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Entry version 128 (26 Feb 2020)
Sequence version 1 (01 Mar 2001)
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Protein

ATP-binding cassette sub-family A member 2

Gene

Abca2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1024 – 1031ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi2088 – 2095ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-1369062 ABC transporters in lipid homeostasis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 2
Alternative name(s):
ATP-binding cassette transporter 2
Short name:
ATP-binding cassette 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Abca2Imported
Synonyms:Abc2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
620238 Abca2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei699 – 719HelicalSequence analysisAdd BLAST21
Transmembranei750 – 770HelicalSequence analysisAdd BLAST21
Transmembranei782 – 802HelicalSequence analysisAdd BLAST21
Transmembranei813 – 833HelicalSequence analysisAdd BLAST21
Transmembranei857 – 877HelicalSequence analysisAdd BLAST21
Transmembranei893 – 913HelicalSequence analysisAdd BLAST21
Transmembranei1461 – 1481HelicalSequence analysisAdd BLAST21
Transmembranei1793 – 1813HelicalSequence analysisAdd BLAST21
Transmembranei1842 – 1862HelicalSequence analysisAdd BLAST21
Transmembranei1873 – 1893HelicalSequence analysisAdd BLAST21
Transmembranei1906 – 1926HelicalSequence analysisAdd BLAST21
Transmembranei1992 – 2012HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000932921 – 2434ATP-binding cassette sub-family A member 2Add BLAST2434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi14N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei271N5-methylglutamineBy similarity1
Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi379N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi420N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi432N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi476N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi484N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi494N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi530N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi549N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi590N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi600N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi628N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1238PhosphoserineBy similarity1
Glycosylationi1247N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1327PhosphoserineCombined sources1
Modified residuei1331PhosphoserineCombined sources1
Glycosylationi1496N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1549N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1557N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1613N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1678N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1776N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2055N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2411PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication
Methylated at Gln-271 by N6AMT1.By similarity

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ESR9

PRoteomics IDEntifications database

More...
PRIDEi
Q9ESR9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ESR9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ESR9

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
Q9ESR9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in brain, at moderate levels in heart, kidney and lung, and at low levels in skeletal muscle, stomach, spleen, colon and pancreas. Not detected in the liver or small intestine. In brain, highly expressed in white matter and detected in oligodendrocytes.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
249446, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000020339

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ESR9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini990 – 1221ABC transporter 1PROSITE-ProRule annotationAdd BLAST232
Domaini2051 – 2286ABC transporter 2PROSITE-ProRule annotationAdd BLAST236

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0059 Eukaryota
COG1131 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ESR9

KEGG Orthology (KO)

