Inpp5d

Functionⁱ

Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.19 Publications

Catalytic activityⁱ

1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H₂O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate.3 Publications

Activity regulationⁱ

Activated upon translocation to the sites of synthesis of PtdIns(3,4,5)P3 in the membrane.

GO - Molecular functionⁱ

inositol-4,5-bisphosphate 5-phosphatase activity Source: MGI
inositol-polyphosphate 5-phosphatase activity
Source: MGI
Inferred from direct assayⁱ
- 8643691
phosphatidylinositol trisphosphate phosphatase activity
Source: MGI
Inferred from direct assayⁱ
- 8890215
PTB domain binding
Source: MGI
Inferred from direct assayⁱ
- 8654924
SH3 domain binding
Source: MGI
Inferred from direct assayⁱ
- 8643691

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
determination of adult lifespan
Source: MGI
Inferred from mutant phenotypeⁱ
- 9620849
immunoglobulin mediated immune response
Source: MGI
Inferred from mutant phenotypeⁱ
- 10704460
intracellular signal transduction
Source: MGI
Inferred from mutant phenotypeⁱ
- 10704460
negative regulation of B cell activation
Source: MGI
Inferred from mutant phenotypeⁱ
- 10704460
negative regulation of B cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 10704460
negative regulation of bone resorption
Source: MGI
Inferred from mutant phenotypeⁱ
- 12161749
negative regulation of cell proliferation
Source: MGI
Inferred from direct assayⁱ
- 8890215
negative regulation of granulocyte differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 9620849
negative regulation of immune response
Source: MGI
Inferred from mutant phenotypeⁱ
- 10704460
negative regulation of interleukin-6 biosynthetic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 12161749
negative regulation of monocyte differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 9620849
negative regulation of neutrophil differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 9620849
negative regulation of osteoclast differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 12161749
negative regulation of signal transduction
Source: MGI
Inferred from mutant phenotypeⁱ
phosphatidylinositol dephosphorylation Source: InterPro
positive regulation of apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 12161749
positive regulation of B cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 10704460
- 9620849
positive regulation of erythrocyte differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 9620849
positive regulation of lymphocyte differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 9620849

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Apoptosis, Immunity

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1660499 Synthesis of PIPs at the plasma membrane R-MMU-1855204 Synthesis of IP3 and IP4 in the cytosol R-MMU-202424 Downstream TCR signaling R-MMU-912526 Interleukin receptor SHC signaling

Reactomeⁱ

R-MMU-1660499 Synthesis of PIPs at the plasma membrane
R-MMU-1855204 Synthesis of IP3 and IP4 in the cytosol
R-MMU-202424 Downstream TCR signaling
R-MMU-912526 Interleukin receptor SHC signaling

Chemistry databases

SwissLipidsⁱ	SLP:000000873

SwissLipidsⁱ

SLP:000000873

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC:3.1.3.86) Alternative name(s): Inositol polyphosphate-5-phosphatase of 145 kDa Short name: SIP-145 SH2 domain-containing inositol 5'-phosphatase 1 Short name: SH2 domain-containing inositol phosphatase 1 Short name: SHIP-1 p150Ship
Gene namesⁱ	Name:Inpp5d Synonyms:7a33, Ship, Ship1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:107357 Inpp5d

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice are viable and fertile. They however fail to thrive and only 40% survive by 14 weeks of age. Mortality is associated with extensive consolidation of the lungs resulting from infiltration by myeloid cells. Increased numbers of granulocyte-macrophage progenitors are observed in both the bone marrow and spleen. Absence of Inpp5d leads to steel factor-induced degranulation of mast cells. They also display increased numbers of osteoclast precursors leading to a severe osteoporosis.3 Publications

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	676	D → G: Loss of function. 1 Publication	1
Mutagenesisⁱ	918	Y → F: Strongly impairs function, tyrosine phosphorylation, subcellular location and interaction with DOK1; when associated with F-1021. 3 Publications	1
Mutagenesisⁱ	1021	Y → F: Strongly impairs function, tyrosine phosphorylation, subcellular location and interaction with DOK1; when associated with F-918. 3 Publications	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000302867	1 – 1191	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1Add BLAST		1191

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	246	PhosphoserineCombined sources	1
Modified residueⁱ	918	Phosphotyrosine1 Publication	1
Modified residueⁱ	935	PhosphoserineCombined sources	1
Modified residueⁱ	945	PhosphotyrosineCombined sources	1
Modified residueⁱ	964	PhosphothreonineCombined sources	1
Modified residueⁱ	967	PhosphoserineCombined sources	1
Modified residueⁱ	972	PhosphoserineCombined sources	1
Modified residueⁱ	1021	Phosphotyrosine1 Publication	1

Post-translational modificationⁱ

Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli such as cytokines, growth factors, antibodies, chemokines, integrin ligands and hypertonic and oxidative stress. Phosphorylated upon IgG receptor FCGR2B-binding.7 Publications

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9ES52
PeptideAtlas More...PeptideAtlasⁱ	Q9ES52
PRIDEⁱ	Q9ES52

