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Entry version 168 (13 Feb 2019)
Sequence version 1 (01 Mar 2001)
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Protein

C-Jun-amino-terminal kinase-interacting protein 3

Gene

Mapk8ip3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (PubMed:10523642, PubMed:10629060). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner (PubMed:23576431, PubMed:25944905, PubMed:28259553). Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation (PubMed:23576431, PubMed:25944905, PubMed:28259553). Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration (PubMed:23576431, PubMed:25944905, PubMed:28259553). Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (PubMed:23576431, PubMed:25944905, PubMed:28259553). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:23576431, PubMed:25944905, PubMed:28259553).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • JUN kinase binding Source: BHF-UCL
  • kinesin binding Source: UniProtKB
  • MAP-kinase scaffold activity Source: BHF-UCL
  • mitogen-activated protein kinase kinase binding Source: BHF-UCL
  • mitogen-activated protein kinase kinase kinase binding Source: BHF-UCL
  • receptor signaling complex scaffold activity Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C-Jun-amino-terminal kinase-interacting protein 3
Short name:
JIP-3
Short name:
JNK-interacting protein 3
Alternative name(s):
JNK MAP kinase scaffold protein 3
JNK/SAPK-associated protein 1
Short name:
JSAP1
Mitogen-activated protein kinase 8-interacting protein 3
Sunday driver 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mapk8ip3
Synonyms:Jip3, Jsap1, Syd2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1353598 Mapk8ip3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

The cerebral cortex in the embryonic brain is a little thinner and the distribution of neurons is more disordered than that found in the wild-type littermates.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi205R → G: Results in inhibition of JNK binding. 1 Publication1
Mutagenesisi206P → G: Results in inhibition of JNK binding. 1 Publication1
Mutagenesisi207T → G: Results in inhibition of JNK binding. 1 Publication1
Mutagenesisi208S → G: Results in inhibition of JNK binding. 1 Publication1
Mutagenesisi209L → G: Results in inhibition of JNK binding. 1 Publication1
Mutagenesisi266T → A: Results in loss of phosphorylation of MAPK8IP3; when associated with A-276 and A-287. Does not effect binding of components of the JNK pathway. 1 Publication1
Mutagenesisi276T → A: Results in loss of phosphorylation of MAPK8IP3; when associated with A-266 and A-287. Does not effect binding of components of the JNK pathway. 1 Publication1
Mutagenesisi287T → A: Results in loss of phosphorylation of MAPK8IP3; when associated with A-266 and A-287. Does not effect binding of components of the JNK pathway. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002206341 – 1337C-Jun-amino-terminal kinase-interacting protein 3Add BLAST1337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei266Phosphothreonine; by MAPK1 Publication1
Modified residuei276Phosphothreonine; by MAPK1 Publication1
Modified residuei287Phosphothreonine; by MAPKCombined sources1 Publication1
Modified residuei315Phosphoserine; by ROCK1By similarity1
Modified residuei365Phosphoserine; by ROCK1By similarity1
Modified residuei366PhosphoserineCombined sources1
Modified residuei603PhosphoserineCombined sources1
Modified residuei677PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by ROCK1 is crucial for the recruitment of JNK.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ESN9

