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Protein

WAP four-disulfide core domain protein 1

Gene

Wfdc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has growth inhibitory activity.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI17.004

Names & Taxonomyi

Protein namesi
Recommended name:
WAP four-disulfide core domain protein 1
Alternative name(s):
Prostate stromal protein ps20
ps20 growth inhibitor
Gene namesi
Name:Wfdc1
Synonyms:Ps20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1915116 Wfdc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000004136624 – 211WAP four-disulfide core domain protein 1Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 87PROSITE-ProRule annotation
Disulfide bondi69 ↔ 91PROSITE-ProRule annotation
Disulfide bondi74 ↔ 86PROSITE-ProRule annotation
Disulfide bondi80 ↔ 95PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9ESH5
PaxDbiQ9ESH5
PRIDEiQ9ESH5

PTM databases

PhosphoSitePlusiQ9ESH5

Expressioni

Gene expression databases

BgeeiENSMUSG00000023336 Expressed in 131 organ(s), highest expression level in aorta
CleanExiMM_WFDC1
ExpressionAtlasiQ9ESH5 baseline and differential
GenevisibleiQ9ESH5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024107

Structurei

3D structure databases

ProteinModelPortaliQ9ESH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 99WAPPROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH18 Eukaryota
ENOG41106Q5 LUCA
GeneTreeiENSGT00390000014299
HOGENOMiHOG000290176
HOVERGENiHBG075889
InParanoidiQ9ESH5
OrthoDBiEOG091G0I2U
PhylomeDBiQ9ESH5
TreeFamiTF328768

Family and domain databases

Gene3Di4.10.75.10, 1 hit
InterProiView protein in InterPro
IPR036645 Elafin-like_sf
IPR008197 WAP_dom
PfamiView protein in Pfam
PF00095 WAP, 1 hit
SMARTiView protein in SMART
SM00217 WAP, 1 hit
SUPFAMiSSF57256 SSF57256, 1 hit
PROSITEiView protein in PROSITE
PS51390 WAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9ESH5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNCGRKVLR ALSFLLLLGS SSAQGTWEAM LPARLAEKSR AEEVAATGSR
60 70 80 90 100
QPHADRCPPP PRTLPPGACQ ATRCQADSEC PRHRRCCYNG CAYACLEAVP
110 120 130 140 150
PPPVLDWLVQ PKPRWLGGNG WLLDGPEEVL QAETCSTTED GAEPLLCPSG
160 170 180 190 200
YECHILQPGD EAQGIPNHGQ CVKQRRQAEG RVLRQRLHKE YPEGDSKNVA
210
EPGKGQQRHF P
Length:211
Mass (Da):23,079
Last modified:March 1, 2001 - v1
Checksum:i605E7E6B0FC64FE5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9CQZ8Q9CQZ8_MOUSE
WAP four-disulfide core domain prot...
Wfdc1
201Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132Missing in AAH25850 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170446, AF169632 Genomic DNA Translation: AAG21086.1
BC025850 mRNA Translation: AAH25850.1
CCDSiCCDS22711.1
RefSeqiNP_075884.1, NM_023395.2
UniGeneiMm.87599

Genome annotation databases

EnsembliENSMUST00000024107; ENSMUSP00000024107; ENSMUSG00000023336
GeneIDi67866
KEGGimmu:67866
UCSCiuc009nqe.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170446, AF169632 Genomic DNA Translation: AAG21086.1
BC025850 mRNA Translation: AAH25850.1
CCDSiCCDS22711.1
RefSeqiNP_075884.1, NM_023395.2
UniGeneiMm.87599

3D structure databases

ProteinModelPortaliQ9ESH5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024107

Protein family/group databases

MEROPSiI17.004

PTM databases

PhosphoSitePlusiQ9ESH5

Proteomic databases

MaxQBiQ9ESH5
PaxDbiQ9ESH5
PRIDEiQ9ESH5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024107; ENSMUSP00000024107; ENSMUSG00000023336
GeneIDi67866
KEGGimmu:67866
UCSCiuc009nqe.1 mouse

Organism-specific databases

CTDi58189
MGIiMGI:1915116 Wfdc1

Phylogenomic databases

eggNOGiENOG410IH18 Eukaryota
ENOG41106Q5 LUCA
GeneTreeiENSGT00390000014299
HOGENOMiHOG000290176
HOVERGENiHBG075889
InParanoidiQ9ESH5
OrthoDBiEOG091G0I2U
PhylomeDBiQ9ESH5
TreeFamiTF328768

Miscellaneous databases

PROiPR:Q9ESH5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023336 Expressed in 131 organ(s), highest expression level in aorta
CleanExiMM_WFDC1
ExpressionAtlasiQ9ESH5 baseline and differential
GenevisibleiQ9ESH5 MM

Family and domain databases

Gene3Di4.10.75.10, 1 hit
InterProiView protein in InterPro
IPR036645 Elafin-like_sf
IPR008197 WAP_dom
PfamiView protein in Pfam
PF00095 WAP, 1 hit
SMARTiView protein in SMART
SM00217 WAP, 1 hit
SUPFAMiSSF57256 SSF57256, 1 hit
PROSITEiView protein in PROSITE
PS51390 WAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWFDC1_MOUSE
AccessioniPrimary (citable) accession number: Q9ESH5
Secondary accession number(s): Q8R110
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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