UniProtKB - Q9ESK9 (RBCC1_MOUSE)
RB1-inducible coiled-coil protein 1
Rb1cc1
Functioni
Involved in autophagy (PubMed:23262492, PubMed:19258318).
Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225, PubMed:23285000, PubMed:19258318).
Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (PubMed:21525242).
Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (PubMed:21807966).
Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (By similarity).
Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (PubMed:21795712).
Functions as a DNA-binding transcription factor (PubMed:12095676).
Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:15968549).
Plays a crucial role in muscular differentiation (PubMed:15968549).
Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (PubMed:19940130, PubMed:21088496).
By similarity11 PublicationsGO - Molecular functioni
- molecular adaptor activity Source: GO_Central
- protein kinase binding Source: UniProtKB
GO - Biological processi
- autophagosome assembly Source: ComplexPortal
- autophagy Source: GO_Central
- autophagy of mitochondrion Source: GO_Central
- autophagy of peroxisome Source: GO_Central
- cell cycle Source: UniProtKB-KW
- glycophagy Source: GO_Central
- heart development Source: MGI
- liver development Source: MGI
- negative regulation of apoptotic process Source: MGI
- negative regulation of cell population proliferation Source: ComplexPortal
- negative regulation of extrinsic apoptotic signaling pathway Source: MGI
- piecemeal microautophagy of the nucleus Source: GO_Central
- positive regulation of autophagy Source: ComplexPortal
- positive regulation of cell size Source: MGI
- positive regulation of JNK cascade Source: MGI
- positive regulation of protein phosphorylation Source: MGI
- protein autophosphorylation Source: ComplexPortal
- protein phosphorylation Source: ComplexPortal
- regulation of protein lipidation Source: ComplexPortal
- reticulophagy Source: MGI
Keywordsi
Biological process | Autophagy, Cell cycle, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-1632852, Macroautophagy |
Names & Taxonomyi
Protein namesi | Recommended name: RB1-inducible coiled-coil protein 1CuratedAlternative name(s): Coiled-coil-forming protein 1 FAK family kinase-interacting protein of 200 kDa Short name: FIP200 LaXp180 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1341850, Rb1cc1 |
VEuPathDBi | HostDB:ENSMUSG00000025907 |
Subcellular locationi
Lysosome
- Lysosome By similarity
Nucleus
- Nucleus 1 Publication
Cytoplasm and Cytosol
Other locations
- Preautophagosomal structure 1 Publication
Note: Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.1 Publication
Cytosol
- cytosol Source: MGI
Lysosome
- lysosome Source: UniProtKB
Nucleus
- nuclear membrane Source: MGI
- nucleus Source: MGI
Other locations
- Atg1/ULK1 kinase complex Source: MGI
- autophagosome membrane Source: MGI
- cytoplasm Source: MGI
- extrinsic component of membrane Source: GO_Central
- phagophore assembly site Source: UniProtKB
- phagophore assembly site membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Lysosome, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097184 | 1 – 1588 | RB1-inducible coiled-coil protein 1Add BLAST | 1588 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 222 | PhosphoserineBy similarity | 1 | |
Modified residuei | 229 | PhosphoserineBy similarity | 1 | |
Modified residuei | 237 | PhosphoserineCombined sources | 1 | |
Modified residuei | 238 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 243 | PhosphoserineCombined sources | 1 | |
Modified residuei | 253 | PhosphoserineBy similarity | 1 | |
Modified residuei | 257 | PhosphoserineBy similarity | 1 | |
Modified residuei | 261 | PhosphoserineCombined sources | 1 | |
Modified residuei | 623 | PhosphoserineCombined sources | 1 | |
Modified residuei | 646 | PhosphoserineCombined sources | 1 | |
Modified residuei | 649 | PhosphoserineCombined sources | 1 | |
Modified residuei | 652 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1087 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1366 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1478 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9ESK9 |
jPOSTi | Q9ESK9 |
MaxQBi | Q9ESK9 |
PaxDbi | Q9ESK9 |
PeptideAtlasi | Q9ESK9 |
PRIDEi | Q9ESK9 |
ProteomicsDBi | 253180 |
PTM databases
iPTMneti | Q9ESK9 |
PhosphoSitePlusi | Q9ESK9 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000025907, Expressed in spermatocyte and 298 other tissues |
Genevisiblei | Q9ESK9, MM |
Interactioni
Subunit structurei
Part of a complex containing ATG13/KIAA0652, ULK1 and RB1CC1 (PubMed:19258318). This complex associates with ATG101 (By similarity).
