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UniProtKB - Q9ES97 (RTN3_MOUSE)

Protein

Reticulon-3

Gene

Rtn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress (By similarity). Induces the formation of endoplasmic reticulum tubules (PubMed:24262037).By similarity1 Publication

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processApoptosis, ER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-8849932 Synaptic adhesion-like molecules

Protein family/group databases

TCDBi8.A.102.1.2 the reticulon (reticulon) family

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-3
Gene namesi
Name:Rtn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1339970 Rtn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 795CytoplasmicSequence analysisAdd BLAST794
Intramembranei796 – 819HelicalSequence analysisAdd BLAST24
Topological domaini820 – 876CytoplasmicSequence analysisAdd BLAST57
Intramembranei877 – 899HelicalSequence analysisAdd BLAST23
Topological domaini900 – 903CytoplasmicSequence analysis4
Intramembranei904 – 926HelicalSequence analysisAdd BLAST23
Topological domaini927 – 964CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001681642 – 964Reticulon-3Add BLAST963

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei31PhosphoserineBy similarity1
Modified residuei217PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei230PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei270PhosphoserineBy similarity1
Modified residuei303PhosphoserineBy similarity1
Modified residuei429PhosphoserineBy similarity1
Modified residuei529PhosphoserineCombined sources1
Modified residuei593PhosphothreonineBy similarity1
Modified residuei596PhosphoserineCombined sources1
Modified residuei597PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9ES97
PeptideAtlasiQ9ES97
PRIDEiQ9ES97
TopDownProteomicsiQ9ES97-1 [Q9ES97-1]
Q9ES97-3 [Q9ES97-3]
Q9ES97-4 [Q9ES97-4]
Q9ES97-5 [Q9ES97-5]

PTM databases

iPTMnetiQ9ES97
PhosphoSitePlusiQ9ES97
SwissPalmiQ9ES97

Expressioni

Tissue specificityi

Isoform 1, isoform 3, isoform 4 and isoform 5 are expressed in spinal cord. Isoform 1 is present in brain, where it is expressed in the neurons of cerebral cortex, hippocampus, hypothalamus and cerebellum (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000024758 Expressed in 318 organ(s), highest expression level in facial nucleus
CleanExiMM_RTN3
GenevisibleiQ9ES97 MM

Interactioni

Subunit structurei

Homodimer. Interacts with RTN4. Isoform 3 interacts with BACE1, BACE2, BCL2 and FADD (By similarity). Interacts with ATL1 and ATL2 (PubMed:19665976). Isoform 3 interacts with TMEM33 (PubMed:25612671). Interacts with ZFYVE27 and with KIF5A in a ZFYVE27-dependent manner (By similarity).By similarity2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi203034, 1 interactor
CORUMiQ9ES97
IntActiQ9ES97, 7 interactors
MINTiQ9ES97
STRINGi10090.ENSMUSP00000065810

Structurei

3D structure databases

ProteinModelPortaliQ9ES97
SMRiQ9ES97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini776 – 964ReticulonPROSITE-ProRule annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni919 – 964Interaction with FADDBy similarityAdd BLAST46
Regioni932 – 934Interaction with BACE1By similarity3

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1792 Eukaryota
ENOG410XPKH LUCA
GeneTreeiENSGT00390000009934
HOVERGENiHBG093922
InParanoidiQ9ES97
KOiK20723
OMAiIAHDIAI
OrthoDBiEOG091G0TIO
PhylomeDBiQ9ES97
TreeFamiTF105431

Family and domain databases

InterProiView protein in InterPro
IPR003388 Reticulon
PfamiView protein in Pfam
PF02453 Reticulon, 1 hit
PROSITEiView protein in PROSITE
PS50845 RETICULON, 1 hit