PeptideAtlas

More...
PeptideAtlasi
Q9ESN9

PRoteomics IDEntifications database

More...
PRIDEi
Q9ESN9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ESN9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ESN9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed throughout many regions of the brain and at lower levels in the heart, liver, lung, testes and kidney. All isoforms have been identified in the brain, isoform 1a is also expressed in the spleen and lung.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in the brain of embryonic mice. Expression levels gradually increase from 10 dpc to postnatal day 10 (P10) (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expressed in neurites 5 days following initiation of nerve growth factor induced differentiation. NGF withdrawal results in the down-regulation of MAPK8IP3 protein by caspase-mediated cleavage.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024163 Expressed in 273 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9ESN9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9ESN9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homo- or heterooligomeric complexes. The central region of MAPK8IP3 interacts with the C-terminal of MAPK8IP2 but not MAPK8IP1. Binds specific components of the JNK signaling pathway namely MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 to the N-terminal region, MAP2K4/MKK4 and MAP2K7/MKK7 to the central region and MAP3K11 to the C-terminal region. Binds the TPR motif-containing C-terminal of kinesin light chain, KLC1. Pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location (PubMed:10523642, PubMed:10629060, PubMed:11238452, PubMed:11106729). Interacts with ROCK1 and this interaction is enhanced by ultraviolet-B (UVB) radiation. Interacts with SH3RF2 (By similarity). Interacts with NTRK2/TRKB and NTRK3/TRKC (PubMed:21775604).By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
206033, 7 interactors

Protein interaction database and analysis system

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IntActi
Q9ESN9, 16 interactors

Molecular INTeraction database

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MINTi
Q9ESN9

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000085683

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11337
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6EJNX-ray3.20C/D417-486[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9ESN9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9ESN9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 100RH1PROSITE-ProRule annotationAdd BLAST89
Domaini521 – 595RH2PROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni50 – 80Kinesin-binding domain (KBD); essential for its function in axon elongation1 PublicationAdd BLAST31
Regioni210 – 226JNK-binding domain (JBD); essential for its function in axon elongation1 PublicationAdd BLAST17
Regioni424 – 459Leucine zipper-like domain (LZ); essential for its function in axon elongation1 PublicationAdd BLAST36
Regioni459 – 515Interaction with NTRK21 PublicationAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili58 – 177Sequence analysisAdd BLAST120
Coiled coili437 – 555Sequence analysisAdd BLAST119

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the JIP scaffold family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2077 Eukaryota
ENOG410XQ19 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153496

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG024110

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9ESN9

KEGG Orthology (KO)

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KOi
K04436

Identification of Orthologs from Complete Genome Data

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OMAi
YPPGEIF

Database of Orthologous Groups

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OrthoDBi
324912at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9ESN9

