UniProtKB - Q9ES52 (SHIP1_MOUSE)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Inpp5d
Functioni
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate3 PublicationsEC:3.1.3.863 Publications
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate1 PublicationEC:3.1.3.361 Publication
- 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphateBy similarityEC:3.1.3.56By similarity
Activity regulationi
GO - Molecular functioni
- inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Source: UniProtKB-EC
- inositol-1,4,5-trisphosphate 5-phosphatase activity Source: UniProtKB-EC
- inositol-4,5-bisphosphate 5-phosphatase activity Source: MGI
- inositol-polyphosphate 5-phosphatase activity Source: MGI
- phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Source: UniProtKB-EC
- phosphatidylinositol trisphosphate phosphatase activity Source: MGI
- PTB domain binding Source: MGI
- SH3 domain binding Source: MGI
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- determination of adult lifespan Source: MGI
- immunoglobulin mediated immune response Source: MGI
- intracellular signal transduction Source: MGI
- negative regulation of B cell activation Source: MGI
- negative regulation of B cell proliferation Source: MGI
- negative regulation of bone resorption Source: MGI
- negative regulation of cell population proliferation Source: MGI
- negative regulation of granulocyte differentiation Source: MGI
- negative regulation of immune response Source: MGI
- negative regulation of interleukin-6 production Source: MGI
- negative regulation of monocyte differentiation Source: MGI
- negative regulation of neutrophil differentiation Source: MGI
- negative regulation of osteoclast differentiation Source: MGI
- negative regulation of signal transduction Source: MGI
- phosphatidylinositol dephosphorylation Source: InterPro
- positive regulation of apoptotic process Source: MGI
- positive regulation of B cell differentiation Source: MGI
- positive regulation of erythrocyte differentiation Source: MGI
- positive regulation of lymphocyte differentiation Source: MGI
Keywordsi
Molecular function | Hydrolase |
Biological process | Apoptosis, Immunity |
Enzyme and pathway databases
Reactomei | R-MMU-1660499, Synthesis of PIPs at the plasma membrane R-MMU-1855204, Synthesis of IP3 and IP4 in the cytosol R-MMU-202424, Downstream TCR signaling R-MMU-210990, PECAM1 interactions R-MMU-912526, Interleukin receptor SHC signaling |
Chemistry databases
SwissLipidsi | SLP:000000873 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1Curated (EC:3.1.3.863 Publications)Alternative name(s): Inositol polyphosphate-5-phosphatase D (EC:3.1.3.56By similarity) Inositol polyphosphate-5-phosphatase of 145 kDa1 Publication Short name: SIP-1451 Publication Phosphatidylinositol-4,5-bisphosphate 5-phosphatase (EC:3.1.3.361 Publication) SH2 domain-containing inositol 5'-phosphatase 1 Short name: SH2 domain-containing inositol phosphatase 1 Short name: SHIP-1 p150Ship1 Publication |
Gene namesi | Name:Inpp5d Synonyms:7a33, Ship, Ship1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107357, Inpp5d |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
Other locations
- Cytoplasm 1 Publication
- Membrane raft 1 Publication
Note: Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type (PubMed:12393695). Translocates from the cytoplasm to membrane ruffles in a FCGR3/CD16-dependent manner (PubMed:12393695). Colocalizes with FC-gamma-RIIB receptor (FCGR2B) or FCGR3/CD16 at membrane ruffles (PubMed:12393695). Tyrosine phosphorylation may also participate in membrane localization (PubMed:12393695).1 Publication
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
Note: Constitutively present at the cell membrane (PubMed:11567986).1 Publication
Cytoskeleton
- actin filament Source: MGI
- cortical cytoskeleton Source: MGI
Cytosol
- cytosol Source: MGI
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- membrane raft Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 676 | D → G: Loss of function. 1 Publication | 1 | |
Mutagenesisi | 918 | Y → F: Strongly impairs function, tyrosine phosphorylation, subcellular location and interaction with DOK1; when associated with F-1021. 3 Publications | 1 | |
Mutagenesisi | 1021 | Y → F: Strongly impairs function, tyrosine phosphorylation, subcellular location and interaction with DOK1; when associated with F-918. 3 Publications | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000302867 | 1 – 1191 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1Add BLAST | 1191 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 246 | PhosphoserineCombined sources | 1 | |
Modified residuei | 918 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 935 | PhosphoserineCombined sources | 1 | |
Modified residuei | 945 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 964 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 967 | PhosphoserineCombined sources | 1 | |
Modified residuei | 972 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1021 | Phosphotyrosine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q9ES52 |
PaxDbi | Q9ES52 |
PeptideAtlasi | Q9ES52 |
PRIDEi | Q9ES52 |
PTM databases
iPTMneti | Q9ES52 |
PhosphoSitePlusi | Q9ES52 |
SwissPalmi | Q9ES52 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000026288, Expressed in cardiac ventricle and 238 other tissues |
Genevisiblei | Q9ES52, MM |
Interactioni
Subunit structurei
Interacts with tyrosine phosphorylated form of SHC1 (PubMed:8654924, PubMed:8643691, PubMed:10068665, PubMed:9083021, PubMed:9099679, PubMed:10395202).