Interacts with PTK2/FAK1 and PTK2B/PYK2 (By similarity).
Interacts with GABARAP and GABARAPL1 (By similarity).
Interacts with ATG16L1; the interaction is required for ULK1 complex-dependent autophagy (PubMed:23392225, PubMed:23262492).
Interacts with RNF111, SKI and SMAD7 (PubMed:21795712).
Interacts with COP1 in the cytoplasm of proliferating cells in response to UV stimulation (By similarity).
Interacts with TP53 (By similarity).
Interacts with C9orf72 (By similarity).
Interacts with WDR45B (PubMed:28561066).
Interacts with ATG13; this interaction is increased in the absence of TMEM39A (By similarity).
Interacts with WIPI2 (By similarity).
By similarity5 PublicationsBinary interactionsi
Q9ESK9
With | #Exp. | IntAct |
---|---|---|
Atg16l1 [Q8C0J2] | 4 | EBI-647302,EBI-769195 |
Atg16l1 - isoform 3 [Q8C0J2-3] | 3 | EBI-647302,EBI-16029274 |
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 198540, 12 interactors |
ComplexPortali | CPX-380, ULK1-ATG13-RB1CC1-ATG101 autophagy initiation complex |
DIPi | DIP-49679N |
IntActi | Q9ESK9, 7 interactors |
MINTi | Q9ESK9 |
STRINGi | 10090.ENSMUSP00000027040 |
Miscellaneous databases
RNActi | Q9ESK9, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 638 – 674 | DisorderedSequence analysisAdd BLAST | 37 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 858 – 1393 | Sequence analysisAdd BLAST | 536 | |
Coiled coili | 1440 – 1479 | Sequence analysisAdd BLAST | 40 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 565 – 568 | Nuclear localization signal | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 638 – 673 | Polar residuesSequence analysisAdd BLAST | 36 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4572, Eukaryota |
GeneTreei | ENSGT00390000015871 |
HOGENOMi | CLU_003711_0_0_1 |
InParanoidi | Q9ESK9 |
OMAi | EMQNIRT |
OrthoDBi | 91906at2759 |
PhylomeDBi | Q9ESK9 |
TreeFami | TF323750 |
Family and domain databases
InterProi | View protein in InterPro IPR040040, ATG11 IPR019460, Atg11_C IPR045326, ATG17_like_dom |
PANTHERi | PTHR13222, PTHR13222, 1 hit |
Pfami | View protein in Pfam PF10377, ATG11, 1 hit PF04108, ATG17_like, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MKLYVFLVNT GTTLTFDTEL TVQTVADLKH AIQSKYKIAI QHQVLVVNGG
60 70 80 90 100
ECMAADRRVC TYSAGTDTNP IFLFNKEMIL CDRAPAIPKA TFSTENDMEI
110 120 130 140 150
KVEESLMMPA VFHTVASRTQ LAVEMYDVAK KLCSFCEGLV HDEHLQHQGW
160 170 180 190 200
AAIMANLEDC SNSYQKLLFK FESIYSDYLQ SIEDIKLKLT HLGTAVSVMA
210 220 230 240 250
KIPLLECLTR HSYRECLGRP DSLNEHEGSE KAEMKRSTEL VLSPDMPRTT
260 270 280 290 300
NTSLVTSFHK SMEHVAPDPT GTERGKELRE SCQSTVQQEE ASVDAKDSDL
310 320 330 340 350
PFFNVSLLDW INVQDRPNDV ESLVRKCFDS MSRLDPKIIQ PFMLECHQTI
360 370 380 390 400
AKLDNQNMKA IKGLEDRLYA LDQMIASCSR LVNEQKELAQ GFLANQMRAE
410 420 430 440 450
NLKDASVLPD LCLSHANQLM IMLQNHRKLL DIKQKCTTAK QELANNLHVR
460 470 480 490 500
LKWCCFVMLH ADQDGEKLQA LLRLVIELLE RVRIVEALST VPQMYCLAVV
510 520 530 540 550
EVVRRKMFIK HYREWAGALV KDGKQLYEAE KSKRESFGKL FRKSFLRNRL
560 570 580 590 600
