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Protein

Popeye domain-containing protein 3

Gene

Popdc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding.2 Publications

GO - Molecular functioni

  • cAMP binding Source: UniProtKB

GO - Biological processi

  • heart development Source: GO_Central
  • regulation of membrane potential Source: MGI
  • skeletal muscle tissue development Source: GO_Central

Keywordsi

LigandcAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Popeye domain-containing protein 3
Short name:
Popeye protein 3
Gene namesi
Name:Popdc3
Synonyms:Pop3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1930153 Popdc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 44HelicalSequence analysisAdd BLAST18
Transmembranei48 – 70HelicalSequence analysisAdd BLAST23
Transmembranei77 – 99HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000467961 – 291Popeye domain-containing protein 3Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9ES81
PRIDEiQ9ES81

PTM databases

iPTMnetiQ9ES81
PhosphoSitePlusiQ9ES81

Expressioni

Tissue specificityi

Expressed in cardiac and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000019848 Expressed in 149 organ(s), highest expression level in quadriceps femoris
CleanExiMM_POPDC3
ExpressionAtlasiQ9ES81 baseline and differential
GenevisibleiQ9ES81 MM

Structurei

3D structure databases

ProteinModelPortaliQ9ES81
SMRiQ9ES81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the popeye family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGHK Eukaryota
ENOG410ZTIT LUCA
GeneTreeiENSGT00390000002563
HOGENOMiHOG000050233
HOVERGENiHBG053639
InParanoidiQ9ES81
OMAiDIRLPNY
OrthoDBiEOG091G0CVO
PhylomeDBiQ9ES81
TreeFamiTF326644

Family and domain databases

InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR006916 Popeye_prot
PANTHERiPTHR12101 PTHR12101, 1 hit
PfamiView protein in Pfam
PF04831 Popeye, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9ES81-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKNSSLWKS LVTEHPLCTT WKQEAEGAIY HLASILFVVG FMGGSGFFGL
60 70 80 90 100
LYVFSLLGLG FLSSAVWAWV DICAADIFSW NFVLFVICFM QFVHIAYQVH
110 120 130 140 150
SITFARDFHV LYSSLFKPLG IPLPVFRTIA LSSEVVSLEK EHCYAMQGKT
160 170 180 190 200
SIDRLSVLIS GRIRVTVDGE FLHYISPFQF LDSPEWDSLR PTEEGIFQVT
210 220 230 240 250
LTADTDCRYV SWRRKKLYLL FAQHRYISRL FSVLIGSDIA DKLYALNDRV
260 270 280 290
YIGKKHHYDI RLPNYYHMST PDLSRSPLTE QFRNSRQHCN K
Length:291
Mass (Da):33,612
Last modified:March 1, 2001 - v1
Checksum:i8AC6BFE107AEEE12
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CZB6E0CZB6_MOUSE
Popeye domain-containing protein 3
Popdc3
171Annotation score:
H3BKF9H3BKF9_MOUSE
Popeye domain-containing protein 3
Popdc3
106Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204176 mRNA Translation: AAG23409.1
AK052325 mRNA Translation: BAC34938.1
BC114993 mRNA Translation: AAI14994.1
CCDSiCCDS23827.1
RefSeqiNP_077248.1, NM_024286.1
UniGeneiMm.24748

Genome annotation databases

EnsembliENSMUST00000019994; ENSMUSP00000019994; ENSMUSG00000019848
GeneIDi78977
KEGGimmu:78977
UCSCiuc007ezy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204176 mRNA Translation: AAG23409.1
AK052325 mRNA Translation: BAC34938.1
BC114993 mRNA Translation: AAI14994.1
CCDSiCCDS23827.1
RefSeqiNP_077248.1, NM_024286.1
UniGeneiMm.24748

3D structure databases

ProteinModelPortaliQ9ES81
SMRiQ9ES81
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9ES81
PhosphoSitePlusiQ9ES81

Proteomic databases

PaxDbiQ9ES81
PRIDEiQ9ES81

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019994; ENSMUSP00000019994; ENSMUSG00000019848
GeneIDi78977
KEGGimmu:78977
UCSCiuc007ezy.1 mouse

Organism-specific databases

CTDi64208
MGIiMGI:1930153 Popdc3

Phylogenomic databases

eggNOGiENOG410IGHK Eukaryota
ENOG410ZTIT LUCA
GeneTreeiENSGT00390000002563
HOGENOMiHOG000050233
HOVERGENiHBG053639
InParanoidiQ9ES81
OMAiDIRLPNY
OrthoDBiEOG091G0CVO
PhylomeDBiQ9ES81
TreeFamiTF326644

Miscellaneous databases

PROiPR:Q9ES81
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019848 Expressed in 149 organ(s), highest expression level in quadriceps femoris
CleanExiMM_POPDC3
ExpressionAtlasiQ9ES81 baseline and differential
GenevisibleiQ9ES81 MM

Family and domain databases

InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR006916 Popeye_prot
PANTHERiPTHR12101 PTHR12101, 1 hit
PfamiView protein in Pfam
PF04831 Popeye, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPOPD3_MOUSE
AccessioniPrimary (citable) accession number: Q9ES81
Secondary accession number(s): Q1RME0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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