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UniProtKB - Q9ESK3 (CAN10_MOUSE)
Protein
Calpain-10
Gene
Capn10
Organism
Mus musculus (Mouse)
Status
Functioni
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake (By similarity).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 73 | By similarity | 1 | |
Active sitei | 238 | By similarity | 1 | |
Active sitei | 263 | By similarity | 1 |
GO - Molecular functioni
- calcium-dependent cysteine-type endopeptidase activity Source: MGI
- cytoskeletal protein binding Source: MGI
- SNARE binding Source: MGI
GO - Biological processi
- actin cytoskeleton reorganization Source: BHF-UCL
- aging Source: MGI
- autophagy of mitochondrion Source: MGI
- cellular response to insulin stimulus Source: BHF-UCL
- mitochondrion organization Source: MGI
- positive regulation of apoptotic process Source: MGI
- positive regulation of glucose import Source: BHF-UCL
- positive regulation of insulin secretion Source: MGI
- positive regulation of intracellular transport Source: BHF-UCL
- positive regulation of type B pancreatic cell apoptotic process Source: MGI
- proteolysis Source: MGI
- response to nutrient levels Source: MGI
- type B pancreatic cell apoptotic process Source: BHF-UCL
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Enzyme and pathway databases
BRENDAi | 3.4.22.B30, 3474 |
Reactomei | R-MMU-1474228, Degradation of the extracellular matrix |
Protein family/group databases
MEROPSi | C02.018 |
Names & Taxonomyi
Protein namesi | Recommended name: Calpain-10 (EC:3.4.22.-)Alternative name(s): Calcium-activated neutral proteinase 10 Short name: CANP 10 |
Gene namesi | Name:Capn10 Synonyms:Capn8 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1344392, Capn10 |
VEuPathDBi | HostDB:ENSMUSG00000026270 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Source: MGI
Cytosol
- cytosol Source: MGI
Mitochondrion
- mitochondrial inner membrane Source: MGI
- mitochondrial intermembrane space Source: MGI
- mitochondrial matrix Source: MGI
- mitochondrial outer membrane Source: MGI
- mitochondrion Source: MGI
Nucleus
- nucleus Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cell cortex Source: MGI
- cytoplasm Source: MGI
- intracellular membrane-bounded organelle Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000207727 | 1 – 666 | Calpain-10Add BLAST | 666 |
Proteomic databases
PaxDbi | Q9ESK3 |
PRIDEi | Q9ESK3 |
ProteomicsDBi | 265521 |
PTM databases
iPTMneti | Q9ESK3 |
PhosphoSitePlusi | Q9ESK3 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000026270, Expressed in adult mammalian kidney and 292 other tissues |
Genevisiblei | Q9ESK3, MM |
Interactioni
GO - Molecular functioni
- cytoskeletal protein binding Source: MGI
- SNARE binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204746, 2 interactors |
STRINGi | 10090.ENSMUSP00000027488 |
Miscellaneous databases
RNActi | Q9ESK3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 321 | Calpain catalyticPROSITE-ProRule annotationAdd BLAST | 309 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 322 – 488 | Domain III 1Add BLAST | 167 | |
Regioni | 507 – 648 | Domain III 2Add BLAST | 142 |
Sequence similaritiesi
Belongs to the peptidase C2 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0045, Eukaryota |
GeneTreei | ENSGT00940000159706 |
HOGENOMi | CLU_010982_3_3_1 |
InParanoidi | Q9ESK3 |
OMAi | NPWGRCC |
OrthoDBi | 704215at2759 |
PhylomeDBi | Q9ESK3 |
TreeFami | TF314748 |
Family and domain databases
CDDi | cd00214, Calpain_III, 2 hits cd00044, CysPc, 1 hit |
InterProi | View protein in InterPro IPR033883, C2_III IPR022684, Calpain_cysteine_protease IPR022682, Calpain_domain_III IPR022683, Calpain_III IPR036213, Calpain_III_sf IPR028791, CAPN10 IPR038765, Papain-like_cys_pep_sf IPR000169, Pept_cys_AS IPR001300, Peptidase_C2_calpain_cat |
PANTHERi | PTHR10183:SF30, PTHR10183:SF30, 1 hit |
Pfami | View protein in Pfam PF01067, Calpain_III, 2 hits PF00648, Peptidase_C2, 1 hit |
PRINTSi | PR00704, CALPAIN |
SMARTi | View protein in SMART SM00720, calpain_III, 2 hits SM00230, CysPc, 1 hit |
SUPFAMi | SSF49758, SSF49758, 2 hits SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS50203, CALPAIN_CAT, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9ESK3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRAVRAETPA RELFRDAAFP ASDSSLFYNL STPLAQFRED ITWRRPQEIC
60 70 80 90 100
ATPQLFPDNP WEGQVKQGLL GDCWFLCACA ALQKSQHLLD QVFPPGQPGW
110 120 130 140 150
SDQKYQGFFT CRIWQFGHWE EVTIDDRLPC LAGRLCFSRC QREDVFWLPL
160 170 180 190 200
LEKAYAKVHG SYEHLWAGQV ADALVDLTGS LAERWSLKDV TKASGQQDRP