Interacts with tyrosine phosphorylated form of DOK1 (PubMed:11031258).
Interacts with tyrosine phosphorylated form of DOK3 (PubMed:14993273).
Interacts with tyrosine phosphorylated form of SLAMF1/CD150 (By similarity).
Interacts with PTPN11/SHP-2 in response to IL-3 (PubMed:9110989, PubMed:9393882).
Interacts with receptor EPOR (PubMed:10660611).
Interacts with receptors MS4A2/FCER1B and FCER1G (By similarity).
Interacts with receptors FCGR2B and FCGR3 (PubMed:10395202, PubMed:11016922, PubMed:10779347, PubMed:15456754, PubMed:12393695).
Interacts with receptor FCGR2A, leading to regulate gene expression during the phagocytic process (PubMed:12370370).
Interacts with GRB2 (PubMed:8643691, PubMed:10068665).
Interacts with PLCG1 (PubMed:16000869).
Interacts with tyrosine kinases SRC and TEC (PubMed:10794720, PubMed:15492005).
Interacts with CRKL (PubMed:11031258).
Interacts with c-Met/MET (PubMed:11896575).
Interacts with MILR1 (tyrosine-phosphorylated) (PubMed:20526344).
Isoform 5 interacts with IL6ST/gp130 (PubMed:17105399). Can weakly interact (via NPXY motif 2) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (PubMed:11247302).
By similarity23 PublicationsBinary interactionsi
Hide detailsQ9ES52
With | #Exp. | IntAct |
---|---|---|
Plcg2 [Q8CIH5] | 3 | EBI-300210,EBI-617954 |
Isoform 1 [Q9ES52-1]
With | #Exp. | IntAct |
---|---|---|
PIK3R1 [P23727] from Bos taurus. | 2 | EBI-1452545,EBI-520244 |
GO - Molecular functioni
- PTB domain binding Source: MGI
- SH3 domain binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 200769, 29 interactors |
CORUMi | Q9ES52 |
IntActi | Q9ES52, 16 interactors |
MINTi | Q9ES52 |
STRINGi | 10090.ENSMUSP00000127941 |
Miscellaneous databases
RNActi | Q9ES52, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9ES52 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 104 | SH2PROSITE-ProRule annotationAdd BLAST | 97 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1015 – 1029 | Interaction with DAB21 PublicationAdd BLAST | 15 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 127 – 132 | SH3-binding 1 | 6 | |
Motifi | 915 – 918 | NPXY motif 1 | 4 | |
Motifi | 970 – 975 | SH3-binding 2 | 6 | |
Motifi | 1018 – 1021 | NPXY motif 2 | 4 | |
Motifi | 1039 – 1050 | SH3-binding 3Add BLAST | 12 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 962 – 1153 | Pro-richAdd BLAST | 192 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, SH2 domain, SH3-bindingPhylogenomic databases
eggNOGi | KOG0565, Eukaryota |
GeneTreei | ENSGT00940000156202 |
