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Protein

Protein lifeguard 1

Gene

Grina

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential apoptotic regulator.By similarity

GO - Molecular functioni

  • ion channel binding Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 1
Alternative name(s):
Glutamate [NMDA] receptor-associated protein 1
NMDA receptor glutamate-binding subunit
Gene namesi
Name:Grina
Synonyms:Lag, Lfg1, Nmdara1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1913418 Grina

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003144401 – 345Protein lifeguard 1Add BLAST345

Proteomic databases

PaxDbiQ9ESF4
PRIDEiQ9ESF4

PTM databases

PhosphoSitePlusiQ9ESF4

Expressioni

Gene expression databases

BgeeiENSMUSG00000022564 Expressed in 298 organ(s), highest expression level in CA1 field of hippocampus
GenevisibleiQ9ESF4 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023225

Structurei

3D structure databases

ProteinModelPortaliQ9ESF4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 114Pro-richAdd BLAST100

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2322 Eukaryota
COG0670 LUCA
GeneTreeiENSGT00500000044791
HOGENOMiHOG000060393
HOVERGENiHBG012084
InParanoidiQ9ESF4
KOiK06890
OMAiYYVSYAI
OrthoDBiEOG091G0JRK
PhylomeDBiQ9ESF4
TreeFamiTF319996

Family and domain databases

InterProiView protein in InterPro
IPR006214 Bax_inhibitor_1-related
PANTHERiPTHR23291 PTHR23291, 1 hit
PfamiView protein in Pfam
PF01027 Bax1-I, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9ESF4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHEKSFLVS GDSYPPQNIV GPQAPMPPYV QAPYPGAPYP QAPFQPSPYG
60 70 80 90 100
QPGYPHGPSP YPQGGYPQGP YPQGGYPQGP YPQSPFPPNP YGQPPPFQDP
110 120 130 140 150
GSPQHGNYQE EGPPSYYDNQ DFPAVNWDKN IRQAFIRKVF LVLTLQLSVT
160 170 180 190 200
LSTVAIFTFV GEVKGFVREN VWTYYVSYAI FFISLIVLSC CGDFRRKHPW
210 220 230 240 250
NLVALSILTV SLSYMVGMIA SFYNTEAVIM AVGITTAVCF TVVIFSMQTR
260 270 280 290 300
YDFTSCMGVL LVSVVVLFIF AILCIFIRNR ILEIVYASLG ALLFTCFLAV
310 320 330 340
DTQLLLGNKQ LSLSPEEYVF AALNLYTDII NIFLYILTII GRAKE
Length:345
Mass (Da):38,408
Last modified:March 1, 2001 - v1
Checksum:iA76F722EB678A2F7
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VHD1A0A2R8VHD1_MOUSE
Protein lifeguard 1
Grina
79Annotation score:
A0A2R8VI53A0A2R8VI53_MOUSE
Protein lifeguard 1
Grina
23Annotation score:
A0A2R8VHX7A0A2R8VHX7_MOUSE
Protein lifeguard 1
Grina
121Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182040 mRNA Translation: AAG16897.1
BC010802 mRNA Translation: AAH10802.1
BC019157 mRNA Translation: AAH19157.1
BC037667 mRNA Translation: AAH37667.2
CCDSiCCDS27563.1
RefSeqiNP_075657.1, NM_023168.3
XP_006521312.1, XM_006521249.3
XP_006521313.1, XM_006521250.3
XP_006521314.1, XM_006521251.3
XP_011244011.1, XM_011245709.2
UniGeneiMm.41665

Genome annotation databases

EnsembliENSMUST00000023225; ENSMUSP00000023225; ENSMUSG00000022564
GeneIDi66168
KEGGimmu:66168
UCSCiuc007wjl.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182040 mRNA Translation: AAG16897.1
BC010802 mRNA Translation: AAH10802.1
BC019157 mRNA Translation: AAH19157.1
BC037667 mRNA Translation: AAH37667.2
CCDSiCCDS27563.1
RefSeqiNP_075657.1, NM_023168.3
XP_006521312.1, XM_006521249.3
XP_006521313.1, XM_006521250.3
XP_006521314.1, XM_006521251.3
XP_011244011.1, XM_011245709.2
UniGeneiMm.41665

3D structure databases

ProteinModelPortaliQ9ESF4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023225

PTM databases

PhosphoSitePlusiQ9ESF4

Proteomic databases

PaxDbiQ9ESF4
PRIDEiQ9ESF4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023225; ENSMUSP00000023225; ENSMUSG00000022564
GeneIDi66168
KEGGimmu:66168
UCSCiuc007wjl.1 mouse

Organism-specific databases

CTDi2907
MGIiMGI:1913418 Grina

Phylogenomic databases

eggNOGiKOG2322 Eukaryota
COG0670 LUCA
GeneTreeiENSGT00500000044791
HOGENOMiHOG000060393
HOVERGENiHBG012084
InParanoidiQ9ESF4
KOiK06890
OMAiYYVSYAI
OrthoDBiEOG091G0JRK
PhylomeDBiQ9ESF4
TreeFamiTF319996

Miscellaneous databases

ChiTaRSiGrina mouse
PROiPR:Q9ESF4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022564 Expressed in 298 organ(s), highest expression level in CA1 field of hippocampus
GenevisibleiQ9ESF4 MM

Family and domain databases

InterProiView protein in InterPro
IPR006214 Bax_inhibitor_1-related
PANTHERiPTHR23291 PTHR23291, 1 hit
PfamiView protein in Pfam
PF01027 Bax1-I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLFG1_MOUSE
AccessioniPrimary (citable) accession number: Q9ESF4
Secondary accession number(s): Q8CI25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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