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UniProtKB - Q9ESL0 (SCO2B_MOUSE)
Protein
Succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial
Gene
Oxct2b
Organism
Mus musculus (Mouse)
Status
Functioni
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).
Probably play and important roles in the energy metabolism of spermatozoa.
By similarityCatalytic activityi
- EC:2.8.3.5PROSITE-ProRule annotation
: succinyl-CoA degradation Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes acetoacetyl-CoA from succinyl-CoA. This subpathway is part of the pathway succinyl-CoA degradation, which is itself part of Ketone metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetyl-CoA from succinyl-CoA, the pathway succinyl-CoA degradation and in Ketone metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 342 | 5-glutamyl coenzyme A thioester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacid CoA-transferase activity Source: GO_Central
- CoA-transferase activity Source: GO_Central
GO - Biological processi
- cellular ketone body metabolic process Source: GO_Central
- generation of precursor metabolites and energy Source: MGI
- ketone body catabolic process Source: InterPro
Keywordsi
Molecular function | Transferase |
Enzyme and pathway databases
Reactomei | R-MMU-77108, Utilization of Ketone Bodies |
UniPathwayi | UPA00929;UER00894 |
Names & Taxonomyi
Protein namesi | Recommended name: Succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial (EC:2.8.3.5)Alternative name(s): 3-oxoacid CoA-transferase 2B Testis-specific succinyl-CoA:3-oxoacid CoA-transferase 2 Short name: SCOT-t2 |
Gene namesi | Name:Oxct2b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2664115, Oxct2b |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: MGI
Other locations
- motile cilium Source: MGI
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 39 | MitochondrionBy similarityAdd BLAST | 39 | |
ChainiPRO_0000366211 | 40 – 520 | Succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrialAdd BLAST | 481 |
Proteomic databases
jPOSTi | Q9ESL0 |
PaxDbi | Q9ESL0 |
PeptideAtlasi | Q9ESL0 |
PRIDEi | Q9ESL0 |
ProteomicsDBi | 256934 |
Expressioni
Tissue specificityi
Testis specific. Expressed in late spermatids. Accumulates during spermiogenesis. Also detected in the midpiece of spermatozoa.1 Publication
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000099708 |
Miscellaneous databases
RNActi | Q9ESL0, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 280 – 299 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the 3-oxoacid CoA-transferase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG3822, Eukaryota |
InParanoidi | Q9ESL0 |
OrthoDBi | 460209at2759 |
PhylomeDBi | Q9ESL0 |
TreeFami | TF313991 |
Family and domain databases
InterProi | View protein in InterPro IPR012792, 3-oxoacid_CoA-transf_A IPR012791, 3-oxoacid_CoA-transf_B IPR014388, 3-oxoacid_CoA-transferase IPR004165, CoA_trans_fam_I IPR004164, CoA_transf_AS IPR004163, CoA_transf_BS IPR037171, NagB/RpiA_transferase-like |
PANTHERi | PTHR13707, PTHR13707, 1 hit |
Pfami | View protein in Pfam PF01144, CoA_trans, 2 hits |
PIRSFi | PIRSF000858, SCOT-t, 1 hit |
SMARTi | View protein in SMART SM00882, CoA_trans, 2 hits |
SUPFAMi | SSF100950, SSF100950, 2 hits |
TIGRFAMsi | TIGR02429, pcaI_scoA_fam, 1 hit TIGR02428, pcaJ_scoB_fam, 1 hit |