210 220 230 240 250
SGGEHRTCRQ LLHLKDRCLI SCSVLSPRAG ARELGEFHAF IISDLQELRS
260 270 280 290 300
QTGQGILLLR IHNPWGRRCW QGLWREGGEG WNQVEPAKES ELLAQLQEGE
310 320 330 340 350
FWVEEEEFLR EFDEVTIGYP VTEAGHLQSL HTERVLCHTR TLPGAWVTGQ
360 370 380 390 400
SAGGCRNNSC FPCNPKFWLR LLEPSEVCVA VLQRPRRRLV GQTRALAGAS
410 420 430 440 450
PAPVNLPGKD YQAVGLHIWK VEKRKISLPR VLSAPPVAGT ACHAYDREIH
460 470 480 490 500
LRCELSPGYY LAVPSTFLKD VPGQFLLRVF STGKISLSAV RLATKGASPG
510 520 530 540 550
TALPAGEWET VQLQGCWRAG QTAGGSRNFA SYPCNPCLPF SVPEGAGPRY
560 570 580 590 600
IRITLQQHCR LSDSQLHPIG FHVFQVPADG ENQDACSLLL QEPLLSCVPH
610 620 630 640 650
RYAQEVSRLC LLSVGNYRIV PSTYLPDTEG TFTVTIATRI DRQSIHSQEM
660
LGQLLQEVSF MAVMKA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WSM6 | A0A087WSM6_MOUSE | Calpain-10 | Capn10 | 179 | Annotation score: | ||
Q9CPY2 | Q9CPY2_MOUSE | Calpain-10 | Capn10 | 264 | Annotation score: | ||
D6RGR0 | D6RGR0_MOUSE | Calpain-10 | Capn10 | 507 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 481 | S → F (PubMed:11017071).Curated | 1 | |
Sequence conflicti | 481 | S → F (Ref. 2) Curated | 1 | |
Sequence conflicti | 602 – 605 | YAQE → TPRK (Ref. 3) Curated | 4 | |
Sequence conflicti | 663 | V → E in BAC40211 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF089089 mRNA Translation: AAG17967.1 AF203031 Genomic DNA Translation: AAL54919.1 AF126867 mRNA Translation: AAD41779.1 AK088207 mRNA Translation: BAC40211.1 BC005681 mRNA Translation: AAH05681.1 BC010969 mRNA Translation: AAH10969.1 |
CCDSi | CCDS15181.1 |
RefSeqi | NP_035926.2, NM_011796.2 |
Genome annotation databases
Ensembli | ENSMUST00000027488; ENSMUSP00000027488; ENSMUSG00000026270 |
GeneIDi | 23830 |
KEGGi | mmu:23830 |
UCSCi | uc007cby.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF089089 mRNA Translation: AAG17967.1 AF203031 Genomic DNA Translation: AAL54919.1 AF126867 mRNA Translation: AAD41779.1 AK088207 mRNA Translation: BAC40211.1 BC005681 mRNA Translation: AAH05681.1 BC010969 mRNA Translation: AAH10969.1 |
CCDSi | CCDS15181.1 |
RefSeqi | NP_035926.2, NM_011796.2 |
3D structure databases
SMRi | Q9ESK3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204746, 2 interactors |
STRINGi | 10090.ENSMUSP00000027488 |
Protein family/group databases
MEROPSi | C02.018 |
PTM databases
iPTMneti | Q9ESK3 |
PhosphoSitePlusi | Q9ESK3 |
Proteomic databases
PaxDbi | Q9ESK3 |
PRIDEi | Q9ESK3 |
ProteomicsDBi | 265521 |
Protocols and materials databases
Antibodypediai | 1333, 172 antibodies from 23 providers |
DNASUi | 23830 |
Genome annotation databases
Ensembli | ENSMUST00000027488; ENSMUSP00000027488; ENSMUSG00000026270 |
GeneIDi | 23830 |
KEGGi | mmu:23830 |
UCSCi | uc007cby.1, mouse |
Organism-specific databases
CTDi | 11132 |
MGIi | MGI:1344392, Capn10 |
VEuPathDBi | HostDB:ENSMUSG00000026270 |
Phylogenomic databases
eggNOGi | KOG0045, Eukaryota |
GeneTreei | ENSGT00940000159706 |
HOGENOMi | CLU_010982_3_3_1 |
InParanoidi | Q9ESK3 |
OMAi | NPWGRCC |
OrthoDBi | 704215at2759 |
PhylomeDBi | Q9ESK3 |
TreeFami | TF314748 |
Enzyme and pathway databases
BRENDAi | 3.4.22.B30, 3474 |
Reactomei | R-MMU-1474228, Degradation of the extracellular matrix |
Miscellaneous databases
BioGRID-ORCSi | 23830, 0 hits in 63 CRISPR screens |
ChiTaRSi | Capn10, mouse |
PROi | PR:Q9ESK3 |
RNActi | Q9ESK3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026270, Expressed in adult mammalian kidney and 292 other tissues |
Genevisiblei | Q9ESK3, MM |
Family and domain databases
CDDi | cd00214, Calpain_III, 2 hits cd00044, CysPc, 1 hit |
InterProi | View protein in InterPro IPR033883, C2_III IPR022684, Calpain_cysteine_protease IPR022682, Calpain_domain_III IPR022683, Calpain_III IPR036213, Calpain_III_sf IPR028791, CAPN10 IPR038765, Papain-like_cys_pep_sf IPR000169, Pept_cys_AS IPR001300, Peptidase_C2_calpain_cat |
PANTHERi | PTHR10183:SF30, PTHR10183:SF30, 1 hit |
Pfami | View protein in Pfam PF01067, Calpain_III, 2 hits PF00648, Peptidase_C2, 1 hit |
PRINTSi | PR00704, CALPAIN |
SMARTi | View protein in SMART SM00720, calpain_III, 2 hits SM00230, CysPc, 1 hit |
SUPFAMi | SSF49758, SSF49758, 2 hits SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS50203, CALPAIN_CAT, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CAN10_MOUSE | |
Accessioni | Q9ESK3Primary (citable) accession number: Q9ESK3 Secondary accession number(s): Q99J13, Q9WVF0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2002 |
Last sequence update: | February 12, 2003 | |
Last modified: | February 23, 2022 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families