PTM databases

iPTMnetⁱ	Q9ES52
PhosphoSitePlusⁱ	Q9ES52

Expressionⁱ

Tissue specificityⁱ

Specifically expressed in immune and hematopoietic cells. Levels vary considerably within this compartment. Lost during erythropoiesis when erythroid cells become Ter119+. Increases substantially with T-cell maturation and when resting B-cells are activated. Also present in mature granulocytes, monocyte/macrophages, mast cells and platelets. Isoform 5 is the only form expressed in embryonic stem (ES) cells and is coexpressed with other isoforms in hematopoietic stem cells, and disappears with differentiation.4 Publications

Developmental stageⁱ

Expressed in late primitive-streak stage embryos (7.5 dpc), when hematopoiesis is thought to begin, and the expression is restricted to the hematopoietic lineage in embryo. In adults expression continues to be in the majority of cells from hematopoietic origin, including granulocytes, monocytes and lymphocytes, and is also found in the spermatids of the testis.2 Publications

Inductionⁱ

By activin/TGF-beta (at protein level). Regulated by the Smad pathway. Isoform 3 is expressed during myeloid development.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000026288 Expressed in 216 organ(s), highest expression level in stroma of bone marrow
CleanExⁱ	MM_INPP5D
ExpressionAtlasⁱ	Q9ES52 baseline and differential
Genevisibleⁱ	Q9ES52 MM

Interactionⁱ

Subunit structureⁱ

Interacts with tyrosine phosphorylated form of SHC1 (PubMed:8654924, PubMed:8643691, PubMed:10068665, PubMed:9083021, PubMed:9099679, PubMed:10395202). Interacts with tyrosine phosphorylated form of DOK1 (PubMed:11031258). Interacts with tyrosine phosphorylated form of DOK3 (PubMed:14993273). Interacts with tyrosine phosphorylated form of SLAMF1/CD150 (By similarity). Interacts with PTPN11/SHP-2 in response to IL-3 (PubMed:9110989, PubMed:9393882). Interacts with receptor EPOR (PubMed:10660611). Interacts with receptors MS4A2/FCER1B and FCER1G (By similarity). Interacts with receptors FCGR2B and FCGR3 (PubMed:10395202, PubMed:11016922, PubMed:10779347, PubMed:15456754, PubMed:12393695). Interacts with receptor FCGR2A, leading to regulate gene expression during the phagocytic process (PubMed:12370370). Interacts with GRB2 (PubMed:8643691, PubMed:10068665). Interacts with PLCG1 (PubMed:16000869). Interacts with tyrosine kinases SRC and TEC (PubMed:10794720, PubMed:15492005). Interacts with CRKL (PubMed:11031258). Interacts with c-Met/MET (PubMed:11896575). Interacts with MILR1 (tyrosine-phosphorylated) (PubMed:20526344). Isoform 5 interacts with IL6ST/gp130 (PubMed:17105399). Can weakly interact (via NPXY motif 2) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (PubMed:11247302).By similarity23 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PIK3R1	P23727	2	EBI-1452545,EBI-520244	From Bos taurus.
Plcg2	Q8CIH5	3	EBI-300210,EBI-617954

GO - Molecular functionⁱ

PTB domain binding
Source: MGI
Inferred from direct assayⁱ
- 8654924
SH3 domain binding
Source: MGI
Inferred from direct assayⁱ
- 8643691

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	200769, 25 interactors
CORUMⁱ	Q9ES52
IntActⁱ	Q9ES52, 15 interactors
Molecular INTeraction database More...MINTⁱ	Q9ES52
STRINGⁱ	10090.ENSMUSP00000127941

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9ES52
SMRⁱ	Q9ES52
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	8 – 104	SH2PROSITE-ProRule annotationAdd BLAST		97

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1015 – 1029	Interaction with DAB21 PublicationAdd BLAST		15

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	127 – 132	SH3-binding 1	6
Motifⁱ	915 – 918	NPXY motif 1	4
Motifⁱ	970 – 975	SH3-binding 2	6
Motifⁱ	1018 – 1021	NPXY motif 2	4
Motifⁱ	1039 – 1050	SH3-binding 3Add BLAST	12

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	962 – 1153	Pro-richAdd BLAST		192

Domainⁱ

The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or PTPN11/SHP-2. It competes with that of GRB2 for binding to phosphorylated SHC1 to inhibit the Ras pathway. It is also required for tyrosine phosphorylation.1 Publication

The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain.1 Publication

Sequence similaritiesⁱ

Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.Curated

Keywords - Domainⁱ

Repeat, SH2 domain, SH3-binding

Phylogenomic databases

eggNOGⁱ	KOG0565 Eukaryota COG5411 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119075
HOVERGENⁱ	HBG106726
InParanoidⁱ	Q9ES52
KEGG Orthology (KO) More...KOⁱ	K03084
OMAⁱ	LTKPEMF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00P6
PhylomeDBⁱ	Q9ES52
TreeFamⁱ	TF323475