More...
KOi
K05642

Database of Orthologous Groups

More...
OrthoDBi
131191at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ESR9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229 PTHR19229, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9ESR9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGFLHQLQLL LWKNVTLKRR SPWVLAFEIF IPLVLFFILL GLRQKKPTIS
60 70 80 90 100
VKEAFYTAAP LTSAGILPVM QSLCPDGQRD EFGFLQYANS TVTQLLERLN
110 120 130 140 150
RVVEESNLFD PERPSLGSEL EALHQRLEAL SSGPGTWESH SARPAVSSFS
160 170 180 190 200
LDSVARDKRE LWRFLMQNLS LPNSTAQALL AARVDPSEVY RLLFGPLPDL
210 220 230 240 250
DGKLGFLRKQ EPWSHLGSNP LFQMEELLLA PALLEQLTCA PGSGELGRIL
260 270 280 290 300
TMPEGHQVDL QGYRDAVCSG QATARAQHFS DLATELRNQL DIAKIAQQLG
310 320 330 340 350
FNVPNGSDPQ PQAPSPQSLQ ALLGDLLDVQ KVLQDVDVLS ALALLLPQGA
360 370 380 390 400
CAGRAPAPQA GSPSGPANST GVGANTGPNT TVEEGTQSPV TPASPDTLQG
410 420 430 440 450
QCSAFVQLWA GLQPILCGNN RTIEPEALRR GNMSSLGFTS KEQRNLGLLV
460 470 480 490 500
HLMTSNPKIL YAPAGSEADH VILKANETFA FVGNVTHYAQ VWLNISAEIR
510 520 530 540 550
SFLEQGRLQQ HLHWLQQYVA DLRLHPEAMN LSLDELPPAL RLDYFSLPNG
560 570 580 590 600
TALLQQLDTI DNAACGWIQF MSKVSVDIFK GFPDEESIVN YTLNQAYQDN
610 620 630 640 650
VTVFASVIFQ TRKDGSLPPH VHYKIRQNSS FTEKTNEIRR AYWRPGPNTG
660 670 680 690 700
GRFYFLYGFV WIQDMIERAI INTFVGHDVV EPGNYVQMFP YPCYTRDDFL
710 720 730 740 750
FVIEHMMPLC MVISWVYSVA MTIQHIVAEK EHRLKEVMKT MGLNNAVHWV
760 770 780 790 800
AWFITGFVQL SISVTALTAI LKYGQVLMHS HVLIIWLFLA VYAVATIMFC
810 820 830 840 850
FLVSVLYSKA KLASACGGII YFLSYVPYMY VAIREEVAHD KITAFEKCIA
860 870 880 890 900
SLMSTTAFGL GSKYFALYEV AGVGIQWHTF SQSPVEGDDF NLLLAVTMLM
910 920 930 940 950
VDTVVYGVLT WYIEAVHPGM YGLPRPWYFP LQKSYWLGSG RTETWEWSWP
960 970 980 990 1000
WAHAPRLSVM EEDQACAMES RHFEETRGME EEPTHLPLVV CVDKLTKVYK
1010 1020 1030 1040 1050
NDKKLALNKL SLNLYENQVV SFLGHNGAGK TTTMSILTGL FPPTSGSATI
1060 1070 1080 1090 1100
YGHDIRTEMD EIRKNLGMCP QHNVLFDQLT VEEHLWFYSR LKSMAQEEIR
1110 1120 1130 1140 1150
KEMDKMIEDL ELSNKRHSLV QTLSGGMKRK LSVAIAFVGG SRAIILDEPT
1160 1170 1180 1190 1200
AGVDPYARRA IWDLILKYKP GRTILLSTHH MDEADLLGDR IAIISHGKLK
1210 1220 1230 1240 1250
CCGSPLFLKG AYGDGYRLTL VKRPAEPGTS QEPGMASSPS GRPQLSNCSE
1260 1270 1280 1290 1300
MQVSQFIRKH VASSLLVSDT STELSYILPS EAVKKGAFER LFQQLEHSLD
1310 1320 1330 1340 1350
ALHLSSFGLM DTTLEEVFLK VSEEDQSLEN SEADVKESRK DALPGAEGLT
1360 1370 1380 1390 1400
AVESQAGNLA RCSELAQSQA SLQSASSVGS ARGDEGAGYT DGYGDYRPLF
1410 1420 1430 1440 1450
DNLQDPDSVS LQEAEMEALA RVGQGSRKLE GWWLKMRQFH GLLVKRFHCA
1460 1470 1480 1490 1500
RRNSKALCSQ ILLPAFFVCV AMTVALSVPE IGDLPPLVLS PSQYHNYTQP
1510 1520 1530 1540 1550
RGNFIPYANE ERREYRLRLS PDASPQQLVS TFRLPSGVGA TCVLKSPANG
1560 1570 1580 1590 1600
SLGPMLNLSS GESRLLAARF FDSMCLESFT QGLPLSNFVP PPPSPAPSDS
1610 1620 1630 1640 1650
PLSPDEDSLL AWNTSLPPTA GPETWTWAPS LPRLVHEPVR CTCSAQGTGF
1660 1670 1680 1690 1700
SCPSSVGGHP PQMRVVTGDI LTDITGHNVS EYLLFTSDRF RLHRYGAITF
1710 1720 1730 1740 1750
GNIQKSIPAP IGTRTPLMVR KIAVRRVAQV LYNNKGYHSM PTYLNSLNNA
1760 1770 1780 1790 1800
ILRANLPKSK GNPAAYGITV TNHPMNKTSA SLSLDYLLQG TDVVIAIFII
1810 1820 1830 1840 1850
VAMSFVPASF VVFLVAEKST KAKHLQFVSG CNPVIYWLAN YVWDMLNYLV
1860 1870 1880 1890 1900
PATCCIIILF VFDLPAYTSP TNFPAVLSLF LLYGWSITPI MYPASFWFEV
1910 1920 1930 1940 1950
PSSAYVFLIV INLFIGITAT VATFLLQLFE HDKDLKVVNS YLKSCFLIFP
1960 1970 1980 1990 2000
NYNLGHGLME IAYNEYINEY YAKIGQFDKM KSPFEWDIVT RGLVAMTVEG
2010 2020 2030 2040 2050
FVGFFLTIMC QYNFLRQPQR LPVSTKPVED DVDVASERQR VLRGDADNDM
2060 2070 2080 2090 2100
VKIENLTKVY KSRKIGRILA VDRLCLGVRP GECFGLLGVN GAGKTSTFKM
2110 2120 2130 2140 2150
LTGDESTTGG EAFVNGHSVL KDLLQVQQSL GYCPQFDALF DELTAREHLQ
2160 2170 2180 2190 2200
LYTRLRGIPW KDEAQVVRWA LEKLELTKCA DKPAGSYSGG NKRKLSTAIA
2210 2220 2230 2240 2250
LIGYPAFIFL DEPTTGMDPK ARRFLWNLIL DLIKTGRSVV LTSHSMEECE
2260 2270 2280 2290 2300
AVCTRLAIMV NGRLRCLGSI QHLKNRFGDG YMITVRTKSS QNVKDVVRFF
2310 2320 2330 2340 2350
NRNFPEAMLK ERHHTKVQYQ LKSEHISLAQ VFSKMEHVVG VLGIEDYSVS
2360 2370 2380 2390 2400
QTTLDNVFVN FAKKQSDNVE QQEAEPSTLP SPLGLLSLLR PRPAPTELRA
2410 2420 2430
LVADEPEDLD TEDEGLISFE EERAQLSFNT DTLC
Length:2,434
Mass (Da):270,928
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD424A9C4F63513F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V7X4G3V7X4_RAT
ATP-binding cassette sub-family A m...
Abca2
2,434Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB037937 mRNA Translation: BAB16596.1

NCBI Reference Sequences

More...
RefSeqi
NP_077372.1, NM_024396.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79248

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:79248

UCSC genome browser

More...
UCSCi
RGD:620238 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037937 mRNA Translation: BAB16596.1
RefSeqiNP_077372.1, NM_024396.1

3D structure databases

SMRiQ9ESR9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi249446, 1 interactor
STRINGi10116.ENSRNOP00000020339

PTM databases

iPTMnetiQ9ESR9
PhosphoSitePlusiQ9ESR9
UniCarbKBiQ9ESR9

Proteomic databases

PaxDbiQ9ESR9
PRIDEiQ9ESR9

Genome annotation databases

GeneIDi79248
KEGGirno:79248
UCSCiRGD:620238 rat

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
20
RGDi620238 Abca2

Phylogenomic databases

eggNOGiKOG0059 Eukaryota
COG1131 LUCA
InParanoidiQ9ESR9
KOiK05642
OrthoDBi131191at2759
PhylomeDBiQ9ESR9

Enzyme and pathway databases

ReactomeiR-RNO-1369062 ABC transporters in lipid homeostasis

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9ESR9

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR027417 P-loop_NTPase
PANTHERiPTHR19229 PTHR19229, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCA2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ESR9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2001
Last modified: February 26, 2020
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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