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Protein

CDK5 and ABL1 enzyme substrate 1

Gene

Cables1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).By similarity1 Publication

Caution

PubMed:10896159 demonstrated that CABLES1 is not associated with CDK3.Curated

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • G1/S transition of mitotic cell cycle Source: MGI
  • nervous system development Source: MGI
  • regulation of cell cycle Source: MGI

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-MMU-69202 Cyclin E associated events during G1/S transition
R-MMU-69656 Cyclin A:Cdk2-associated events at S phase entry

Names & Taxonomyi

Protein namesi
Recommended name:
CDK5 and ABL1 enzyme substrate 1
Alternative name(s):
Interactor with CDK3 1
Short name:
Ik3-1
Gene namesi
Name:Cables1
Synonyms:Cables
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1927065 Cables1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi274S → A: Less efficiently phosphorylated in vitro. 1 Publication1
Mutagenesisi274S → T: Efficiently phosphorylated in vitro. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000805111 – 568CDK5 and ABL1 enzyme substrate 1Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248PhosphoserineBy similarity1
Modified residuei274Phosphoserine; by CDK2 and CDK31 Publication1
Modified residuei350PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated on Ser-274 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9ESJ1
PaxDbiQ9ESJ1
PRIDEiQ9ESJ1

PTM databases

iPTMnetiQ9ESJ1
PhosphoSitePlusiQ9ESJ1

Expressioni

Tissue specificityi

Ubiquitous. Expressed in postnatal day 1 (P1), in postmitotic neurons of the subplate, cortex (V/VI) and marginal zone; in postnatal day 7 (P7), in all layers of the cerebral cortex and in the CA1 and CA2 regions of the hippocampus (at protein level). Highly expressed in brain, kidney, liver and lung.2 Publications

Developmental stagei

Expressed in embryo at 15 dpc and strongly expressed in postmitotic neurons of the subplate, cortical plate, subventrical and marginal zones at 18 dpc (at protein level). Expressed in embryo at 7 dpc onwards.1 Publication

Gene expression databases

BgeeiENSMUSG00000040957 Expressed in 254 organ(s), highest expression level in female gonad
CleanExiMM_CABLES1
ExpressionAtlasiQ9ESJ1 baseline and differential
GenevisibleiQ9ESJ1 MM

Interactioni

Subunit structurei

Found in a complex with p53/TP53 (By similarity). Found in a number of complexes with CDK2, CDK3, CDK5, ABL1, TDRD7, CDK17, CCNA1, CCNE1 and TP73. Interacts with CDK2, CDK3, CDK5, ABL1 and TDRD7.By similarity5 Publications

Binary interactionsi

Protein-protein interaction databases

CORUMiQ9ESJ1
ELMiQ9ESJ1
IntActiQ9ESJ1, 3 interactors
MINTiQ9ESJ1
STRINGi10090.ENSMUSP00000129463

Structurei

3D structure databases

ProteinModelPortaliQ9ESJ1
SMRiQ9ESJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 98Interaction with TDRD71 PublicationAdd BLAST98
Regioni140 – 427Interaction with CDK31 PublicationAdd BLAST288

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 54Pro-richAdd BLAST21

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiKOG4164 Eukaryota
ENOG4110WYV LUCA
GeneTreeiENSGT00400000022086
HOGENOMiHOG000231236
HOVERGENiHBG050759
InParanoidiQ9ESJ1