Family and domain databases

Gene3Dⁱ	3.30.505.10, 1 hit 3.60.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR036691 Endo/exonu/phosph_ase_sf IPR005135 Endo/exonuclease/phosphatase IPR000300 IPPc IPR000980 SH2 IPR036860 SH2_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03372 Exo_endo_phos, 1 hit PF00017 SH2, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN
SMARTⁱ	View protein in SMART SM00128 IPPc, 1 hit SM00252 SH2, 1 hit
SUPFAMⁱ	SSF55550 SSF55550, 1 hit SSF56219 SSF56219, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001 SH2, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9ES52-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAMVPGWNH GNITRSKAEE LLSRAGKDGS FLVRASESIP RAYALCVLFR 
        60         70         80         90        100
NCVYTYRILP NEDDKFTVQA SEGVPMRFFT KLDQLIDFYK KENMGLVTHL 
       110        120        130        140        150
QYPVPLEEED AIDEAEEDTV ESVMSPPELP PRNIPMSAGP SEAKDLPLAT 
       160        170        180        190        200
ENPRAPEVTR LSLSETLFQR LQSMDTSGLP EEHLKAIQDY LSTQLLLDSD 
       210        220        230        240        250
FLKTGSSNLP HLKKLMSLLC KELHGEVIRT LPSLESLQRL FDQQLSPGLR 
       260        270        280        290        300
PRPQVPGEAS PITMVAKLSQ LTSLLSSIED KVKSLLHEGS ESTNRRSLIP 
       310        320        330        340        350
PVTFEVKSES LGIPQKMHLK VDVESGKLIV KKSKDGSEDK FYSHKKILQL 
       360        370        380        390        400
IKSQKFLNKL VILVETEKEK ILRKEYVFAD SKKREGFCQL LQQMKNKHSE 
       410        420        430        440        450
QPEPDMITIF IGTWNMGNAP PPKKITSWFL SKGQGKTRDD SADYIPHDIY 
       460        470        480        490        500
VIGTQEDPLG EKEWLELLRH SLQEVTSMTF KTVAIHTLWN IRIVVLAKPE 
       510        520        530        540        550
HENRISHICT DNVKTGIANT LGNKGAVGVS FMFNGTSLGF VNSHLTSGSE 
       560        570        580        590        600
KKLRRNQNYM NILRFLALGD KKLSPFNITH RFTHLFWLGD LNYRVELPTW 
       610        620        630        640        650
EAEAIIQKIK QQQYSDLLAH DQLLLERKDQ KVFLHFEEEE ITFAPTYRFE 
       660        670        680        690        700
RLTRDKYAYT KQKATGMKYN LPSWCDRVLW KSYPLVHVVC QSYGSTSDIM 
       710        720        730        740        750
TSDHSPVFAT FEAGVTSQFV SKNGPGTVDS QGQIEFLACY ATLKTKSQTK 
       760        770        780        790        800
FYLEFHSSCL ESFVKSQEGE NEEGSEGELV VRFGETLPKL KPIISDPEYL 
       810        820        830        840        850
LDQHILISIK SSDSDESYGE GCIALRLETT EAQHPIYTPL THHGEMTGHF 
       860        870        880        890        900
RGEIKLQTSQ GKMREKLYDF VKTERDESSG MKCLKNLTSH DPMRQWEPSG 
       910        920        930        940        950
RVPACGVSSL NEMINPNYIG MGPFGQPLHG KSTLSPDQQL TAWSYDQLPK 
       960        970        980        990       1000
DSSLGPGRGE GPPTPPSQPP LSPKKFSSST ANRGPCPRVQ EARPGDLGKV 
      1010       1020       1030       1040       1050
EALLQEDLLL TKPEMFENPL YGSVSSFPKL VPRKEQESPK MLRKEPPPCP 
      1060       1070       1080       1090       1100
DPGISSPSIV LPKAQEVESV KGTSKQAPVP VLGPTPRIRS FTCSSSAEGR 
      1110       1120       1130       1140       1150
MTSGDKSQGK PKASASSQAP VPVKRPVKPS RSEMSQQTTP IPAPRPPLPV 
      1160       1170       1180       1190 
KSPAVLQLQH SKGRDYRDNT ELPHHGKHRQ EEGLLGRTAM Q

Length:1,191

Mass (Da):133,542

Last modified:September 11, 2007 - v2

Checksum:ⁱAF9F21326A59EC7A

GO

Isoform 2 (identifier: Q9ES52-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
120-120: Missing.