FKGLDSWPSS FCTQKPRKFD CELPDISLKD LQFLQSFCPS EVQPFLRVPL
610 620 630 640 650
LCDFEPLHQH VLALHNLVKA AQSLDEMSQT ITDLLNEQKV STSQASPQSA
660 670 680 690 700
ASPRIESTTG ITTTTSPKTP PPLTVQDTLC PAVCPLEELS PDSIDAHTFD
710 720 730 740 750
FETISHPNTE QPVHQASIDL DSLAESPESD FMSAVNEFVI EENLSSPNPI
760 770 780 790 800
SDPQSPEMMV ESLYSSVINA IDSRRMQDTS TRGNEGFGDR AALHVQLEKC
810 820 830 840 850
RAAAQDSHSS IQTIKDDLCH FRTFVQKEQC DLANYLKCTA VEIRNIIEKV
860 870 880 890 900
KCSLEITLKE KHQQELQSLK IEYECKLDAL VKDSEENVNK ILKLKENLVS
910 920 930 940 950
LEEALQNKDN EFTSIKHEKD AIVCVQQEKD QKLLEMEKIM HTQHCEIKEL
960 970 980 990 1000
KQSREMALED LKKLHDEKIE SLRAEFQCLE QNHLKELEDT LHIRHTQEFE
1010 1020 1030 1040 1050
KVMTDHNMSL EKLKKENQQR IDQMLESHAS TIQEKEQQLQ ELKLKVSDLS
1060 1070 1080 1090 1100
DMRCKLEVEL ALKEAETDEI KILLEESRTQ QKEMLKSLLE QETENLRTEI
1110 1120 1130 1140 1150
SKLNQKIHDN NESYQVGLSE LRALMTIEKD QCISELISRH EEESNILKAE
1160 1170 1180 1190 1200
LDNVTSLHRQ AYEIEKKLKE QIVELQTRLN SELSALEKQK DEKITQQEEK
1210 1220 1230 1240 1250
YEALIQNLEK DKERLVKNHE QDKEHLIQEL NFEKNKAVQT ALDEFKVERE
1260 1270 1280 1290 1300
LVEKELLEKV KHLENQIAKT PAFESAREDS SSLVAELQEK LQEEKAKFLE
1310 1320 1330 1340 1350
QLEEQEKRKN EEMQNVRTSL IAEQQTNFNT VLTREKMRKE NIINDLSDKL
1360 1370 1380 1390 1400
KSTMQQQERD KDLIESLSED RARLLEEKKQ LEEEVSKLRT SSFLSSAPVA
1410 1420 1430 1440 1450
AAPELYGACA PELPGEPERS VMETADEGRL DSAMETSMMS VQENMLSEEK
1460 1470 1480 1490 1500
QRIMLLERTL QLKEEENKRL NQRLMSQSLS SVSSRHSEKI AIRDFQVGDL
1510 1520 1530 1540 1550
VLIILDERHD NYVLFTVSPT LYFLHSESLP ALDLKPGEGA SGASRRPWVL
1560 1570 1580
GKVMEKEYCQ AKKAQNRFKV PLGTKFYRVK AVSWNKKV
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PX56 | E9PX56_MOUSE | RB1-inducible coiled-coil protein 1 | Rb1cc1 | 873 | Annotation score: | ||
F7CC56 | F7CC56_MOUSE | RB1-inducible coiled-coil protein 1 | Rb1cc1 | 1,468 | Annotation score: | ||
F7CCJ3 | F7CCJ3_MOUSE | RB1-inducible coiled-coil protein 1 | Rb1cc1 | 536 | Annotation score: | ||
F6TLJ4 | F6TLJ4_MOUSE | RB1-inducible coiled-coil protein 1 | Rb1cc1 | 227 | Annotation score: | ||
E0CYY6 | E0CYY6_MOUSE | RB1-inducible coiled-coil protein 1 | Rb1cc1 | 164 | Annotation score: | ||
E0CZG6 | E0CZG6_MOUSE | RB1-inducible coiled-coil protein 1 | Rb1cc1 | 93 | Annotation score: | ||
E0CYU7 | E0CYU7_MOUSE | RB1-inducible coiled-coil protein 1 | Rb1cc1 | 40 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 809 | S → T in BAB16846 (PubMed:12095676).Curated | 1 | |
Sequence conflicti | 809 | S → T in BAB85610 (PubMed:12095676).Curated | 1 | |
Sequence conflicti | 981 | Q → E in BAB16846 (PubMed:12095676).Curated | 1 | |
Sequence conflicti | 981 | Q → E in BAB85610 (PubMed:12095676).Curated | 1 | |
Sequence conflicti | 1222 | D → A in CAA57761 (PubMed:7724523).Curated | 1 | |
Sequence conflicti | 1450 – 1451 | KQ → NE in CAB92238 (PubMed:11207567).Curated | 2 | |
