Slc13a2

Functionⁱ

Cotransport of sodium ions and dicarboxylates such as succinate and citrate.

GO - Molecular functionⁱ

symporter activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

sodium ion transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ion transport, Sodium transport, Symport, Transport
Ligand	Sodium

Enzyme and pathway databases

Reactomeⁱ	R-MMU-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters

Reactomeⁱ

R-MMU-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Solute carrier family 13 member 2 Alternative name(s): Na(+)/dicarboxylate cotransporter 1 Short name: NaDC-1 Renal sodium/dicarboxylate cotransporter
Gene namesⁱ	Name:Slc13a2 Synonyms:Nadc1, Sdct1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:1276558 Slc13a2

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	13 – 33	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	53 – 73	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	86 – 106	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	215 – 235	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	264 – 284	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	319 – 339	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	366 – 386	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	407 – 427	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	445 – 465	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	478 – 498	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	506 – 526	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	535 – 555	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000172489	1 – 586	Solute carrier family 13 member 2Add BLAST		586

Proteomic databases

PaxDbⁱ	Q9ES88
PRIDEⁱ	Q9ES88

PTM databases

iPTMnetⁱ	Q9ES88
PhosphoSitePlusⁱ	Q9ES88

Expressionⁱ

Tissue specificityⁱ

Highly expressed in kidney and small intestine. Not detectable in brain, heart, stomach and skeletal muscle.

Gene expression databases

Bgeeⁱ	ENSMUSG00000001095 Expressed in 82 organ(s), highest expression level in jejunum
Genevisibleⁱ	Q9ES88 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000001122

STRINGⁱ

10090.ENSMUSP00000001122

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9ES88
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1281 Eukaryota COG0471 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074480
HOGENOMⁱ	HOG000278432
HOVERGENⁱ	HBG055339
InParanoidⁱ	Q9ES88
KEGG Orthology (KO) More...KOⁱ	K14445
OMAⁱ	IWWMTEA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G092X
PhylomeDBⁱ	Q9ES88
TreeFamⁱ	TF312913

Family and domain databases

InterProⁱ	View protein in InterPro IPR031312 Na/sul_symport_CS IPR001898 SLC13A/DASS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00939 Na_sulph_symp, 1 hit
PROSITEⁱ	View protein in PROSITE PS01271 NA_SULFATE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9ES88-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATCWQALWA YRSYLIVLCL PIFLLPLPLI VQTKEAYCAY SIILMALLWC 
        60         70         80         90        100
TEALPLAVTA LFPIILFPLM GIMEASKVCL EYFKDTNILF VGGLMVAIAV 
       110        120        130        140        150
EHWNLHKRIA LGVLLIIGVR PALLLLGFML VTAFLSMWIS NTATTAMMLP 
       160        170        180        190        200
IGYAVLEQLQ GSQKDVEEGN SNPSFELQEA SPQKEETKLD NGQAVSVSSE 
       210        220        230        240        250
PRAQKTKEHH RFSQGLSLCI CYSASIGGIA TLTGTTPNLV LQGQVNSIFP 
       260        270        280        290        300
ENSNVVNFAS WFGFAFPTMV ILLLLAWLWL QVLFLGVNFR KNFGFGEGEE 
       310        320        330        340        350
ERKQAAFQVI KTQHRLLGPM SFAEKAVTFL FVLLVVLWFT REPGFFPGWG 
       360        370        380        390        400
DTAFANKKGQ SMVSDGTVAI FISLIMFIIP SKIPGLTEDP KKPGKLKAPP 
       410        420        430        440        450
AILTWKTVND KMPWNILILL GGGFALAKGS EESGLSKWLG DKLTPLQHVP 
       460        470        480        490        500
PSATVLILSL LVAIFTECTS NVATTTLFLP ILASMAQAIC LHPLYVMLPC 
       510        520        530        540        550
TLAASLAFML PVATPPNAIV FSFGGLKVSD MARAGFLLNI IGVLTITLSI 
       560        570        580 
NSWSIPIFKL DTFPTWAYSN TSQCLLNPPN STVPGH

Length:586

Mass (Da):64,111

Last modified:March 1, 2001 - v1

Checksum:ⁱ56EEAE21532833EE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF201903 mRNA Translation: AAG15426.1 BC013493 mRNA Translation: AAH13493.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25103.1
NCBI Reference Sequences More...RefSeqⁱ	NP_071856.1, NM_022411.3
UniGeneⁱ	Mm.274058

Genome annotation databases

Ensemblⁱ	ENSMUST00000001122; ENSMUSP00000001122; ENSMUSG00000001095
GeneIDⁱ	20500
KEGGⁱ	mmu:20500
UCSC genome browser More...UCSCⁱ	uc007kjf.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9ES88	Solute carrier family 13 member 2		RAT		587	UniRef90_Q9ES88
UPI00042ACC48		PERMB		586
UPI000A31B1D9		MUSCR		586
Sodium-dependent dicarboxylate transporter		RAT		587
UPI0003D0CFE7		RAT		543
+1

Protein	Similar proteins		Species	Score	Length	Source
Q9ES88	Solute carrier family 13 member 2		HUMAN		592	UniRef50_Q13183
Solute carrier family 13 member 2		RAT		587
Solute carrier family 13 member 2		RABIT		593
Uncharacterized protein		PANPA		592
SLC13A2 isoform 2		PANTR		592
+291

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF201903 mRNA Translation: AAG15426.1 BC013493 mRNA Translation: AAH13493.1
CCDSⁱ	CCDS25103.1
RefSeqⁱ	NP_071856.1, NM_022411.3
UniGeneⁱ	Mm.274058

3D structure databases

ProteinModelPortalⁱ	Q9ES88
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000001122

STRINGⁱ

10090.ENSMUSP00000001122

PTM databases

iPTMnetⁱ	Q9ES88
PhosphoSitePlusⁱ	Q9ES88

Proteomic databases

PaxDbⁱ	Q9ES88
PRIDEⁱ	Q9ES88

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000001122; ENSMUSP00000001122; ENSMUSG00000001095
GeneIDⁱ	20500
KEGGⁱ	mmu:20500
UCSCⁱ	uc007kjf.1 mouse

Organism-specific databases

CTDⁱ	9058
MGIⁱ	MGI:1276558 Slc13a2

Phylogenomic databases

eggNOGⁱ	KOG1281 Eukaryota COG0471 LUCA
GeneTreeⁱ	ENSGT00550000074480
HOGENOMⁱ	HOG000278432
HOVERGENⁱ	HBG055339
InParanoidⁱ	Q9ES88
KOⁱ	K14445
OMAⁱ	IWWMTEA
OrthoDBⁱ	EOG091G092X
PhylomeDBⁱ	Q9ES88
TreeFamⁱ	TF312913

Enzyme and pathway databases

Reactomeⁱ	R-MMU-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters

Reactomeⁱ

R-MMU-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9ES88
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000001095 Expressed in 82 organ(s), highest expression level in jejunum
Genevisibleⁱ	Q9ES88 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR031312 Na/sul_symport_CS IPR001898 SLC13A/DASS
Pfamⁱ	View protein in Pfam PF00939 Na_sulph_symp, 1 hit
PROSITEⁱ	View protein in PROSITE PS01271 NA_SULFATE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S13A2_MOUSE
Accessionⁱ	Q9ES88Primary (citable) accession number: Q9ES88
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9ES88 (S13A2_MOUSE)

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Solute carrier family 13 member 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