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9ES97-1) [UniParc]FASTAAdd to basket
Also known as: A1, A4b, B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAESSAATQS PSVSSSSSGA EPSALGGGGG SPGACPALGA KSCGSSCADS 
        60         70         80         90        100
FVSSSSSQPV SIFSTSQAGL SSLCSDEPPS KSMTSSFLSS SEIHNPDPTT 
       110        120        130        140        150
PLGEKSETLG SQFVLAKGKD PLVLLDKKKL DSPQGTNKDR VDAPVSLATG 
       160        170        180        190        200
IPCSHPSIPD SFPEQPAFLS KEIGPAEEWV VKDQEPKNPN KVPDGEDRSA 
       210        220        230        240        250
LDFGQSKAEH ICTYSLSPSE LPVASVEKDS PESPFEVIID KATFDREFKD 
       260        270        280        290        300
LYKENPNDLG GWAAHGDRES PADLLEMNDK LFPLRNKEAG RYPSSVLLGR 
       310        320        330        340        350
QFSHTTAALE EVSRCVNDMH NFTNEILTWD LDPQAKQQAN KTSCTTESTG 
       360        370        380        390        400
LDRSELRSEI PVINLKTNPQ QKMPVCSFNG STPITKSTGD WTEAFTEGKP 
       410        420        430        440        450
VRDYLSSTKE AGGNGVPGSS QLHSELPGSM PEKWVSGSGA ATVEVTLPNL 
       460        470        480        490        500
RGAWPNSVMG EVTEVDSSGE SDDTVIEDIT EKPDSLPSAA AKTSEREIKE 
       510        520        530        540        550
TPSRETVRSE MCENSEQPQA QPETPTQKSL EGEVASQVPN TLNEVTPEKL 
       560        570        580        590        600
DMTNNPKVCS AAPPSVLNET GFSLTVPASA KLESLLGKYV EDTDGSSPED 
       610        620        630        640        650
LMAVLTGAEE KGIVDKEEGD VLEAVLEKIA DFKNTLPVEL LHESELSGSE 
       660        670        680        690        700
TKNIKSKYSE DSRETTGGAP TMSPDLEQEQ LTIRAIKELG ERQAEKVQDE 
       710        720        730        740        750
GISSGGKLKQ TFAPQSGPQS SSDILEHTDV KTGSDLGIPK NPTIIKNTRI 
       760        770        780        790        800
DSISSLTKTE MVNKNVLARL LSDFPVHDLI FWRDVKKTGF VFGTTLIMLL 
       810        820        830        840        850
SLAAFSVISV VSYLILALLS VTISFRVYKS VIQAVQKSEE GHPFKAYLDV 
       860        870        880        890        900
DITLSSEAFH NYMNAAMVHV NKALKLIIRL FLVEDLVDSL KLAVFMWLMT 
       910        920        930        940        950
YVGAVFNGIT LLILAELLVF SVPIVYEKYK TQIDHYVGIA RDQTKSIVEK 
       960 
IQAKLPGIAK KKAE
Length:964
Mass (Da):103,879
Last modified:March 20, 2007 - v2
Checksum:i5170809A696F8F7A
GO
Isoform 2 (identifier: Q9ES97-2) [UniParc]FASTAAdd to basket
Also known as: A2, A3b

The sequence of this isoform differs from the canonical sequence as follows:
     49-67: Missing.

Show »
Length:945
Mass (Da):101,920
Checksum:i28DD47E72CBEC824
GO
Isoform 3 (identifier: Q9ES97-3) [UniParc]FASTAAdd to basket
Also known as: B1, A1, Rtn3c

The sequence of this isoform differs from the canonical sequence as follows:
     49-775: Missing.

Show »
Length:237
Mass (Da):25,428
Checksum:iEB60A0A7AC45F0DE
GO
Isoform 4 (identifier: Q9ES97-4) [UniParc]FASTAAdd to basket
Also known as: B2, A2

The sequence of this isoform differs from the canonical sequence as follows:
     68-775: Missing.

Show »
Length:256
Mass (Da):27,387
Checksum:i5EE394BAA15E38B0
GO
Isoform 5 (identifier: Q9ES97-5) [UniParc]FASTAAdd to basket
Also known as: A4a

The sequence of this isoform differs from the canonical sequence as follows:
     68-388: Missing.

