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Protein

Beta-parvin

Gene

Parvb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-parvin
Gene namesi
Name:Parvb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2153063 Parvb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001215841 – 365Beta-parvinAdd BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by ILK.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9ES46
PaxDbiQ9ES46
PRIDEiQ9ES46

PTM databases

iPTMnetiQ9ES46
PhosphoSitePlusiQ9ES46

Expressioni

Tissue specificityi

Expressed predominantly in heart and moderately in spleen, lung and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000022438 Expressed in 216 organ(s), highest expression level in blood
CleanExiMM_PARVB
ExpressionAtlasiQ9ES46 baseline and differential
GenevisibleiQ9ES46 MM

Interactioni

Subunit structurei

Interacts with ILK, ARHGEF6, PXN (via LD motifs), ACTN2 and actin (By similarity). Interacts with DYSF.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-57659N
IntActiQ9ES46, 2 interactors
MINTiQ9ES46
STRINGi10090.ENSMUSP00000023072

Structurei

3D structure databases

ProteinModelPortaliQ9ES46
SMRiQ9ES46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 195Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST108
Domaini255 – 362Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Belongs to the parvin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3631 Eukaryota
ENOG410XQWH LUCA
GeneTreeiENSGT00390000009673
HOGENOMiHOG000247027
HOVERGENiHBG053517
InParanoidiQ9ES46
KOiK06275
OMAiGLLQTTH
OrthoDBiEOG091G0ULB
PhylomeDBiQ9ES46
TreeFamiTF314025

Family and domain databases

Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR028433 Parvin
PANTHERiPTHR12114 PTHR12114, 1 hit
PfamiView protein in Pfam
PF00307 CH, 2 hits
PIRSFiPIRSF039131 Parvin, 1 hit
SMARTiView protein in SMART
SM00033 CH, 2 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9ES46-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSAPPRSPT PRAPKMKKDE SFLGKLGGTL ARKKKTREVT DLQEEGKSAI
60 70 80 90 100
NSPMAPALVD IHPEDTQLEE NEERTMIDPT SREDPKFKEL VKVLLDWIND
110 120 130 140 150
VLAEERIIVK QLEEDLYDGQ VLQKLLEKLA HCKLNVAEVT QSEIGQKQKL
160 170 180 190 200
QTVLEAVQDL LRPHGWPLRW NVDSIHGKNL VAILHLLVSL AMHFRAPIHL
210 220 230 240 250
PEHVTVQVVV VRKREGLLHS SHISEELTTT TEIMMGRFER DAFDTLFDHA
260 270 280 290 300
PDKLNLVKKS LITFVNKHLN KLNLEVTDLE TQFADGVYLV LLLGLLEDYF
310 320 330 340 350
VPLHNFYLTP DSFDQKVHNV AFAFELMLDG GLKKPKARPE DVVNLDLKST
360
LRVLYTLFTK YKDVE
Length:365
Mass (Da):41,669
Last modified:March 1, 2001 - v1
Checksum:iA3C6B8B3D5875CEA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z417F2Z417_MOUSE
Beta-parvin
Parvb
93Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237770 mRNA Translation: AAG27172.1
CCDSiCCDS37167.1
RefSeqiNP_573395.1, NM_133167.3
UniGeneiMm.323892

Genome annotation databases

EnsembliENSMUST00000023072; ENSMUSP00000023072; ENSMUSG00000022438
GeneIDi170736
KEGGimmu:170736
UCSCiuc007xby.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237770 mRNA Translation: AAG27172.1
CCDSiCCDS37167.1
RefSeqiNP_573395.1, NM_133167.3
UniGeneiMm.323892

3D structure databases

ProteinModelPortaliQ9ES46
SMRiQ9ES46
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-57659N
IntActiQ9ES46, 2 interactors
MINTiQ9ES46
STRINGi10090.ENSMUSP00000023072

PTM databases

iPTMnetiQ9ES46
PhosphoSitePlusiQ9ES46

Proteomic databases

MaxQBiQ9ES46
PaxDbiQ9ES46
PRIDEiQ9ES46

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023072; ENSMUSP00000023072; ENSMUSG00000022438
GeneIDi170736
KEGGimmu:170736
UCSCiuc007xby.1 mouse

Organism-specific databases

CTDi29780
MGIiMGI:2153063 Parvb

Phylogenomic databases

eggNOGiKOG3631 Eukaryota
ENOG410XQWH LUCA
GeneTreeiENSGT00390000009673
HOGENOMiHOG000247027
HOVERGENiHBG053517
InParanoidiQ9ES46
KOiK06275
OMAiGLLQTTH
OrthoDBiEOG091G0ULB
PhylomeDBiQ9ES46
TreeFamiTF314025

Enzyme and pathway databases

ReactomeiR-MMU-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

Miscellaneous databases

PROiPR:Q9ES46
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022438 Expressed in 216 organ(s), highest expression level in blood
CleanExiMM_PARVB
ExpressionAtlasiQ9ES46 baseline and differential
GenevisibleiQ9ES46 MM

Family and domain databases

Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR028433 Parvin
PANTHERiPTHR12114 PTHR12114, 1 hit
PfamiView protein in Pfam
PF00307 CH, 2 hits
PIRSFiPIRSF039131 Parvin, 1 hit
SMARTiView protein in SMART
SM00033 CH, 2 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPARVB_MOUSE
AccessioniPrimary (citable) accession number: Q9ES46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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