« Hide

        10         20         30         40         50
MPAMVPGWNH GNITRSKAEE LLSRAGKDGS FLVRASESIP RAYALCVLFR 
        60         70         80         90        100
NCVYTYRILP NEDDKFTVQA SEGVPMRFFT KLDQLIDFYK KENMGLVTHL 
       110        120        130        140        150
QYPVPLEEED AIDEAEEDTE SVMSPPELPP RNIPMSAGPS EAKDLPLATE 
       160        170        180        190        200
NPRAPEVTRL SLSETLFQRL QSMDTSGLPE EHLKAIQDYL STQLLLDSDF 
       210        220        230        240        250
LKTGSSNLPH LKKLMSLLCK ELHGEVIRTL PSLESLQRLF DQQLSPGLRP 
       260        270        280        290        300
RPQVPGEASP ITMVAKLSQL TSLLSSIEDK VKSLLHEGSE STNRRSLIPP 
       310        320        330        340        350
VTFEVKSESL GIPQKMHLKV DVESGKLIVK KSKDGSEDKF YSHKKILQLI 
       360        370        380        390        400
KSQKFLNKLV ILVETEKEKI LRKEYVFADS KKREGFCQLL QQMKNKHSEQ 
       410        420        430        440        450
PEPDMITIFI GTWNMGNAPP PKKITSWFLS KGQGKTRDDS ADYIPHDIYV 
       460        470        480        490        500
IGTQEDPLGE KEWLELLRHS LQEVTSMTFK TVAIHTLWNI RIVVLAKPEH 
       510        520        530        540        550
ENRISHICTD NVKTGIANTL GNKGAVGVSF MFNGTSLGFV NSHLTSGSEK 
       560        570        580        590        600
KLRRNQNYMN ILRFLALGDK KLSPFNITHR FTHLFWLGDL NYRVELPTWE 
       610        620        630        640        650
AEAIIQKIKQ QQYSDLLAHD QLLLERKDQK VFLHFEEEEI TFAPTYRFER 
       660        670        680        690        700
LTRDKYAYTK QKATGMKYNL PSWCDRVLWK SYPLVHVVCQ SYGSTSDIMT 
       710        720        730        740        750
SDHSPVFATF EAGVTSQFVS KNGPGTVDSQ GQIEFLACYA TLKTKSQTKF 
       760        770        780        790        800
YLEFHSSCLE SFVKSQEGEN EEGSEGELVV RFGETLPKLK PIISDPEYLL 
       810        820        830        840        850
DQHILISIKS SDSDESYGEG CIALRLETTE AQHPIYTPLT HHGEMTGHFR 
       860        870        880        890        900
GEIKLQTSQG KMREKLYDFV KTERDESSGM KCLKNLTSHD PMRQWEPSGR 
       910        920        930        940        950
VPACGVSSLN EMINPNYIGM GPFGQPLHGK STLSPDQQLT AWSYDQLPKD 
       960        970        980        990       1000
SSLGPGRGEG PPTPPSQPPL SPKKFSSSTA NRGPCPRVQE ARPGDLGKVE 
      1010       1020       1030       1040       1050
ALLQEDLLLT KPEMFENPLY GSVSSFPKLV PRKEQESPKM LRKEPPPCPD 
      1060       1070       1080       1090       1100
PGISSPSIVL PKAQEVESVK GTSKQAPVPV LGPTPRIRSF TCSSSAEGRM 
      1110       1120       1130       1140       1150
TSGDKSQGKP KASASSQAPV PVKRPVKPSR SEMSQQTTPI PAPRPPLPVK 
      1160       1170       1180       1190
SPAVLQLQHS KGRDYRDNTE LPHHGKHRQE EGLLGRTAMQ

Show »

Length:1,190

Mass (Da):133,443

Checksum:ⁱDF81F3046F33A07F

GO

Isoform 3 (identifier: Q9ES52-3) [UniParc]FASTA Add to basket

Also known as: 135 kDa SHIP

The sequence of this isoform differs from the canonical sequence as follows:
920-980: Missing.

« Hide

        10         20         30         40         50
MPAMVPGWNH GNITRSKAEE LLSRAGKDGS FLVRASESIP RAYALCVLFR 
        60         70         80         90        100
NCVYTYRILP NEDDKFTVQA SEGVPMRFFT KLDQLIDFYK KENMGLVTHL 
       110        120        130        140        150
QYPVPLEEED AIDEAEEDTV ESVMSPPELP PRNIPMSAGP SEAKDLPLAT 
       160        170        180        190        200
ENPRAPEVTR LSLSETLFQR LQSMDTSGLP EEHLKAIQDY LSTQLLLDSD 
       210        220        230        240        250
FLKTGSSNLP HLKKLMSLLC KELHGEVIRT LPSLESLQRL FDQQLSPGLR 
       260        270        280        290        300
PRPQVPGEAS PITMVAKLSQ LTSLLSSIED KVKSLLHEGS ESTNRRSLIP 
       310        320        330        340        350
PVTFEVKSES LGIPQKMHLK VDVESGKLIV KKSKDGSEDK FYSHKKILQL 
       360        370        380        390        400
IKSQKFLNKL VILVETEKEK ILRKEYVFAD SKKREGFCQL LQQMKNKHSE 
       410        420        430        440        450
QPEPDMITIF IGTWNMGNAP PPKKITSWFL SKGQGKTRDD SADYIPHDIY 
       460        470        480        490        500
VIGTQEDPLG EKEWLELLRH SLQEVTSMTF KTVAIHTLWN IRIVVLAKPE 
       510        520        530        540        550
HENRISHICT DNVKTGIANT LGNKGAVGVS FMFNGTSLGF VNSHLTSGSE 
       560        570        580        590        600
KKLRRNQNYM NILRFLALGD KKLSPFNITH RFTHLFWLGD LNYRVELPTW 
       610        620        630        640        650
EAEAIIQKIK QQQYSDLLAH DQLLLERKDQ KVFLHFEEEE ITFAPTYRFE 
       660        670        680        690        700
RLTRDKYAYT KQKATGMKYN LPSWCDRVLW KSYPLVHVVC QSYGSTSDIM 
       710        720        730        740        750
TSDHSPVFAT FEAGVTSQFV SKNGPGTVDS QGQIEFLACY ATLKTKSQTK 
       760        770        780        790        800
FYLEFHSSCL ESFVKSQEGE NEEGSEGELV VRFGETLPKL KPIISDPEYL 
       810        820        830        840        850
LDQHILISIK SSDSDESYGE GCIALRLETT EAQHPIYTPL THHGEMTGHF 
       860        870        880        890        900
RGEIKLQTSQ GKMREKLYDF VKTERDESSG MKCLKNLTSH DPMRQWEPSG 
       910        920        930        940        950
RVPACGVSSL NEMINPNYIA NRGPCPRVQE ARPGDLGKVE ALLQEDLLLT 
       960        970        980        990       1000
KPEMFENPLY GSVSSFPKLV PRKEQESPKM LRKEPPPCPD PGISSPSIVL 
      1010       1020       1030       1040       1050
PKAQEVESVK GTSKQAPVPV LGPTPRIRSF TCSSSAEGRM TSGDKSQGKP 
      1060       1070       1080       1090       1100
KASASSQAPV PVKRPVKPSR SEMSQQTTPI PAPRPPLPVK SPAVLQLQHS 
      1110       1120       1130
KGRDYRDNTE LPHHGKHRQE EGLLGRTAMQ

