UniProtKB - Q9ES67 (ARHGB_RAT)
Protein
Rho guanine nucleotide exchange factor 11
Gene
Arhgef11
Organism
Rattus norvegicus (Rat)
Status
Functioni
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth (By similarity).By similarity1 Publication
GO - Molecular functioni
- G protein-coupled receptor binding Source: RGD
- GTPase activator activity Source: UniProtKB-KW
- Rho guanyl-nucleotide exchange factor activity Source: InterPro
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- regulation of neurotransmitter levels Source: RGD
- Rho protein signal transduction Source: RGD
Keywordsi
Molecular function | GTPase activation, Guanine-nucleotide releasing factor |
Enzyme and pathway databases
Reactomei | R-RNO-193648, NRAGE signals death through JNK R-RNO-194840, Rho GTPase cycle R-RNO-416482, G alpha (12/13) signalling events R-RNO-416572, Sema4D induced cell migration and growth-cone collapse |
Names & Taxonomyi
Protein namesi | Recommended name: Rho guanine nucleotide exchange factor 11Alternative name(s): RhoGEF glutamate transport modulator GTRAP48 |
Gene namesi | Name:Arhgef11 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 619705, Arhgef11 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080929 | 1 – 1527 | Rho guanine nucleotide exchange factor 11Add BLAST | 1527 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | PhosphoserineBy similarity | 1 | |
Modified residuei | 30 | PhosphoserineCombined sources | 1 | |
Modified residuei | 32 | PhosphoserineBy similarity | 1 | |
Modified residuei | 51 | PhosphoserineCombined sources | 1 | |
Modified residuei | 262 | PhosphoserineBy similarity | 1 | |
Modified residuei | 268 | PhosphoserineCombined sources | 1 | |
Modified residuei | 271 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 272 | PhosphoserineCombined sources | 1 | |
Modified residuei | 288 | PhosphoserineCombined sources | 1 | |
Modified residuei | 643 | PhosphoserineBy similarity | 1 | |
Modified residuei | 671 | PhosphoserineBy similarity | 1 | |
Modified residuei | 676 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 680 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1299 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1304 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1462 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1463 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1467 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1480 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1485 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14).By similarity
Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex when previously phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14), leading to its degradation, thereby restricting RhoA activity and facilitating growth cone spreading and neurite outgrowth.By similarity
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q9ES67 |
PaxDbi | Q9ES67 |
PeptideAtlasi | Q9ES67 |
PRIDEi | Q9ES67 |
PTM databases
iPTMneti | Q9ES67 |
PhosphoSitePlusi | Q9ES67 |
SwissPalmi | Q9ES67 |
Interactioni
Subunit structurei
Interacts with RHOA, GNA13 and SLC1A6.
Interacts with GNA12, PLXNB1 and PLXNB2 (By similarity).
Interacts (via DH domain) with GCSAM (via C-terminus) (By similarity).
By similarityBinary interactionsi
Q9ES67
With | #Exp. | IntAct |
---|---|---|
Gna13 [P27601] from Mus musculus. | 3 | EBI-15735216,EBI-2255627 |
GO - Molecular functioni
- G protein-coupled receptor binding Source: RGD
