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Protein

Forkhead box protein J2

Gene

Foxj2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Able to bind to two different type of DNA binding sites.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi66 – 143Fork-headPROSITE-ProRule annotationAdd BLAST78

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein J2
Alternative name(s):
Fork head homologous X
Gene namesi
Name:Foxj2
Synonyms:Fhx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1926805 Foxj2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000918542 – 565Forkhead box protein J2Add BLAST564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineBy similarity1
Modified residuei46PhosphoserineBy similarity1
Modified residuei161PhosphoserineBy similarity1
Modified residuei164PhosphoserineBy similarity1
Modified residuei172PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9ES18
PaxDbiQ9ES18
PRIDEiQ9ES18

PTM databases

iPTMnetiQ9ES18
PhosphoSitePlusiQ9ES18

Expressioni

Tissue specificityi

In embryos, both cell layers of the blastocyst: the trophectoderm (TE) and the inner cell mass (ICM) show expression. Expressed in adult brain, heart skeletal muscle, lung, kidney and gonads. Liver, small intestine, and spleen also show expression but at lower levels. In the testis, expressed from pachytene spermatocytes to round spermatids, but not in spermatogonia. In addition to the germ lineage, also expressed in Sertoli cells of the testis. In the ovary, only granulosa cells of the follicles show expression. In the brain, expressed in the piriform cortex, hippocampus, habenula and in the granula cell layer in the cerebellum.2 Publications

Developmental stagei

Expressed both maternally and zygotically. Zygotic expression first begins in 8-cell stage embryos, with expression increasing in blastocysts.1 Publication

Gene expression databases

BgeeiENSMUSG00000003154 Expressed in 312 organ(s), highest expression level in cardiac ventricle
CleanExiMM_FOXJ2
ExpressionAtlasiQ9ES18 baseline and differential
GenevisibleiQ9ES18 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208639, 1 interactor
STRINGi10090.ENSMUSP00000003238

Structurei

3D structure databases

ProteinModelPortaliQ9ES18
SMRiQ9ES18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi266 – 269Poly-Ser4
Compositional biasi290 – 296Poly-Gln7
Compositional biasi306 – 314Poly-Gln9

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00930000150834
HOGENOMiHOG000231184
HOVERGENiHBG051648
InParanoidiQ9ES18
KOiK09403
OMAiPSPMYPI
OrthoDBiEOG091G0U7S
PhylomeDBiQ9ES18
TreeFamiTF333250

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9ES18-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASDLESSLT SIDWLPQLTL RATIEKLGSA SQAGPPGGAR KCSPGSPTDP
60 70 80 90 100
NATLSKDEAA VHQDGKPRYS YATLITYAIN SSPAKKMTLS EIYRWICDNF
110 120 130 140 150
PYYKNAGIGW KNSIRHNLSL NKCFRKVPRP RDDPGKGSYW TIDTCPDISR
160 170 180 190 200
KRRHPPDDDL SQDSPEQEAS KSPRGGVPGS GEASLSHEGT PQMSLQSPSS
210 220 230 240 250
VANYSQGPGS VDGGAVAAGA PGQESTEGAP PLYNTNHDFK FSYSEINFQD
260 270 280 290 300
LSWSFRNLYK SMLERSSSSQ HGFSSLLGDM PPSNNYYVYQ QQQQQQPPPQ
310 320 330 340 350
PQPPPQQPQP QQQQAPTQGP SNVGGAPPLH TPSPDGCTTP GGKQAGAEGY
360 370 380 390 400
GPPTGMAMHP PPLQHGGYHP HQHHPHSHPA QQPPQPQAQS QASINSTGFA
410 420 430 440 450
FPPDWCSNID SLKESFKMVN RLNWSSIEQS QFSELMESLR QAEQRNWTLD
460 470 480 490 500
QHHIANLCDS LNHFLTQTGH MPQQGGSHRP PAPSRITDSC ALTSGKPEPS
510 520 530 540 550
MNQVNSYGHP QASHLYPGPA PMYPISTQDS AGYNRPAHHM VPRPPVPPPG
560
ANEEITDDFD WDLIT
Length:565
Mass (Da):61,570
Last modified:March 1, 2001 - v1
Checksum:i9178AFF3F9227AD4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SWA4A0A0N4SWA4_MOUSE
Forkhead box protein J2
Foxj2
205Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF253052 mRNA Translation: AAG30406.1
BC040395 mRNA Translation: AAH40395.1
CCDSiCCDS20503.1
RefSeqiNP_068699.1, NM_021899.3
UniGeneiMm.87142

Genome annotation databases

EnsembliENSMUST00000003238; ENSMUSP00000003238; ENSMUSG00000003154
ENSMUST00000177927; ENSMUSP00000137645; ENSMUSG00000003154
GeneIDi60611
KEGGimmu:60611
UCSCiuc012esh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF253052 mRNA Translation: AAG30406.1
BC040395 mRNA Translation: AAH40395.1
CCDSiCCDS20503.1
RefSeqiNP_068699.1, NM_021899.3
UniGeneiMm.87142

3D structure databases

ProteinModelPortaliQ9ES18
SMRiQ9ES18
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208639, 1 interactor
STRINGi10090.ENSMUSP00000003238

PTM databases

iPTMnetiQ9ES18
PhosphoSitePlusiQ9ES18

Proteomic databases

MaxQBiQ9ES18
PaxDbiQ9ES18
PRIDEiQ9ES18

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003238; ENSMUSP00000003238; ENSMUSG00000003154
ENSMUST00000177927; ENSMUSP00000137645; ENSMUSG00000003154
GeneIDi60611
KEGGimmu:60611
UCSCiuc012esh.1 mouse

Organism-specific databases

CTDi55810
MGIiMGI:1926805 Foxj2

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00930000150834
HOGENOMiHOG000231184
HOVERGENiHBG051648
InParanoidiQ9ES18
KOiK09403
OMAiPSPMYPI
OrthoDBiEOG091G0U7S
PhylomeDBiQ9ES18
TreeFamiTF333250

Miscellaneous databases

PROiPR:Q9ES18
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003154 Expressed in 312 organ(s), highest expression level in cardiac ventricle
CleanExiMM_FOXJ2
ExpressionAtlasiQ9ES18 baseline and differential
GenevisibleiQ9ES18 MM

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOXJ2_MOUSE
AccessioniPrimary (citable) accession number: Q9ES18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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