HOGENOMi | CLU_007493_1_0_1 |
InParanoidi | Q9ES52 |
OMAi | GPCLRTQ |
OrthoDBi | 311217at2759 |
PhylomeDBi | Q9ES52 |
TreeFami | TF323475 |
Family and domain databases
Gene3Di | 3.30.505.10, 1 hit 3.60.10.10, 1 hit |
InterProi | View protein in InterPro IPR036691, Endo/exonu/phosph_ase_sf IPR005135, Endo/exonuclease/phosphatase IPR000300, IPPc IPR000980, SH2 IPR036860, SH2_dom_sf |
Pfami | View protein in Pfam PF03372, Exo_endo_phos, 1 hit PF00017, SH2, 1 hit |
PRINTSi | PR00401, SH2DOMAIN |
SMARTi | View protein in SMART SM00128, IPPc, 1 hit SM00252, SH2, 1 hit |
SUPFAMi | SSF55550, SSF55550, 1 hit SSF56219, SSF56219, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPAMVPGWNH GNITRSKAEE LLSRAGKDGS FLVRASESIP RAYALCVLFR
60 70 80 90 100
NCVYTYRILP NEDDKFTVQA SEGVPMRFFT KLDQLIDFYK KENMGLVTHL
110 120 130 140 150
QYPVPLEEED AIDEAEEDTV ESVMSPPELP PRNIPMSAGP SEAKDLPLAT
160 170 180 190 200
ENPRAPEVTR LSLSETLFQR LQSMDTSGLP EEHLKAIQDY LSTQLLLDSD
210 220 230 240 250
FLKTGSSNLP HLKKLMSLLC KELHGEVIRT LPSLESLQRL FDQQLSPGLR
260 270 280 290 300
PRPQVPGEAS PITMVAKLSQ LTSLLSSIED KVKSLLHEGS ESTNRRSLIP
310 320 330 340 350
PVTFEVKSES LGIPQKMHLK VDVESGKLIV KKSKDGSEDK FYSHKKILQL
360 370 380 390 400
IKSQKFLNKL VILVETEKEK ILRKEYVFAD SKKREGFCQL LQQMKNKHSE
410 420 430 440 450
QPEPDMITIF IGTWNMGNAP PPKKITSWFL SKGQGKTRDD SADYIPHDIY
460 470 480 490 500
VIGTQEDPLG EKEWLELLRH SLQEVTSMTF KTVAIHTLWN IRIVVLAKPE
510 520 530 540 550
HENRISHICT DNVKTGIANT LGNKGAVGVS FMFNGTSLGF VNSHLTSGSE
560 570 580 590 600
KKLRRNQNYM NILRFLALGD KKLSPFNITH RFTHLFWLGD LNYRVELPTW
610 620 630 640 650
EAEAIIQKIK QQQYSDLLAH DQLLLERKDQ KVFLHFEEEE ITFAPTYRFE
660 670 680 690 700
RLTRDKYAYT KQKATGMKYN LPSWCDRVLW KSYPLVHVVC QSYGSTSDIM
710 720 730 740 750
TSDHSPVFAT FEAGVTSQFV SKNGPGTVDS QGQIEFLACY ATLKTKSQTK
760 770 780 790 800
FYLEFHSSCL ESFVKSQEGE NEEGSEGELV VRFGETLPKL KPIISDPEYL
810 820 830 840 850
LDQHILISIK SSDSDESYGE GCIALRLETT EAQHPIYTPL THHGEMTGHF
860 870 880 890 900
RGEIKLQTSQ GKMREKLYDF VKTERDESSG MKCLKNLTSH DPMRQWEPSG
910 920 930 940 950
RVPACGVSSL NEMINPNYIG MGPFGQPLHG KSTLSPDQQL TAWSYDQLPK
960 970 980 990 1000
DSSLGPGRGE GPPTPPSQPP LSPKKFSSST ANRGPCPRVQ EARPGDLGKV
1010 1020 1030 1040 1050
EALLQEDLLL TKPEMFENPL YGSVSSFPKL VPRKEQESPK MLRKEPPPCP
1060 1070 1080 1090 1100
DPGISSPSIV LPKAQEVESV KGTSKQAPVP VLGPTPRIRS FTCSSSAEGR
1110 1120 1130 1140 1150
MTSGDKSQGK PKASASSQAP VPVKRPVKPS RSEMSQQTTP IPAPRPPLPV
1160 1170 1180 1190
KSPAVLQLQH SKGRDYRDNT ELPHHGKHRQ EEGLLGRTAM Q
The sequence of this isoform differs from the canonical sequence as follows:
120-120: Missing.
920-960: GMGPFGQPLH...DSSLGPGRGE → VFIFHSQPRS...GPAADEARDV
961-1191: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q752 | E9Q752_MOUSE | Phosphatidylinositol 3,4,5-trisphos... | Inpp5d | 35 | Annotation score: | ||
F7BZA7 | F7BZA7_MOUSE | Phosphatidylinositol 3,4,5-trisphos... | Inpp5d | 124 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 43 | Y → C in AAB18937 (PubMed:8643691).Curated | 1 | |
Sequence conflicti | 527 | V → A in AAC53023 (PubMed:9027494).Curated | 1 | |
Sequence conflicti | 534 | N → I in AAC53023 (PubMed:9027494).Curated | 1 | |
Sequence conflicti | 905 | C → E AA sequence (PubMed:8643691).Curated | 1 | |
Sequence conflicti | 981 | A → T in AAB18937 (PubMed:8643691).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027980 | 1 – 263 | Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST | 263 | |
Alternative sequenceiVSP_027981 | 120 | Missing in isoform 2 and isoform 4. 4 Publications | 1 | |
Alternative sequenceiVSP_027982 | 920 – 980 | Missing in isoform 3 and isoform 6. 1 PublicationAdd BLAST | 61 | |
Alternative sequenceiVSP_027983 | 920 – 960 | GMGPF…PGRGE → VFIFHSQPRSLPQGARGKTW GSGKGGSSAPGGPAADEARD V in isoform 4. 1 PublicationAdd BLAST | 41 | |
Alternative sequenceiVSP_027984 | 961 – 1191 | Missing in isoform 4. 1 PublicationAdd BLAST | 231 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U51742 mRNA Translation: AAC52606.1 U39203 mRNA Translation: AAB18937.1 U52044 mRNA Translation: AAC53023.1 AF125996 mRNA Translation: AAD37118.1 AF235502 , AF235496, AF235498, AF235499, AF235500, AF235501 Genomic DNA Translation: AAG23922.1 AF228679 mRNA Translation: AAF69143.1 AF184912 mRNA Translation: AAF25823.1 AF184913 mRNA Translation: AAF25824.1 AK143560 mRNA Translation: BAE25436.1 BC108328 mRNA Translation: AAI08329.1 |
CCDSi | CCDS35655.1 [Q9ES52-1] CCDS48310.1 [Q9ES52-3] CCDS48311.1 [Q9ES52-2] |
PIRi | JC6118 |
RefSeqi | NP_001103662.1, NM_001110192.2 [Q9ES52-2] NP_001103663.1, NM_001110193.2 [Q9ES52-3] NP_034696.2, NM_010566.3 [Q9ES52-1] |
Genome annotation databases
Ensembli | ENSMUST00000042275; ENSMUSP00000044647; ENSMUSG00000026288 [Q9ES52-2] ENSMUST00000072999; ENSMUSP00000072763; ENSMUSG00000026288 [Q9ES52-4] ENSMUST00000167032; ENSMUSP00000126569; ENSMUSG00000026288 [Q9ES52-5] ENSMUST00000168783; ENSMUSP00000131244; ENSMUSG00000026288 [Q9ES52-3] ENSMUST00000169754; ENSMUSP00000127941; ENSMUSG00000026288 [Q9ES52-1] ENSMUST00000170300; ENSMUSP00000132384; ENSMUSG00000026288 [Q9ES52-6] |
GeneIDi | 16331 |
KEGGi | mmu:16331 |
UCSCi | uc007bxc.3, mouse [Q9ES52-1] uc007bxd.3, mouse [Q9ES52-3] uc007bxf.3, mouse [Q9ES52-2] uc007bxg.3, mouse [Q9ES52-6] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U51742 mRNA Translation: AAC52606.1 U39203 mRNA Translation: AAB18937.1 U52044 mRNA Translation: AAC53023.1 AF125996 mRNA Translation: AAD37118.1 AF235502 , AF235496, AF235498, AF235499, AF235500, AF235501 Genomic DNA Translation: AAG23922.1 AF228679 mRNA Translation: AAF69143.1 AF184912 mRNA Translation: AAF25823.1 AF184913 mRNA Translation: AAF25824.1 AK143560 mRNA Translation: BAE25436.1 BC108328 mRNA Translation: AAI08329.1 |