Show »

Length:1,130

Mass (Da):127,199

Checksum:ⁱC3E2F1EB206034BF

GO

Isoform 4 (identifier: Q9ES52-4) [UniParc]FASTA Add to basket

Also known as: SHIPdelta

The sequence of this isoform differs from the canonical sequence as follows:
     120-120: Missing.
     920-960: GMGPFGQPLH...DSSLGPGRGE → VFIFHSQPRS...GPAADEARDV
     961-1191: Missing.

« Hide

        10         20         30         40         50
MPAMVPGWNH GNITRSKAEE LLSRAGKDGS FLVRASESIP RAYALCVLFR 
        60         70         80         90        100
NCVYTYRILP NEDDKFTVQA SEGVPMRFFT KLDQLIDFYK KENMGLVTHL 
       110        120        130        140        150
QYPVPLEEED AIDEAEEDTE SVMSPPELPP RNIPMSAGPS EAKDLPLATE 
       160        170        180        190        200
NPRAPEVTRL SLSETLFQRL QSMDTSGLPE EHLKAIQDYL STQLLLDSDF 
       210        220        230        240        250
LKTGSSNLPH LKKLMSLLCK ELHGEVIRTL PSLESLQRLF DQQLSPGLRP 
       260        270        280        290        300
RPQVPGEASP ITMVAKLSQL TSLLSSIEDK VKSLLHEGSE STNRRSLIPP 
       310        320        330        340        350
VTFEVKSESL GIPQKMHLKV DVESGKLIVK KSKDGSEDKF YSHKKILQLI 
       360        370        380        390        400
KSQKFLNKLV ILVETEKEKI LRKEYVFADS KKREGFCQLL QQMKNKHSEQ 
       410        420        430        440        450
PEPDMITIFI GTWNMGNAPP PKKITSWFLS KGQGKTRDDS ADYIPHDIYV 
       460        470        480        490        500
IGTQEDPLGE KEWLELLRHS LQEVTSMTFK TVAIHTLWNI RIVVLAKPEH 
       510        520        530        540        550
ENRISHICTD NVKTGIANTL GNKGAVGVSF MFNGTSLGFV NSHLTSGSEK 
       560        570        580        590        600
KLRRNQNYMN ILRFLALGDK KLSPFNITHR FTHLFWLGDL NYRVELPTWE 
       610        620        630        640        650
AEAIIQKIKQ QQYSDLLAHD QLLLERKDQK VFLHFEEEEI TFAPTYRFER 
       660        670        680        690        700
LTRDKYAYTK QKATGMKYNL PSWCDRVLWK SYPLVHVVCQ SYGSTSDIMT 
       710        720        730        740        750
SDHSPVFATF EAGVTSQFVS KNGPGTVDSQ GQIEFLACYA TLKTKSQTKF 
       760        770        780        790        800
YLEFHSSCLE SFVKSQEGEN EEGSEGELVV RFGETLPKLK PIISDPEYLL 
       810        820        830        840        850
DQHILISIKS SDSDESYGEG CIALRLETTE AQHPIYTPLT HHGEMTGHFR 
       860        870        880        890        900
GEIKLQTSQG KMREKLYDFV KTERDESSGM KCLKNLTSHD PMRQWEPSGR 
       910        920        930        940        950
VPACGVSSLN EMINPNYIVF IFHSQPRSLP QGARGKTWGS GKGGSSAPGG 

PAADEARDV

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:959

Mass (Da):108,345

Checksum:ⁱB95D49476957345E

GO

Isoform 5 (identifier: Q9ES52-5) [UniParc]FASTA Add to basket

Also known as: s-SHIP

The sequence of this isoform differs from the canonical sequence as follows:
1-263: Missing.

« Hide

        10         20         30         40         50
MVAKLSQLTS LLSSIEDKVK SLLHEGSEST NRRSLIPPVT FEVKSESLGI 
        60         70         80         90        100
PQKMHLKVDV ESGKLIVKKS KDGSEDKFYS HKKILQLIKS QKFLNKLVIL 
       110        120        130        140        150
VETEKEKILR KEYVFADSKK REGFCQLLQQ MKNKHSEQPE PDMITIFIGT 
       160        170        180        190        200
WNMGNAPPPK KITSWFLSKG QGKTRDDSAD YIPHDIYVIG TQEDPLGEKE 
       210        220        230        240        250
WLELLRHSLQ EVTSMTFKTV AIHTLWNIRI VVLAKPEHEN RISHICTDNV 
       260        270        280        290        300
KTGIANTLGN KGAVGVSFMF NGTSLGFVNS HLTSGSEKKL RRNQNYMNIL 
       310        320        330        340        350
RFLALGDKKL SPFNITHRFT HLFWLGDLNY RVELPTWEAE AIIQKIKQQQ 
       360        370        380        390        400
YSDLLAHDQL LLERKDQKVF LHFEEEEITF APTYRFERLT RDKYAYTKQK 
       410        420        430        440        450
ATGMKYNLPS WCDRVLWKSY PLVHVVCQSY GSTSDIMTSD HSPVFATFEA 
       460        470        480        490        500
GVTSQFVSKN GPGTVDSQGQ IEFLACYATL KTKSQTKFYL EFHSSCLESF 
       510        520        530        540        550
VKSQEGENEE GSEGELVVRF GETLPKLKPI ISDPEYLLDQ HILISIKSSD 
       560        570        580        590        600
SDESYGEGCI ALRLETTEAQ HPIYTPLTHH GEMTGHFRGE IKLQTSQGKM 
       610        620        630        640        650
REKLYDFVKT ERDESSGMKC LKNLTSHDPM RQWEPSGRVP ACGVSSLNEM 
       660        670        680        690        700
INPNYIGMGP FGQPLHGKST LSPDQQLTAW SYDQLPKDSS LGPGRGEGPP 
       710        720        730        740        750
TPPSQPPLSP KKFSSSTANR GPCPRVQEAR PGDLGKVEAL LQEDLLLTKP 
       760        770        780        790        800
EMFENPLYGS VSSFPKLVPR KEQESPKMLR KEPPPCPDPG ISSPSIVLPK 
       810        820        830        840        850
AQEVESVKGT SKQAPVPVLG PTPRIRSFTC SSSAEGRMTS GDKSQGKPKA 
       860        870        880        890        900
SASSQAPVPV KRPVKPSRSE MSQQTTPIPA PRPPLPVKSP AVLQLQHSKG 
       910        920 
RDYRDNTELP HHGKHRQEEG LLGRTAMQ

Show »

Length:928

Mass (Da):104,101

Checksum:ⁱ7390D08E57505B82

GO

Isoform 6 (identifier: Q9ES52-6) [UniParc]FASTA Add to basket

Also known as: s-SHIPD183

The sequence of this isoform differs from the canonical sequence as follows:
1-263: Missing.
920-980: Missing.

« Hide

        10         20         30         40         50
MVAKLSQLTS LLSSIEDKVK SLLHEGSEST NRRSLIPPVT FEVKSESLGI 
        60         70         80         90        100
PQKMHLKVDV ESGKLIVKKS KDGSEDKFYS HKKILQLIKS QKFLNKLVIL 
       110        120        130        140        150
VETEKEKILR KEYVFADSKK REGFCQLLQQ MKNKHSEQPE PDMITIFIGT 
       160        170        180        190        200
WNMGNAPPPK KITSWFLSKG QGKTRDDSAD YIPHDIYVIG TQEDPLGEKE 
       210        220        230        240        250
WLELLRHSLQ EVTSMTFKTV AIHTLWNIRI VVLAKPEHEN RISHICTDNV 
       260        270        280        290        300
KTGIANTLGN KGAVGVSFMF NGTSLGFVNS HLTSGSEKKL RRNQNYMNIL 
       310        320        330        340        350
RFLALGDKKL SPFNITHRFT HLFWLGDLNY RVELPTWEAE AIIQKIKQQQ 
       360        370        380        390        400
YSDLLAHDQL LLERKDQKVF LHFEEEEITF APTYRFERLT RDKYAYTKQK 
       410        420        430        440        450
ATGMKYNLPS WCDRVLWKSY PLVHVVCQSY GSTSDIMTSD HSPVFATFEA 
       460        470        480        490        500
GVTSQFVSKN GPGTVDSQGQ IEFLACYATL KTKSQTKFYL EFHSSCLESF 
       510        520        530        540        550
VKSQEGENEE GSEGELVVRF GETLPKLKPI ISDPEYLLDQ HILISIKSSD 
       560        570        580        590        600
SDESYGEGCI ALRLETTEAQ HPIYTPLTHH GEMTGHFRGE IKLQTSQGKM 
       610        620        630        640        650
REKLYDFVKT ERDESSGMKC LKNLTSHDPM RQWEPSGRVP ACGVSSLNEM 
       660        670        680        690        700
INPNYIANRG PCPRVQEARP GDLGKVEALL QEDLLLTKPE MFENPLYGSV 
       710        720        730        740        750
SSFPKLVPRK EQESPKMLRK EPPPCPDPGI SSPSIVLPKA QEVESVKGTS 
       760        770        780        790        800
KQAPVPVLGP TPRIRSFTCS SSAEGRMTSG DKSQGKPKAS ASSQAPVPVK 
       810        820        830        840        850
RPVKPSRSEM SQQTTPIPAP RPPLPVKSPA VLQLQHSKGR DYRDNTELPH 
       860 
HGKHRQEEGL LGRTAMQ

Show »

