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Protein

Exportin-4

Gene

Xpo4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).By similarity

GO - Molecular functioni

  • nuclear export signal receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-4
Short name:
Exp4
Gene namesi
Name:Xpo4
Synonyms:Kiaa1721
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1888526 Xpo4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047121 – 1151Exportin-4Add BLAST1151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei464PhosphoserineCombined sources1
Modified residuei521PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9ESJ0
MaxQBiQ9ESJ0
PaxDbiQ9ESJ0
PeptideAtlasiQ9ESJ0
PRIDEiQ9ESJ0

PTM databases

iPTMnetiQ9ESJ0
PhosphoSitePlusiQ9ESJ0

Expressioni

Gene expression databases

BgeeiENSMUSG00000021952 Expressed in 244 organ(s), highest expression level in heart
CleanExiMM_XPO4
ExpressionAtlasiQ9ESJ0 baseline and differential
GenevisibleiQ9ESJ0 MM

Interactioni

Subunit structurei

Found in a complex with XPO4, Ran and EIF5A. Found in a complex with XPO4, Ran and SMAD3. Interacts with SMAD3. Interacts with Ran and cargo proteins in a GTP-dependent manner (By similarity).By similarity

Protein-protein interaction databases

BioGridi208228, 4 interactors
IntActiQ9ESJ0, 2 interactors
STRINGi10090.ENSMUSP00000133280

Structurei

Secondary structure

11151
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiQ9ESJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

eggNOGiKOG4541 Eukaryota
ENOG410XNNN LUCA
GeneTreeiENSGT00730000111055
HOGENOMiHOG000154878
HOVERGENiHBG023214
InParanoidiQ9ESJ0
OrthoDBiEOG091G01OG
TreeFamiTF312991

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR014877 XPO1_C_dom
PfamiView protein in Pfam
PF08767 CRM1_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9ESJ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAAALGPPE VIAQLENAAK VLMAPPSMVS NEQRQHAEHI FLSFRKSKSP
60 70 80 90 100
FAVCRHILET SKVDYVLFQA ATAIMEAVVR EWVLLEKGSI ESLRTFLLTY
110 120 130 140 150
VLQRPNLQKY VREQILLAVA VIVKRGSLDK SIDCKSIFHE VSQLISSGNP
160 170 180 190 200
TVQTLACSIL TALLSEFSSS SKTSNIGLSM EFHGNCKRVF QEEDLRQIFM
210 220 230 240 250
LTVGVLQEFS RRENLSAQMS SVFQRYLALA NQVLSWNFLP PKLGRHYIAM
260 270 280 290 300
FESSQNVLLK PTESWREALL DSRVMELFFT VHRKIREDSD MAQDSLQCLA
310 320 330 340 350
QLASLHGPIF PDEGSQVDYL AHFIEGLLNT INGIEIEDSE AVGISSIISN
360 370 380 390 400
LITVFPRNVL TAIPSELFSS FVNCLTHLTC SFGRSAALEE VLDKDDMVYM
410 420 430 440 450
EAYDKLLESW LTLVRDDKHF HKGFFTQHAV QVFNSYIQCH LAAPDGTRNL
460 470 480 490 500
TANGVASREE EEISELQEDD RDQFSDQLAS VGMLGRIAAE HCMPLLTSLL
510 520 530 540 550
EERVTRLHGQ LQRHQQQFLA SPGSSTIDNK MLDDLYEDIH WLILVTGYLL
560 570 580 590 600
ADDTQGETPL IPPEIMEYSI KHSSEVDINT TLQILGSPGE KASSIPGYSR
610 620 630 640 650
TDSVIRLLSA VLRVSEVESR AIRADLTHLL SPQMGKDIVW FLKRWAKTYL
660 670 680 690 700
LVDEKLYDQI SLPLSTAFGA DTEGSQWIIG YLLQKVISNL SVWSSEQDLA
710 720 730 740 750
NDTVQLLVTL VERRERANLV IQCENWWNLA KQFASRSPPL NFLSSPVQRT
760 770 780 790 800
LMKALVLGGF AHMDTETKQQ YWTEVLQPLQ QRFLRVINQE NFQQMCQQEE
810 820 830 840 850
VKQEITATLE ALCGIAEATQ IDNVAILFNF LMDFLNNCIG LMEVYKNTPE
860 870 880 890 900
TVNLIIEVFV EVAHKQICYL GESKAMHLYE ACLTLLQVYS KNNLGRQRID
910 920 930 940 950
VTAEEEQYQD LLLIMELLTN LLSKEFIDFS DTDEVFRGHE PGQAAGRSVS
960 970 980 990 1000
AADVVLYGVN LILPLMSQDL LKFPTLCNQY YKLITFICEI FPEKIPQLPE
1010 1020 1030 1040 1050
DLFKSLMYSL ELGMTSMSSE VCQLCLEALT PLAEQCAKAQ ETDSPLFLAT
1060 1070 1080 1090 1100
RHFLKLVFDM LVLQKHNTEM TTAAGEAFYT LVCLHQAEYS ELVETLLSSQ
1110 1120 1130 1140 1150
QDPVIYQRLA DAFNKLTASS TPPALDRKQK MAFLKSLEEF MANVGGLLCV

