UniProtKB - Q9ESN4 (C1QL3_MOUSE)
Protein
Complement C1q-like protein 3
Gene
C1ql3
Organism
Mus musculus (Mouse)
Status
Functioni
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production.2 Publications
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- regulation of synapse organization Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Complement C1q-like protein 3Alternative name(s): C1q and tumor necrosis factor-related protein 13 Short name: C1q/TNF-related protein 13 Short name: CTRP13 Gliacolin |
Gene namesi | Name:C1ql3 Synonyms:C1ql, Ctrp13 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2387350, C1ql3 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: MGI
Other locations
- collagen trimer Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 28 | C → A: Does not affect heterooligomerization with C1QL4; when associated with A-32. 2 Publications | 1 | |
Mutagenesisi | 28 | C → S: Does not affect heterooligomerization with C1QL2; when associated with S-32. 2 Publications | 1 | |
Mutagenesisi | 32 | C → A: Does not affect heterooligomerization with C1QL4; when associated with A-28. 2 Publications | 1 | |
Mutagenesisi | 32 | C → S: Does not affect heterooligomerization with C1QL2; when associated with S-28. 2 Publications | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000003542 | 21 – 255 | Complement C1q-like protein 3Add BLAST | 235 |
Proteomic databases
MaxQBi | Q9ESN4 |
PaxDbi | Q9ESN4 |
PeptideAtlasi | Q9ESN4 |
PRIDEi | Q9ESN4 |
PTM databases
PhosphoSitePlusi | Q9ESN4 |
Expressioni
Tissue specificityi
Highly expressed in brain and white adipose tissue. In gonadal fat pad, expressed at lower levels in adipocytes than in the stromal vascular fraction (VSP), which contains preadipocytes, fibroblasts, endothelial cells and occasional immune cells. Expression exhibits sexually dimorphism, with higher levels in females than in males (at protein level). Tends to be up-regulated in adipose tissue from obese males, but not females. Expressed in glial cells.1 Publication
Inductioni
In adipocytes, up-regulated by rosiglitazone, an insulin-sensitizing drug.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000049630, Expressed in lumbar subsegment of spinal cord and 133 other tissues |
ExpressionAtlasi | Q9ESN4, baseline and differential |
Genevisiblei | Q9ESN4, MM |
Interactioni
Subunit structurei
Forms homooligomers.
Interacts with ADGRB3 (PubMed:21262840). Forms heterooligomers with C1QL2 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.
3 PublicationsBinary interactionsi
Hide detailsQ9ESN4
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-15907894,EBI-15907894 |
ADGRB3 [O60242] from Homo sapiens. | 4 | EBI-15907894,EBI-2682765 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
DIPi | DIP-59699N |
IntActi | Q9ESN4, 1 interactor |
STRINGi | 10090.ENSMUSP00000056188 |
Miscellaneous databases
RNActi | Q9ESN4, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9ESN4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 61 – 111 | Collagen-likeAdd BLAST | 51 | |
Domaini | 122 – 255 | C1qPROSITE-ProRule annotationAdd BLAST | 134 |
Keywords - Domaini
Collagen, SignalPhylogenomic databases
eggNOGi | ENOG502QSKV, Eukaryota |
GeneTreei | ENSGT00940000161639 |
HOGENOMi | CLU_001074_3_1_1 |
InParanoidi | Q9ESN4 |
OMAi | DNSLMQS |
OrthoDBi | 1320954at2759 |
PhylomeDBi | Q9ESN4 |
TreeFami | TF329591 |
Family and domain databases
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR001073, C1q_dom IPR008160, Collagen IPR008983, Tumour_necrosis_fac-like_dom |
Pfami | View protein in Pfam PF00386, C1q, 1 hit PF01391, Collagen, 1 hit |
