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UniProtKB - Q9ES97 (RTN3_MOUSE)

Entry version 147 (29 Sep 2021)
Sequence version 2 (20 Mar 2007)
Previous versions | rss
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Protein

Reticulon-3

Gene

Rtn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress (By similarity).

Induces the formation of endoplasmic reticulum tubules (PubMed:24262037).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, ER-Golgi transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-8849932, Synaptic adhesion-like molecules

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.102.1.2, the reticulon (reticulon) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reticulon-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rtn3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1339970, Rtn3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000024758

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 795CytoplasmicSequence analysisAdd BLAST794
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei796 – 819HelicalSequence analysisAdd BLAST24
Topological domaini820 – 876CytoplasmicSequence analysisAdd BLAST57
Intramembranei877 – 899HelicalSequence analysisAdd BLAST23
Topological domaini900 – 903CytoplasmicSequence analysis4
Intramembranei904 – 926HelicalSequence analysisAdd BLAST23
Topological domaini927 – 964CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001681642 – 964Reticulon-3Add BLAST963

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei31PhosphoserineBy similarity1
Modified residuei217PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei230PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei270PhosphoserineBy similarity1
Modified residuei303PhosphoserineBy similarity1
Modified residuei429PhosphoserineBy similarity1
Modified residuei529PhosphoserineCombined sources1
Modified residuei593PhosphothreonineBy similarity1
Modified residuei596PhosphoserineCombined sources1
Modified residuei597PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9ES97

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9ES97

PeptideAtlas

More...PeptideAtlasi		Q9ES97

PRoteomics IDEntifications database

More...PRIDEi		Q9ES97

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		256803 [Q9ES97-1]
256804 [Q9ES97-2]
256805 [Q9ES97-3]
256806 [Q9ES97-4]
256807 [Q9ES97-5]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q9ES97-1 [Q9ES97-1]
Q9ES97-3 [Q9ES97-3]
Q9ES97-4 [Q9ES97-4]
Q9ES97-5 [Q9ES97-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9ES97

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9ES97

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9ES97

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1, isoform 3, isoform 4 and isoform 5 are expressed in spinal cord. Isoform 1 is present in brain, where it is expressed in the neurons of cerebral cortex, hippocampus, hypothalamus and cerebellum (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000024758, Expressed in facial nucleus and 339 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9ES97, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with RTN4.

Isoform 3 interacts with BACE1, BACE2, BCL2 and FADD (By similarity).

Interacts with ATL1 and ATL2 (PubMed:19665976).

Isoform 3 interacts with TMEM33 (PubMed:25612671).

Interacts with ZFYVE27 and with KIF5A in a ZFYVE27-dependent manner (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		203034, 5 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9ES97

Protein interaction database and analysis system

More...IntActi		Q9ES97, 5 interactors

Molecular INTeraction database

More...MINTi		Q9ES97

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000065810

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9ES97, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9ES97

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini776 – 964ReticulonPROSITE-ProRule annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 32DisorderedSequence analysisAdd BLAST32
Regioni68 – 109DisorderedSequence analysisAdd BLAST42
Regioni179 – 200DisorderedSequence analysisAdd BLAST22
Regioni479 – 536DisorderedSequence analysisAdd BLAST58
Regioni645 – 674DisorderedSequence analysisAdd BLAST30
Regioni697 – 723DisorderedSequence analysisAdd BLAST27
Regioni919 – 964Interaction with FADDBy similarityAdd BLAST46
Regioni932 – 934Interaction with BACE1By similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 22Polar residuesSequence analysisAdd BLAST22
Compositional biasi68 – 107Polar residuesSequence analysisAdd BLAST40
Compositional biasi493 – 511Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi512 – 536Polar residuesSequence analysisAdd BLAST25
Compositional biasi645 – 662Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi704 – 723Polar residuesSequence analysisAdd BLAST20

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1792, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157482

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_011704_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9ES97

Identification of Orthologs from Complete Genome Data

More...OMAi		KYQDHVD

Database of Orthologous Groups

More...OrthoDBi		423549at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9ES97