K
Length:1,151
Mass (Da):129,979
Last modified:July 27, 2011 - v2
Checksum:i91428FC24FB54628
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J254A0A0R4J254_MOUSE
Exportin-4
Xpo4
1,151Annotation score:
G3UX04G3UX04_MOUSE
Exportin-4
Xpo4
70Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242K → N in AAG09133 (PubMed:10944119).Curated1
Sequence conflicti242K → N in BAC98240 (PubMed:14621295).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145021 mRNA Translation: AAG09133.1
AC154504 Genomic DNA No translation available.
AC154675 Genomic DNA No translation available.
AK129430 mRNA Translation: BAC98240.1
CCDSiCCDS56961.1
RefSeqiNP_065252.1, NM_020506.1
UniGeneiMm.202747

Genome annotation databases

EnsembliENSMUST00000089482; ENSMUSP00000086909; ENSMUSG00000021952
GeneIDi57258
KEGGimmu:57258
UCSCiuc007udf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145021 mRNA Translation: AAG09133.1
AC154504 Genomic DNA No translation available.
AC154675 Genomic DNA No translation available.
AK129430 mRNA Translation: BAC98240.1
CCDSiCCDS56961.1
RefSeqiNP_065252.1, NM_020506.1
UniGeneiMm.202747

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DLQX-ray3.20A/B1-1151[»]
SMRiQ9ESJ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208228, 4 interactors
IntActiQ9ESJ0, 2 interactors
STRINGi10090.ENSMUSP00000133280

PTM databases

iPTMnetiQ9ESJ0
PhosphoSitePlusiQ9ESJ0

Proteomic databases

EPDiQ9ESJ0
MaxQBiQ9ESJ0
PaxDbiQ9ESJ0
PeptideAtlasiQ9ESJ0
PRIDEiQ9ESJ0

Protocols and materials databases

DNASUi57258
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089482; ENSMUSP00000086909; ENSMUSG00000021952
GeneIDi57258
KEGGimmu:57258
UCSCiuc007udf.1 mouse

Organism-specific databases

CTDi64328
MGIiMGI:1888526 Xpo4
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4541 Eukaryota
ENOG410XNNN LUCA
GeneTreeiENSGT00730000111055
HOGENOMiHOG000154878
HOVERGENiHBG023214
InParanoidiQ9ESJ0
OrthoDBiEOG091G01OG
TreeFamiTF312991

Miscellaneous databases

PROiPR:Q9ESJ0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021952 Expressed in 244 organ(s), highest expression level in heart
CleanExiMM_XPO4
ExpressionAtlasiQ9ESJ0 baseline and differential
GenevisibleiQ9ESJ0 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR014877 XPO1_C_dom
PfamiView protein in Pfam
PF08767 CRM1_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiXPO4_MOUSE
AccessioniPrimary (citable) accession number: Q9ESJ0
Secondary accession number(s): E9QLH3, Q6ZPJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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