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UniProtKB - Q9ES88 (S13A2_MOUSE)
Protein
Solute carrier family 13 member 2
Gene
Slc13a2
Organism
Mus musculus (Mouse)
Status
Functioni
Cotransport of sodium ions and dicarboxylates such as succinate and citrate.
GO - Molecular functioni
- succinate transmembrane transporter activity Source: ARUK-UCL
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- anion transmembrane transport Source: GO_Central
- sodium ion transport Source: UniProtKB-KW
- succinate transmembrane transport Source: ARUK-UCL
Keywordsi
Biological process | Ion transport, Sodium transport, Symport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-MMU-433137, Sodium-coupled sulphate, di- and tri-carboxylate transporters |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 13 member 2Alternative name(s): Na(+)/dicarboxylate cotransporter 1 Short name: NaDC-1 Renal sodium/dicarboxylate cotransporter |
Gene namesi | Name:Slc13a2 Synonyms:Nadc1, Sdct1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1276558, Slc13a2 |
VEuPathDBi | HostDB:ENSMUSG00000001095 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 13 – 33 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 53 – 73 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 86 – 106 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 215 – 235 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 264 – 284 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 319 – 339 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 366 – 386 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 407 – 427 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 445 – 465 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 478 – 498 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 506 – 526 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 535 – 555 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000172489 | 1 – 586 | Solute carrier family 13 member 2Add BLAST | 586 |
Proteomic databases
PaxDbi | Q9ES88 |
PRIDEi | Q9ES88 |
ProteomicsDBi | 255441 |
PTM databases
iPTMneti | Q9ES88 |
PhosphoSitePlusi | Q9ES88 |
Expressioni
Tissue specificityi
Highly expressed in kidney and small intestine. Not detectable in brain, heart, stomach and skeletal muscle.
Gene expression databases
Bgeei | ENSMUSG00000001095, Expressed in jejunum and 99 other tissues |
Genevisiblei | Q9ES88, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000001122 |
Miscellaneous databases
RNActi | Q9ES88, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 165 – 209 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 165 – 180 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 187 – 201 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1281, Eukaryota |
GeneTreei | ENSGT01030000234550 |
HOGENOMi | CLU_005170_9_1_1 |
InParanoidi | Q9ES88 |
OMAi | EAYCAYT |
OrthoDBi | 389981at2759 |
PhylomeDBi | Q9ES88 |
TreeFami | TF312913 |
Family and domain databases
InterProi | View protein in InterPro IPR031312, Na/sul_symport_CS IPR001898, SLC13A/DASS |
Pfami | View protein in Pfam PF00939, Na_sulph_symp, 1 hit |
PROSITEi | View protein in PROSITE PS01271, NA_SULFATE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9ES88-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATCWQALWA YRSYLIVLCL PIFLLPLPLI VQTKEAYCAY SIILMALLWC
60 70 80 90 100
TEALPLAVTA LFPIILFPLM GIMEASKVCL EYFKDTNILF VGGLMVAIAV
110 120 130 140 150
EHWNLHKRIA LGVLLIIGVR PALLLLGFML VTAFLSMWIS NTATTAMMLP
160 170 180 190 200
IGYAVLEQLQ GSQKDVEEGN SNPSFELQEA SPQKEETKLD NGQAVSVSSE
210 220 230 240 250
PRAQKTKEHH RFSQGLSLCI CYSASIGGIA TLTGTTPNLV LQGQVNSIFP
260 270 280 290 300
ENSNVVNFAS WFGFAFPTMV ILLLLAWLWL QVLFLGVNFR KNFGFGEGEE
310 320 330 340 350
ERKQAAFQVI KTQHRLLGPM SFAEKAVTFL FVLLVVLWFT REPGFFPGWG
360 370 380 390 400
DTAFANKKGQ SMVSDGTVAI FISLIMFIIP SKIPGLTEDP KKPGKLKAPP
410 420 430 440 450
AILTWKTVND KMPWNILILL GGGFALAKGS EESGLSKWLG DKLTPLQHVP
460 470 480 490 500
PSATVLILSL LVAIFTECTS NVATTTLFLP ILASMAQAIC LHPLYVMLPC
510 520 530 540 550
TLAASLAFML PVATPPNAIV FSFGGLKVSD MARAGFLLNI IGVLTITLSI
560 570 580
NSWSIPIFKL DTFPTWAYSN TSQCLLNPPN STVPGH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF201903 mRNA Translation: AAG15426.1 BC013493 mRNA Translation: AAH13493.1 |
CCDSi | CCDS25103.1 |
RefSeqi | NP_071856.1, NM_022411.3 |
Genome annotation databases
Ensembli | ENSMUST00000001122; ENSMUSP00000001122; ENSMUSG00000001095 |
GeneIDi | 20500 |
KEGGi | mmu:20500 |
UCSCi | uc007kjf.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF201903 mRNA Translation: AAG15426.1 BC013493 mRNA Translation: AAH13493.1 |
CCDSi | CCDS25103.1 |
RefSeqi | NP_071856.1, NM_022411.3 |
3D structure databases
AlphaFoldDBi | Q9ES88 |
SMRi | Q9ES88 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000001122 |
PTM databases
iPTMneti | Q9ES88 |
PhosphoSitePlusi | Q9ES88 |
Proteomic databases
PaxDbi | Q9ES88 |
PRIDEi | Q9ES88 |
ProteomicsDBi | 255441 |
Protocols and materials databases
Antibodypediai | 14078, 77 antibodies from 21 providers |
DNASUi | 20500 |
Genome annotation databases
Ensembli | ENSMUST00000001122; ENSMUSP00000001122; ENSMUSG00000001095 |
GeneIDi | 20500 |
KEGGi | mmu:20500 |
UCSCi | uc007kjf.1, mouse |
Organism-specific databases
CTDi | 9058 |
MGIi | MGI:1276558, Slc13a2 |
VEuPathDBi | HostDB:ENSMUSG00000001095 |
Phylogenomic databases
eggNOGi | KOG1281, Eukaryota |
GeneTreei | ENSGT01030000234550 |
HOGENOMi | CLU_005170_9_1_1 |
InParanoidi | Q9ES88 |
OMAi | EAYCAYT |
OrthoDBi | 389981at2759 |
PhylomeDBi | Q9ES88 |
TreeFami | TF312913 |
Enzyme and pathway databases
Reactomei | R-MMU-433137, Sodium-coupled sulphate, di- and tri-carboxylate transporters |
Miscellaneous databases
BioGRID-ORCSi | 20500, 4 hits in 72 CRISPR screens |
PROi | PR:Q9ES88 |
RNActi | Q9ES88, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000001095, Expressed in jejunum and 99 other tissues |
Genevisiblei | Q9ES88, MM |
Family and domain databases
InterProi | View protein in InterPro IPR031312, Na/sul_symport_CS IPR001898, SLC13A/DASS |
Pfami | View protein in Pfam PF00939, Na_sulph_symp, 1 hit |
PROSITEi | View protein in PROSITE PS01271, NA_SULFATE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S13A2_MOUSE | |
Accessioni | Q9ES88Primary (citable) accession number: Q9ES88 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | March 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families