UniProtKB - Q9ES97 (RTN3_MOUSE)
Reticulon-3
Rtn3
Functioni
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- endoplasmic reticulum tubular network formation Source: UniProtKB
- endoplasmic reticulum tubular network organization Source: MGI
- vesicle-mediated transport Source: UniProtKB-KW
Keywordsi
Biological process | Apoptosis, ER-Golgi transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-8849932, Synaptic adhesion-like molecules |
Protein family/group databases
TCDBi | 8.A.102.1.2, the reticulon (reticulon) family |
Names & Taxonomyi
Protein namesi | Recommended name: Reticulon-3 |
Gene namesi | Name:Rtn3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1339970, Rtn3 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Golgi apparatus
- Golgi apparatus membrane By similarity; Multi-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- endoplasmic reticulum membrane Source: MGI
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- synapse Source: SynGO
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 795 | CytoplasmicSequence analysisAdd BLAST | 794 | |
Intramembranei | 796 – 819 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 820 – 876 | CytoplasmicSequence analysisAdd BLAST | 57 | |
Intramembranei | 877 – 899 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 900 – 903 | CytoplasmicSequence analysis | 4 | |
Intramembranei | 904 – 926 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 927 – 964 | CytoplasmicSequence analysisAdd BLAST | 38 |
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000168164 | 2 – 964 | Reticulon-3Add BLAST | 963 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 31 | PhosphoserineBy similarity | 1 | |
Modified residuei | 217 | PhosphoserineCombined sources | 1 | |
Modified residuei | 225 | PhosphoserineCombined sources | 1 | |
Modified residuei | 230 | PhosphoserineCombined sources | 1 | |
Modified residuei | 233 | PhosphoserineCombined sources | 1 | |
Modified residuei | 270 | PhosphoserineBy similarity | 1 | |
Modified residuei | 303 | PhosphoserineBy similarity | 1 | |
Modified residuei | 429 | PhosphoserineBy similarity | 1 | |
Modified residuei | 529 | PhosphoserineCombined sources | 1 | |
Modified residuei | 593 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 596 | PhosphoserineCombined sources | 1 | |
Modified residuei | 597 | PhosphoserineCombined sources | 1 | |
Modified residuei | 673 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q9ES97 |
PaxDbi | Q9ES97 |
PeptideAtlasi | Q9ES97 |
PRIDEi | Q9ES97 |
TopDownProteomicsi | Q9ES97-1 [Q9ES97-1] Q9ES97-3 [Q9ES97-3] Q9ES97-4 [Q9ES97-4] Q9ES97-5 [Q9ES97-5] |
PTM databases
iPTMneti | Q9ES97 |
PhosphoSitePlusi | Q9ES97 |
SwissPalmi | Q9ES97 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000024758, Expressed in facial nucleus and 332 other tissues |
Genevisiblei | Q9ES97, MM |
Interactioni
Subunit structurei
Homodimer.
Interacts with RTN4.
Isoform 3 interacts with BACE1, BACE2, BCL2 and FADD (By similarity).
Interacts with ATL1 and ATL2 (PubMed:19665976).
Isoform 3 interacts with TMEM33 (PubMed:25612671).
Interacts with ZFYVE27 and with KIF5A in a ZFYVE27-dependent manner (By similarity).