- Rho guanyl-nucleotide exchange factor activity Source: InterPro
Protein-protein interaction databases
DIPi | DIP-46242N |
IntActi | Q9ES67, 1 interactor |
STRINGi | 10116.ENSRNOP00000020717 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9ES67 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9ES67 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 143 | PDZPROSITE-ProRule annotationAdd BLAST | 80 | |
Domaini | 323 – 503 | RGSLPROSITE-ProRule annotationAdd BLAST | 181 | |
Domaini | 742 – 931 | DHPROSITE-ProRule annotationAdd BLAST | 190 | |
Domaini | 973 – 1087 | PHPROSITE-ProRule annotationAdd BLAST | 115 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 461 – 487 | Sequence analysisAdd BLAST | 27 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3520, Eukaryota |
InParanoidi | Q9ES67 |
OrthoDBi | 319635at2759 |
PhylomeDBi | Q9ES67 |
Family and domain databases
CDDi | cd13391, PH_PRG, 1 hit cd08753, RGS_PDZRhoGEF, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR001331, GDS_CDC24_CS IPR001478, PDZ IPR032919, PDZ-RhoGEF IPR036034, PDZ_sf IPR037889, PDZRhoGEF_RGS IPR011993, PH-like_dom_sf IPR041020, PH_16 IPR001849, PH_domain IPR037803, PRG_PH IPR016137, RGS IPR015212, RGS-like_dom IPR036305, RGS_sf |
PANTHERi | PTHR45872:SF1, PTHR45872:SF1, 2 hits |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit PF17838, PH_16, 1 hit PF09128, RGS-like, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit SM00233, PH, 1 hit SM00315, RGS, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF48097, SSF48097, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS50106, PDZ, 1 hit PS50003, PH_DOMAIN, 1 hit PS50132, RGS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9ES67-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSIRLPHSID RSASKKQSHL SSPIASWLSS LSSLGDSTPE RTSPSHHRQP
60 70 80 90 100
SDTSETTAGL VQRCVIIQKD QHGFGFTVSG DRIVLVQSVR PGGAAMKAGV
110 120 130 140 150
KEGDRIIKVN GTMVTNSSHL EVVKLIKSGA YAALTLLGSS PPSVGVSGLQ
160 170 180 190 200
QNPSVAGVLR VNPIIPPPPP PPPLPPPQHI TGPKPLQDPE VQKHATQILW
210 220 230 240 250
NMLRQEEEEL QDILPPCGET SQRTCEGRLS VDSQEADSGL DSGTERFPSI
260 270 280 290 300
SESLMNRNSV LSDPGLDSPQ TSPVILARVA QHHRRQGSDA ALLPLNHQGI
310 320 330 340 350
DQSPKPLIIG PEEDYDPGYF NNESDIIFQD LEKLKSHPAY LVVFLRYILS
360 370 380 390 400
QADPGPLLFY LCSEVYQQTN PKDSRSLGKD IWNIFLEKNA PLRVKIPEML
410 420 430 440 450
QAEIDLRLRN NEDPRNVLCE AQEAVMLEIQ EQINDYRSKR TLGLGSLYGE
460 470 480 490 500
NDLLGLDGDP LRERQMAEKQ LAALGDILSK YEEDRSAPMD FAVNTFMSHA
510 520 530 540 550
GIRLRESRSS CTAEKTQSAP DKDKWLPFFP KTKKQSSNSK KEKDALEDKK
560 570 580 590 600
RNPILRYIGK PKSSSQSIKP GNVRNIIQHF ENSHQYDVPE PGTQRLSTGS
610 620 630 640 650
FPEDLLESDS SRSEIRLGRS GSLKGREEMK RSRKAENVPR PRSDVDMDAA
660 670 680 690 700
AEAARLHQSA SSSASSLSTR SLENPTPPFT PKMGRRSIES PNLGFCTDVI
710 720 730 740 750
LPHLLEDDLG QLSDLEPEPE VQNWQHTVGK DVVANLTQRE IDRQEVINEL
760 770 780 790 800
FVTEASHLRT LRVLDLIFYQ RMRKENLMPR EELARLFPNL PELIEIHNSW
810 820 830 840 850
CEAMKKLREE GPIIRDISDP MLARFDGPAR EELQQVAAQF CSYQSVALEL
860 870 880 890 900
IRTKQRKESR FQLFMQEAES HPQCRRLQLR DLIVSEMQRL TKYPLLLENI
910 920 930 940 950
IKHTEGGTSE HEKLCRARDQ CREILKFVNE AVKQTENRHR LEGYQKRLDA
960 970 980 990 1000
TALERASNPL AAEFKSLDLT TRKMIHEGPL TWRISKDKTL DLQVLLLEDL
1010 1020 1030 1040 1050
VVLLQRQEER LLLKCHSKTA VGSSDSKQTF SPVLKLNAVL IRSVATDKRA
1060 1070 1080 1090 1100
FFIICTSELG PPQIYELVAL TSSDKNIWME LLEEAVQNAT KHPGAAPIPI
1110 1120 1130 1140 1150