Show »
Length:643
Mass (Da):68,770
Checksum:i15E3335B280533F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17S → P in AAR98631 (PubMed:15350194).Curated1
Sequence conflicti215S → P in AAR98632 (PubMed:15350194).Curated1
Sequence conflicti355E → G in AAR98632 (PubMed:15350194).Curated1
Sequence conflicti899M → I in BAC36028 (PubMed:16141072).Curated1
Sequence conflicti964E → K in BAE28664 (PubMed:16141072).Curated1
Sequence conflicti964E → K in BAE28699 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02376249 – 775Missing in isoform 3. 6 PublicationsAdd BLAST727
Alternative sequenceiVSP_02376349 – 67Missing in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_02376468 – 775Missing in isoform 4. CuratedAdd BLAST708
Alternative sequenceiVSP_02376568 – 388Missing in isoform 5. 1 PublicationAdd BLAST321

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046114 mRNA Translation: BAB62070.1
BK001796 mRNA Translation: DAA01968.1
AY164700 mRNA Translation: AAP47278.1
AY507126 mRNA Translation: AAR98631.1
AY507127 mRNA Translation: AAR98632.1
AY427822 mRNA Translation: AAR08193.1
AY750849 mRNA Translation: AAU81931.1
AF195940 mRNA Translation: AAG31360.1
AK032109 mRNA Translation: BAC27708.1
AK036892 mRNA Translation: BAC29625.1
AK049845 mRNA Translation: BAC33952.1
AK075883 mRNA Translation: BAC36028.1
AK088670 mRNA Translation: BAC40493.1
AK146505 mRNA Translation: BAE27220.1
AK148792 mRNA Translation: BAE28664.1
AK148947 mRNA Translation: BAE28699.1
AK165683 mRNA Translation: BAE38336.1
BC014697 mRNA Translation: AAH14697.1
BC036717 mRNA Translation: AAH36717.1
BC079882 mRNA Translation: AAH79882.1
CCDSiCCDS29525.1 [Q9ES97-2]
CCDS29526.1 [Q9ES97-3]
CCDS37906.1 [Q9ES97-1]
CCDS70927.1 [Q9ES97-4]
RefSeqiNP_001003933.1, NM_001003933.2 [Q9ES97-2]
NP_001003934.1, NM_001003934.2 [Q9ES97-1]
NP_001258415.1, NM_001271486.1 [Q9ES97-5]
NP_001258416.1, NM_001271487.1 [Q9ES97-4]
NP_444306.1, NM_053076.3 [Q9ES97-3]
UniGeneiMm.246990

Genome annotation databases

EnsembliENSMUST00000025667; ENSMUSP00000025667; ENSMUSG00000024758 [Q9ES97-3]
ENSMUST00000065304; ENSMUSP00000065810; ENSMUSG00000024758 [Q9ES97-1]
ENSMUST00000088169; ENSMUSP00000085494; ENSMUSG00000024758 [Q9ES97-4]
ENSMUST00000088171; ENSMUSP00000085496; ENSMUSG00000024758 [Q9ES97-2]
GeneIDi20168
KEGGimmu:20168
UCSCiuc008glb.2 mouse [Q9ES97-1]
uc008gld.2 mouse [Q9ES97-2]
uc008gle.2 mouse [Q9ES97-3]
uc012bhv.2 mouse [Q9ES97-5]
uc033hiw.1 mouse [Q9ES97-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046114 mRNA Translation: BAB62070.1
BK001796 mRNA Translation: DAA01968.1
AY164700 mRNA Translation: AAP47278.1
AY507126 mRNA Translation: AAR98631.1
AY507127 mRNA Translation: AAR98632.1
AY427822 mRNA Translation: AAR08193.1
AY750849 mRNA Translation: AAU81931.1
AF195940 mRNA Translation: AAG31360.1
AK032109 mRNA Translation: BAC27708.1
AK036892 mRNA Translation: BAC29625.1
AK049845 mRNA Translation: BAC33952.1
AK075883 mRNA Translation: BAC36028.1
AK088670 mRNA Translation: BAC40493.1
AK146505 mRNA Translation: BAE27220.1
AK148792 mRNA Translation: BAE28664.1
AK148947 mRNA Translation: BAE28699.1
AK165683 mRNA Translation: BAE38336.1
BC014697 mRNA Translation: AAH14697.1
BC036717 mRNA Translation: AAH36717.1
BC079882 mRNA Translation: AAH79882.1
CCDSiCCDS29525.1 [Q9ES97-2]
CCDS29526.1 [Q9ES97-3]
CCDS37906.1 [Q9ES97-1]
CCDS70927.1 [Q9ES97-4]
RefSeqiNP_001003933.1, NM_001003933.2 [Q9ES97-2]
NP_001003934.1, NM_001003934.2 [Q9ES97-1]
NP_001258415.1, NM_001271486.1 [Q9ES97-5]
NP_001258416.1, NM_001271487.1 [Q9ES97-4]
NP_444306.1, NM_053076.3 [Q9ES97-3]
UniGeneiMm.246990

