UniProtKB - Q9ESK3 (CAN10_MOUSE)

BLAST

>sp|Q9ESK3|CAN10_MOUSE Calpain-10 OS=Mus musculus OX=10090 GN=Capn10 PE=2 SV=2
MRAVRAETPARELFRDAAFPASDSSLFYNLSTPLAQFREDITWRRPQEICATPQLFPDNP
WEGQVKQGLLGDCWFLCACAALQKSQHLLDQVFPPGQPGWSDQKYQGFFTCRIWQFGHWE
EVTIDDRLPCLAGRLCFSRCQREDVFWLPLLEKAYAKVHGSYEHLWAGQVADALVDLTGS
LAERWSLKDVTKASGQQDRPSGGEHRTCRQLLHLKDRCLISCSVLSPRAGARELGEFHAF
IISDLQELRSQTGQGILLLRIHNPWGRRCWQGLWREGGEGWNQVEPAKESELLAQLQEGE
FWVEEEEFLREFDEVTIGYPVTEAGHLQSLHTERVLCHTRTLPGAWVTGQSAGGCRNNSC
FPCNPKFWLRLLEPSEVCVAVLQRPRRRLVGQTRALAGASPAPVNLPGKDYQAVGLHIWK
VEKRKISLPRVLSAPPVAGTACHAYDREIHLRCELSPGYYLAVPSTFLKDVPGQFLLRVF
STGKISLSAVRLATKGASPGTALPAGEWETVQLQGCWRAGQTAGGSRNFASYPCNPCLPF
SVPEGAGPRYIRITLQQHCRLSDSQLHPIGFHVFQVPADGENQDACSLLLQEPLLSCVPH
RYAQEVSRLCLLSVGNYRIVPSTYLPDTEGTFTVTIATRIDRQSIHSQEMLGQLLQEVSF
MAVMKA

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History
Entry version 136 (07 Nov 2018)
Sequence version 2 (12 Feb 2003)
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Protein

Calpain-10

Gene

Capn10

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	73	By similarity	1
Active siteⁱ	238	By similarity	1
Active siteⁱ	263	By similarity	1

GO - Molecular functionⁱ

calcium-dependent cysteine-type endopeptidase activity Source: MGI
cytoskeletal protein binding Source: MGI
SNARE binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton reorganization
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12974673
aging Source: MGI
autophagy of mitochondrion Source: MGI
cellular response to insulin stimulus
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12974673
mitochondrion organization Source: MGI
positive regulation of apoptotic process Source: MGI
positive regulation of glucose import
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12974673
positive regulation of insulin secretion Source: MGI
positive regulation of intracellular transport
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12974673
positive regulation of type B pancreatic cell apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 15044459
proteolysis Source: MGI
response to nutrient levels Source: MGI
type B pancreatic cell apoptotic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15044459

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Thiol protease

Molecular function

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAⁱ	3.4.22.B30 3474
Reactomeⁱ	R-MMU-1474228 Degradation of the extracellular matrix

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C02.018

MEROPSⁱ

C02.018

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Calpain-10 (EC:3.4.22.-) Alternative name(s): Calcium-activated neutral proteinase 10 Short name: CANP 10
Gene namesⁱ	Name:Capn10 Synonyms:Capn8
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:1344392 Capn10

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000207727	1 – 666	Calpain-10Add BLAST		666

Proteomic databases

PaxDbⁱ	Q9ESK3
PRIDEⁱ	Q9ESK3

PTM databases

iPTMnetⁱ	Q9ESK3
PhosphoSitePlusⁱ	Q9ESK3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000026270 Expressed in 269 organ(s), highest expression level in ear vesicle
CleanExⁱ	MM_CAPN10 MM_CAPN8
ExpressionAtlasⁱ	Q9ESK3 baseline and differential
Genevisibleⁱ	Q9ESK3 MM

Interactionⁱ

GO - Molecular functionⁱ

cytoskeletal protein binding Source: MGI
SNARE binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000027488

STRINGⁱ

10090.ENSMUSP00000027488

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9ESK3
SMRⁱ	Q9ESK3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	13 – 321	Calpain catalyticPROSITE-ProRule annotationAdd BLAST		309

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	322 – 488	Domain III 1Add BLAST		167
Regionⁱ	507 – 648	Domain III 2Add BLAST		142

Sequence similaritiesⁱ

Belongs to the peptidase C2 family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0045 Eukaryota ENOG410XP0B LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00750000117668
HOGENOMⁱ	HOG000081807
HOVERGENⁱ	HBG050787
InParanoidⁱ	Q9ESK3
KEGG Orthology (KO) More...KOⁱ	K08579
OMAⁱ	YEQLWAG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02O4
PhylomeDBⁱ	Q9ESK3
TreeFamⁱ	TF314748