TreeFam database of animal gene trees

More...TreeFami		TF105431

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003388, Reticulon

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02453, Reticulon, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50845, RETICULON, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9ES97-1) [UniParc]FASTAAdd to basket
Also known as: A1, A4b, B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAESSAATQS PSVSSSSSGA EPSALGGGGG SPGACPALGA KSCGSSCADS 
        60         70         80         90        100
FVSSSSSQPV SIFSTSQAGL SSLCSDEPPS KSMTSSFLSS SEIHNPDPTT 
       110        120        130        140        150
PLGEKSETLG SQFVLAKGKD PLVLLDKKKL DSPQGTNKDR VDAPVSLATG 
       160        170        180        190        200
IPCSHPSIPD SFPEQPAFLS KEIGPAEEWV VKDQEPKNPN KVPDGEDRSA 
       210        220        230        240        250
LDFGQSKAEH ICTYSLSPSE LPVASVEKDS PESPFEVIID KATFDREFKD 
       260        270        280        290        300
LYKENPNDLG GWAAHGDRES PADLLEMNDK LFPLRNKEAG RYPSSVLLGR 
       310        320        330        340        350
QFSHTTAALE EVSRCVNDMH NFTNEILTWD LDPQAKQQAN KTSCTTESTG 
       360        370        380        390        400
LDRSELRSEI PVINLKTNPQ QKMPVCSFNG STPITKSTGD WTEAFTEGKP 
       410        420        430        440        450
VRDYLSSTKE AGGNGVPGSS QLHSELPGSM PEKWVSGSGA ATVEVTLPNL 
       460        470        480        490        500
RGAWPNSVMG EVTEVDSSGE SDDTVIEDIT EKPDSLPSAA AKTSEREIKE 
       510        520        530        540        550
TPSRETVRSE MCENSEQPQA QPETPTQKSL EGEVASQVPN TLNEVTPEKL 
       560        570        580        590        600
DMTNNPKVCS AAPPSVLNET GFSLTVPASA KLESLLGKYV EDTDGSSPED 
       610        620        630        640        650
LMAVLTGAEE KGIVDKEEGD VLEAVLEKIA DFKNTLPVEL LHESELSGSE 
       660        670        680        690        700
TKNIKSKYSE DSRETTGGAP TMSPDLEQEQ LTIRAIKELG ERQAEKVQDE 
       710        720        730        740        750
GISSGGKLKQ TFAPQSGPQS SSDILEHTDV KTGSDLGIPK NPTIIKNTRI 
       760        770        780        790        800
DSISSLTKTE MVNKNVLARL LSDFPVHDLI FWRDVKKTGF VFGTTLIMLL 
       810        820        830        840        850
SLAAFSVISV VSYLILALLS VTISFRVYKS VIQAVQKSEE GHPFKAYLDV 
       860        870        880        890        900
DITLSSEAFH NYMNAAMVHV NKALKLIIRL FLVEDLVDSL KLAVFMWLMT 
       910        920        930        940        950
YVGAVFNGIT LLILAELLVF SVPIVYEKYK TQIDHYVGIA RDQTKSIVEK 
       960 
IQAKLPGIAK KKAE
Length:964
Mass (Da):103,879
Last modified:March 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5170809A696F8F7A
GO
Isoform 2 (identifier: Q9ES97-2) [UniParc]FASTAAdd to basket
Also known as: A2, A3b

The sequence of this isoform differs from the canonical sequence as follows:
     49-67: Missing.

Show »
Length:945
Mass (Da):101,920
Checksum:i28DD47E72CBEC824
GO
Isoform 3 (identifier: Q9ES97-3) [UniParc]FASTAAdd to basket
Also known as: B1, A1, Rtn3c

The sequence of this isoform differs from the canonical sequence as follows:
     49-775: Missing.

Show »
Length:237
Mass (Da):25,428
Checksum:iEB60A0A7AC45F0DE
GO
Isoform 4 (identifier: Q9ES97-4) [UniParc]FASTAAdd to basket
Also known as: B2, A2

The sequence of this isoform differs from the canonical sequence as follows:
     68-775: Missing.

Show »
Length:256
Mass (Da):27,387
Checksum:i5EE394BAA15E38B0
GO
Isoform 5 (identifier: Q9ES97-5) [UniParc]FASTAAdd to basket
Also known as: A4a

The sequence of this isoform differs from the canonical sequence as follows:
     68-388: Missing.

