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Entry version 128 (08 May 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Rho guanine nucleotide exchange factor 11

Gene

Arhgef11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation, Guanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-193648 NRAGE signals death through JNK
R-RNO-194840 Rho GTPase cycle
R-RNO-416572 Sema4D induced cell migration and growth-cone collapse

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 11
Alternative name(s):
RhoGEF glutamate transport modulator GTRAP48
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
619705 Arhgef11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809291 – 1527Rho guanine nucleotide exchange factor 11Add BLAST1527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2PhosphoserineBy similarity1
Modified residuei30PhosphoserineCombined sources1
Modified residuei32PhosphoserineBy similarity1
Modified residuei51PhosphoserineCombined sources1
Modified residuei262PhosphoserineBy similarity1
Modified residuei268PhosphoserineCombined sources1
Modified residuei271PhosphothreonineBy similarity1
Modified residuei272PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei643PhosphoserineBy similarity1
Modified residuei671PhosphoserineBy similarity1
Modified residuei676PhosphothreonineCombined sources1
Modified residuei680PhosphothreonineCombined sources1
Modified residuei1299PhosphoserineBy similarity1
Modified residuei1304PhosphoserineBy similarity1
Modified residuei1462PhosphoserineCombined sources1
Modified residuei1463PhosphoserineCombined sources1
Modified residuei1467PhosphothreonineBy similarity1
Modified residuei1480PhosphothreonineBy similarity1
Modified residuei1485PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14).By similarity
Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex when previously phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14), leading to its degradation, thereby restricting RhoA activity and facilitating growth cone spreading and neurite outgrowth.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9ES67

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ES67

PeptideAtlas

More...
PeptideAtlasi
Q9ES67

PRoteomics IDEntifications database

More...
PRIDEi
Q9ES67

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ES67

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ES67

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9ES67

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RHOA, GNA13 and SLC1A6.

Interacts with GNA12, PLXNB1 and PLXNB2 (By similarity).

Interacts (via DH domain) with GCSAM (via C-terminus) (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Gna13P276013EBI-15735216,EBI-2255627From Mus musculus.

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-46242N

Protein interaction database and analysis system

More...
IntActi
Q9ES67, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000020717

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11527
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ES67

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9ES67

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 143PDZPROSITE-ProRule annotationAdd BLAST80
Domaini323 – 503RGSLPROSITE-ProRule annotationAdd BLAST181
Domaini742 – 931DHPROSITE-ProRule annotationAdd BLAST190
Domaini973 – 1087PHPROSITE-ProRule annotationAdd BLAST115

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili461 – 487Sequence analysisAdd BLAST27

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3520 Eukaryota
COG5422 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000034045

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ES67

KEGG Orthology (KO)

More...
KOi
K12331

Database of Orthologous Groups

More...
OrthoDBi
319635at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ES67

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13391 PH_PRG, 1 hit
cd08753 RGS_PDZRhoGEF, 1 hit
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001478 PDZ
IPR032919 PDZ-RhoGEF
IPR036034 PDZ_sf
IPR037889 PDZRhoGEF_RGS
IPR011993 PH-like_dom_sf
IPR041020 PH_16
IPR001849 PH_domain
IPR037803 PRG_PH
IPR016137 RGS
IPR015212 RGS-like_dom
IPR036305 RGS_sf

The PANTHER Classification System

More...
PANTHERi
PTHR45872:SF1 PTHR45872:SF1, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595 PDZ, 1 hit
PF17838 PH_16, 1 hit
PF09128 RGS-like, 1 hit
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 1 hit
SM00315 RGS, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50132 RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9ES67-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIRLPHSID RSASKKQSHL SSPIASWLSS LSSLGDSTPE RTSPSHHRQP
60 70 80 90 100
SDTSETTAGL VQRCVIIQKD QHGFGFTVSG DRIVLVQSVR PGGAAMKAGV
110 120 130 140 150
KEGDRIIKVN GTMVTNSSHL EVVKLIKSGA YAALTLLGSS PPSVGVSGLQ
160 170 180 190 200
QNPSVAGVLR VNPIIPPPPP PPPLPPPQHI TGPKPLQDPE VQKHATQILW
210 220 230 240 250
NMLRQEEEEL QDILPPCGET SQRTCEGRLS VDSQEADSGL DSGTERFPSI
260 270 280 290 300
SESLMNRNSV LSDPGLDSPQ TSPVILARVA QHHRRQGSDA ALLPLNHQGI
310 320 330 340 350
DQSPKPLIIG PEEDYDPGYF NNESDIIFQD LEKLKSHPAY LVVFLRYILS
360 370 380 390 400
QADPGPLLFY LCSEVYQQTN PKDSRSLGKD IWNIFLEKNA PLRVKIPEML
410 420 430 440 450
QAEIDLRLRN NEDPRNVLCE AQEAVMLEIQ EQINDYRSKR TLGLGSLYGE
460 470 480 490 500
NDLLGLDGDP LRERQMAEKQ LAALGDILSK YEEDRSAPMD FAVNTFMSHA
510 520 530 540 550
GIRLRESRSS CTAEKTQSAP DKDKWLPFFP KTKKQSSNSK KEKDALEDKK
560 570 580 590 600
RNPILRYIGK PKSSSQSIKP GNVRNIIQHF ENSHQYDVPE PGTQRLSTGS
610 620 630 640 650
FPEDLLESDS SRSEIRLGRS GSLKGREEMK RSRKAENVPR PRSDVDMDAA
660 670 680 690 700
AEAARLHQSA SSSASSLSTR SLENPTPPFT PKMGRRSIES PNLGFCTDVI
710 720 730 740 750
LPHLLEDDLG QLSDLEPEPE VQNWQHTVGK DVVANLTQRE IDRQEVINEL
760 770 780 790 800
FVTEASHLRT LRVLDLIFYQ RMRKENLMPR EELARLFPNL PELIEIHNSW
810 820 830 840 850
CEAMKKLREE GPIIRDISDP MLARFDGPAR EELQQVAAQF CSYQSVALEL
860 870 880 890 900
IRTKQRKESR FQLFMQEAES HPQCRRLQLR DLIVSEMQRL TKYPLLLENI
910 920 930 940 950
IKHTEGGTSE HEKLCRARDQ CREILKFVNE AVKQTENRHR LEGYQKRLDA
960 970 980 990 1000
TALERASNPL AAEFKSLDLT TRKMIHEGPL TWRISKDKTL DLQVLLLEDL
1010 1020 1030 1040 1050
VVLLQRQEER LLLKCHSKTA VGSSDSKQTF SPVLKLNAVL IRSVATDKRA
1060 1070 1080 1090 1100
FFIICTSELG PPQIYELVAL TSSDKNIWME LLEEAVQNAT KHPGAAPIPI
1110 1120 1130 1140 1150
HPSPPGSQEP AYQGSTSSRV EINDSEVYHT EKEPKKLPEG PGPEQRVQDK
1160 1170 1180 1190 1200
QLIAQGEPVQ EEDEEELRTL PRAPPSLDGE NRGIRTRDPV LLALTGPLLM
1210 1220 1230 1240 1250
EGLADAALED VENLRHLILW SLLPGHTVKT QAAGEPEDDL TPTPSVVSIT
1260 1270 1280 1290 1300
SHPWDPGSPG QAPTISDSTR LARPEGSQPE GEDVAVSSLA HLPPRTRSSG
1310 1320 1330 1340 1350
VWDSPELDRN PAAEAASTEP AASYKVVRKV SLLPGGGVGA AKVAGSNAIP
1360 1370 1380 1390 1400
DSGQSESELS EVEGGAQATG NCFYVSMPAG PLDSSTEPTG TPPSPSQCHS
1410 1420 1430 1440 1450
LPAWPTEPQP YRGVRGGQCS SLVRRDVDVI FHTIEQLTIK LHRLKDMELA
1460 1470 1480 1490 1500
HRELLKSLGG ESSGGTTPVG SFHTEAARWT DYSLSPPAKE ALASDSQNGQ
1510 1520
EQGSCPEEGS DIALEDSATD TAVSPGP
Length:1,527
Mass (Da):168,534
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iABAEA20F541A3A9A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JZC6A0A0G2JZC6_RAT
Rho guanine nucleotide exchange fac...
Arhgef11
1,576Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LQS9F1LQS9_RAT
Rho guanine nucleotide exchange fac...
Arhgef11
1,527Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF225961 mRNA Translation: AAG28597.1

NCBI Reference Sequences

More...
RefSeqi
NP_076472.1, NM_023982.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
78966

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:78966

UCSC genome browser

More...
UCSCi
RGD:619705 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225961 mRNA Translation: AAG28597.1
RefSeqiNP_076472.1, NM_023982.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CX6X-ray2.50B307-508[»]
3CX7X-ray2.25B307-508[»]
3CX8X-ray2.00B307-508[»]
SMRiQ9ES67
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-46242N
IntActiQ9ES67, 1 interactor
STRINGi10116.ENSRNOP00000020717

PTM databases

iPTMnetiQ9ES67
PhosphoSitePlusiQ9ES67
SwissPalmiQ9ES67

Proteomic databases

jPOSTiQ9ES67
PaxDbiQ9ES67
PeptideAtlasiQ9ES67
PRIDEiQ9ES67

Genome annotation databases

GeneIDi78966
KEGGirno:78966
UCSCiRGD:619705 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9826
RGDi619705 Arhgef11

Phylogenomic databases

eggNOGiKOG3520 Eukaryota
COG5422 LUCA
HOGENOMiHOG000034045
InParanoidiQ9ES67
KOiK12331
OrthoDBi319635at2759
PhylomeDBiQ9ES67

Enzyme and pathway databases

ReactomeiR-RNO-193648 NRAGE signals death through JNK
R-RNO-194840 Rho GTPase cycle
R-RNO-416572 Sema4D induced cell migration and growth-cone collapse

Miscellaneous databases

EvolutionaryTraceiQ9ES67

Protein Ontology

More...
PROi
PR:Q9ES67

Family and domain databases

CDDicd13391 PH_PRG, 1 hit
cd08753 RGS_PDZRhoGEF, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001478 PDZ
IPR032919 PDZ-RhoGEF
IPR036034 PDZ_sf
IPR037889 PDZRhoGEF_RGS
IPR011993 PH-like_dom_sf
IPR041020 PH_16
IPR001849 PH_domain
IPR037803 PRG_PH
IPR016137 RGS
IPR015212 RGS-like_dom
IPR036305 RGS_sf
PANTHERiPTHR45872:SF1 PTHR45872:SF1, 2 hits
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF17838 PH_16, 1 hit
PF09128 RGS-like, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 1 hit
SM00315 RGS, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50132 RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARHGB_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ES67
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 1, 2001
Last modified: May 8, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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