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00214 Calpain_III, 2 hits cd00044 CysPc, 1 hit
InterProⁱ	View protein in InterPro IPR033883 C2_III IPR022684 Calpain_cysteine_protease IPR022682 Calpain_domain_III IPR022683 Calpain_III IPR036213 Calpain_III_sf IPR028791 CAPN10 IPR038765 Papain_like_cys_pep_sf IPR000169 Pept_cys_AS IPR001300 Peptidase_C2_calpain_cat
PANTHERⁱ	PTHR10183:SF30 PTHR10183:SF30, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01067 Calpain_III, 2 hits PF00648 Peptidase_C2, 1 hit
PRINTSⁱ	PR00704 CALPAIN
SMARTⁱ	View protein in SMART SM00720 calpain_III, 2 hits SM00230 CysPc, 1 hit
SUPFAMⁱ	SSF49758 SSF49758, 2 hits SSF54001 SSF54001, 1 hit
PROSITEⁱ	View protein in PROSITE PS50203 CALPAIN_CAT, 1 hit PS00139 THIOL_PROTEASE_CYS, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q9ESK3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRAVRAETPA RELFRDAAFP ASDSSLFYNL STPLAQFRED ITWRRPQEIC 
        60         70         80         90        100
ATPQLFPDNP WEGQVKQGLL GDCWFLCACA ALQKSQHLLD QVFPPGQPGW 
       110        120        130        140        150
SDQKYQGFFT CRIWQFGHWE EVTIDDRLPC LAGRLCFSRC QREDVFWLPL 
       160        170        180        190        200
LEKAYAKVHG SYEHLWAGQV ADALVDLTGS LAERWSLKDV TKASGQQDRP 
       210        220        230        240        250
SGGEHRTCRQ LLHLKDRCLI SCSVLSPRAG ARELGEFHAF IISDLQELRS 
       260        270        280        290        300
QTGQGILLLR IHNPWGRRCW QGLWREGGEG WNQVEPAKES ELLAQLQEGE 
       310        320        330        340        350
FWVEEEEFLR EFDEVTIGYP VTEAGHLQSL HTERVLCHTR TLPGAWVTGQ 
       360        370        380        390        400
SAGGCRNNSC FPCNPKFWLR LLEPSEVCVA VLQRPRRRLV GQTRALAGAS 
       410        420        430        440        450
PAPVNLPGKD YQAVGLHIWK VEKRKISLPR VLSAPPVAGT ACHAYDREIH 
       460        470        480        490        500
LRCELSPGYY LAVPSTFLKD VPGQFLLRVF STGKISLSAV RLATKGASPG 
       510        520        530        540        550
TALPAGEWET VQLQGCWRAG QTAGGSRNFA SYPCNPCLPF SVPEGAGPRY 
       560        570        580        590        600
IRITLQQHCR LSDSQLHPIG FHVFQVPADG ENQDACSLLL QEPLLSCVPH 
       610        620        630        640        650
RYAQEVSRLC LLSVGNYRIV PSTYLPDTEG TFTVTIATRI DRQSIHSQEM 
       660 
LGQLLQEVSF MAVMKA

Length:666

Mass (Da):74,596

Last modified:February 12, 2003 - v2

Checksum:ⁱA0B1B37EE1DE2371

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RGR0	D6RGR0_MOUSE	Calpain-10 Calpain-10	Capn10	507	Annotation score:
Q9CPY2	Q9CPY2_MOUSE	Calpain 10, isoform CRA_a Calpain 10, isoform CRA_a (Calpain-10)	Capn10 mCG_16575	264	Annotation score:
A0A087WSM6	A0A087WSM6_MOUSE	Calpain-10 Calpain-10	Capn10	179	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	481	S → F (PubMed:11017071).Curated	1
Sequence conflictⁱ	481	S → F (Ref. 2) Curated	1
Sequence conflictⁱ	602 – 605	YAQE → TPRK (Ref. 3) Curated	4
Sequence conflictⁱ	663	V → E in BAC40211 (PubMed:16141072).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF089089 mRNA Translation: AAG17967.1 AF203031 Genomic DNA Translation: AAL54919.1 AF126867 mRNA Translation: AAD41779.1 AK088207 mRNA Translation: BAC40211.1 BC005681 mRNA Translation: AAH05681.1 BC010969 mRNA Translation: AAH10969.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15181.1
NCBI Reference Sequences More...RefSeqⁱ	NP_035926.2, NM_011796.2
UniGeneⁱ	Mm.294315