Show »
Length:643
Mass (Da):68,770
Checksum:i15E3335B280533F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti17S → P in AAR98631 (PubMed:15350194).Curated1
Sequence conflicti215S → P in AAR98632 (PubMed:15350194).Curated1
Sequence conflicti355E → G in AAR98632 (PubMed:15350194).Curated1
Sequence conflicti899M → I in BAC36028 (PubMed:16141072).Curated1
Sequence conflicti964E → K in BAE28664 (PubMed:16141072).Curated1
Sequence conflicti964E → K in BAE28699 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02376249 – 775Missing in isoform 3. 6 PublicationsAdd BLAST727
Alternative sequenceiVSP_02376349 – 67Missing in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_02376468 – 775Missing in isoform 4. CuratedAdd BLAST708
Alternative sequenceiVSP_02376568 – 388Missing in isoform 5. 1 PublicationAdd BLAST321

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB046114 mRNA Translation: BAB62070.1
BK001796 mRNA Translation: DAA01968.1
AY164700 mRNA Translation: AAP47278.1
AY507126 mRNA Translation: AAR98631.1
AY507127 mRNA Translation: AAR98632.1
AY427822 mRNA Translation: AAR08193.1
AY750849 mRNA Translation: AAU81931.1
AF195940 mRNA Translation: AAG31360.1
AK032109 mRNA Translation: BAC27708.1
AK036892 mRNA Translation: BAC29625.1
AK049845 mRNA Translation: BAC33952.1
AK075883 mRNA Translation: BAC36028.1
AK088670 mRNA Translation: BAC40493.1
AK146505 mRNA Translation: BAE27220.1
AK148792 mRNA Translation: BAE28664.1
AK148947 mRNA Translation: BAE28699.1
AK165683 mRNA Translation: BAE38336.1
BC014697 mRNA Translation: AAH14697.1
BC036717 mRNA Translation: AAH36717.1
BC079882 mRNA Translation: AAH79882.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS29525.1 [Q9ES97-2]
CCDS29526.1 [Q9ES97-3]
CCDS37906.1 [Q9ES97-1]
CCDS70927.1 [Q9ES97-4]
CCDS89331.1 [Q9ES97-5]

NCBI Reference Sequences

More...RefSeqi		NP_001003933.1, NM_001003933.2 [Q9ES97-2]
NP_001003934.1, NM_001003934.2 [Q9ES97-1]
NP_001258415.1, NM_001271486.1 [Q9ES97-5]
NP_001258416.1, NM_001271487.1 [Q9ES97-4]
NP_444306.1, NM_053076.3 [Q9ES97-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000025667; ENSMUSP00000025667; ENSMUSG00000024758 [Q9ES97-4]
ENSMUST00000065304; ENSMUSP00000065810; ENSMUSG00000024758 [Q9ES97-1]
ENSMUST00000088169; ENSMUSP00000085494; ENSMUSG00000024758 [Q9ES97-3]
ENSMUST00000088171; ENSMUSP00000085496; ENSMUSG00000024758 [Q9ES97-2]
ENSMUST00000235593; ENSMUSP00000158024; ENSMUSG00000024758 [Q9ES97-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		20168

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:20168

UCSC genome browser

More...UCSCi		uc008glb.2, mouse [Q9ES97-1]
uc008gld.2, mouse [Q9ES97-2]
uc008gle.2, mouse [Q9ES97-3]
uc012bhv.2, mouse [Q9ES97-5]
uc033hiw.1, mouse [Q9ES97-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046114 mRNA Translation: BAB62070.1
BK001796 mRNA Translation: DAA01968.1
AY164700 mRNA Translation: AAP47278.1
AY507126 mRNA Translation: AAR98631.1
AY507127 mRNA Translation: AAR98632.1
AY427822 mRNA Translation: AAR08193.1
AY750849 mRNA Translation: AAU81931.1
AF195940 mRNA Translation: AAG31360.1
AK032109 mRNA Translation: BAC27708.1
AK036892 mRNA Translation: BAC29625.1
AK049845 mRNA Translation: BAC33952.1
AK075883 mRNA Translation: BAC36028.1
AK088670 mRNA Translation: BAC40493.1
AK146505 mRNA Translation: BAE27220.1
AK148792 mRNA Translation: BAE28664.1
AK148947 mRNA Translation: BAE28699.1
AK165683 mRNA Translation: BAE38336.1
BC014697 mRNA Translation: AAH14697.1
BC036717 mRNA Translation: AAH36717.1
BC079882 mRNA Translation: AAH79882.1
CCDSiCCDS29525.1 [Q9ES97-2]
CCDS29526.1 [Q9ES97-3]
CCDS37906.1 [Q9ES97-1]
CCDS70927.1 [Q9ES97-4]
CCDS89331.1 [Q9ES97-5]
RefSeqiNP_001003933.1, NM_001003933.2 [Q9ES97-2]
NP_001003934.1, NM_001003934.2 [Q9ES97-1]
NP_001258415.1, NM_001271486.1 [Q9ES97-5]
NP_001258416.1, NM_001271487.1 [Q9ES97-4]
NP_444306.1, NM_053076.3 [Q9ES97-3]

3D structure databases

SMRiQ9ES97
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi203034, 5 interactors
CORUMiQ9ES97
IntActiQ9ES97, 5 interactors
MINTiQ9ES97
STRINGi10090.ENSMUSP00000065810

Protein family/group databases

TCDBi8.A.102.1.2, the reticulon (reticulon) family

PTM databases

iPTMnetiQ9ES97
PhosphoSitePlusiQ9ES97
SwissPalmiQ9ES97

Proteomic databases

jPOSTiQ9ES97
PaxDbiQ9ES97
PeptideAtlasiQ9ES97
PRIDEiQ9ES97
ProteomicsDBi256803 [Q9ES97-1]
256804 [Q9ES97-2]
256805 [Q9ES97-3]
256806 [Q9ES97-4]
256807 [Q9ES97-5]
TopDownProteomicsiQ9ES97-1 [Q9ES97-1]
Q9ES97-3 [Q9ES97-3]
Q9ES97-4 [Q9ES97-4]
Q9ES97-5 [Q9ES97-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2923, 194 antibodies

The DNASU plasmid repository

More...DNASUi		20168

Genome annotation databases

EnsembliENSMUST00000025667; ENSMUSP00000025667; ENSMUSG00000024758 [Q9ES97-4]
ENSMUST00000065304; ENSMUSP00000065810; ENSMUSG00000024758 [Q9ES97-1]
ENSMUST00000088169; ENSMUSP00000085494; ENSMUSG00000024758 [Q9ES97-3]
ENSMUST00000088171; ENSMUSP00000085496; ENSMUSG00000024758 [Q9ES97-2]
ENSMUST00000235593; ENSMUSP00000158024; ENSMUSG00000024758 [Q9ES97-5]
GeneIDi20168
KEGGimmu:20168
UCSCiuc008glb.2, mouse [Q9ES97-1]
uc008gld.2, mouse [Q9ES97-2]
uc008gle.2, mouse [Q9ES97-3]
uc012bhv.2, mouse [Q9ES97-5]
uc033hiw.1, mouse [Q9ES97-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10313
MGIiMGI:1339970, Rtn3
VEuPathDBiHostDB:ENSMUSG00000024758

Phylogenomic databases

eggNOGiKOG1792, Eukaryota
GeneTreeiENSGT00940000157482
HOGENOMiCLU_011704_0_0_1
InParanoidiQ9ES97
OMAiKYQDHVD
OrthoDBi423549at2759
PhylomeDBiQ9ES97
TreeFamiTF105431

Enzyme and pathway databases

ReactomeiR-MMU-8849932, Synaptic adhesion-like molecules

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		20168, 2 hits in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Rtn3, mouse

Protein Ontology

More...PROi		PR:Q9ES97
RNActiQ9ES97, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000024758, Expressed in facial nucleus and 339 other tissues
GenevisibleiQ9ES97, MM

Family and domain databases

InterProiView protein in InterPro
IPR003388, Reticulon
PfamiView protein in Pfam
PF02453, Reticulon, 1 hit
PROSITEiView protein in PROSITE
PS50845, RETICULON, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRTN3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ES97
Secondary accession number(s): Q3UF62
, Q544J1, Q68FE4, Q6IM69, Q6R8K6, Q6R8K7, Q6T929, Q8C6D5, Q8CCU2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 20, 2007
Last modified: September 29, 2021
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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