CCDSi | CCDS35655.1 [Q9ES52-1] CCDS48310.1 [Q9ES52-3] CCDS48311.1 [Q9ES52-2] |
PIRi | JC6118 |
RefSeqi | NP_001103662.1, NM_001110192.2 [Q9ES52-2] NP_001103663.1, NM_001110193.2 [Q9ES52-3] NP_034696.2, NM_010566.3 [Q9ES52-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6DLG | X-ray | 1.50 | A | 402-861 | [»] | |
SMRi | Q9ES52 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 200769, 29 interactors |
CORUMi | Q9ES52 |
IntActi | Q9ES52, 16 interactors |
MINTi | Q9ES52 |
STRINGi | 10090.ENSMUSP00000127941 |
Chemistry databases
SwissLipidsi | SLP:000000873 |
PTM databases
iPTMneti | Q9ES52 |
PhosphoSitePlusi | Q9ES52 |
SwissPalmi | Q9ES52 |
Proteomic databases
jPOSTi | Q9ES52 |
PaxDbi | Q9ES52 |
PeptideAtlasi | Q9ES52 |
PRIDEi | Q9ES52 |
Protocols and materials databases
Antibodypediai | 4272, 562 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000042275; ENSMUSP00000044647; ENSMUSG00000026288 [Q9ES52-2] ENSMUST00000072999; ENSMUSP00000072763; ENSMUSG00000026288 [Q9ES52-4] ENSMUST00000167032; ENSMUSP00000126569; ENSMUSG00000026288 [Q9ES52-5] ENSMUST00000168783; ENSMUSP00000131244; ENSMUSG00000026288 [Q9ES52-3] ENSMUST00000169754; ENSMUSP00000127941; ENSMUSG00000026288 [Q9ES52-1] ENSMUST00000170300; ENSMUSP00000132384; ENSMUSG00000026288 [Q9ES52-6] |
GeneIDi | 16331 |
KEGGi | mmu:16331 |
UCSCi | uc007bxc.3, mouse [Q9ES52-1] uc007bxd.3, mouse [Q9ES52-3] uc007bxf.3, mouse [Q9ES52-2] uc007bxg.3, mouse [Q9ES52-6] |
Organism-specific databases
CTDi | 3635 |
MGIi | MGI:107357, Inpp5d |
Phylogenomic databases
eggNOGi | KOG0565, Eukaryota |
GeneTreei | ENSGT00940000156202 |
HOGENOMi | CLU_007493_1_0_1 |
InParanoidi | Q9ES52 |
OMAi | GPCLRTQ |
OrthoDBi | 311217at2759 |
PhylomeDBi | Q9ES52 |
TreeFami | TF323475 |
Enzyme and pathway databases
Reactomei | R-MMU-1660499, Synthesis of PIPs at the plasma membrane R-MMU-1855204, Synthesis of IP3 and IP4 in the cytosol R-MMU-202424, Downstream TCR signaling R-MMU-210990, PECAM1 interactions R-MMU-912526, Interleukin receptor SHC signaling |
Miscellaneous databases
BioGRID-ORCSi | 16331, 0 hits in 17 CRISPR screens |
ChiTaRSi | Inpp5d, mouse |
PROi | PR:Q9ES52 |
RNActi | Q9ES52, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026288, Expressed in cardiac ventricle and 238 other tissues |
Genevisiblei | Q9ES52, MM |
Family and domain databases
Gene3Di | 3.30.505.10, 1 hit 3.60.10.10, 1 hit |
InterProi | View protein in InterPro IPR036691, Endo/exonu/phosph_ase_sf IPR005135, Endo/exonuclease/phosphatase IPR000300, IPPc IPR000980, SH2 IPR036860, SH2_dom_sf |
Pfami | View protein in Pfam PF03372, Exo_endo_phos, 1 hit PF00017, SH2, 1 hit |
PRINTSi | PR00401, SH2DOMAIN |
SMARTi | View protein in SMART SM00128, IPPc, 1 hit SM00252, SH2, 1 hit |
SUPFAMi | SSF55550, SSF55550, 1 hit SSF56219, SSF56219, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SHIP1_MOUSE | |
Accessioni | Q9ES52Primary (citable) accession number: Q9ES52 Secondary accession number(s): Q3UPF9 Q9WUC2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | September 11, 2007 | |
Last modified: | December 2, 2020 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families