PROSITEi | View protein in PROSITE PS01273, COA_TRANSF_1, 1 hit PS01274, COA_TRANSF_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9ESL0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAALRLLAWA LPRGVSALRP RPALPHRLIR RYVSDRSGSV HFYTDPVKAV
60 70 80 90 100
EGVKDGSTVM LGGFGLCGIP ENLIGALKTK GVKDLKIVSS NVGVDDFGLG
110 120 130 140 150
ILLASKQVRR VVCSYLGENA LCEKLYLAGE LELEMTPQGT LAERIRACGT
160 170 180 190 200
GVPAFYTPTG YGTLVQEGGS PIRYAPDGHL ITLSEPREVR EFQGRFYLLE
210 220 230 240 250
HAIRADFALI KGWKADRSGN VIFRGSARNF NVPMCKAADI SVVEVEEIVD
260 270 280 290 300
VGTFAPEDIH IPNIYVDRVI KGPKFEKRIE RLTTRDSKPA PGSKDNDPSR
310 320 330 340 350
TRIIKRAALE FQDGMYANLG IGIPVLASNY ISPKMTVYLH SENGILGLGP
360 370 380 390 400
FPLKNEVDAD VINAGKQTVT VVPGGCFFAS DDSFAMIRGG HLQLTMLGAM
410 420 430 440 450
QVSQYGDLAN WMVPGKKVKG MGGAMDLVSS KKTRVVVTME HCTKTKQPKI
460 470 480 490 500
LKKCTMPLTG KRCVDLIITE KAVFEVNHSK GLTLVELWEG SSVDDIKATT
510 520
ACSFAVSPNL KPMQQIKLDA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J198 | A0A0R4J198_MOUSE | Succinyl-CoA:3-ketoacid-coenzyme A ... | Oxct2b | 520 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 148 | C → G in AAI13759 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB049996 mRNA Translation: BAB16879.1 AB105455 Genomic DNA Translation: BAC87739.1 BC113758 mRNA Translation: AAI13759.1 |
CCDSi | CCDS18609.1 |
RefSeqi | NP_862907.2, NM_181859.3 |
Genome annotation databases
GeneIDi | 353371 |
KEGGi | mmu:353371 |
UCSCi | uc008uou.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB049996 mRNA Translation: BAB16879.1 AB105455 Genomic DNA Translation: BAC87739.1 BC113758 mRNA Translation: AAI13759.1 |
CCDSi | CCDS18609.1 |
RefSeqi | NP_862907.2, NM_181859.3 |
3D structure databases
SMRi | Q9ESL0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000099708 |
Proteomic databases
jPOSTi | Q9ESL0 |
PaxDbi | Q9ESL0 |
PeptideAtlasi | Q9ESL0 |
PRIDEi | Q9ESL0 |
ProteomicsDBi | 256934 |
Protocols and materials databases
DNASUi | 353371 |
Genome annotation databases
GeneIDi | 353371 |
KEGGi | mmu:353371 |
UCSCi | uc008uou.2, mouse |
Organism-specific databases
CTDi | 353371 |
MGIi | MGI:2664115, Oxct2b |
Phylogenomic databases
eggNOGi | KOG3822, Eukaryota |
InParanoidi | Q9ESL0 |
OrthoDBi | 460209at2759 |
PhylomeDBi | Q9ESL0 |
TreeFami | TF313991 |
Enzyme and pathway databases
UniPathwayi | UPA00929;UER00894 |
Reactomei | R-MMU-77108, Utilization of Ketone Bodies |
Miscellaneous databases
BioGRID-ORCSi | 353371, 1 hit in 45 CRISPR screens |
PROi | PR:Q9ESL0 |
RNActi | Q9ESL0, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR012792, 3-oxoacid_CoA-transf_A IPR012791, 3-oxoacid_CoA-transf_B IPR014388, 3-oxoacid_CoA-transferase IPR004165, CoA_trans_fam_I IPR004164, CoA_transf_AS IPR004163, CoA_transf_BS IPR037171, NagB/RpiA_transferase-like |
PANTHERi | PTHR13707, PTHR13707, 1 hit |
Pfami | View protein in Pfam PF01144, CoA_trans, 2 hits |
PIRSFi | PIRSF000858, SCOT-t, 1 hit |
SMARTi | View protein in SMART SM00882, CoA_trans, 2 hits |
SUPFAMi | SSF100950, SSF100950, 2 hits |
TIGRFAMsi | TIGR02429, pcaI_scoA_fam, 1 hit TIGR02428, pcaJ_scoB_fam, 1 hit |
PROSITEi | View protein in PROSITE PS01273, COA_TRANSF_1, 1 hit PS01274, COA_TRANSF_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SCO2B_MOUSE | |
Accessioni | Q9ESL0Primary (citable) accession number: Q9ESL0 Secondary accession number(s): Q2HJ06 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 3, 2009 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families