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Protein

Gasdermin-A

Gene

Gsdma

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May promote pyroptosis. Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity. The physiological relevance of these observations is unknown.By similarity

GO - Biological processi

Keywordsi

Biological processNecrosis

Names & Taxonomyi

Protein namesi
Recommended name:
Gasdermin-A
Alternative name(s):
Gasdermin-1
Gasdermin-A1
Gene namesi
Name:Gsdma
Synonyms:Gsdm, Gsdm1, Gsdma1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1889509 Gsdma

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001481741 – 446Gasdermin-AAdd BLAST446

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9EST1
PaxDbiQ9EST1
PRIDEiQ9EST1

PTM databases

PhosphoSitePlusiQ9EST1
SwissPalmiQ9EST1

Expressioni

Tissue specificityi

Expressed predominantly in the gastrointestinal (GI) tract and in the skin at a lower level. In the GI tract, the expression is highly restricted to the esophagus and forestomach.2 Publications

Developmental stagei

Expression is first detected at E12.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000017204 Expressed in 51 organ(s), highest expression level in prostate gland
CleanExiMM_GSDMA1
GenevisibleiQ9EST1 MM

Interactioni

Subunit structurei

The N-terminal moiety forms homooligomer; disulfide-linked. May form an 16-mer complex. Oligomerization occurs in the presence of membranes.By similarity

Protein-protein interaction databases

BioGridi208361, 1 interactor
IntActiQ9EST1, 1 interactor
MINTiQ9EST1
STRINGi10090.ENSMUSP00000017348

Structurei

3D structure databases

ProteinModelPortaliQ9EST1
SMRiQ9EST1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 252Triggers pyroptosisBy similarityAdd BLAST252

Domaini

Intramolecular interactions between N- and C-terminal domains may be important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain.By similarity

Sequence similaritiesi

Belongs to the gasdermin family.Curated

Phylogenomic databases

eggNOGiENOG410IH8H Eukaryota
ENOG41116WI LUCA
GeneTreeiENSGT00530000063218
HOGENOMiHOG000082450
HOVERGENiHBG107968
InParanoidiQ9EST1
KOiK22141
OMAiFRVRQLM
OrthoDBiEOG091G09ST
PhylomeDBiQ9EST1
TreeFamiTF331886

Family and domain databases

InterProiView protein in InterPro
IPR007677 Gasdermin
PANTHERiPTHR16399 PTHR16399, 1 hit
PfamiView protein in Pfam
PF04598 Gasdermin, 1 hit

Sequencei

Sequence statusi: Complete.

Q9EST1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMFENVTRA LARQLNPRGD LTPLDSLIDF KRFHPFCLVL RKRKSTLFWG
60 70 80 90 100
ARYVHTDYTL LDVLEPGSSP SDPTDSGNFS FKNMLDARVE GDVDVPKTVK
110 120 130 140 150
VKGTAGLSRS STLEVQTLSV APTALENLHK ERKLSADHPF LKEMRERGEN
160 170 180 190 200
LYVVMEVVET LQEVTLERAG KAEGCFSLPF FAPLGLQGSV NHKEAVTIPK
210 220 230 240 250
GCVLAYRVRQ LMVNGKDEWG IPHICNDSMQ TFPPGEKPGE GKFILIQASD
260 270 280 290 300
VGEMHEDFKT LKEEVQRETQ EVEKLSPVGR SSLLTSLSHL LGKKKELQDL
310 320 330 340 350
EQTLEGALDK GHEVTLEALP KDVLLSKDAM DAILYFLGAL TVLSEAQQKL
360 370 380 390 400
LVKSLEKKIL PVQLKLVEST MEKNFLQDKE GVFPLQPDLL SSLGEEELIL
410 420 430 440
TEALVGLSGL EVQRSGPQYT WDPDTLPHLC ALYAGLSLLQ LLSKNS
Length:446
Mass (Da):49,593
Last modified:March 1, 2001 - v1
Checksum:i603673EC007CB305
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033595 mRNA Translation: BAB13697.1
AK028645 mRNA Translation: BAC26045.1
AK028698 mRNA Translation: BAC26073.1
AK029062 mRNA Translation: BAC26272.1
AL590963 Genomic DNA No translation available.
CCDSiCCDS25358.1
RefSeqiNP_067322.1, NM_021347.4
UniGeneiMm.458085

Genome annotation databases

EnsembliENSMUST00000017348; ENSMUSP00000017348; ENSMUSG00000017204
GeneIDi57911
KEGGimmu:57911
UCSCiuc007lgv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033595 mRNA Translation: BAB13697.1
AK028645 mRNA Translation: BAC26045.1
AK028698 mRNA Translation: BAC26073.1
AK029062 mRNA Translation: BAC26272.1
AL590963 Genomic DNA No translation available.
CCDSiCCDS25358.1
RefSeqiNP_067322.1, NM_021347.4
UniGeneiMm.458085

3D structure databases

ProteinModelPortaliQ9EST1
SMRiQ9EST1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208361, 1 interactor
IntActiQ9EST1, 1 interactor
MINTiQ9EST1
STRINGi10090.ENSMUSP00000017348

PTM databases

PhosphoSitePlusiQ9EST1
SwissPalmiQ9EST1

Proteomic databases

MaxQBiQ9EST1
PaxDbiQ9EST1
PRIDEiQ9EST1

Protocols and materials databases

DNASUi57911
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017348; ENSMUSP00000017348; ENSMUSG00000017204
GeneIDi57911
KEGGimmu:57911
UCSCiuc007lgv.1 mouse

Organism-specific databases

CTDi284110
MGIiMGI:1889509 Gsdma

Phylogenomic databases

eggNOGiENOG410IH8H Eukaryota
ENOG41116WI LUCA
GeneTreeiENSGT00530000063218
HOGENOMiHOG000082450
HOVERGENiHBG107968
InParanoidiQ9EST1
KOiK22141
OMAiFRVRQLM
OrthoDBiEOG091G09ST
PhylomeDBiQ9EST1
TreeFamiTF331886

Miscellaneous databases

PROiPR:Q9EST1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017204 Expressed in 51 organ(s), highest expression level in prostate gland
CleanExiMM_GSDMA1
GenevisibleiQ9EST1 MM

Family and domain databases

InterProiView protein in InterPro
IPR007677 Gasdermin
PANTHERiPTHR16399 PTHR16399, 1 hit
PfamiView protein in Pfam
PF04598 Gasdermin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGSDMA_MOUSE
AccessioniPrimary (citable) accession number: Q9EST1
Secondary accession number(s): A3KFN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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