Genome annotation databases

Ensemblⁱ	ENSMUST00000027488; ENSMUSP00000027488; ENSMUSG00000026270
GeneIDⁱ	23830
KEGGⁱ	mmu:23830
UCSC genome browser More...UCSCⁱ	uc007cby.1 mouse

Protein	Similar proteins		Species	Score	Length	Source
Q9ESK3	Calpain-10		RAT		666	UniRef90_Q9ES66
calpain-10		MESAU		666
Uncharacterized protein		NEOLE		666
Calpain 10		MERUN		666
UPI000454BB6B		CRIGR		694
+12

Protein	Similar proteins		Species	Score	Length	Source
Q9ESK3	Calpain-10		HUMAN		672	UniRef50_Q9HC96
Calpain-10		MACFA		653
Calpain-10		RAT		666
Uncharacterized protein		PAPAN		681
CAPN10 isoform 11		PONAB		680
+191

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF089089 mRNA Translation: AAG17967.1 AF203031 Genomic DNA Translation: AAL54919.1 AF126867 mRNA Translation: AAD41779.1 AK088207 mRNA Translation: BAC40211.1 BC005681 mRNA Translation: AAH05681.1 BC010969 mRNA Translation: AAH10969.1
CCDSⁱ	CCDS15181.1
RefSeqⁱ	NP_035926.2, NM_011796.2
UniGeneⁱ	Mm.294315

3D structure databases

ProteinModelPortalⁱ	Q9ESK3
SMRⁱ	Q9ESK3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000027488

STRINGⁱ

10090.ENSMUSP00000027488

Protein family/group databases

MEROPSⁱ	C02.018

MEROPSⁱ

C02.018

PTM databases

iPTMnetⁱ	Q9ESK3
PhosphoSitePlusⁱ	Q9ESK3

Proteomic databases

PaxDbⁱ	Q9ESK3
PRIDEⁱ	Q9ESK3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000027488; ENSMUSP00000027488; ENSMUSG00000026270
GeneIDⁱ	23830
KEGGⁱ	mmu:23830
UCSCⁱ	uc007cby.1 mouse

Organism-specific databases

CTDⁱ	11132
MGIⁱ	MGI:1344392 Capn10

Phylogenomic databases

eggNOGⁱ	KOG0045 Eukaryota ENOG410XP0B LUCA
GeneTreeⁱ	ENSGT00750000117668
HOGENOMⁱ	HOG000081807
HOVERGENⁱ	HBG050787
InParanoidⁱ	Q9ESK3
KOⁱ	K08579
OMAⁱ	YEQLWAG
OrthoDBⁱ	EOG091G02O4
PhylomeDBⁱ	Q9ESK3
TreeFamⁱ	TF314748

Enzyme and pathway databases

BRENDAⁱ	3.4.22.B30 3474
Reactomeⁱ	R-MMU-1474228 Degradation of the extracellular matrix

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9ESK3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000026270 Expressed in 269 organ(s), highest expression level in ear vesicle
CleanExⁱ	MM_CAPN10 MM_CAPN8
ExpressionAtlasⁱ	Q9ESK3 baseline and differential
Genevisibleⁱ	Q9ESK3 MM

Family and domain databases

CDDⁱ	cd00214 Calpain_III, 2 hits cd00044 CysPc, 1 hit
InterProⁱ	View protein in InterPro IPR033883 C2_III IPR022684 Calpain_cysteine_protease IPR022682 Calpain_domain_III IPR022683 Calpain_III IPR036213 Calpain_III_sf IPR028791 CAPN10 IPR038765 Papain_like_cys_pep_sf IPR000169 Pept_cys_AS IPR001300 Peptidase_C2_calpain_cat
PANTHERⁱ	PTHR10183:SF30 PTHR10183:SF30, 1 hit
Pfamⁱ	View protein in Pfam PF01067 Calpain_III, 2 hits PF00648 Peptidase_C2, 1 hit
PRINTSⁱ	PR00704 CALPAIN
SMARTⁱ	View protein in SMART SM00720 calpain_III, 2 hits SM00230 CysPc, 1 hit
SUPFAMⁱ	SSF49758 SSF49758, 2 hits SSF54001 SSF54001, 1 hit
PROSITEⁱ	View protein in PROSITE PS50203 CALPAIN_CAT, 1 hit PS00139 THIOL_PROTEASE_CYS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CAN10_MOUSE
Accessionⁱ	Q9ESK3Primary (citable) accession number: Q9ESK3 Secondary accession number(s): Q99J13, Q9WVF0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
	Last sequence update:	February 12, 2003
	Last modified:	November 7, 2018
	This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Peptidase families
Classification of peptidase families and list of entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9ESK3 (CAN10_MOUSE)

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Calpain-10

Capn10

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

Mitochondrion

Nucleus

Plasma Membrane

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