Length:867

Mass (Da):97,758

Checksum:ⁱF848515DE853AD65

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F7BZA7	F7BZA7_MOUSE	Phosphatidylinositol 3,4,5-trisphos... Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	Inpp5d	124	Annotation score:
E9Q752	E9Q752_MOUSE	Phosphatidylinositol 3,4,5-trisphos... Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	Inpp5d	35	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	43	Y → C in AAB18937 (PubMed:8643691).Curated	1
Sequence conflictⁱ	527	V → A in AAC53023 (PubMed:9027494).Curated	1
Sequence conflictⁱ	534	N → I in AAC53023 (PubMed:9027494).Curated	1
Sequence conflictⁱ	905	C → E AA sequence (PubMed:8643691).Curated	1
Sequence conflictⁱ	981	A → T in AAB18937 (PubMed:8643691).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_027980	1 – 263	Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST	263
Alternative sequenceⁱVSP_027981	120	Missing in isoform 2 and isoform 4. 4 Publications	1
Alternative sequenceⁱVSP_027982	920 – 980	Missing in isoform 3 and isoform 6. 1 PublicationAdd BLAST	61
Alternative sequenceⁱVSP_027983	920 – 960	GMGPF…PGRGE → VFIFHSQPRSLPQGARGKTW GSGKGGSSAPGGPAADEARD V in isoform 4. 1 PublicationAdd BLAST	41
Alternative sequenceⁱVSP_027984	961 – 1191	Missing in isoform 4. 1 PublicationAdd BLAST	231

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U51742 mRNA Translation: AAC52606.1 U39203 mRNA Translation: AAB18937.1 U52044 mRNA Translation: AAC53023.1 AF125996 mRNA Translation: AAD37118.1 AF235502 AF235501 Genomic DNA Translation: AAG23922.1 AF228679 mRNA Translation: AAF69143.1 AF184912 mRNA Translation: AAF25823.1 AF184913 mRNA Translation: AAF25824.1 AK143560 mRNA Translation: BAE25436.1 BC108328 mRNA Translation: AAI08329.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35655.1 [Q9ES52-1] CCDS48310.1 [Q9ES52-3] CCDS48311.1 [Q9ES52-2]
PIRⁱ	JC6118
NCBI Reference Sequences More...RefSeqⁱ	NP_001103662.1, NM_001110192.2 [Q9ES52-2] NP_001103663.1, NM_001110193.2 [Q9ES52-3] NP_034696.2, NM_010566.3 [Q9ES52-1]
UniGeneⁱ	Mm.15105

Genome annotation databases

Ensemblⁱ	ENSMUST00000042275; ENSMUSP00000044647; ENSMUSG00000026288 [Q9ES52-2] ENSMUST00000072999; ENSMUSP00000072763; ENSMUSG00000026288 [Q9ES52-4] ENSMUST00000167032; ENSMUSP00000126569; ENSMUSG00000026288 [Q9ES52-5] ENSMUST00000168783; ENSMUSP00000131244; ENSMUSG00000026288 [Q9ES52-3] ENSMUST00000169754; ENSMUSP00000127941; ENSMUSG00000026288 [Q9ES52-1] ENSMUST00000170300; ENSMUSP00000132384; ENSMUSG00000026288 [Q9ES52-6]
GeneIDⁱ	16331
KEGGⁱ	mmu:16331
UCSC genome browser More...UCSCⁱ	uc007bxc.3 mouse [Q9ES52-1] uc007bxd.3 mouse [Q9ES52-3] uc007bxf.3 mouse [Q9ES52-2] uc007bxg.3 mouse [Q9ES52-6]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9ES52	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1		RAT		1190	UniRef90_Q9ES52
Isoform 5 of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1		MOUSE		928
UPI0004ED24FC		NANGA		1193
UPI00042ABE14		PERMB		1191
UPI000A30FF2B		MUSPA		1191
+14
Q9ES52-3	Isoform 6 of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1		MOUSE		867	UniRef90_Q9ES52-3
UPI000A30525A		MUSPA		1130
UPI000A315AED		MUSCR		1130
UPI000B4F6237		MERUN		954
Isoform 4 of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1		MOUSE		959
+3
Q9ES52-4	Isoform 3 of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1		MOUSE		1130	UniRef90_Q9ES52-3
UPI000A30525A		MUSPA		1130
UPI000A315AED		MUSCR		1130
UPI000B4F6237		MERUN		954
Isoform 6 of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1		MOUSE		867
+3
Q9ES52-6	Isoform 3 of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1		MOUSE		1130	UniRef90_Q9ES52-3
UPI000A30525A		MUSPA		1130
UPI000A315AED		MUSCR		1130
UPI000B4F6237		MERUN		954
Isoform 4 of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1		MOUSE		959
+3

Protein	Similar proteins		Species	Score	Length	Source
Q9ES52	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1		RAT		1190	UniRef50_Q9ES52
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	)	HUMAN		1189
Isoform 5 of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1		MOUSE		928
Uncharacterized protein		MANLE		1180
Uncharacterized protein		RHIBE		1194
+194
Q9ES52-3	Isoform 6 of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1		MOUSE		867	UniRef50_Q9ES52-3
Inositol polyphosphate-5-phosphatase D (Fragment)		DANRE		835
Uncharacterized protein		FUNHE		1125
Inositol polyphosphate-5-phosphatase D		MELGA		1171
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (Fragment)		TINGU		1177
+75
Q9ES52-4	Isoform 3 of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1		MOUSE		1130	UniRef50_Q9ES52-3
Inositol polyphosphate-5-phosphatase D (Fragment)		DANRE		835
Uncharacterized protein		FUNHE		1125
Inositol polyphosphate-5-phosphatase D		MELGA		1171
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (Fragment)		TINGU		1177
+75
Q9ES52-6	Isoform 3 of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1		MOUSE		1130	UniRef50_Q9ES52-3
Inositol polyphosphate-5-phosphatase D (Fragment)		DANRE		835
Uncharacterized protein		FUNHE		1125
Inositol polyphosphate-5-phosphatase D		MELGA		1171
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (Fragment)		TINGU		1177
+75