By similarity2 PublicationsBinary interactionsi
Hide detailsIsoform 3 [Q9ES97-3]
With | #Exp. | IntAct |
---|---|---|
ATL1 [Q8WXF7] from Homo sapiens. | 3 | EBI-1487798,EBI-2410266 |
ATL2 [Q8NHH9] from Homo sapiens. | 2 | EBI-1487798,EBI-2410430 |
Protein-protein interaction databases
BioGRIDi | 203034, 3 interactors |
CORUMi | Q9ES97 |
IntActi | Q9ES97, 7 interactors |
MINTi | Q9ES97 |
STRINGi | 10090.ENSMUSP00000065810 |
Miscellaneous databases
RNActi | Q9ES97, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 776 – 964 | ReticulonPROSITE-ProRule annotationAdd BLAST | 189 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 919 – 964 | Interaction with FADDBy similarityAdd BLAST | 46 | |
Regioni | 932 – 934 | Interaction with BACE1By similarity | 3 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1792, Eukaryota |
GeneTreei | ENSGT00940000157482 |
HOGENOMi | CLU_011704_0_0_1 |
InParanoidi | Q9ES97 |
OMAi | KYQDHVD |
OrthoDBi | 423549at2759 |
PhylomeDBi | Q9ES97 |
TreeFami | TF105431 |
Family and domain databases
InterProi | View protein in InterPro IPR003388, Reticulon |
Pfami | View protein in Pfam PF02453, Reticulon, 1 hit |
PROSITEi | View protein in PROSITE PS50845, RETICULON, 1 hit |
s (5)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAESSAATQS PSVSSSSSGA EPSALGGGGG SPGACPALGA KSCGSSCADS
60 70 80 90 100
FVSSSSSQPV SIFSTSQAGL SSLCSDEPPS KSMTSSFLSS SEIHNPDPTT
110 120 130 140 150
PLGEKSETLG SQFVLAKGKD PLVLLDKKKL DSPQGTNKDR VDAPVSLATG
160 170 180 190 200
IPCSHPSIPD SFPEQPAFLS KEIGPAEEWV VKDQEPKNPN KVPDGEDRSA
210 220 230 240 250
LDFGQSKAEH ICTYSLSPSE LPVASVEKDS PESPFEVIID KATFDREFKD
260 270 280 290 300
LYKENPNDLG GWAAHGDRES PADLLEMNDK LFPLRNKEAG RYPSSVLLGR
310 320 330 340 350
QFSHTTAALE EVSRCVNDMH NFTNEILTWD LDPQAKQQAN KTSCTTESTG
360 370 380 390 400
LDRSELRSEI PVINLKTNPQ QKMPVCSFNG STPITKSTGD WTEAFTEGKP
410 420 430 440 450
VRDYLSSTKE AGGNGVPGSS QLHSELPGSM PEKWVSGSGA ATVEVTLPNL
460 470 480 490 500
RGAWPNSVMG EVTEVDSSGE SDDTVIEDIT EKPDSLPSAA AKTSEREIKE
510 520 530 540 550
TPSRETVRSE MCENSEQPQA QPETPTQKSL EGEVASQVPN TLNEVTPEKL
560 570 580 590 600
DMTNNPKVCS AAPPSVLNET GFSLTVPASA KLESLLGKYV EDTDGSSPED
610 620 630 640 650
LMAVLTGAEE KGIVDKEEGD VLEAVLEKIA DFKNTLPVEL LHESELSGSE
660 670 680 690 700
TKNIKSKYSE DSRETTGGAP TMSPDLEQEQ LTIRAIKELG ERQAEKVQDE
710 720 730 740 750
GISSGGKLKQ TFAPQSGPQS SSDILEHTDV KTGSDLGIPK NPTIIKNTRI
760 770 780 790 800
DSISSLTKTE MVNKNVLARL LSDFPVHDLI FWRDVKKTGF VFGTTLIMLL
810 820 830 840 850
SLAAFSVISV VSYLILALLS VTISFRVYKS VIQAVQKSEE GHPFKAYLDV
860 870 880 890 900
DITLSSEAFH NYMNAAMVHV NKALKLIIRL FLVEDLVDSL KLAVFMWLMT
910 920 930 940 950
YVGAVFNGIT LLILAELLVF SVPIVYEKYK TQIDHYVGIA RDQTKSIVEK
960
IQAKLPGIAK KKAE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 17 | S → P in AAR98631 (PubMed:15350194).Curated | 1 | |
Sequence conflicti | 215 | S → P in AAR98632 (PubMed:15350194).Curated | 1 | |
Sequence conflicti | 355 | E → G in AAR98632 (PubMed:15350194).Curated | 1 | |
Sequence conflicti | 899 | M → I in BAC36028 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 964 | E → K in BAE28664 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 964 | E → K in BAE28699 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023762 | 49 – 775 | Missing in isoform 3. 6 PublicationsAdd BLAST | 727 | |
