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Protein

Calpain-10

Gene

Capn10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73By similarity1
Active sitei238By similarity1
Active sitei263By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.22.B30 3474
ReactomeiR-MMU-1474228 Degradation of the extracellular matrix

Protein family/group databases

MEROPSiC02.018

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-10 (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase 10
Short name:
CANP 10
Gene namesi
Name:Capn10
Synonyms:Capn8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1344392 Capn10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002077271 – 666Calpain-10Add BLAST666

Proteomic databases

PaxDbiQ9ESK3
PRIDEiQ9ESK3

PTM databases

iPTMnetiQ9ESK3
PhosphoSitePlusiQ9ESK3

Expressioni

Gene expression databases

BgeeiENSMUSG00000026270 Expressed in 269 organ(s), highest expression level in ear vesicle
CleanExiMM_CAPN10
MM_CAPN8
ExpressionAtlasiQ9ESK3 baseline and differential
GenevisibleiQ9ESK3 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027488

Structurei

3D structure databases

ProteinModelPortaliQ9ESK3
SMRiQ9ESK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 321Calpain catalyticPROSITE-ProRule annotationAdd BLAST309

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni322 – 488Domain III 1Add BLAST167
Regioni507 – 648Domain III 2Add BLAST142

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00750000117668
HOGENOMiHOG000081807
HOVERGENiHBG050787
InParanoidiQ9ESK3
KOiK08579
OMAiYEQLWAG
OrthoDBiEOG091G02O4
PhylomeDBiQ9ESK3
TreeFamiTF314748

Family and domain databases

CDDicd00214 Calpain_III, 2 hits
cd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR028791 CAPN10
IPR038765 Papain_like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF30 PTHR10183:SF30, 1 hit
PfamiView protein in Pfam
PF01067 Calpain_III, 2 hits
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00720 calpain_III, 2 hits
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 2 hits
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9ESK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAVRAETPA RELFRDAAFP ASDSSLFYNL STPLAQFRED ITWRRPQEIC
60 70 80 90 100
ATPQLFPDNP WEGQVKQGLL GDCWFLCACA ALQKSQHLLD QVFPPGQPGW
110 120 130 140 150
SDQKYQGFFT CRIWQFGHWE EVTIDDRLPC LAGRLCFSRC QREDVFWLPL
160 170 180 190 200
LEKAYAKVHG SYEHLWAGQV ADALVDLTGS LAERWSLKDV TKASGQQDRP
210 220 230 240 250
SGGEHRTCRQ LLHLKDRCLI SCSVLSPRAG ARELGEFHAF IISDLQELRS
260 270 280 290 300
QTGQGILLLR IHNPWGRRCW QGLWREGGEG WNQVEPAKES ELLAQLQEGE
310 320 330 340 350
FWVEEEEFLR EFDEVTIGYP VTEAGHLQSL HTERVLCHTR TLPGAWVTGQ
360 370 380 390 400
SAGGCRNNSC FPCNPKFWLR LLEPSEVCVA VLQRPRRRLV GQTRALAGAS
410 420 430 440 450
PAPVNLPGKD YQAVGLHIWK VEKRKISLPR VLSAPPVAGT ACHAYDREIH
460 470 480 490 500
LRCELSPGYY LAVPSTFLKD VPGQFLLRVF STGKISLSAV RLATKGASPG
510 520 530 540 550
TALPAGEWET VQLQGCWRAG QTAGGSRNFA SYPCNPCLPF SVPEGAGPRY
560 570 580 590 600
IRITLQQHCR LSDSQLHPIG FHVFQVPADG ENQDACSLLL QEPLLSCVPH
610 620 630 640 650
RYAQEVSRLC LLSVGNYRIV PSTYLPDTEG TFTVTIATRI DRQSIHSQEM
660
LGQLLQEVSF MAVMKA
Length:666
Mass (Da):74,596
Last modified:February 12, 2003 - v2
Checksum:iA0B1B37EE1DE2371
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RGR0D6RGR0_MOUSE
Calpain-10
Capn10
507Annotation score:
Q9CPY2Q9CPY2_MOUSE
Calpain 10, isoform CRA_a
Capn10 mCG_16575
264Annotation score:
A0A087WSM6A0A087WSM6_MOUSE
Calpain-10
Capn10
179Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti481S → F (PubMed:11017071).Curated1
Sequence conflicti481S → F (Ref. 2) Curated1
Sequence conflicti602 – 605YAQE → TPRK (Ref. 3) Curated4
Sequence conflicti663V → E in BAC40211 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089089 mRNA Translation: AAG17967.1
AF203031 Genomic DNA Translation: AAL54919.1
AF126867 mRNA Translation: AAD41779.1
AK088207 mRNA Translation: BAC40211.1
BC005681 mRNA Translation: AAH05681.1
BC010969 mRNA Translation: AAH10969.1
CCDSiCCDS15181.1
RefSeqiNP_035926.2, NM_011796.2
UniGeneiMm.294315

Genome annotation databases

EnsembliENSMUST00000027488; ENSMUSP00000027488; ENSMUSG00000026270
GeneIDi23830
KEGGimmu:23830
UCSCiuc007cby.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089089 mRNA Translation: AAG17967.1
AF203031 Genomic DNA Translation: AAL54919.1
AF126867 mRNA Translation: AAD41779.1
AK088207 mRNA Translation: BAC40211.1
BC005681 mRNA Translation: AAH05681.1
BC010969 mRNA Translation: AAH10969.1
CCDSiCCDS15181.1
RefSeqiNP_035926.2, NM_011796.2
UniGeneiMm.294315

3D structure databases

ProteinModelPortaliQ9ESK3
SMRiQ9ESK3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027488

Protein family/group databases

MEROPSiC02.018

PTM databases

iPTMnetiQ9ESK3
PhosphoSitePlusiQ9ESK3

Proteomic databases

PaxDbiQ9ESK3
PRIDEiQ9ESK3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027488; ENSMUSP00000027488; ENSMUSG00000026270
GeneIDi23830
KEGGimmu:23830
UCSCiuc007cby.1 mouse

Organism-specific databases

CTDi11132
MGIiMGI:1344392 Capn10

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00750000117668
HOGENOMiHOG000081807
HOVERGENiHBG050787
InParanoidiQ9ESK3
KOiK08579
OMAiYEQLWAG
OrthoDBiEOG091G02O4
PhylomeDBiQ9ESK3
TreeFamiTF314748

Enzyme and pathway databases

BRENDAi3.4.22.B30 3474
ReactomeiR-MMU-1474228 Degradation of the extracellular matrix

Miscellaneous databases

PROiPR:Q9ESK3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026270 Expressed in 269 organ(s), highest expression level in ear vesicle
CleanExiMM_CAPN10
MM_CAPN8
ExpressionAtlasiQ9ESK3 baseline and differential
GenevisibleiQ9ESK3 MM

Family and domain databases

CDDicd00214 Calpain_III, 2 hits
cd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR028791 CAPN10
IPR038765 Papain_like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF30 PTHR10183:SF30, 1 hit
PfamiView protein in Pfam
PF01067 Calpain_III, 2 hits
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00720 calpain_III, 2 hits
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 2 hits
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAN10_MOUSE
AccessioniPrimary (citable) accession number: Q9ESK3
Secondary accession number(s): Q99J13, Q9WVF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: February 12, 2003
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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