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U51742 mRNA Translation: AAC52606.1 U39203 mRNA Translation: AAB18937.1 U52044 mRNA Translation: AAC53023.1 AF125996 mRNA Translation: AAD37118.1 AF235502 AF235501 Genomic DNA Translation: AAG23922.1 AF228679 mRNA Translation: AAF69143.1 AF184912 mRNA Translation: AAF25823.1 AF184913 mRNA Translation: AAF25824.1 AK143560 mRNA Translation: BAE25436.1 BC108328 mRNA Translation: AAI08329.1
CCDSⁱ	CCDS35655.1 [Q9ES52-1] CCDS48310.1 [Q9ES52-3] CCDS48311.1 [Q9ES52-2]
PIRⁱ	JC6118
RefSeqⁱ	NP_001103662.1, NM_001110192.2 [Q9ES52-2] NP_001103663.1, NM_001110193.2 [Q9ES52-3] NP_034696.2, NM_010566.3 [Q9ES52-1]
UniGeneⁱ	Mm.15105

3D structure databases

ProteinModelPortalⁱ	Q9ES52
SMRⁱ	Q9ES52
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	200769, 25 interactors
CORUMⁱ	Q9ES52
IntActⁱ	Q9ES52, 15 interactors
MINTⁱ	Q9ES52
STRINGⁱ	10090.ENSMUSP00000127941

Chemistry databases

SwissLipidsⁱ	SLP:000000873

SwissLipidsⁱ

SLP:000000873

PTM databases

iPTMnetⁱ	Q9ES52
PhosphoSitePlusⁱ	Q9ES52

Proteomic databases

PaxDbⁱ	Q9ES52
PeptideAtlasⁱ	Q9ES52
PRIDEⁱ	Q9ES52

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000042275; ENSMUSP00000044647; ENSMUSG00000026288 [Q9ES52-2] ENSMUST00000072999; ENSMUSP00000072763; ENSMUSG00000026288 [Q9ES52-4] ENSMUST00000167032; ENSMUSP00000126569; ENSMUSG00000026288 [Q9ES52-5] ENSMUST00000168783; ENSMUSP00000131244; ENSMUSG00000026288 [Q9ES52-3] ENSMUST00000169754; ENSMUSP00000127941; ENSMUSG00000026288 [Q9ES52-1] ENSMUST00000170300; ENSMUSP00000132384; ENSMUSG00000026288 [Q9ES52-6]
GeneIDⁱ	16331
KEGGⁱ	mmu:16331
UCSCⁱ	uc007bxc.3 mouse [Q9ES52-1] uc007bxd.3 mouse [Q9ES52-3] uc007bxf.3 mouse [Q9ES52-2] uc007bxg.3 mouse [Q9ES52-6]

Organism-specific databases

CTDⁱ	3635
MGIⁱ	MGI:107357 Inpp5d

Phylogenomic databases

eggNOGⁱ	KOG0565 Eukaryota COG5411 LUCA
GeneTreeⁱ	ENSGT00760000119075
HOVERGENⁱ	HBG106726
InParanoidⁱ	Q9ES52
KOⁱ	K03084
OMAⁱ	LTKPEMF
OrthoDBⁱ	EOG091G00P6
PhylomeDBⁱ	Q9ES52
TreeFamⁱ	TF323475

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1660499 Synthesis of PIPs at the plasma membrane R-MMU-1855204 Synthesis of IP3 and IP4 in the cytosol R-MMU-202424 Downstream TCR signaling R-MMU-912526 Interleukin receptor SHC signaling

Reactomeⁱ

R-MMU-1660499 Synthesis of PIPs at the plasma membrane
R-MMU-1855204 Synthesis of IP3 and IP4 in the cytosol
R-MMU-202424 Downstream TCR signaling
R-MMU-912526 Interleukin receptor SHC signaling

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9ES52
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000026288 Expressed in 216 organ(s), highest expression level in stroma of bone marrow
CleanExⁱ	MM_INPP5D
ExpressionAtlasⁱ	Q9ES52 baseline and differential
Genevisibleⁱ	Q9ES52 MM

Family and domain databases

Gene3Dⁱ	3.30.505.10, 1 hit 3.60.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR036691 Endo/exonu/phosph_ase_sf IPR005135 Endo/exonuclease/phosphatase IPR000300 IPPc IPR000980 SH2 IPR036860 SH2_dom_sf
Pfamⁱ	View protein in Pfam PF03372 Exo_endo_phos, 1 hit PF00017 SH2, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN
SMARTⁱ	View protein in SMART SM00128 IPPc, 1 hit SM00252 SH2, 1 hit
SUPFAMⁱ	SSF55550 SSF55550, 1 hit SSF56219 SSF56219, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001 SH2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SHIP1_MOUSE
Accessionⁱ	Q9ES52Primary (citable) accession number: Q9ES52 Secondary accession number(s): Q3UPF9 Q9WUC2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
	Last sequence update:	September 11, 2007
	Last modified:	September 12, 2018
	This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9ES52 (SHIP1_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytoskeleton

Other locations

Plasma membrane

Cytoskeleton

Cytosol

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