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UniProtKB - Q9ES67 (ARHGB_RAT)

Entry version 137 (02 Jun 2021)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
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Protein

Rho guanine nucleotide exchange factor 11

Gene

Arhgef11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation, Guanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-193648, NRAGE signals death through JNK
R-RNO-194840, Rho GTPase cycle
R-RNO-416482, G alpha (12/13) signalling events
R-RNO-416572, Sema4D induced cell migration and growth-cone collapse

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 11
Alternative name(s):
RhoGEF glutamate transport modulator GTRAP48
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arhgef11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...RGDi		619705, Arhgef11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809291 – 1527Rho guanine nucleotide exchange factor 11Add BLAST1527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2PhosphoserineBy similarity1
Modified residuei30PhosphoserineCombined sources1
Modified residuei32PhosphoserineBy similarity1
Modified residuei51PhosphoserineCombined sources1
Modified residuei262PhosphoserineBy similarity1
Modified residuei268PhosphoserineCombined sources1
Modified residuei271PhosphothreonineBy similarity1
Modified residuei272PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei643PhosphoserineBy similarity1
Modified residuei671PhosphoserineBy similarity1
Modified residuei676PhosphothreonineCombined sources1
Modified residuei680PhosphothreonineCombined sources1
Modified residuei1299PhosphoserineBy similarity1
Modified residuei1304PhosphoserineBy similarity1
Modified residuei1462PhosphoserineCombined sources1
Modified residuei1463PhosphoserineCombined sources1
Modified residuei1467PhosphothreonineBy similarity1
Modified residuei1480PhosphothreonineBy similarity1
Modified residuei1485PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14).By similarity
Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex when previously phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14), leading to its degradation, thereby restricting RhoA activity and facilitating growth cone spreading and neurite outgrowth.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9ES67

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9ES67

PeptideAtlas

More...PeptideAtlasi		Q9ES67

PRoteomics IDEntifications database

More...PRIDEi		Q9ES67

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9ES67

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9ES67

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9ES67

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RHOA, GNA13 and SLC1A6.

Interacts with GNA12, PLXNB1 and PLXNB2 (By similarity).

Interacts (via DH domain) with GCSAM (via C-terminus) (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Database of interacting proteins

More...DIPi		DIP-46242N

Protein interaction database and analysis system

More...IntActi		Q9ES67, 1 interactor

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000020717

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11527
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9ES67

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9ES67

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 143PDZPROSITE-ProRule annotationAdd BLAST80
Domaini323 – 503RGSLPROSITE-ProRule annotationAdd BLAST181
Domaini742 – 931DHPROSITE-ProRule annotationAdd BLAST190
Domaini973 – 1087PHPROSITE-ProRule annotationAdd BLAST115

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 56DisorderedSequence analysisAdd BLAST56
Regioni216 – 247DisorderedSequence analysisAdd BLAST32
Regioni506 – 569DisorderedSequence analysisAdd BLAST64
Regioni582 – 687DisorderedSequence analysisAdd BLAST106
Regioni1090 – 1184DisorderedSequence analysisAdd BLAST95
Regioni1231 – 1321DisorderedSequence analysisAdd BLAST91
Regioni1379 – 1411DisorderedSequence analysisAdd BLAST33
Regioni1480 – 1527DisorderedSequence analysisAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili461 – 487Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 40Polar residuesSequence analysisAdd BLAST26
Compositional biasi223 – 247Polar residuesSequence analysisAdd BLAST25
Compositional biasi517 – 555Basic and acidic residuesSequence analysisAdd BLAST39
Compositional biasi582 – 606Polar residuesSequence analysisAdd BLAST25
Compositional biasi607 – 651Basic and acidic residuesSequence analysisAdd BLAST45
Compositional biasi656 – 676Polar residuesSequence analysisAdd BLAST21
Compositional biasi1108 – 1123Polar residuesSequence analysisAdd BLAST16
Compositional biasi1124 – 1143Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1243 – 1273Polar residuesSequence analysisAdd BLAST31
Compositional biasi1382 – 1403Polar residuesSequence analysisAdd BLAST22
Compositional biasi1490 – 1505Polar residuesSequence analysisAdd BLAST16

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3520, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9ES67

Database of Orthologous Groups

More...OrthoDBi		319635at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9ES67