HPSPPGSQEP AYQGSTSSRV EINDSEVYHT EKEPKKLPEG PGPEQRVQDK
1160 1170 1180 1190 1200
QLIAQGEPVQ EEDEEELRTL PRAPPSLDGE NRGIRTRDPV LLALTGPLLM
1210 1220 1230 1240 1250
EGLADAALED VENLRHLILW SLLPGHTVKT QAAGEPEDDL TPTPSVVSIT
1260 1270 1280 1290 1300
SHPWDPGSPG QAPTISDSTR LARPEGSQPE GEDVAVSSLA HLPPRTRSSG
1310 1320 1330 1340 1350
VWDSPELDRN PAAEAASTEP AASYKVVRKV SLLPGGGVGA AKVAGSNAIP
1360 1370 1380 1390 1400
DSGQSESELS EVEGGAQATG NCFYVSMPAG PLDSSTEPTG TPPSPSQCHS
1410 1420 1430 1440 1450
LPAWPTEPQP YRGVRGGQCS SLVRRDVDVI FHTIEQLTIK LHRLKDMELA
1460 1470 1480 1490 1500
HRELLKSLGG ESSGGTTPVG SFHTEAARWT DYSLSPPAKE ALASDSQNGQ
1510 1520
EQGSCPEEGS DIALEDSATD TAVSPGP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JZC6 | A0A0G2JZC6_RAT | Rho guanine nucleotide exchange fac... | Arhgef11 | 1,576 | Annotation score: | ||
F1LQS9 | F1LQS9_RAT | Rho guanine nucleotide exchange fac... | Arhgef11 | 1,527 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF225961 mRNA Translation: AAG28597.1 |
RefSeqi | NP_076472.1, NM_023982.1 |
Genome annotation databases
GeneIDi | 78966 |
KEGGi | rno:78966 |
UCSCi | RGD:619705, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF225961 mRNA Translation: AAG28597.1 |
RefSeqi | NP_076472.1, NM_023982.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3CX6 | X-ray | 2.50 | B | 307-508 | [»] | |
3CX7 | X-ray | 2.25 | B | 307-508 | [»] | |
3CX8 | X-ray | 2.00 | B | 307-508 | [»] | |
SMRi | Q9ES67 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-46242N |
IntActi | Q9ES67, 1 interactor |
STRINGi | 10116.ENSRNOP00000020717 |
PTM databases
iPTMneti | Q9ES67 |
PhosphoSitePlusi | Q9ES67 |
SwissPalmi | Q9ES67 |
Proteomic databases
jPOSTi | Q9ES67 |
PaxDbi | Q9ES67 |
PeptideAtlasi | Q9ES67 |
PRIDEi | Q9ES67 |
Genome annotation databases
GeneIDi | 78966 |
KEGGi | rno:78966 |
UCSCi | RGD:619705, rat |
Organism-specific databases
CTDi | 9826 |
RGDi | 619705, Arhgef11 |
Phylogenomic databases
eggNOGi | KOG3520, Eukaryota |
InParanoidi | Q9ES67 |
OrthoDBi | 319635at2759 |
PhylomeDBi | Q9ES67 |
Enzyme and pathway databases
Reactomei | R-RNO-193648, NRAGE signals death through JNK R-RNO-194840, Rho GTPase cycle R-RNO-416482, G alpha (12/13) signalling events R-RNO-416572, Sema4D induced cell migration and growth-cone collapse |
Miscellaneous databases
EvolutionaryTracei | Q9ES67 |
PROi | PR:Q9ES67 |
Family and domain databases
CDDi | cd13391, PH_PRG, 1 hit cd08753, RGS_PDZRhoGEF, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR001331, GDS_CDC24_CS IPR001478, PDZ IPR032919, PDZ-RhoGEF IPR036034, PDZ_sf IPR037889, PDZRhoGEF_RGS IPR011993, PH-like_dom_sf IPR041020, PH_16 IPR001849, PH_domain IPR037803, PRG_PH IPR016137, RGS IPR015212, RGS-like_dom IPR036305, RGS_sf |
PANTHERi | PTHR45872:SF1, PTHR45872:SF1, 2 hits |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit PF17838, PH_16, 1 hit PF09128, RGS-like, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit SM00233, PH, 1 hit SM00315, RGS, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF48097, SSF48097, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS00741, DH_1, 1 hit PS50010, DH_2, 1 hit PS50106, PDZ, 1 hit PS50003, PH_DOMAIN, 1 hit PS50132, RGS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARHGB_RAT | |
Accessioni | Q9ES67Primary (citable) accession number: Q9ES67 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 29, 2003 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references