Sequence conflicti | 1537 – 1539 | Missing in CAB92238 (PubMed:11207567).Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB050017 mRNA Translation: BAB16846.2 AB070619 mRNA Translation: BAB85610.1 AC102781 Genomic DNA No translation available. AC139064 Genomic DNA No translation available. AK041038 mRNA Translation: BAC30793.1 Different initiation. AK159066 mRNA Translation: BAE34792.1 X82318 mRNA Translation: CAA57761.1 AJ242720 mRNA Translation: CAB92238.1 |
CCDSi | CCDS35507.1 |
PIRi | I48282 |
RefSeqi | NP_033956.2, NM_009826.4 |
Genome annotation databases
Ensembli | ENSMUST00000027040; ENSMUSP00000027040; ENSMUSG00000025907 |
GeneIDi | 12421 |
KEGGi | mmu:12421 |
UCSCi | uc007afr.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB050017 mRNA Translation: BAB16846.2 AB070619 mRNA Translation: BAB85610.1 AC102781 Genomic DNA No translation available. AC139064 Genomic DNA No translation available. AK041038 mRNA Translation: BAC30793.1 Different initiation. AK159066 mRNA Translation: BAE34792.1 X82318 mRNA Translation: CAA57761.1 AJ242720 mRNA Translation: CAB92238.1 |
CCDSi | CCDS35507.1 |
PIRi | I48282 |
RefSeqi | NP_033956.2, NM_009826.4 |
3D structure databases
SMRi | Q9ESK9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198540, 12 interactors |
ComplexPortali | CPX-380, ULK1-ATG13-RB1CC1-ATG101 autophagy initiation complex |
DIPi | DIP-49679N |
IntActi | Q9ESK9, 7 interactors |
MINTi | Q9ESK9 |
STRINGi | 10090.ENSMUSP00000027040 |
PTM databases
iPTMneti | Q9ESK9 |
PhosphoSitePlusi | Q9ESK9 |
Proteomic databases
EPDi | Q9ESK9 |
jPOSTi | Q9ESK9 |
MaxQBi | Q9ESK9 |
PaxDbi | Q9ESK9 |
PeptideAtlasi | Q9ESK9 |
PRIDEi | Q9ESK9 |
ProteomicsDBi | 253180 |
Protocols and materials databases
Antibodypediai | 24432, 321 antibodies from 30 providers |
DNASUi | 12421 |
Genome annotation databases
Ensembli | ENSMUST00000027040; ENSMUSP00000027040; ENSMUSG00000025907 |
GeneIDi | 12421 |
KEGGi | mmu:12421 |
UCSCi | uc007afr.2, mouse |
Organism-specific databases
CTDi | 9821 |
MGIi | MGI:1341850, Rb1cc1 |
VEuPathDBi | HostDB:ENSMUSG00000025907 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG4572, Eukaryota |
GeneTreei | ENSGT00390000015871 |
HOGENOMi | CLU_003711_0_0_1 |
InParanoidi | Q9ESK9 |
OMAi | EMQNIRT |
OrthoDBi | 91906at2759 |
PhylomeDBi | Q9ESK9 |
TreeFami | TF323750 |
Enzyme and pathway databases
Reactomei | R-MMU-1632852, Macroautophagy |
Miscellaneous databases
BioGRID-ORCSi | 12421, 22 hits in 68 CRISPR screens |
ChiTaRSi | Rb1cc1, mouse |
PROi | PR:Q9ESK9 |
RNActi | Q9ESK9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025907, Expressed in spermatocyte and 298 other tissues |
Genevisiblei | Q9ESK9, MM |
Family and domain databases
InterProi | View protein in InterPro IPR040040, ATG11 IPR019460, Atg11_C IPR045326, ATG17_like_dom |
PANTHERi | PTHR13222, PTHR13222, 1 hit |
Pfami | View protein in Pfam PF10377, ATG11, 1 hit PF04108, ATG17_like, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RBCC1_MOUSE | |
Accessioni | Q9ESK9Primary (citable) accession number: Q9ESK9 Secondary accession number(s): E9QLQ2 Q9JK14 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 150 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot