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Protein

Palmitoyltransferase ZDHHC16

Gene

Zdhhc16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (PubMed:26644582). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (PubMed:26644582). Also required for eye development (PubMed:26644582). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (By similarity). May play a role in DNA damage response (PubMed:27159997). May be involved in apoptosis regulation (PubMed:12021275). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity).By similarity3 Publications

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei185S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cellular response to DNA damage stimulus Source: UniProtKB
  • eye development Source: UniProtKB
  • heart development Source: UniProtKB
  • protein palmitoylation Source: UniProtKB
  • telencephalon development Source: UniProtKB

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processApoptosis, DNA damage

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC16Curated (EC:2.3.1.2251 Publication)
Alternative name(s):
Abl-philin 21 Publication
Zinc finger DHHC domain-containing protein 16
Short name:
DHHC-16
Gene namesi
Name:Zdhhc16Imported
Synonyms:Aph21 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1921418 Zdhhc16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 77CytoplasmicSequence analysisAdd BLAST77
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 116LumenalSequence analysisAdd BLAST18
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 198CytoplasmicSequence analysisAdd BLAST61
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 250LumenalSequence analysisAdd BLAST31
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 361CytoplasmicSequence analysisAdd BLAST90

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Lethality one day after birth (PubMed:26644582). Pups and embryos show eye malformation and heart defects (PubMed:26644582). Mice display cardiomyopathy and cardiac defects including bradycardia (PubMed:26644582). Heart defects are characterized by thinner and enlarged ventricular walls, cardiomyocyte disarray and abnormal nucleus morphology (PubMed:26644582).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128991 – 361Palmitoyltransferase ZDHHC16Add BLAST361

Proteomic databases

PaxDbiQ9ESG8
PRIDEiQ9ESG8

PTM databases

PhosphoSitePlusiQ9ESG8
SwissPalmiQ9ESG8

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000025157
CleanExiMM_ZDHHC16
GenevisibleiQ9ESG8 MM

Interactioni

Subunit structurei

Interacts with ABL1 (PubMed:12021275). Interacts with COPS5 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi216543, 1 interactor
STRINGi10090.ENSMUSP00000026154

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 205DHHCPROSITE-ProRule annotationAdd BLAST51

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1313 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00900000140969
HOGENOMiHOG000234766
HOVERGENiHBG054667
InParanoidiQ9ESG8
KOiK18932
OMAiKNWKLFL
OrthoDBiEOG091G0FLT
PhylomeDBiQ9ESG8
TreeFamiTF320809

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ESG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGQRSLLLG PARLCLRLLL LLGYRRRCPP LLRGLVQRWR YGKVCLRSLL
60 70 80 90 100
YNSFGGSDTA VDAAFEPVYW LVDNVIRWFG VVFVVLVIVL TGSIVAIAYL
110 120 130 140 150
CVLPLILRTY SVPRLCWHFF YSHWNLILIV FHYYQAITTP PGYPPQGRND
160 170 180 190 200
IATVSICKKC IYPKPARTHH CSICNRCVLK MDHHCPWLNN CVGHYNHRYF
210 220 230 240 250
FSFCFFMTLG CVYCSYGSWD LFREAYAAIE TYHQTPPPTF SFRERITHKS
260 270 280 290 300
LVYLWFLCSS VALALGALTM WHAVLISRGE TSIERHINKK ERRRLQAKGR
310 320 330 340 350
VFRNPYNYGC LDNWKVFLGV DTGRHWLTRV LLPSSHLPHG NGMSWDPPPW
360
VTAHSASVMA V
Length:361
Mass (Da):41,794
Last modified:November 22, 2005 - v2
Checksum:iB9A4D4B4C4170FE9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33R → Q in BAE40024 (PubMed:16141072).Curated1
Sequence conflicti63A → S in AAG09269 (PubMed:12021275).Curated1
Sequence conflicti171C → R in AAH10835 (PubMed:15489334).Curated1
Sequence conflicti335S → N in AAG09269 (PubMed:12021275).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176814 mRNA Translation: AAG09269.1
AK151505 mRNA Translation: BAE30456.1
AK168042 mRNA Translation: BAE40024.1
BC010835 mRNA Translation: AAH10835.1
CCDSiCCDS29817.1
RefSeqiNP_076229.2, NM_023740.2
UniGeneiMm.20387

Genome annotation databases

EnsembliENSMUST00000026154; ENSMUSP00000026154; ENSMUSG00000025157
GeneIDi74168
KEGGimmu:74168
UCSCiuc008hmq.2 mouse

Similar proteinsi

Entry informationi

Entry nameiZDH16_MOUSE
AccessioniPrimary (citable) accession number: Q9ESG8
Secondary accession number(s): Q3TI22, Q3UA59, Q91XC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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