PRINTSi | PR00007, COMPLEMNTC1Q |
SMARTi | View protein in SMART SM00110, C1Q, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS50871, C1Q, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9ESN4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVLLLVILIP VLVSSAGTSA HYEMLGTCRM VCDPYGGTKA PSTAATPDRG
60 70 80 90 100
LMQSLPTFIQ GPKGEAGRPG KAGPRGPPGE PGPPGPVGPP GEKGEPGRQG
110 120 130 140 150
LPGPPGAPGL NAAGAISAAT YSTVPKIAFY AGLKRQHEGY EVLKFDDVVT
160 170 180 190 200
NLGNHYDPTT GKFTCSIPGI YFFTYHVLMR GGDGTSMWAD LCKNNQVRAS
210 220 230 240 250
AIAQDADQNY DYASNSVVLH LEPGDEVYIK LDGGKAHGGN NNKYSTFSGF
IIYAD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB044560 mRNA Translation: BAB15806.1 EU399230 mRNA Translation: ABY86415.1 AB045983 Genomic DNA Translation: BAB59006.1 AL929209 Genomic DNA No translation available. CH466542 Genomic DNA Translation: EDL08047.1 BC024634 mRNA Translation: AAH24634.1 |
CCDSi | CCDS15692.1 |
RefSeqi | NP_694795.1, NM_153155.2 |
Genome annotation databases
Ensembli | ENSMUST00000061545; ENSMUSP00000056188; ENSMUSG00000049630 |
GeneIDi | 227580 |
KEGGi | mmu:227580 |
UCSCi | uc008ijv.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB044560 mRNA Translation: BAB15806.1 EU399230 mRNA Translation: ABY86415.1 AB045983 Genomic DNA Translation: BAB59006.1 AL929209 Genomic DNA No translation available. CH466542 Genomic DNA Translation: EDL08047.1 BC024634 mRNA Translation: AAH24634.1 |
CCDSi | CCDS15692.1 |
RefSeqi | NP_694795.1, NM_153155.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4QQH | X-ray | 1.20 | A | 119-255 | [»] | |
4QQL | X-ray | 2.39 | A/B/C/D/E/F/G/H/I | 119-255 | [»] | |
4QQO | X-ray | 2.03 | A | 119-255 | [»] | |
4QQP | X-ray | 1.46 | A | 119-255 | [»] | |
5YBZ | X-ray | 1.71 | A/C/D | 125-255 | [»] | |
SMRi | Q9ESN4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-59699N |
IntActi | Q9ESN4, 1 interactor |
STRINGi | 10090.ENSMUSP00000056188 |
PTM databases
PhosphoSitePlusi | Q9ESN4 |
Proteomic databases
MaxQBi | Q9ESN4 |
PaxDbi | Q9ESN4 |
PeptideAtlasi | Q9ESN4 |
PRIDEi | Q9ESN4 |
Protocols and materials databases
Antibodypediai | 56786, 75 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000061545; ENSMUSP00000056188; ENSMUSG00000049630 |
GeneIDi | 227580 |
KEGGi | mmu:227580 |
UCSCi | uc008ijv.1, mouse |
Organism-specific databases
CTDi | 389941 |
MGIi | MGI:2387350, C1ql3 |
Phylogenomic databases
eggNOGi | ENOG502QSKV, Eukaryota |
GeneTreei | ENSGT00940000161639 |
HOGENOMi | CLU_001074_3_1_1 |
InParanoidi | Q9ESN4 |
OMAi | DNSLMQS |
OrthoDBi | 1320954at2759 |
PhylomeDBi | Q9ESN4 |
TreeFami | TF329591 |
Miscellaneous databases
BioGRID-ORCSi | 227580, 1 hit in 17 CRISPR screens |
PROi | PR:Q9ESN4 |
RNActi | Q9ESN4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000049630, Expressed in lumbar subsegment of spinal cord and 133 other tissues |
ExpressionAtlasi | Q9ESN4, baseline and differential |
Genevisiblei | Q9ESN4, MM |
Family and domain databases
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR001073, C1q_dom IPR008160, Collagen IPR008983, Tumour_necrosis_fac-like_dom |
Pfami | View protein in Pfam PF00386, C1q, 1 hit PF01391, Collagen, 1 hit |
PRINTSi | PR00007, COMPLEMNTC1Q |
SMARTi | View protein in SMART SM00110, C1Q, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS50871, C1Q, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C1QL3_MOUSE | |
Accessioni | Q9ESN4Primary (citable) accession number: Q9ESN4 Secondary accession number(s): A2AUR9, B0LXL6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references