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Protein

Lipopolysaccharide-responsive and beige-like anchor protein

Gene

Lrba

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cellular response to leukemia inhibitory factor Source: MGI
  • endosomal transport Source: MGI
  • protein localization Source: MGI
  • signal transduction Source: MGI

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lipopolysaccharide-responsive and beige-like anchor protein
Alternative name(s):
Beige-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lrba
Synonyms:Bgl, Lba
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1933162 Lrba

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1529 – 1545HelicalSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Lysosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003865452 – 2856Lipopolysaccharide-responsive and beige-like anchor proteinAdd BLAST2855

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei10PhosphoserineBy similarity1
Modified residuei979PhosphoserineCombined sources1
Modified residuei1003PhosphoserineCombined sources1
Modified residuei1097PhosphoserineBy similarity1
Modified residuei1132PhosphoserineBy similarity1
Modified residuei1136PhosphoserineBy similarity1
Modified residuei1219PhosphoserineCombined sources1
Modified residuei1221PhosphoserineCombined sources1
Modified residuei1228PhosphoserineCombined sources1
Modified residuei1244PhosphoserineBy similarity1
Modified residuei1258PhosphoserineBy similarity1
Modified residuei1487PhosphoserineBy similarity1
Modified residuei1497PhosphoserineBy similarity1
Modified residuei1608PhosphoserineBy similarity1
Modified residuei1770PhosphoserineCombined sources1
Modified residuei1773PhosphoserineCombined sources1
Modified residuei2057PhosphoserineBy similarity1
Modified residuei2489PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9ESE1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ESE1

PeptideAtlas

More...
PeptideAtlasi
Q9ESE1

PRoteomics IDEntifications database

More...
PRIDEi
Q9ESE1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ESE1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ESE1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is expressed in the brain, is absent from the lung and the bone marrow and is less abundant in the spleen. Isoform 2 is expressed in the spleen, lung, brain and bone marrow. Isoform 3 is expressed in the brain, is absent from the bone marrow and is less abundant in the spleen and lung.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By lipopolysaccharide (LPS).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9ESE1, 3 interactors

Molecular INTeraction database

More...
MINTi
Q9ESE1

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000103261

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9ESE1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ESE1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1298 – 1340WD 1Add BLAST43
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2066 – 2174BEACH-type PHPROSITE-ProRule annotationAdd BLAST109
Domaini2193 – 2482BEACHPROSITE-ProRule annotationAdd BLAST290
Repeati2584 – 2626WD 2Add BLAST43
Repeati2629 – 2672WD 3Add BLAST44
Repeati2688 – 2728WD 4Add BLAST41
Repeati2770 – 2809WD 5Add BLAST40
Repeati2812 – 2851WD 6Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1994 – 1998Poly-Arg5

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1786 Eukaryota
ENOG410XNQC LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082375

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9ESE1

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ESE1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06071 Beach, 1 hit
cd01201 PH_BEACH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1540.10, 1 hit
1.25.10.10, 1 hit
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000409 BEACH_dom
IPR036372 BEACH_dom_sf
IPR013320 ConA-like_dom_sf
IPR010508 DUF1088
IPR031570 DUF4704
IPR023362 PH-BEACH_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02138 Beach, 1 hit
PF06469 DUF1088, 1 hit
PF15787 DUF4704, 1 hit
PF14844 PH_BEACH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01026 Beach, 1 hit
SM00320 WD40, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF49899 SSF49899, 1 hit
SSF50978 SSF50978, 1 hit
SSF81837 SSF81837, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50197 BEACH, 1 hit
PS51783 PH_BEACH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ESE1-1) [UniParc]FASTAAdd to basket
Also known as: lba-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASEDNRAPS RPPTGDDGGG GGKEETPTEG GALSLKPGLP IRGIRMKFAV
60 70 80 90 100
LTGLVEVGEV SNRDIVETVF NLLVGGQFDL EMNFIIQEGE SIMCMVELLE
110 120 130 140 150
KCDVTCQAEV WSMFTAILKK SIRNLQVCTE VGLVEKVLGK IEKVDSMIAD
160 170 180 190 200
LLVDMLGVLA SYNLTVRELK LFFSKLQGDK GQWPPHAGKL LSVLKHMPQK
210 220 230 240 250
YGPDAFFNFP GKSAAAIALP PIARWPYQNG FTFHTWLRMD PVNNINVDKD
260 270 280 290 300
KPYLYCFRTS KGLGYSAHFV GGCLIITSIK SKGKGFQHCV KFDFKPQKWY
310 320 330 340 350
MVTIVHIYNR WKNSELRCYV NGELASYGEI TWFVNTSDTF DKCFLGSSET
360 370 380 390 400
ADANRVFCGQ MTAVYLFSDA LNAAQIFAIY QLGLGYKGTF KFKAESDLFL
410 420 430 440 450
AEHHKLLLYD GKLSSAIAFM YNPRATDAQL CLESSPKDNP SIFVHSPHAL
460 470 480 490 500
MLQDVKAVLT HSIQSAMHSI GGVQVLFPLF AQLDYKQYLS DEVDLTICTT
510 520 530 540 550
LLAFIMELLK NSIAMQEQML ACKGFLVIGY SLEKSSKSHV SRAVLELCLA
560 570 580 590 600
FSKYLSNLQN GMPLLKQLCD HILLNPAVWI HTPAKVQLML YTYLSTEFIG
610 620 630 640 650
TVNIYNTIRR VGTVLLIMHT LKYYYWAVNP QDRSGITPKG LDGPRPNQKE
660 670 680 690 700
ILSLRAFLLM FIKQLVMKDS GVKEDELQAI LNYLLTMHED DNLMDVLQLL
710 720 730 740 750
VALMAEHPNS MIPAFDQRNG LRVIYKLLAS KSEGIRVQAL KALGYFLKHL
760 770 780 790 800
APKRKAEVML GHGLFSLLAE RLMLQTNLIT MTMYNVLFEI LIEQICTQVI
810 820 830 840 850
HKQHPDPDST VKIQNPQILK VIATLLRNSP QCPESMEVRR AFLSDMIKLF
860 870 880 890 900
NNSRENRRSL LQCSVWQEWM LSLCYFNPKN SDEQKITEMV YAIFRILLYH
910 920 930 940 950
AVKYEWGGWR VWVDTLSITH SKVTFEIHKE NLANIFREEQ RKGDEETGPC
960 970 980 990 1000
SSSLVPEGTG ATRGVDVSVG SQHEDRKDSP ISPHFTRNSD ENSSIGRASS
1010 1020 1030 1040 1050
IDSASNTELQ THDMSSDEKK VERENQELLD QATVEETATN GAKDDLETSS
1060 1070 1080 1090 1100
DAAEPVTINS NSLEPGKDTV TISEVSASIS SPSEEDAAEM PELLEKSGVE
1110 1120 1130 1140 1150
EKEDDDYVEL KVEGSPTEEA GLPTELQGEG LSVAASGGRE EPDMCGHGCE
1160 1170 1180 1190 1200
VQVEAPITKI HNDPETTDSE DSRFPTVATA GSLATSSEVP VPQATVQSDS
1210 1220 1230 1240 1250
HEMLDGGMKA TNLAGETESV SDCADNVSEA PATSEQKITK LDVSSVASDT
1260 1270 1280 1290 1300
ERFELKASTS TEAPQPQRHG LEISRQQEQT AQGTAPDAVD QQRRDSRSTM
1310 1320 1330 1340 1350
FRIPEFKWSQ MHQRLLTDLL FSIETDIQMW RSHSTKTVMD FVNSSDNVIF
1360 1370 1380 1390 1400
VHNTIHLISQ VMDNMVMACG GILPLLSAAT SATHELENIE PTQGLSIEAS
1410 1420 1430 1440 1450
VTFLQRLISL VDVLIFASSL GFTEIEAEKN MSSGGILRQC LRLVCAVAVR
1460 1470 1480 1490 1500
NCLECQQHSQ LKARGDTAKS SKTIHSLIPM GKSAAKSPVD IVTGGISSVR
1510 1520 1530 1540 1550
DLDRLPARTW TLIGLRAVVF RDIEDSKQAQ FLALAVVYFI SVLMVSKYRD
1560 1570 1580 1590 1600
ILEPQDERHS QSLKETSSDN GNASLPDAEN TPAEFSSLTL SSVEESLEGT
1610 1620 1630 1640 1650
SCTRRRDSGL GEETASGLGS GLSVASPAAP LGVSAGPDAI SEVLCTLSLE
1660 1670 1680 1690 1700
VNKSQETRID GGNELDRKVT PSVPVSKNVN VKDILRSLVN MPADGVTVDP
1710 1720 1730 1740 1750
ALLPPACLGA LGDLSVDPPM QFRSFDRSVI IATKKSSVLP SALTTSAPSS
1760 1770 1780 1790 1800
AVSVVSSVDP THASDTGGES PGSRSPKCKT ALSCKQLAPS HKTPAAHMSI
1810 1820 1830 1840 1850
TERLEHALEK AAPLLREIFV DFAPFLSRTL LGSHGQELLI EGTSLVCMKS
1860 1870 1880 1890 1900
SSSVVELVML LCSQEWQNSI QKNAGLAFIE LVNEGRLLSQ TMKDHLVRVA
1910 1920 1930 1940 1950
NEAEFILSRQ RAEDIHRHAE FESLCAQYSA DKREEEKMCD HLIRAAKYRD
1960 1970 1980 1990 2000
HVTATQLIQK IINLLTDKHG AWGSSAVSRP REFWRLDYWE DDLRRRRRFV
2010 2020 2030 2040 2050
RNPLGSTHPE ATLKTAVEHA ADEDILAKGK QSIKSQALGN QNSENEALLE
2060 2070 2080 2090 2100
GDDDTLSSVD EKDLENLAGP VSLSTPAQLV APSVVVKGTL SVTSSELYFE
2110 2120 2130 2140 2150
VDEEDPNFKK IDPKILAYTE GLHGKWLFTE IRSIFSRRYL LQNTALEIFM
2160 2170 2180 2190 2200
ANRVAVMFNF PDPATVKKVV NYLPRVGVGT SFGLPQTRRI SLATPRQLFK
2210 2220 2230 2240 2250
ASNMTQRWQH REISNFEYLM FLNTIAGRSY NDLNQYPVFP WVITNYESEE
2260 2270 2280 2290 2300
LDLTLPSNFR DLSKPIGALN PKRAAFFAER FESWEDDQVP KFHYGTHYST
2310 2320 2330 2340 2350
ASFVLAWLLR IEPFTTYFLN LQGGKFDHAD RTFSSVSRAW RNSQRDTSDI
2360 2370 2380 2390 2400
KELIPEFYYL PEMFVNFNNY NLGVMDDGTV VSDVELPPWA KTSEEFVRIN
2410 2420 2430 2440 2450
RLALESEFVS CQLHQWIDLI FGYKQQGPEA VRALNVFYYL TYEGAVNLNS
2460 2470 2480 2490 2500
ITDPVLREAV EAQIRSFGQT PSQLLIEPHP PRGSAMQASP LMFTDQAQQD
2510 2520 2530 2540 2550
VIMVLKFPSN SPVTHVAANT QPGLAMPAVI TVTANRLFAV NKWHNLPAHQ
2560 2570 2580 2590 2600
GAVQDQPYQL PVEIDPLIAC GTGTHRRQVT DLLDQSIQVH SQCFVITSDN
2610 2620 2630 2640 2650
RYILVCGFWD KSFRVYSTDT GKLIQVVFGH WDVVTCLARS ESYIGGNCYI
2660 2670 2680 2690 2700
LSGSRDATLL LWYWNGKSSG IGDNPGGETA TPRAILTGHD YEITCAAVCA
2710 2720 2730 2740 2750
ELGLVLSGSQ EGPCLIHSMN GDLLRTLEGP ENCLKPKLIQ ASREGHCVIF
2760 2770 2780 2790 2800
YENGCFCTFS VNGKLQATVE TDDHIRAIQL SRDGQYLLTG GDNGVVIVRQ
2810 2820 2830 2840 2850
VSDLKQLFAY PGCDAGIRAM ALSFDQRCII SGMASGSIVL FYNDFNRWHH

EYQTRY
Length:2,856
Mass (Da):317,064
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E7C5DD865384BEA
GO
Isoform 2 (identifier: Q9ESE1-2) [UniParc]FASTAAdd to basket
Also known as: lba-beta

The sequence of this isoform differs from the canonical sequence as follows:
     2777-2792: AIQLSRDGQYLLTGGD → VSAVGSTLFLLLGSSK
     2793-2856: Missing.

Show »
Length:2,792
Mass (Da):309,623
Checksum:i734FB37825AE405B
GO
Isoform 3 (identifier: Q9ESE1-3) [UniParc]FASTAAdd to basket
Also known as: lba-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     2569-2579: ACGTGTHRRQV → GLPLLSLFAIH
     2580-2856: Missing.

Show »
Length:2,579
Mass (Da):286,453
Checksum:i5733D4AC76C7C3B8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q3Y4E9Q3Y4_MOUSE
Lipopolysaccharide-responsive and b...
Lrba
2,854Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YXX3A0A0A6YXX3_MOUSE
Lipopolysaccharide-responsive and b...
Lrba
2,577Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YXL6A0A0A6YXL6_MOUSE
Lipopolysaccharide-responsive and b...
Lrba
2,790Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8BSM6Q8BSM6_MOUSE
Lipopolysaccharide-responsive and b...
Lrba
758Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RM41A0A1D5RM41_MOUSE
Lipopolysaccharide-responsive and b...
Lrba
2,124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0382272569 – 2579ACGTGTHRRQV → GLPLLSLFAIH in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0382282580 – 2856Missing in isoform 3. 1 PublicationAdd BLAST277
Alternative sequenceiVSP_0382292777 – 2792AIQLS…LTGGD → VSAVGSTLFLLLGSSK in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0382302793 – 2856Missing in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF187731 mRNA Translation: AAG14003.1
AF188506 mRNA Translation: AAG15400.1
AF188507 mRNA Translation: AAG15401.1

NCBI Reference Sequences

More...
RefSeqi
NP_001071155.1, NM_001077687.1
NP_001071156.1, NM_001077688.1
NP_109620.2, NM_030695.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.439825

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80877

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:80877

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187731 mRNA Translation: AAG14003.1
AF188506 mRNA Translation: AAG15400.1
AF188507 mRNA Translation: AAG15401.1
RefSeqiNP_001071155.1, NM_001077687.1
NP_001071156.1, NM_001077688.1
NP_109620.2, NM_030695.2
UniGeneiMm.439825

3D structure databases

ProteinModelPortaliQ9ESE1
SMRiQ9ESE1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9ESE1, 3 interactors
MINTiQ9ESE1
STRINGi10090.ENSMUSP00000103261

PTM databases

iPTMnetiQ9ESE1
PhosphoSitePlusiQ9ESE1

Proteomic databases

EPDiQ9ESE1
PaxDbiQ9ESE1
PeptideAtlasiQ9ESE1
PRIDEiQ9ESE1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi80877
KEGGimmu:80877

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
987
MGIiMGI:1933162 Lrba

Phylogenomic databases

eggNOGiKOG1786 Eukaryota
ENOG410XNQC LUCA
HOGENOMiHOG000082375
InParanoidiQ9ESE1
PhylomeDBiQ9ESE1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Lrba mouse

Protein Ontology

More...
PROi
PR:Q9ESE1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd06071 Beach, 1 hit
cd01201 PH_BEACH, 1 hit
Gene3Di1.10.1540.10, 1 hit
1.25.10.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000409 BEACH_dom
IPR036372 BEACH_dom_sf
IPR013320 ConA-like_dom_sf
IPR010508 DUF1088
IPR031570 DUF4704
IPR023362 PH-BEACH_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF02138 Beach, 1 hit
PF06469 DUF1088, 1 hit
PF15787 DUF4704, 1 hit
PF14844 PH_BEACH, 1 hit
SMARTiView protein in SMART
SM01026 Beach, 1 hit
SM00320 WD40, 5 hits
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49899 SSF49899, 1 hit
SSF50978 SSF50978, 1 hit
SSF81837 SSF81837, 1 hit
PROSITEiView protein in PROSITE
PS50197 BEACH, 1 hit
PS51783 PH_BEACH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRBA_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ESE1
Secondary accession number(s): Q9ESD3, Q9ESD4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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