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR012388 CABLES1/2
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
PANTHERiPTHR22896 PTHR22896, 2 hits
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
PIRSFiPIRSF025798 Cables, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9ESJ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAATATAGT AACSSSSSSR GGSTDAAATS GVQPPPPPPA TAPPEPLRKP
60 70 80 90 100
RMDPRRRQAA LSFLTNISLD GRPPLQDHEW GGGEEGGGTK PGARARLSLL
110 120 130 140 150
AAGCNAFSAP GTAAAPWTAG SGSSPCPLPP SLVPRVLGEP SQPPRSAPAV
160 170 180 190 200
TGAQLQLPDG PGGAGQEELE EDDAFTNVQV PSASFLGSGT PGSTSGSRGR
210 220 230 240 250
LNSFTQGILP IAFSRQNSQN YCALEQSGQG GSTSALEQLQ RSRRRLISQR
260 270 280 290 300
SSLETLEDIE ENAPLRRCRT LSGSPRPKNF KKIHFIKNMR QHDTKNGRDL
310 320 330 340 350
KLDGGRQSAG AMSLKEIIGL EGVELGADGK TVSYTQFLLP TNAFGNRRNT
360 370 380 390 400
IDSTASFSQF RSLSHRSLSM GRAGSTQGSL DAGSDLGDFM DYDPNLLDDP
410 420 430 440 450
QWPCGKHKRV LTFPSYMTTV IDYVKPSDLK KDMNETFKEK FPHIKLTLSK
460 470 480 490 500
IRSLKREMRK LAQEDCGFEE PTVAMAFVYF EKLALRGKLN KQNRKLCAGA
510 520 530 540 550
CVLLAAKVGS DLRKHEVKHL IDKLEEKFRL NRRELIAFEF PVLVALEFAL
560
HLPEHEVMPH YRRLIQSS
Length:568
Mass (Da):61,429
Last modified:July 27, 2011 - v2
Checksum:iA5B8131FCDAD1B7D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3U148Q3U148_MOUSE
CDK5 and ABL1 enzyme substrate 1
Cables1
594Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84 – 85EE → DQ in AAG33933 (PubMed:10896159).Curated2
Sequence conflicti242S → A in AAG33933 (PubMed:10896159).Curated1
Sequence conflicti384S → C in AAG33933 (PubMed:10896159).Curated1
Sequence conflicti390M → V in AAG33933 (PubMed:10896159).Curated1
Sequence conflicti390M → V in AAG42916 (PubMed:10873625).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133208 mRNA Translation: AAG33933.1
AF328140 mRNA Translation: AAG42916.1
AC100751 Genomic DNA No translation available.
AC132941 Genomic DNA No translation available.
CCDSiCCDS29061.1
PIRiJC7317
RefSeqiNP_071304.2, NM_022021.2
UniGeneiMm.40717

Genome annotation databases

EnsembliENSMUST00000046948; ENSMUSP00000040639; ENSMUSG00000040957
GeneIDi63955
KEGGimmu:63955
UCSCiuc012azi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133208 mRNA Translation: AAG33933.1
AF328140 mRNA Translation: AAG42916.1
AC100751 Genomic DNA No translation available.
AC132941 Genomic DNA No translation available.
CCDSiCCDS29061.1
PIRiJC7317
RefSeqiNP_071304.2, NM_022021.2
UniGeneiMm.40717

3D structure databases

ProteinModelPortaliQ9ESJ1
SMRiQ9ESJ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ9ESJ1
ELMiQ9ESJ1
IntActiQ9ESJ1, 3 interactors
MINTiQ9ESJ1
STRINGi10090.ENSMUSP00000129463

PTM databases

iPTMnetiQ9ESJ1
PhosphoSitePlusiQ9ESJ1

Proteomic databases

MaxQBiQ9ESJ1
PaxDbiQ9ESJ1
PRIDEiQ9ESJ1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046948; ENSMUSP00000040639; ENSMUSG00000040957
GeneIDi63955
KEGGimmu:63955
UCSCiuc012azi.1 mouse

Organism-specific databases

CTDi91768
MGIiMGI:1927065 Cables1

Phylogenomic databases

eggNOGiKOG4164 Eukaryota
ENOG4110WYV LUCA
GeneTreeiENSGT00400000022086
HOGENOMiHOG000231236
HOVERGENiHBG050759
InParanoidiQ9ESJ1

Enzyme and pathway databases

ReactomeiR-MMU-69202 Cyclin E associated events during G1/S transition
R-MMU-69656 Cyclin A:Cdk2-associated events at S phase entry

Miscellaneous databases

PROiPR:Q9ESJ1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040957 Expressed in 254 organ(s), highest expression level in female gonad
CleanExiMM_CABLES1
ExpressionAtlasiQ9ESJ1 baseline and differential
GenevisibleiQ9ESJ1 MM

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR012388 CABLES1/2
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
PANTHERiPTHR22896 PTHR22896, 2 hits
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
PIRSFiPIRSF025798 Cables, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCABL1_MOUSE
AccessioniPrimary (citable) accession number: Q9ESJ1
Secondary accession number(s): E9QNI6, Q9EPR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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