Alternative sequenceiVSP_023763 | 49 – 67 | Missing in isoform 2. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_023764 | 68 – 775 | Missing in isoform 4. CuratedAdd BLAST | 708 | |
Alternative sequenceiVSP_023765 | 68 – 388 | Missing in isoform 5. 1 PublicationAdd BLAST | 321 |
Sequence databases
Genome annotation databases
Ensembli | ENSMUST00000025667; ENSMUSP00000025667; ENSMUSG00000024758 [Q9ES97-4] ENSMUST00000065304; ENSMUSP00000065810; ENSMUSG00000024758 [Q9ES97-1] ENSMUST00000088169; ENSMUSP00000085494; ENSMUSG00000024758 [Q9ES97-3] ENSMUST00000088171; ENSMUSP00000085496; ENSMUSG00000024758 [Q9ES97-2] ENSMUST00000235593; ENSMUSP00000158024; ENSMUSG00000024758 [Q9ES97-5] |
GeneIDi | 20168 |
KEGGi | mmu:20168 |
UCSCi | uc008glb.2, mouse [Q9ES97-1] uc008gld.2, mouse [Q9ES97-2] uc008gle.2, mouse [Q9ES97-3] uc012bhv.2, mouse [Q9ES97-5] uc033hiw.1, mouse [Q9ES97-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | Q9ES97 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203034, 3 interactors |
CORUMi | Q9ES97 |
IntActi | Q9ES97, 7 interactors |
MINTi | Q9ES97 |
STRINGi | 10090.ENSMUSP00000065810 |
Protein family/group databases
TCDBi | 8.A.102.1.2, the reticulon (reticulon) family |
PTM databases
iPTMneti | Q9ES97 |
PhosphoSitePlusi | Q9ES97 |
SwissPalmi | Q9ES97 |
Proteomic databases
jPOSTi | Q9ES97 |
PaxDbi | Q9ES97 |
PeptideAtlasi | Q9ES97 |
PRIDEi | Q9ES97 |
TopDownProteomicsi | Q9ES97-1 [Q9ES97-1] Q9ES97-3 [Q9ES97-3] Q9ES97-4 [Q9ES97-4] Q9ES97-5 [Q9ES97-5] |
Protocols and materials databases
Antibodypediai | 2923, 187 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000025667; ENSMUSP00000025667; ENSMUSG00000024758 [Q9ES97-4] ENSMUST00000065304; ENSMUSP00000065810; ENSMUSG00000024758 [Q9ES97-1] ENSMUST00000088169; ENSMUSP00000085494; ENSMUSG00000024758 [Q9ES97-3] ENSMUST00000088171; ENSMUSP00000085496; ENSMUSG00000024758 [Q9ES97-2] ENSMUST00000235593; ENSMUSP00000158024; ENSMUSG00000024758 [Q9ES97-5] |
GeneIDi | 20168 |
KEGGi | mmu:20168 |
UCSCi | uc008glb.2, mouse [Q9ES97-1] uc008gld.2, mouse [Q9ES97-2] uc008gle.2, mouse [Q9ES97-3] uc012bhv.2, mouse [Q9ES97-5] uc033hiw.1, mouse [Q9ES97-4] |
Organism-specific databases
CTDi | 10313 |
MGIi | MGI:1339970, Rtn3 |
Phylogenomic databases
eggNOGi | KOG1792, Eukaryota |
GeneTreei | ENSGT00940000157482 |
HOGENOMi | CLU_011704_0_0_1 |
InParanoidi | Q9ES97 |
OMAi | KYQDHVD |
OrthoDBi | 423549at2759 |
PhylomeDBi | Q9ES97 |
TreeFami | TF105431 |
Enzyme and pathway databases
Reactomei | R-MMU-8849932, Synaptic adhesion-like molecules |
Miscellaneous databases
BioGRID-ORCSi | 20168, 1 hit in 17 CRISPR screens |
ChiTaRSi | Rtn3, mouse |
PROi | PR:Q9ES97 |
RNActi | Q9ES97, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024758, Expressed in facial nucleus and 332 other tissues |
Genevisiblei | Q9ES97, MM |
Family and domain databases
InterProi | View protein in InterPro IPR003388, Reticulon |
Pfami | View protein in Pfam PF02453, Reticulon, 1 hit |
PROSITEi | View protein in PROSITE PS50845, RETICULON, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RTN3_MOUSE | |
Accessioni | Q9ES97Primary (citable) accession number: Q9ES97 Secondary accession number(s): Q3UF62 Q8CCU2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | March 20, 2007 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot