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Protein

Trafficking protein particle complex subunit 4

Gene

Trappc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi. May play a role in dendrite postsynaptic membrane trafficking.

GO - Molecular functioni

  • Rab guanyl-nucleotide exchange factor activity Source: GO_Central

GO - Biological processi

  • dendrite development Source: UniProtKB
  • ER to Golgi vesicle-mediated transport Source: GO_Central
  • neurotransmitter receptor biosynthetic process Source: UniProtKB
  • vesicle-mediated transport Source: UniProtKB

Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 4
Alternative name(s):
Synbindin
TRS23 homolog
Gene namesi
Name:Trappc4
Synonyms:Sbdn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1926211 Trappc4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115701 – 219Trafficking protein particle complex subunit 4Add BLAST219

Proteomic databases

EPDiQ9ES56
MaxQBiQ9ES56
PaxDbiQ9ES56
PRIDEiQ9ES56

PTM databases

iPTMnetiQ9ES56
PhosphoSitePlusiQ9ES56

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSMUSG00000032112 Expressed in 300 organ(s), highest expression level in neocortex
CleanExiMM_TRAPPC4
ExpressionAtlasiQ9ES56 baseline and differential
GenevisibleiQ9ES56 MM

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12 (By similarity). Interacts with SDC2.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208560, 1 interactor
IntActiQ9ES56, 1 interactor
STRINGi10090.ENSMUSP00000034623

Structurei

3D structure databases

ProteinModelPortaliQ9ES56
SMRiQ9ES56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3369 Eukaryota
COG5122 LUCA
GeneTreeiENSGT00510000047061
HOGENOMiHOG000165618
HOVERGENiHBG054226
InParanoidiQ9ES56
KOiK20303
OMAiGQRDGIN
OrthoDBiEOG091G0JDZ
PhylomeDBiQ9ES56
TreeFamiTF314561

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR007233 TRAPPC
PANTHERiPTHR23249 PTHR23249, 1 hit
PfamiView protein in Pfam
PF04099 Sybindin, 1 hit
SMARTiView protein in SMART
SM01399 Sybindin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9ES56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIFSVYVVN KAGGLIYQWD SYSPRAEAEK TFSYPLDLLL KLHDERVLVA
60 70 80 90 100
FGQRDGIRVG HAVLAINGMD VNGKYTADGK EVLEYLGNPA NYPVSIRFGR
110 120 130 140 150
PRLTSNEKLM LASMFHSLFA IGSQLSPEQG SSGIEMLETD TFKLHCFQTL
160 170 180 190 200
TGIKFVVLAD PRQAGIDSLL RKIYEIYSDF ALKNPFYSLE MPIRCELFDQ
210
NLKLALEVAE KAGTFGPGS
Length:219
Mass (Da):24,385
Last modified:March 1, 2001 - v1
Checksum:i7B03F1E772857E92
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3V493Q3V493_MOUSE
Trafficking protein particle comple...
Trappc4
194Annotation score:
A0A1L1SR61A0A1L1SR61_MOUSE
Trafficking protein particle comple...
Trappc4
58Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233340 mRNA Translation: AAG24950.1
BC038898 mRNA Translation: AAH38898.1
AK005276 mRNA No translation available.
CCDSiCCDS23109.1
RefSeqiNP_068561.1, NM_021789.2
UniGeneiMm.29814

Genome annotation databases

EnsembliENSMUST00000034623; ENSMUSP00000034623; ENSMUSG00000032112
GeneIDi60409
KEGGimmu:60409
UCSCiuc009pdk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233340 mRNA Translation: AAG24950.1
BC038898 mRNA Translation: AAH38898.1
AK005276 mRNA No translation available.
CCDSiCCDS23109.1
RefSeqiNP_068561.1, NM_021789.2
UniGeneiMm.29814

3D structure databases

ProteinModelPortaliQ9ES56
SMRiQ9ES56
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208560, 1 interactor
IntActiQ9ES56, 1 interactor
STRINGi10090.ENSMUSP00000034623

PTM databases

iPTMnetiQ9ES56
PhosphoSitePlusiQ9ES56

Proteomic databases

EPDiQ9ES56
MaxQBiQ9ES56
PaxDbiQ9ES56
PRIDEiQ9ES56

Protocols and materials databases

DNASUi60409
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034623; ENSMUSP00000034623; ENSMUSG00000032112
GeneIDi60409
KEGGimmu:60409
UCSCiuc009pdk.1 mouse

Organism-specific databases

CTDi51399
MGIiMGI:1926211 Trappc4

Phylogenomic databases

eggNOGiKOG3369 Eukaryota
COG5122 LUCA
GeneTreeiENSGT00510000047061
HOGENOMiHOG000165618
HOVERGENiHBG054226
InParanoidiQ9ES56
KOiK20303
OMAiGQRDGIN
OrthoDBiEOG091G0JDZ
PhylomeDBiQ9ES56
TreeFamiTF314561

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiTrappc4 mouse
PROiPR:Q9ES56
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032112 Expressed in 300 organ(s), highest expression level in neocortex
CleanExiMM_TRAPPC4
ExpressionAtlasiQ9ES56 baseline and differential
GenevisibleiQ9ES56 MM

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR007233 TRAPPC
PANTHERiPTHR23249 PTHR23249, 1 hit
PfamiView protein in Pfam
PF04099 Sybindin, 1 hit
SMARTiView protein in SMART
SM01399 Sybindin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPPC4_MOUSE
AccessioniPrimary (citable) accession number: Q9ES56
Secondary accession number(s): Q9DB31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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