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Entry version 134 (13 Feb 2019)
Sequence version 3 (27 Jul 2011)
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Protein

RB1-inducible coiled-coil protein 1

Gene

Rb1cc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in autophagy (PubMed:23262492, PubMed:19258318). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225, PubMed:23285000, PubMed:19258318). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (PubMed:21525242). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (PubMed:21807966). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (By similarity). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (PubMed:21795712). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:15968549). Plays a crucial role in muscular differentiation (PubMed:15968549). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (PubMed:19940130, PubMed:21088496).By similarity11 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein-containing complex scaffold activity Source: GO_Central
  • protein kinase binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy, Cell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1632852 Macroautophagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RB1-inducible coiled-coil protein 1
Alternative name(s):
Coiled-coil-forming protein 1
FAK family kinase-interacting protein of 200 kDa
Short name:
FIP200
LaXp180
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rb1cc1
Synonyms:Cc1, Kiaa0203
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1341850 Rb1cc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lysosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000971841 – 1588RB1-inducible coiled-coil protein 1Add BLAST1588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei222PhosphoserineBy similarity1
Modified residuei229PhosphoserineBy similarity1
Modified residuei237PhosphoserineCombined sources1
Modified residuei238PhosphothreonineCombined sources1
Modified residuei243PhosphoserineCombined sources1
Modified residuei253PhosphoserineBy similarity1
Modified residuei257PhosphoserineBy similarity1
Modified residuei261PhosphoserineCombined sources1
Modified residuei623PhosphoserineCombined sources1
Modified residuei646PhosphoserineCombined sources1
Modified residuei649PhosphoserineCombined sources1
Modified residuei652PhosphoserineCombined sources1
Modified residuei1087PhosphoserineCombined sources1
Modified residuei1366PhosphoserineBy similarity1
Modified residuei1478PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9ESK9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9ESK9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9ESK9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ESK9

PeptideAtlas

More...
PeptideAtlasi
Q9ESK9

PRoteomics IDEntifications database

More...
PRIDEi
Q9ESK9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ESK9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ESK9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed abundantly in heart and testis, and moderately in kidney, liver and skeletal muscles. Very low expression levels in lung and spleen. Colocalizes with RB1 in various tissues.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Abundantly expressed from an early stage of the embryo throughout development. Ubiquitously expressed, especially in the musculoskeletal system, heart and neural tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025907 Expressed in 274 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9ESK9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ESK9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a complex containing ATG13/KIAA0652, ULK1 and RB1CC1 (PubMed:19258318). This complex associates with ATG101 (By similarity). Interacts with PTK2/FAK1 and PTK2B/PYK2 (By similarity). Interacts with GABARAP and GABARAPL1 (By similarity). Interacts with ATG16L1; the interaction is required for ULK1 complex-dependent autophagy (PubMed:23392225, PubMed:23262492). Interacts with RNF111, SKI and SMAD7 (PubMed:21795712). Interacts with COP1 in the cytoplasm of proliferating cells in response to UV stimulation (By similarity). Interacts with TP53 (By similarity). Interacts with C9orf72 (By similarity). Interacts with WDR45B (PubMed:28561066).By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
198540, 6 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-380 ULK1-ATG13-RB1CC1-ATG101 autophagy initiation complex

Database of interacting proteins

More...
DIPi
DIP-49679N

Protein interaction database and analysis system

More...
IntActi
Q9ESK9, 6 interactors

Molecular INTeraction database

More...
MINTi
Q9ESK9

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000027040

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ESK9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili858 – 1393Sequence analysisAdd BLAST536
Coiled coili1440 – 1479Sequence analysisAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi565 – 568Nuclear localization signal4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi662 – 665Poly-Thr4

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4572 Eukaryota
ENOG410XSY4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015871

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154076

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG091209

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ESK9

KEGG Orthology (KO)

More...
KOi
K17589

Database of Orthologous Groups

More...
OrthoDBi
91906at2759

TreeFam database of animal gene trees

More...
TreeFami
TF323750

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040040 ATG11
IPR019460 Atg11_C