TreeFam database of animal gene trees

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TreeFami
TF313096

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039911 JIP3/JIP4
IPR032486 JIP_LZII
IPR019143 JNK/Rab-associated_protein-1_N
IPR034743 RH1
IPR034744 RH2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13886 PTHR13886, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF16471 JIP_LZII, 1 hit
PF09744 Jnk-SapK_ap_N, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51776 RH1, 1 hit
PS51777 RH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1c (identifier: Q9ESN9-1) [UniParc]FASTAAdd to basket
Also known as: 3b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMEIQMDEGG GVVVYQDDYC SGSVMSERVS GLAGSIYREF ERLIHCYDEE
60 70 80 90 100
VVKELMPLVV NVLENLDSVL SENQEHEVEL ELLREDNEQL LTQYEREKAL
110 120 130 140 150
RKQAEEKFIE FEDALEQEKK ELQIQVEHYE FQTRQLELKA KNYADQISRL
160 170 180 190 200
EERESEMKKE YNALHQRHTE MIQTYVEHIE RSKMQQVGGS GQTESSLPGR
210 220 230 240 250
SRKERPTSLN VFPLADGMVR AQMGGKLVPA GDHWHLSDLG QLQSSSSYQC
260 270 280 290 300
PNDEMSESGQ SSAAATPSTT GTKSNTPTSS VPSAAVTPLN ESLQPLGDYV
310 320 330 340 350
SVTKNNKQAR EKRNSRNMEV QVTQEMRNVS IGMGSSDEWS DVQDIIDSTP
360 370 380 390 400
ELDVCPETRL ERTGSSPTQG IVNKAFGINT DSLYHELSTA GSEVIGDVDE
410 420 430 440 450
GADLLGEFSV RDDFFGMGKE VGNLLLENSQ LLETKNALNV VKNDLIAKVD
460 470 480 490 500
QLSGEQEVLK GELEAAKQAK VKLENRIKEL EEELKRVKSE AVTARREPRE
510 520 530 540 550
EVEDVSSYLC TELDKIPMAQ RRRFTRVEMA RVLMERNQYK ERLMELQEAV
560 570 580 590 600
RWTEMIRASR EHPSVQEKKK STIWQFFSRL FSSSSSPPPA KRSYPSVNIH
610 620 630 640 650
YKSPTAAGFS QRRSHALCQI SAGSRPLEFF PDDDCTSSAR REQKREQYRQ
660 670 680 690 700
VREHVRNDDG RLQACGWSLP AKYKQLSPNG GQEDTRMKNV PVPVYCRPLV
710 720 730 740 750
EKDPSTKLWC AAGVNLSGWK PHEEDSSNGP KPVPGRDPLT CDREGEGEPK
760 770 780 790 800
STHPSPEKKK AKETPEADAT SSRVWILTST LTTSKVVIID ANQPGTIVDQ
810 820 830 840 850
FTVCNAHVLC ISSIPAASDS DYPPGEMFLD SDVNPEDSGA DGVLAGITLV
860 870 880 890 900
GCATRCNVPR SNCSSRGDTP VLDKGQGDVA TTANGKVNPS QSTEEATEAT
910 920 930 940 950
EVPDPGPSES EATTVRPGPL TEHVFTDPAP TPSSSTQPAS ENGSESNGTI
960 970 980 990 1000
VQPQVEPSGE LSTTTSSAAP TMWLGAQNGW LYVHSAVANW KKCLHSIKLK
1010 1020 1030 1040 1050
DSVLSLVHVK GRVLVALADG TLAIFHRGED GQWDLSNYHL MDLGHPHHSI
1060 1070 1080 1090 1100
RCMAVVNDRV WCGYKNKVHV IQPKTMQIEK SFDAHPRRES QVRQLAWIGD
1110 1120 1130 1140 1150
GVWVSIRLDS TLRLYHAHTH QHLQDVDIEP YVSKMLGTGK LGFSFVRITA
1160 1170 1180 1190 1200
LLIAGNRLWV GTGNGVVISI PLTETVVLHR GQLLGLRANK TSPTSGEGTR
1210 1220 1230 1240 1250
PGGIIHVYGD DSSDKAASSF IPYCSMAQAQ LCFHGHRDAV KFFVSVPGNV
1260 1270 1280 1290 1300
LATLNGSVLD SPSEGPGPAA PAADAEGQKL KNALVLSGGE GYIDFRIGDG
1310 1320 1330
EDDETEECAG DVNQTKPSLS KAERSHIIVW QVSYTPE
Length:1,337
Mass (Da):147,561
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7DEE54C17B74106
GO
Isoform 1a (identifier: Q9ESN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-201: Missing.
     219-249: Missing.

Show »
Length:1,305
Mass (Da):144,138
Checksum:i0BF7257DCFF6D236
GO
Isoform 1b (identifier: Q9ESN9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-201: S → SPRQSWRKS
     219-249: Missing.

Show »
Length:1,314
Mass (Da):145,251
Checksum:i1EAD24AC1DAD9AB7
GO
Isoform 1d (identifier: Q9ESN9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-201: Missing.

Show »
Length:1,336
Mass (Da):147,474
Checksum:i362061FA2B2AA3C1
GO
Isoform 3a (identifier: Q9ESN9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-415: Missing.
     505-513: Missing.