3D structure databases

ProteinModelPortaliQ9ES97
SMRiQ9ES97
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203034, 1 interactor
CORUMiQ9ES97
IntActiQ9ES97, 7 interactors
MINTiQ9ES97
STRINGi10090.ENSMUSP00000065810

Protein family/group databases

TCDBi8.A.102.1.2 the reticulon (reticulon) family

PTM databases

iPTMnetiQ9ES97
PhosphoSitePlusiQ9ES97
SwissPalmiQ9ES97

Proteomic databases

PaxDbiQ9ES97
PeptideAtlasiQ9ES97
PRIDEiQ9ES97
TopDownProteomicsiQ9ES97-1 [Q9ES97-1]
Q9ES97-3 [Q9ES97-3]
Q9ES97-4 [Q9ES97-4]
Q9ES97-5 [Q9ES97-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025667; ENSMUSP00000025667; ENSMUSG00000024758 [Q9ES97-3]
ENSMUST00000065304; ENSMUSP00000065810; ENSMUSG00000024758 [Q9ES97-1]
ENSMUST00000088169; ENSMUSP00000085494; ENSMUSG00000024758 [Q9ES97-4]
ENSMUST00000088171; ENSMUSP00000085496; ENSMUSG00000024758 [Q9ES97-2]
GeneIDi20168
KEGGimmu:20168
UCSCiuc008glb.2 mouse [Q9ES97-1]
uc008gld.2 mouse [Q9ES97-2]
uc008gle.2 mouse [Q9ES97-3]
uc012bhv.2 mouse [Q9ES97-5]
uc033hiw.1 mouse [Q9ES97-4]

Organism-specific databases

CTDi10313
MGIiMGI:1339970 Rtn3

Phylogenomic databases

eggNOGiKOG1792 Eukaryota
ENOG410XPKH LUCA
GeneTreeiENSGT00390000009934
HOVERGENiHBG093922
InParanoidiQ9ES97
KOiK20723
OMAiIAHDIAI
OrthoDBiEOG091G0TIO
PhylomeDBiQ9ES97
TreeFamiTF105431

Enzyme and pathway databases

ReactomeiR-MMU-8849932 Synaptic adhesion-like molecules

Miscellaneous databases

ChiTaRSiRtn3 mouse
PROiPR:Q9ES97
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024758 Expressed in 318 organ(s), highest expression level in facial nucleus
CleanExiMM_RTN3
GenevisibleiQ9ES97 MM

Family and domain databases

InterProiView protein in InterPro
IPR003388 Reticulon
PfamiView protein in Pfam
PF02453 Reticulon, 1 hit
PROSITEiView protein in PROSITE
PS50845 RETICULON, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRTN3_MOUSE
AccessioniPrimary (citable) accession number: Q9ES97
Secondary accession number(s): Q3UF62
, Q544J1, Q68FE4, Q6IM69, Q6R8K6, Q6R8K7, Q6T929, Q8C6D5, Q8CCU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 20, 2007
Last modified: November 7, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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