The PANTHER Classification System

More...
PANTHERi
PTHR13222 PTHR13222, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10377 ATG11, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q9ESK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLYVFLVNT GTTLTFDTEL TVQTVADLKH AIQSKYKIAI QHQVLVVNGG
60 70 80 90 100
ECMAADRRVC TYSAGTDTNP IFLFNKEMIL CDRAPAIPKA TFSTENDMEI
110 120 130 140 150
KVEESLMMPA VFHTVASRTQ LAVEMYDVAK KLCSFCEGLV HDEHLQHQGW
160 170 180 190 200
AAIMANLEDC SNSYQKLLFK FESIYSDYLQ SIEDIKLKLT HLGTAVSVMA
210 220 230 240 250
KIPLLECLTR HSYRECLGRP DSLNEHEGSE KAEMKRSTEL VLSPDMPRTT
260 270 280 290 300
NTSLVTSFHK SMEHVAPDPT GTERGKELRE SCQSTVQQEE ASVDAKDSDL
310 320 330 340 350
PFFNVSLLDW INVQDRPNDV ESLVRKCFDS MSRLDPKIIQ PFMLECHQTI
360 370 380 390 400
AKLDNQNMKA IKGLEDRLYA LDQMIASCSR LVNEQKELAQ GFLANQMRAE
410 420 430 440 450
NLKDASVLPD LCLSHANQLM IMLQNHRKLL DIKQKCTTAK QELANNLHVR
460 470 480 490 500
LKWCCFVMLH ADQDGEKLQA LLRLVIELLE RVRIVEALST VPQMYCLAVV
510 520 530 540 550
EVVRRKMFIK HYREWAGALV KDGKQLYEAE KSKRESFGKL FRKSFLRNRL
560 570 580 590 600
FKGLDSWPSS FCTQKPRKFD CELPDISLKD LQFLQSFCPS EVQPFLRVPL
610 620 630 640 650
LCDFEPLHQH VLALHNLVKA AQSLDEMSQT ITDLLNEQKV STSQASPQSA
660 670 680 690 700
ASPRIESTTG ITTTTSPKTP PPLTVQDTLC PAVCPLEELS PDSIDAHTFD
710 720 730 740 750
FETISHPNTE QPVHQASIDL DSLAESPESD FMSAVNEFVI EENLSSPNPI
760 770 780 790 800
SDPQSPEMMV ESLYSSVINA IDSRRMQDTS TRGNEGFGDR AALHVQLEKC
810 820 830 840 850
RAAAQDSHSS IQTIKDDLCH FRTFVQKEQC DLANYLKCTA VEIRNIIEKV
860 870 880 890 900
KCSLEITLKE KHQQELQSLK IEYECKLDAL VKDSEENVNK ILKLKENLVS
910 920 930 940 950
LEEALQNKDN EFTSIKHEKD AIVCVQQEKD QKLLEMEKIM HTQHCEIKEL
960 970 980 990 1000
KQSREMALED LKKLHDEKIE SLRAEFQCLE QNHLKELEDT LHIRHTQEFE
1010 1020 1030 1040 1050
KVMTDHNMSL EKLKKENQQR IDQMLESHAS TIQEKEQQLQ ELKLKVSDLS
1060 1070 1080 1090 1100
DMRCKLEVEL ALKEAETDEI KILLEESRTQ QKEMLKSLLE QETENLRTEI
1110 1120 1130 1140 1150
SKLNQKIHDN NESYQVGLSE LRALMTIEKD QCISELISRH EEESNILKAE
1160 1170 1180 1190 1200
LDNVTSLHRQ AYEIEKKLKE QIVELQTRLN SELSALEKQK DEKITQQEEK
1210 1220 1230 1240 1250
YEALIQNLEK DKERLVKNHE QDKEHLIQEL NFEKNKAVQT ALDEFKVERE
1260 1270 1280 1290 1300
LVEKELLEKV KHLENQIAKT PAFESAREDS SSLVAELQEK LQEEKAKFLE
1310 1320 1330 1340 1350
QLEEQEKRKN EEMQNVRTSL IAEQQTNFNT VLTREKMRKE NIINDLSDKL
1360 1370 1380 1390 1400
KSTMQQQERD KDLIESLSED RARLLEEKKQ LEEEVSKLRT SSFLSSAPVA
1410 1420 1430 1440 1450
AAPELYGACA PELPGEPERS VMETADEGRL DSAMETSMMS VQENMLSEEK
1460 1470 1480 1490 1500
QRIMLLERTL QLKEEENKRL NQRLMSQSLS SVSSRHSEKI AIRDFQVGDL
1510 1520 1530 1540 1550
VLIILDERHD NYVLFTVSPT LYFLHSESLP ALDLKPGEGA SGASRRPWVL
1560 1570 1580
GKVMEKEYCQ AKKAQNRFKV PLGTKFYRVK AVSWNKKV
Length:1,588
Mass (Da):182,350
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D14F1434604C0AF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PX56E9PX56_MOUSE
RB1-inducible coiled-coil protein 1
Rb1cc1
873Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CC56F7CC56_MOUSE
RB1-inducible coiled-coil protein 1
Rb1cc1
1,468Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TLJ4F6TLJ4_MOUSE
RB1-inducible coiled-coil protein 1
Rb1cc1
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CCJ3F7CCJ3_MOUSE
RB1-inducible coiled-coil protein 1
Rb1cc1
536Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CYY6E0CYY6_MOUSE
RB1-inducible coiled-coil protein 1
Rb1cc1
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CZG6E0CZG6_MOUSE
RB1-inducible coiled-coil protein 1
Rb1cc1
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CYU7E0CYU7_MOUSE
RB1-inducible coiled-coil protein 1
Rb1cc1
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC30793 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti809S → T in BAB16846 (PubMed:12095676).Curated1
Sequence conflicti809S → T in BAB85610 (PubMed:12095676).Curated1
Sequence conflicti981Q → E in BAB16846 (PubMed:12095676).Curated1
Sequence conflicti981Q → E in BAB85610 (PubMed:12095676).Curated1
Sequence conflicti1222D → A in CAA57761 (PubMed:7724523).Curated1
Sequence conflicti1450 – 1451KQ → NE in CAB92238 (PubMed:11207567).Curated2
Sequence conflicti1537 – 1539Missing in CAB92238 (PubMed:11207567).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB050017 mRNA Translation: BAB16846.2
AB070619 mRNA Translation: BAB85610.1
AC102781 Genomic DNA No translation available.
AC139064 Genomic DNA No translation available.
AK041038 mRNA Translation: BAC30793.1 Different initiation.
AK159066 mRNA Translation: BAE34792.1
X82318 mRNA Translation: CAA57761.1
AJ242720 mRNA Translation: CAB92238.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS35507.1

