UniProtKB - Q9ESS6 (BCAM_RAT)
Protein
Basal cell adhesion molecule
Gene
Bcam
Organism
Rattus norvegicus (Rat)
Status
Functioni
Laminin alpha-5 receptor. May mediate intracellular signaling (By similarity).By similarity
GO - Molecular functioni
- laminin binding Source: RGD
- laminin receptor activity Source: RGD
- protein C-terminus binding Source: RGD
GO - Biological processi
- cell adhesion Source: RGD
- cell-matrix adhesion Source: RGD
Keywordsi
Molecular function | Receptor |
Biological process | Cell adhesion |
Names & Taxonomyi
Protein namesi | Recommended name: Basal cell adhesion moleculeAlternative name(s): B-CAM cell surface glycoprotein Lutheran antigen CD_antigen: CD239 |
Gene namesi | Name:Bcam Synonyms:Lu |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 68378, Bcam |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- cell surface Source: RGD
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 543 | ExtracellularSequence analysisAdd BLAST | 518 | |
Transmembranei | 544 – 564 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 565 – 624 | CytoplasmicSequence analysisAdd BLAST | 60 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000383339 | 26 – 624 | Basal cell adhesion moleculeAdd BLAST | 599 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 47 ↔ 119 | PROSITE-ProRule annotation | ||
Disulfide bondi | 166 ↔ 231 | PROSITE-ProRule annotation | ||
Disulfide bondi | 285 ↔ 331 | PROSITE-ProRule annotation | ||
Glycosylationi | 315 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 371 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 378 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 379 ↔ 419 | PROSITE-ProRule annotation | ||
Disulfide bondi | 468 ↔ 518 | PROSITE-ProRule annotation | ||
Modified residuei | 592 | PhosphoserineBy similarity | 1 | |
Modified residuei | 594 | PhosphoserineBy similarity | 1 | |
Modified residuei | 596 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q9ESS6 |
PaxDbi | Q9ESS6 |
PRIDEi | Q9ESS6 |
PTM databases
GlyGeni | Q9ESS6, 3 sites |
iPTMneti | Q9ESS6 |
PhosphoSitePlusi | Q9ESS6 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000029399, Expressed in lung and 21 other tissues |
Genevisiblei | Q9ESS6, RN |
Interactioni
GO - Molecular functioni
- laminin binding Source: RGD
- laminin receptor activity Source: RGD
- protein C-terminus binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 249366, 1 interactor |
STRINGi | 10116.ENSRNOP00000047809 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 136 | Ig-like V-type 1Add BLAST | 111 | |
Domaini | 141 – 251 | Ig-like V-type 2Add BLAST | 111 | |
Domaini | 268 – 343 | Ig-like C2-type 1Add BLAST | 76 | |
Domaini | 357 – 436 | Ig-like C2-type 2Add BLAST | 80 | |
Domaini | 443 – 534 | Ig-like C2-type 3Add BLAST | 92 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QWC8, Eukaryota |
GeneTreei | ENSGT00940000161038 |
HOGENOMi | CLU_028888_1_0_1 |
InParanoidi | Q9ESS6 |
OMAi | GCRVEDF |
OrthoDBi | 864786at2759 |
PhylomeDBi | Q9ESS6 |
TreeFami | TF330534 |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit PF13895, Ig_2, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 5 hits SM00408, IGc2, 3 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 5 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9ESS6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPPDARAGL LWLTLLLSGY SGAQAELHVS VPPRVEVMRG EQIALDCTPR
60 70 80 90 100
EHPENYVLEW LLVDASGARH RLASVEPQGS EFLGTIHNSR GRRPPYKIDS
110 120 130 140 150
LGRLVIAEAQ VGDERDYVCV VKAGAAGTSE ATSSVRVFAT PEATEVAPNK
160 170 180 190 200
GTLSVMEQFA QEIATCSSNN GNPVPRITWY QNGQRLDVPM ELNSKGYMTS
210 220 230 240 250
RTVREASGLY SLTSTLYLRL HKEDRDASFH CAAHYDLPSG QHGRLDSHTF
260 270 280 290 300
RLTLHYPTEH VEFWVGSPST TEGWVREGDA VQLLCQGDGS PSPEYSFFRE
310 320 330 340 350
QGNQEEQLNV NLKGNLTLEG VHRSQSGIYG CRVEDYDADE EVQLVKKLKL
360 370 380 390 400
HVAYLDPLEL SVPEEFSVFL NSSGTVVNCS ARGLPAPIVR WTKDSVTVAD
410 420 430 440 450
GPILSLDSVT FDSAGTYTCE ASTPTVPLLS RTQSFQLVVQ GAPELKPNEI
460 470 480 490 500
KPKSGTSWTE GDEVMLTCSA RGFPEPKLTW SQRGDTTPAE PPFEGRGWMS
510 520 530 540 550
SSLTLKVTSA LSREGVSCEA SNIHGKNGHV FHFGSVAPQT AQAGVAVMAV
560 570 580 590 600
AVSVGLLLLV VAAFYCMRRK GRPGCCQRAE KGAPPAREPE LSHSGSERPE
610 620
HTGLLMGGPS GGGRGGNGGF GDEC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB035510 mRNA Translation: BAB16052.1 CH473979 Genomic DNA Translation: EDM08138.1 BC072479 mRNA Translation: AAH72479.1 |
RefSeqi | NP_113940.1, NM_031752.2 |
Genome annotation databases
Ensembli | ENSRNOT00000045574; ENSRNOP00000047809; ENSRNOG00000029399 |
GeneIDi | 78958 |
KEGGi | rno:78958 |
UCSCi | RGD:68378, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB035510 mRNA Translation: BAB16052.1 CH473979 Genomic DNA Translation: EDM08138.1 BC072479 mRNA Translation: AAH72479.1 |
RefSeqi | NP_113940.1, NM_031752.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 249366, 1 interactor |
STRINGi | 10116.ENSRNOP00000047809 |
PTM databases
GlyGeni | Q9ESS6, 3 sites |
iPTMneti | Q9ESS6 |
PhosphoSitePlusi | Q9ESS6 |
Proteomic databases
jPOSTi | Q9ESS6 |
PaxDbi | Q9ESS6 |
PRIDEi | Q9ESS6 |
Genome annotation databases
Ensembli | ENSRNOT00000045574; ENSRNOP00000047809; ENSRNOG00000029399 |
GeneIDi | 78958 |
KEGGi | rno:78958 |
UCSCi | RGD:68378, rat |
Organism-specific databases
CTDi | 4059 |
RGDi | 68378, Bcam |
Phylogenomic databases
eggNOGi | ENOG502QWC8, Eukaryota |
GeneTreei | ENSGT00940000161038 |
HOGENOMi | CLU_028888_1_0_1 |
InParanoidi | Q9ESS6 |
OMAi | GCRVEDF |
OrthoDBi | 864786at2759 |
PhylomeDBi | Q9ESS6 |
TreeFami | TF330534 |
Miscellaneous databases
PROi | PR:Q9ESS6 |
Gene expression databases
Bgeei | ENSRNOG00000029399, Expressed in lung and 21 other tissues |
Genevisiblei | Q9ESS6, RN |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit PF13895, Ig_2, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 5 hits SM00408, IGc2, 3 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BCAM_RAT | |
Accessioni | Q9ESS6Primary (citable) accession number: Q9ESS6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 1, 2009 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |