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Protein

Popeye domain-containing protein 2

Gene

Popdc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density.By similarity1 Publication

GO - Molecular functioni

  • cAMP binding Source: MGI

GO - Biological processi

  • heart development Source: GO_Central
  • regulation of heart rate Source: MGI
  • regulation of membrane potential Source: MGI
  • sinoatrial node cell development Source: MGI
  • skeletal muscle tissue development Source: GO_Central

Keywordsi

LigandcAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Popeye domain-containing protein 2
Short name:
Popeye protein 2
Gene namesi
Name:Popdc2
Synonyms:Pop2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1930150 Popdc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Knockout mice are deficient to adapt heart rate to physiological stress, this deficiency develops in older mice. They show severe sinus node dysfunction with long pauses and intercurrent periods of normal synus rhythm. The sinus node structure is abnormal with a loss of pacemaker tissue from the inferior part of the sinus node and a compact structure of the superior sinus node.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi184D → A: Almost abolishes cAMP-binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000467941 – 367Popeye domain-containing protein 2Add BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei364PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9ES82
PRIDEiQ9ES82

PTM databases

iPTMnetiQ9ES82
PhosphoSitePlusiQ9ES82

Expressioni

Tissue specificityi

Expressed in the developing and adult heart, with high expression levels in the sinus and atrioventricular nodes. Also expressed in the bladder and skeletal muscle.2 Publications

Developmental stagei

Expression was first detected at E7.5 in the cardiac crescent. Expression was observed in the myocardial layer but not in the endocardium. Expression was homogeneous in all heart segments with the exception of the outflow tract. Between E9.5 and E10.5 expression was also observed in the trabeculated areas. In more advanced stages of myocardial differentiation, expression in the ventricle was largely restricted to the compact layer.1 Publication

Gene expression databases

BgeeiENSMUSG00000022803 Expressed in 115 organ(s), highest expression level in heart left ventricle
CleanExiMM_POPDC2
ExpressionAtlasiQ9ES82 baseline and differential
GenevisibleiQ9ES82 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023494

Structurei

3D structure databases

ProteinModelPortaliQ9ES82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the popeye family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGHK Eukaryota
ENOG410ZTIT LUCA
GeneTreeiENSGT00390000002563
HOGENOMiHOG000050233
HOVERGENiHBG053639
InParanoidiQ9ES82
OMAiLYHLANC
PhylomeDBiQ9ES82

Family and domain databases

InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR006916 Popeye_prot
PANTHERiPTHR12101 PTHR12101, 1 hit
PfamiView protein in Pfam
PF04831 Popeye, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9ES82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSANGSSVAQ LLWQPPVCRS WKPDVEGAVY HLANCFLLMG FMAGSGVYGC
60 70 80 90 100
FYLFGILGPG YLCCVLWGWF DACGLDIVLW NVLLTVACLL QLAQLVYRVR
110 120 130 140 150
VNTLPEEFNL LYRTLCLPLQ VPLQVYKEIV HCCHEQVLTL ATEQTYAVEG
160 170 180 190 200
ETPINRLSLL LSGRVRVSQD GQFLHYIFPY QFMDSPEWES LHPSEEGTFQ
210 220 230 240 250
VTLTAETECS YISWPRKNLY LLLNRERYIS RLFSALLGYD ISEKLYTLND
260 270 280 290 300
KLFAKFGLRF DIRLPSLYHV LSPSASDGEP ESEKDDEEAL EAAVSPAQAR
310 320 330 340 350
PICIVPTPPC SAPPATTNFP VPLPRARMPR MPRPDSGNLA SRRPLQNSSQ
360
VMSRSQAPLA PIHTPEL
Length:367
Mass (Da):41,252
Last modified:March 1, 2001 - v1
Checksum:i74D89B4062C85CBA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6P3F7Q6P3F7_MOUSE
Popdc2 protein
Popdc2
371Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204175 mRNA Translation: AAG23408.1
CCDSiCCDS37342.1
RefSeqiNP_071713.1, NM_022318.3
UniGeneiMm.390856

Genome annotation databases

EnsembliENSMUST00000114739; ENSMUSP00000110387; ENSMUSG00000022803
GeneIDi64082
KEGGimmu:64082
UCSCiuc007zeu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204175 mRNA Translation: AAG23408.1
CCDSiCCDS37342.1
RefSeqiNP_071713.1, NM_022318.3
UniGeneiMm.390856

3D structure databases

ProteinModelPortaliQ9ES82
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023494

PTM databases

iPTMnetiQ9ES82
PhosphoSitePlusiQ9ES82

Proteomic databases

PaxDbiQ9ES82
PRIDEiQ9ES82

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114739; ENSMUSP00000110387; ENSMUSG00000022803
GeneIDi64082
KEGGimmu:64082
UCSCiuc007zeu.2 mouse

Organism-specific databases

CTDi64091
MGIiMGI:1930150 Popdc2

Phylogenomic databases

eggNOGiENOG410IGHK Eukaryota
ENOG410ZTIT LUCA
GeneTreeiENSGT00390000002563
HOGENOMiHOG000050233
HOVERGENiHBG053639
InParanoidiQ9ES82
OMAiLYHLANC
PhylomeDBiQ9ES82

Miscellaneous databases

ChiTaRSiCnot7 mouse
PROiPR:Q9ES82
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022803 Expressed in 115 organ(s), highest expression level in heart left ventricle
CleanExiMM_POPDC2
ExpressionAtlasiQ9ES82 baseline and differential
GenevisibleiQ9ES82 MM

Family and domain databases

InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR006916 Popeye_prot
PANTHERiPTHR12101 PTHR12101, 1 hit
PfamiView protein in Pfam
PF04831 Popeye, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPOPD2_MOUSE
AccessioniPrimary (citable) accession number: Q9ES82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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