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Protein
Submitted name:

SMDF neuregulin beta 1a

Gene

Nrg1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
SMDF neuregulin beta 1aImported
Gene namesi
Name:Nrg1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei77 – 100HelicalSequence analysisAdd BLAST24
Transmembranei304 – 326HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi268 ↔ 277PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9ESB1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini234 – 278EGF-likeInterPro annotationAdd BLAST45

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOGENOMiHOG000273863
HOVERGENiHBG006531
PhylomeDBiQ9ESB1

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002154 Neuregulin_C
IPR018250 NRG1
PANTHERiPTHR11100:SF7 PTHR11100:SF7, 1 hit
PfamiView protein in Pfam
PF02158 Neuregulin, 1 hit
PRINTSiPR01089 NEUREGULIN
SMARTiView protein in SMART
SM00181 EGF, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS50026 EGF_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ESB1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIYSPDMSE VAGGRSSSPS TQLSAAPSLD GLPAAEEHIP DTHTEDERSP
60 70 80 90 100
GLLGLAVPCC VCLEAERLRG CLNSEKICIV PILACLVSLC LCIAGLKWVF
110 120 130 140 150
VDKIFEYDSP THLDPGGLGQ DPVISLDPTA APAILVSSEA YTSPVSKAQS
160 170 180 190 200
EAGAHVTVQG DHAAVASEPS AVPTRKNRLS AFPPFHSTAP PFPSPARTPE
210 220 230 240 250
VRTPKSGTQP QTTETNLQTA PKLSTSTSTT GTSHLIKCAE KEKTFCVNGG
260 270 280 290 300
ECFTVKDLSN PSRYLCKCPN EFTGDRCQNY VMASFYKHLG IEFMEAEELY
310 320 330 340 350
QKRVLTITGI CIALLVVGIM CVVAYCKTKK QRQKLHDRLR QSLRSERSNL
360 370 380 390 400
VNIANGPHHP NPPPENVQLV NQYVSKNVIS SEHIVEREVE TSFSTSHYTS
410 420 430 440 450
TAHHSTTVTQ TPSHSWSNGH TESVISESNS VIMMSSVENS RHSSPAGGPR
460 470 480 490 500
GRLHGLGGPR DNSFLRHARE TPDSYRDSPH SERYVSAMTT PARMSPVDFH
510 520 530 540 550
TPSSPKSPPS EMSPPVSSMT VSMPSVAVSP FVEEERPLLL VTPPRLREKK
560 570 580 590 600
YDHHPQQLNS FHHNPAHQST SLPPSPLRIV EDEEYETTQE YESVQEPVKK
610 620 630 640 650
VTNSRRAKRT KPNGHIANRL EMDSNTSSVS SNSESETEDE RVGEDTPFLG
660 670 680 690 700
IQNPLAASLE VAPAFRLAES RTNPAGRFST QEELQARLSS VIANQDPIAV
Length:700
Mass (Da):76,387
Last modified:March 1, 2001 - v1
Checksum:i2F8111B17ECC49DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF194438 mRNA Translation: AAG28427.1
UniGeneiRn.37438

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF194438 mRNA Translation: AAG28427.1
UniGeneiRn.37438

3D structure databases

ProteinModelPortaliQ9ESB1
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000273863
HOVERGENiHBG006531
PhylomeDBiQ9ESB1

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002154 Neuregulin_C
IPR018250 NRG1
PANTHERiPTHR11100:SF7 PTHR11100:SF7, 1 hit
PfamiView protein in Pfam
PF02158 Neuregulin, 1 hit
PRINTSiPR01089 NEUREGULIN
SMARTiView protein in SMART
SM00181 EGF, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS50026 EGF_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ9ESB1_RAT
AccessioniPrimary (citable) accession number: Q9ESB1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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