Show »
Length:1,322
Mass (Da):145,785
Checksum:i8C71A02B7FF3FBB4
GO
Isoform 1e (identifier: Q9ESN9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-201: S → SPRQSWRKS

Show »
Length:1,345
Mass (Da):148,587
Checksum:iAA7157299921450A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q6B6E9Q6B6_MOUSE
C-Jun-amino-terminal kinase-interac...
Mapk8ip3
1,300Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q6E0E9Q6E0_MOUSE
C-Jun-amino-terminal kinase-interac...
Mapk8ip3
1,306Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QNR6J3QNR6_MOUSE
C-Jun-amino-terminal kinase-interac...
Mapk8ip3
1,337Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K3W4S4K3W4S4_MOUSE
C-Jun-amino-terminal kinase-interac...
Mapk8ip3
1,345Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YWH6D3YWH6_MOUSE
C-Jun-amino-terminal kinase-interac...
Mapk8ip3
235Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG36931 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti312K → R in AAG36931 (PubMed:11106729).Curated1
Sequence conflicti376F → L in AAF26843 (PubMed:10629060).Curated1
Sequence conflicti561E → K in AAG36931 (PubMed:11106729).Curated1
Sequence conflicti1272A → V in AAG36931 (PubMed:11106729).Curated1
Sequence conflicti1322A → D in AAG36931 (PubMed:11106729).Curated1
Sequence conflicti1325S → T in AAG36931 (PubMed:11106729).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002775201Missing in isoform 1a and isoform 1d. 1 Publication1
Alternative sequenceiVSP_002776201S → SPRQSWRKS in isoform 1b and isoform 1e. 1 Publication1
Alternative sequenceiVSP_002777219 – 249Missing in isoform 1a and isoform 1b. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_002778410 – 415Missing in isoform 3a. Curated6
Alternative sequenceiVSP_002779505 – 513Missing in isoform 3a. Curated9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB005662 mRNA Translation: BAA85874.1
AB043124 mRNA Translation: BAB16675.1
AB043125 mRNA Translation: BAB16676.1
AB043123 mRNA Translation: BAB16674.1
AB043129 Genomic DNA Translation: BAB16685.1
AF178637 mRNA Translation: AAF26843.1
AF178636 mRNA Translation: AAF26842.1
AF262046 mRNA Translation: AAG36931.1 Different initiation.
BC004003 mRNA Translation: AAH04003.1
BC060603 mRNA Translation: AAH60603.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37498.1 [Q9ESN9-1]
CCDS50024.1 [Q9ESN9-4]
CCDS50025.1 [Q9ESN9-5]
CCDS50026.1 [Q9ESN9-2]
CCDS50029.1 [Q9ESN9-3]

NCBI Reference Sequences

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RefSeqi
NP_001156919.1, NM_001163447.1 [Q9ESN9-4]
NP_001156920.1, NM_001163448.1 [Q9ESN9-5]
NP_001156921.1, NM_001163449.1 [Q9ESN9-3]
NP_001156923.1, NM_001163451.1 [Q9ESN9-2]
NP_038959.2, NM_013931.4 [Q9ESN9-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.43081

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000088345; ENSMUSP00000085683; ENSMUSG00000024163 [Q9ESN9-1]
ENSMUST00000115228; ENSMUSP00000110883; ENSMUSG00000024163 [Q9ESN9-5]
ENSMUST00000117509; ENSMUSP00000112712; ENSMUSG00000024163 [Q9ESN9-3]
ENSMUST00000119115; ENSMUSP00000112955; ENSMUSG00000024163 [Q9ESN9-2]
ENSMUST00000120035; ENSMUSP00000114084; ENSMUSG00000024163 [Q9ESN9-4]
ENSMUST00000146923; ENSMUSP00000114802; ENSMUSG00000024163 [Q9ESN9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
30957