Family and domain databases

Conserved Domains Database

More...CDDi		cd13391, PH_PRG, 1 hit
cd08753, RGS_PDZRhoGEF, 1 hit
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001331, GDS_CDC24_CS
IPR001478, PDZ
IPR032919, PDZ-RhoGEF
IPR036034, PDZ_sf
IPR037889, PDZRhoGEF_RGS
IPR011993, PH-like_dom_sf
IPR041020, PH_16
IPR001849, PH_domain
IPR037803, PRG_PH
IPR016137, RGS
IPR015212, RGS-like_dom
IPR036305, RGS_sf

The PANTHER Classification System

More...PANTHERi		PTHR45872:SF1, PTHR45872:SF1, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00595, PDZ, 1 hit
PF17838, PH_16, 1 hit
PF09128, RGS-like, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00228, PDZ, 1 hit
SM00233, PH, 1 hit
SM00315, RGS, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48065, SSF48065, 1 hit
SSF48097, SSF48097, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit
PS50106, PDZ, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50132, RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9ES67-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIRLPHSID RSASKKQSHL SSPIASWLSS LSSLGDSTPE RTSPSHHRQP 
        60         70         80         90        100
SDTSETTAGL VQRCVIIQKD QHGFGFTVSG DRIVLVQSVR PGGAAMKAGV 
       110        120        130        140        150
KEGDRIIKVN GTMVTNSSHL EVVKLIKSGA YAALTLLGSS PPSVGVSGLQ 
       160        170        180        190        200
QNPSVAGVLR VNPIIPPPPP PPPLPPPQHI TGPKPLQDPE VQKHATQILW 
       210        220        230        240        250
NMLRQEEEEL QDILPPCGET SQRTCEGRLS VDSQEADSGL DSGTERFPSI 
       260        270        280        290        300
SESLMNRNSV LSDPGLDSPQ TSPVILARVA QHHRRQGSDA ALLPLNHQGI 
       310        320        330        340        350
DQSPKPLIIG PEEDYDPGYF NNESDIIFQD LEKLKSHPAY LVVFLRYILS 
       360        370        380        390        400
QADPGPLLFY LCSEVYQQTN PKDSRSLGKD IWNIFLEKNA PLRVKIPEML 
       410        420        430        440        450
QAEIDLRLRN NEDPRNVLCE AQEAVMLEIQ EQINDYRSKR TLGLGSLYGE 
       460        470        480        490        500
NDLLGLDGDP LRERQMAEKQ LAALGDILSK YEEDRSAPMD FAVNTFMSHA 
       510        520        530        540        550
GIRLRESRSS CTAEKTQSAP DKDKWLPFFP KTKKQSSNSK KEKDALEDKK 
       560        570        580        590        600
RNPILRYIGK PKSSSQSIKP GNVRNIIQHF ENSHQYDVPE PGTQRLSTGS 
       610        620        630        640        650
FPEDLLESDS SRSEIRLGRS GSLKGREEMK RSRKAENVPR PRSDVDMDAA 
       660        670        680        690        700
AEAARLHQSA SSSASSLSTR SLENPTPPFT PKMGRRSIES PNLGFCTDVI 
       710        720        730        740        750
LPHLLEDDLG QLSDLEPEPE VQNWQHTVGK DVVANLTQRE IDRQEVINEL 
       760        770        780        790        800
FVTEASHLRT LRVLDLIFYQ RMRKENLMPR EELARLFPNL PELIEIHNSW 
       810        820        830        840        850
CEAMKKLREE GPIIRDISDP MLARFDGPAR EELQQVAAQF CSYQSVALEL 
       860        870        880        890        900
IRTKQRKESR FQLFMQEAES HPQCRRLQLR DLIVSEMQRL TKYPLLLENI 
       910        920        930        940        950
IKHTEGGTSE HEKLCRARDQ CREILKFVNE AVKQTENRHR LEGYQKRLDA 
       960        970        980        990       1000
TALERASNPL AAEFKSLDLT TRKMIHEGPL TWRISKDKTL DLQVLLLEDL 
      1010       1020       1030       1040       1050
VVLLQRQEER LLLKCHSKTA VGSSDSKQTF SPVLKLNAVL IRSVATDKRA 
      1060       1070       1080       1090       1100
FFIICTSELG PPQIYELVAL TSSDKNIWME LLEEAVQNAT KHPGAAPIPI 
      1110       1120       1130       1140       1150
HPSPPGSQEP AYQGSTSSRV EINDSEVYHT EKEPKKLPEG PGPEQRVQDK 
      1160       1170       1180       1190       1200
QLIAQGEPVQ EEDEEELRTL PRAPPSLDGE NRGIRTRDPV LLALTGPLLM 
      1210       1220       1230       1240       1250
EGLADAALED VENLRHLILW SLLPGHTVKT QAAGEPEDDL TPTPSVVSIT 
      1260       1270       1280       1290       1300
SHPWDPGSPG QAPTISDSTR LARPEGSQPE GEDVAVSSLA HLPPRTRSSG 
      1310       1320       1330       1340       1350
VWDSPELDRN PAAEAASTEP AASYKVVRKV SLLPGGGVGA AKVAGSNAIP 
      1360       1370       1380       1390       1400
DSGQSESELS EVEGGAQATG NCFYVSMPAG PLDSSTEPTG TPPSPSQCHS 
      1410       1420       1430       1440       1450
LPAWPTEPQP YRGVRGGQCS SLVRRDVDVI FHTIEQLTIK LHRLKDMELA 
      1460       1470       1480       1490       1500
HRELLKSLGG ESSGGTTPVG SFHTEAARWT DYSLSPPAKE ALASDSQNGQ 
      1510       1520 
EQGSCPEEGS DIALEDSATD TAVSPGP
Length:1,527
Mass (Da):168,534
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iABAEA20F541A3A9A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JZC6A0A0G2JZC6_RAT
Rho guanine nucleotide exchange fac...
Arhgef11
1,576Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LQS9F1LQS9_RAT
Rho guanine nucleotide exchange fac...
Arhgef11
1,527Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF225961 mRNA Translation: AAG28597.1