Protein sequence database of the Protein Information Resource

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PIRi
I48282

NCBI Reference Sequences

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RefSeqi
NP_033956.2, NM_009826.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.293811

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000027040; ENSMUSP00000027040; ENSMUSG00000025907

Database of genes from NCBI RefSeq genomes

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GeneIDi
12421

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:12421

UCSC genome browser

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UCSCi
uc007afr.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB050017 mRNA Translation: BAB16846.2
AB070619 mRNA Translation: BAB85610.1
AC102781 Genomic DNA No translation available.
AC139064 Genomic DNA No translation available.
AK041038 mRNA Translation: BAC30793.1 Different initiation.
AK159066 mRNA Translation: BAE34792.1
X82318 mRNA Translation: CAA57761.1
AJ242720 mRNA Translation: CAB92238.1
CCDSiCCDS35507.1
PIRiI48282
RefSeqiNP_033956.2, NM_009826.4
UniGeneiMm.293811

3D structure databases

SMRiQ9ESK9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198540, 6 interactors
ComplexPortaliCPX-380 ULK1-ATG13-RB1CC1-ATG101 autophagy initiation complex
DIPiDIP-49679N
IntActiQ9ESK9, 6 interactors
MINTiQ9ESK9
STRINGi10090.ENSMUSP00000027040

PTM databases

iPTMnetiQ9ESK9
PhosphoSitePlusiQ9ESK9

Proteomic databases

EPDiQ9ESK9
jPOSTiQ9ESK9
MaxQBiQ9ESK9
PaxDbiQ9ESK9
PeptideAtlasiQ9ESK9
PRIDEiQ9ESK9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027040; ENSMUSP00000027040; ENSMUSG00000025907
GeneIDi12421
KEGGimmu:12421
UCSCiuc007afr.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9821
MGIiMGI:1341850 Rb1cc1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG4572 Eukaryota
ENOG410XSY4 LUCA
GeneTreeiENSGT00390000015871
HOGENOMiHOG000154076
HOVERGENiHBG091209
InParanoidiQ9ESK9
KOiK17589
OrthoDBi91906at2759
TreeFamiTF323750

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Rb1cc1 mouse

Protein Ontology

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PROi
PR:Q9ESK9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000025907 Expressed in 274 organ(s), highest expression level in testis
ExpressionAtlasiQ9ESK9 baseline and differential
GenevisibleiQ9ESK9 MM

Family and domain databases

InterProiView protein in InterPro
IPR040040 ATG11
IPR019460 Atg11_C
PANTHERiPTHR13222 PTHR13222, 2 hits
PfamiView protein in Pfam
PF10377 ATG11, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBCC1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ESK9
Secondary accession number(s): E9QLQ2
, Q3TXX2, Q61384, Q8BRY9, Q9JK14
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 27, 2011
Last modified: February 13, 2019
This is version 134 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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