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:30957

UCSC genome browser

More...
UCSCi
uc008aza.2 mouse [Q9ESN9-5]
uc008azb.2 mouse [Q9ESN9-1]
uc008azc.2 mouse [Q9ESN9-3]
uc008aze.2 mouse [Q9ESN9-2]
uc008azf.2 mouse [Q9ESN9-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005662 mRNA Translation: BAA85874.1
AB043124 mRNA Translation: BAB16675.1
AB043125 mRNA Translation: BAB16676.1
AB043123 mRNA Translation: BAB16674.1
AB043129 Genomic DNA Translation: BAB16685.1
AF178637 mRNA Translation: AAF26843.1
AF178636 mRNA Translation: AAF26842.1
AF262046 mRNA Translation: AAG36931.1 Different initiation.
BC004003 mRNA Translation: AAH04003.1
BC060603 mRNA Translation: AAH60603.1
CCDSiCCDS37498.1 [Q9ESN9-1]
CCDS50024.1 [Q9ESN9-4]
CCDS50025.1 [Q9ESN9-5]
CCDS50026.1 [Q9ESN9-2]
CCDS50029.1 [Q9ESN9-3]
RefSeqiNP_001156919.1, NM_001163447.1 [Q9ESN9-4]
NP_001156920.1, NM_001163448.1 [Q9ESN9-5]
NP_001156921.1, NM_001163449.1 [Q9ESN9-3]
NP_001156923.1, NM_001163451.1 [Q9ESN9-2]
NP_038959.2, NM_013931.4 [Q9ESN9-1]
UniGeneiMm.43081

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6EJNX-ray3.20C/D417-486[»]
ProteinModelPortaliQ9ESN9
SMRiQ9ESN9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206033, 7 interactors
IntActiQ9ESN9, 16 interactors
MINTiQ9ESN9
STRINGi10090.ENSMUSP00000085683

PTM databases

iPTMnetiQ9ESN9
PhosphoSitePlusiQ9ESN9

Proteomic databases

PaxDbiQ9ESN9
PeptideAtlasiQ9ESN9
PRIDEiQ9ESN9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088345; ENSMUSP00000085683; ENSMUSG00000024163 [Q9ESN9-1]
ENSMUST00000115228; ENSMUSP00000110883; ENSMUSG00000024163 [Q9ESN9-5]
ENSMUST00000117509; ENSMUSP00000112712; ENSMUSG00000024163 [Q9ESN9-3]
ENSMUST00000119115; ENSMUSP00000112955; ENSMUSG00000024163 [Q9ESN9-2]
ENSMUST00000120035; ENSMUSP00000114084; ENSMUSG00000024163 [Q9ESN9-4]
ENSMUST00000146923; ENSMUSP00000114802; ENSMUSG00000024163 [Q9ESN9-1]
GeneIDi30957
KEGGimmu:30957
UCSCiuc008aza.2 mouse [Q9ESN9-5]
uc008azb.2 mouse [Q9ESN9-1]
uc008azc.2 mouse [Q9ESN9-3]
uc008aze.2 mouse [Q9ESN9-2]
uc008azf.2 mouse [Q9ESN9-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23162
MGIiMGI:1353598 Mapk8ip3

Phylogenomic databases

eggNOGiKOG2077 Eukaryota
ENOG410XQ19 LUCA
GeneTreeiENSGT00940000153496
HOVERGENiHBG024110
InParanoidiQ9ESN9
KOiK04436
OMAiYPPGEIF
OrthoDBi324912at2759
PhylomeDBiQ9ESN9
TreeFamiTF313096

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9ESN9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024163 Expressed in 273 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ9ESN9 baseline and differential
GenevisibleiQ9ESN9 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR039911 JIP3/JIP4
IPR032486 JIP_LZII
IPR019143 JNK/Rab-associated_protein-1_N
IPR034743 RH1
IPR034744 RH2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13886 PTHR13886, 1 hit
PfamiView protein in Pfam
PF16471 JIP_LZII, 1 hit
PF09744 Jnk-SapK_ap_N, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS51776 RH1, 1 hit
PS51777 RH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJIP3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ESN9
Secondary accession number(s): Q5D062
, Q99KU7, Q9EQD8, Q9ESN7, Q9ESN8, Q9ESP0, Q9JLH2, Q9JLH3, Q9R0U7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: March 1, 2001
Last modified: February 13, 2019
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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