NCBI Reference Sequences

More...RefSeqi		NP_076472.1, NM_023982.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		78966

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:78966

UCSC genome browser

More...UCSCi		RGD:619705, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225961 mRNA Translation: AAG28597.1
RefSeqiNP_076472.1, NM_023982.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CX6X-ray2.50B307-508[»]
3CX7X-ray2.25B307-508[»]
3CX8X-ray2.00B307-508[»]
SMRiQ9ES67
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-46242N
IntActiQ9ES67, 1 interactor
STRINGi10116.ENSRNOP00000020717

PTM databases

iPTMnetiQ9ES67
PhosphoSitePlusiQ9ES67
SwissPalmiQ9ES67

Proteomic databases

jPOSTiQ9ES67
PaxDbiQ9ES67
PeptideAtlasiQ9ES67
PRIDEiQ9ES67

Genome annotation databases

GeneIDi78966
KEGGirno:78966
UCSCiRGD:619705, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9826
RGDi619705, Arhgef11

Phylogenomic databases

eggNOGiKOG3520, Eukaryota
InParanoidiQ9ES67
OrthoDBi319635at2759
PhylomeDBiQ9ES67

Enzyme and pathway databases

ReactomeiR-RNO-193648, NRAGE signals death through JNK
R-RNO-194840, Rho GTPase cycle
R-RNO-416482, G alpha (12/13) signalling events
R-RNO-416572, Sema4D induced cell migration and growth-cone collapse

Miscellaneous databases

EvolutionaryTraceiQ9ES67

Protein Ontology

More...PROi		PR:Q9ES67

Family and domain databases

CDDicd13391, PH_PRG, 1 hit
cd08753, RGS_PDZRhoGEF, 1 hit
cd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001331, GDS_CDC24_CS
IPR001478, PDZ
IPR032919, PDZ-RhoGEF
IPR036034, PDZ_sf
IPR037889, PDZRhoGEF_RGS
IPR011993, PH-like_dom_sf
IPR041020, PH_16
IPR001849, PH_domain
IPR037803, PRG_PH
IPR016137, RGS
IPR015212, RGS-like_dom
IPR036305, RGS_sf
PANTHERiPTHR45872:SF1, PTHR45872:SF1, 2 hits
PfamiView protein in Pfam
PF00595, PDZ, 1 hit
PF17838, PH_16, 1 hit
PF09128, RGS-like, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SM00233, PH, 1 hit
SM00315, RGS, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
SSF48097, SSF48097, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit
PS50106, PDZ, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50132, RGS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARHGB_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ES67
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 1, 2001
Last modified: June 2, 2021
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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