRPTHQVP LVPHVPIVRP AHQLHPGLVQ RLIAQGVHPQ HLPSLLQAGV
860 870 880 890 900
LPPGIDMAPL QGLSGPLLGQ PLYPLVSAAS HPLLNPRPGT PLHLAVMQQQ
910 920 930 940 950
LQRSVLHPPG SSSQAAAISV QTPQNVPSRS GMPHMHSQLE HRTSQRSSSP
960 970 980
VGLAKWFGSD VLQQPLPSMP TKVISVDELE YRQ
Length:983
Mass (Da):107,986
Last modified:July 27, 2011 - v2
Checksum:iC010A10376699DA8
GO
Isoform 2 (identifier: Q9EST3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     504-527: Missing.

Note: No experimental confirmation available.
Show »
Length:959
Mass (Da):105,393
Checksum:i8B4CC73C34EB492C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8Y5K6A8Y5K6_MOUSE
Eukaryotic translation initiation f...
Eif4enif1
808Annotation score:
Q5NBZ7Q5NBZ7_MOUSE
Eukaryotic translation initiation f...
Eif4enif1
194Annotation score:
Q5NBZ4Q5NBZ4_MOUSE
Eukaryotic translation initiation f...
Eif4enif1
239Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti345R → Q in BAB11963 (Ref. 1) Curated1
Sequence conflicti773S → N in BAB11963 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003785504 – 527Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031388 mRNA Translation: BAB11963.1
AL671968 Genomic DNA Translation: CAI35201.1
CH466574 Genomic DNA Translation: EDL40398.1
BC033410 mRNA Translation: AAH33410.1
AK012082 mRNA Translation: BAB28016.1
CCDSiCCDS24354.1 [Q9EST3-1]
CCDS48739.1 [Q9EST3-2]
RefSeqiNP_001160019.1, NM_001166547.1 [Q9EST3-1]
NP_001160020.1, NM_001166548.1 [Q9EST3-2]
NP_001160021.1, NM_001166549.1 [Q9EST3-2]
NP_076232.2, NM_023743.2 [Q9EST3-1]
XP_006514904.1, XM_006514841.2 [Q9EST3-1]
XP_006514905.1, XM_006514842.3 [Q9EST3-1]
XP_006514906.1, XM_006514843.3 [Q9EST3-1]
XP_006514907.1, XM_006514844.2 [Q9EST3-2]
XP_017170295.1, XM_017314806.1 [Q9EST3-2]
UniGeneiMm.255649

Genome annotation databases

EnsembliENSMUST00000020734; ENSMUSP00000020734; ENSMUSG00000020454 [Q9EST3-2]
ENSMUST00000110048; ENSMUSP00000105675; ENSMUSG00000020454 [Q9EST3-2]
ENSMUST00000110049; ENSMUSP00000105676; ENSMUSG00000020454 [Q9EST3-1]
ENSMUST00000179770; ENSMUSP00000136768; ENSMUSG00000020454 [Q9EST3-1]
GeneIDi74203
KEGGimmu:74203
UCSCiuc007hsc.2 mouse [Q9EST3-2]
uc007hse.2 mouse [Q9EST3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031388 mRNA Translation: BAB11963.1
AL671968 Genomic DNA Translation: CAI35201.1
CH466574 Genomic DNA Translation: EDL40398.1
BC033410 mRNA Translation: AAH33410.1
AK012082 mRNA Translation: BAB28016.1
CCDSiCCDS24354.1 [Q9EST3-1]
CCDS48739.1 [Q9EST3-2]
RefSeqiNP_001160019.1, NM_001166547.1 [Q9EST3-1]
NP_001160020.1, NM_001166548.1 [Q9EST3-2]
NP_001160021.1, NM_001166549.1 [Q9EST3-2]
NP_076232.2, NM_023743.2 [Q9EST3-1]
XP_006514904.1, XM_006514841.2 [Q9EST3-1]
XP_006514905.1, XM_006514842.3 [Q9EST3-1]
XP_006514906.1, XM_006514843.3 [Q9EST3-1]
XP_006514907.1, XM_006514844.2 [Q9EST3-2]
XP_017170295.1, XM_017314806.1 [Q9EST3-2]
UniGeneiMm.255649

3D structure databases

SMRiQ9EST3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216574, 6 interactors
STRINGi10090.ENSMUSP00000105676

PTM databases

iPTMnetiQ9EST3
PhosphoSitePlusiQ9EST3

Proteomic databases

EPDiQ9EST3
PaxDbiQ9EST3
PeptideAtlasiQ9EST3
PRIDEiQ9EST3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020734; ENSMUSP00000020734; ENSMUSG00000020454 [Q9EST3-2]
ENSMUST00000110048; ENSMUSP00000105675; ENSMUSG00000020454 [Q9EST3-2]
ENSMUST00000110049; ENSMUSP00000105676; ENSMUSG00000020454 [Q9EST3-1]
ENSMUST00000179770; ENSMUSP00000136768; ENSMUSG00000020454 [Q9EST3-1]
GeneIDi74203
KEGGimmu:74203
UCSCiuc007hsc.2 mouse [Q9EST3-2]
uc007hse.2 mouse [Q9EST3-1]

Organism-specific databases

CTDi56478
MGIiMGI:1921453 Eif4enif1

Phylogenomic databases

eggNOGiENOG410IG0J Eukaryota
ENOG41110MN LUCA
GeneTreeiENSGT00390000012071
HOGENOMiHOG000232370
HOVERGENiHBG023298
InParanoidiQ9EST3
KOiK18728
OMAiYPASGRN
OrthoDBiEOG091G04PY
TreeFamiTF101531

Miscellaneous databases

ChiTaRSiEif4enif1 mouse
PROiPR:Q9EST3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020454 Expressed in 276 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiQ9EST3 baseline and differential
GenevisibleiQ9EST3 MM

Family and domain databases

InterProiView protein in InterPro
IPR018862 eIF4E-T
PANTHERiPTHR12269 PTHR12269, 1 hit
PfamiView protein in Pfam
PF10477 EIF4E-T, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei4ET_MOUSE
AccessioniPrimary (citable) accession number: Q9EST3
Secondary accession number(s): Q8CFW0, Q9CSS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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