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UniProtKB - Q9ES07 (S15A2_MOUSE)

Entry version 117 (29 Sep 2021)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
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Protein

Solute carrier family 15 member 2

Gene

Slc15a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:11027540).

Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity).

Can also transport the aminocephalosporin antibiotic cefadroxil (By similarity).

Also able to transport carnosine (By similarity).

Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (PubMed:29784761).

Probably acts by mediating transport of bacterial peptidoglycans across the plasma membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (PubMed:29784761).

By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=56.6 µM for D-Phe-Ala (at pH 6.0)1 Publication

pH dependencei

Optimum pH is 6.0 or lower.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • dipeptide transmembrane transporter activity Source: UniProtKB
  • high-affinity oligopeptide transmembrane transporter activity Source: MGI
  • peptide:proton symporter activity Source: MGI
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Innate immunity, Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-427975, Proton/oligopeptide cotransporters

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.17.4.4, the proton-dependent oligopeptide transporter (pot/ptr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 15 member 2Curated
Alternative name(s):
Kidney H(+)/peptide cotransporterBy similarity
Oligopeptide transporter, kidney isoformBy similarity
Peptide transporter 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc15a2Imported
Synonyms:Pept21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1890457, Slc15a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 57CytoplasmicCuratedAdd BLAST57
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 87ExtracellularCurated9
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 113CytoplasmicCurated5
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 139ExtracellularCurated5
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161 – 183CytoplasmicCuratedAdd BLAST23
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 217ExtracellularCuratedAdd BLAST13
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 295CytoplasmicCuratedAdd BLAST57
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 343ExtracellularCuratedAdd BLAST27
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Topological domaini365 – 380CytoplasmicCuratedAdd BLAST16
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Topological domaini402 – 611ExtracellularCuratedAdd BLAST210
Transmembranei612 – 632HelicalSequence analysisAdd BLAST21
Topological domaini633 – 643CytoplasmicCuratedAdd BLAST11
Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
Topological domaini665 – 674ExtracellularCurated10
Transmembranei675 – 695HelicalSequence analysisAdd BLAST21
Topological domaini696 – 729CytoplasmicCuratedAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Decreased dipeptide uptake in bone marrow (PubMed:29784761). Decreased cytokine expression in response to LPS stimulation (PubMed:29784761).1 Publication

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2073678

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000643091 – 729Solute carrier family 15 member 2Add BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9PhosphoserineCombined sources1
Modified residuei12PhosphothreonineCombined sources1
Modified residuei28PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi448N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi472N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi528N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi587N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9ES07

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9ES07

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9ES07

PRoteomics IDEntifications database

More...PRIDEi		Q9ES07

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		253352

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9ES07, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9ES07

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9ES07

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9ES07

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in kidney brush border cells (at protein level) (PubMed:11027540). Highly expressed in macrophages (PubMed:29784761).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via extracellular domain region) with trypsin.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000023616

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9ES07, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 34DisorderedSequence analysisAdd BLAST34
Regioni402 – 611Extracellular domain (ECD)By similarityAdd BLAST210

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 16Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The extracellular domain (ECD) region specifically binds trypsin.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1237, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9ES07

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9ES07

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1250.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029028, Alpha/beta_knot_MTases
IPR036259, MFS_trans_sf
IPR004768, Oligopep_transport
IPR000109, POT_fam
IPR018456, PTR2_symporter_CS

The PANTHER Classification System

More...PANTHERi		PTHR11654, PTHR11654, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00854, PTR2, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit
SSF75217, SSF75217, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00926, 2A1704, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01022, PTR2_1, 1 hit
PS01023, PTR2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9ES07-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPFQKNESK ETLFSPVSTE EMLPGPPSPP KKSTPKLFGS SYPLSIAFIV 
        60         70         80         90        100
VNEFCERFSY YGMKAVLTLY FLYFLHWNED TSTSVYHAFS SLCYFTPILG 
       110        120        130        140        150
AAIADSWLGK FKTIIYLSLV YVLGHVFKSL GAIPILGGKM LHTILSLVGL 
       160        170        180        190        200
SLIALGTGGI KPCVAAFGGD QFEEEHAEAR TRYFSVFYLS INAGSLISTF 
       210        220        230        240        250
ITPMLRGDVK CFGEDCYALA FGIPGLLMVL ALVVFAMGSK MYRKPPPEGN 
       260        270        280        290        300
IVAQVTKCIW FAICNRFRNR SEDIPKRQHW LDWAAEKYPK HLIMDVKALT 
       310        320        330        340        350
RILFLYIPLP MFWALLDQQG SRWTLQANKM DGDLGFFVLQ PDQMQVLNPF 
       360        370        380        390        400
LVLVFIPLFD LVIYRLISKC GVNFSSLRKM AVGMILACLA FAVAALVEIK 
       410        420        430        440        450
INGMIHPQPA SQEIFLQVLN LADGEIEVTV QGNRNNPLLV ESISSFQNTT 
       460        470        480        490        500
HYSKLRLETK SQDLHFHLKY NNLSVHNEYS VEEKNCYQLV VHENGESLSS 
       510        520        530        540        550
MLVKDTGIKP ANGMTAIRFI NTLHKDMNIS LDANAPLSVG KDYGVSEYRT 
       560        570        580        590        600
VQRGKYPAVH CETEDNVFSL NLGQLDFGTT YLFVITNITN RGLQAWKAED 
       610        620        630        640        650
IPANKLSIAW QLPQYVLVTA AEVMFSVTGL EFSYSQAPSS MKSVLQAAWL 
       660        670        680        690        700
LTVAVGNIIV LIVAQFSGLV QWAEFVLFSC LLLVVCLIFS VMGYYYVPLK 
       710        720 
SEGIHEATEK QIPHIQGNMI NLETKNTRL
Length:729
Mass (Da):81,632
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3C9D3481B1F671C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9JM03Q9JM03_MOUSE
Proton-dependent high affinity olig...
Slc15a2
740Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q80XC0Q80XC0_MOUSE
Slc15a2 protein
Slc15a2
259Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PYQ9E9PYQ9_MOUSE
Solute carrier family 15 member 2
Slc15a2
709Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3XA51G3XA51_MOUSE
Solute carrier family 15 member 2
Slc15a2
189Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q0L2E9Q0L2_MOUSE
Solute carrier family 15 member 2
Slc15a2
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF257711 Genomic DNA Translation: AAG25926.1

Protein sequence database of the Protein Information Resource

More...PIRi		JC7501

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257711 Genomic DNA Translation: AAG25926.1
PIRiJC7501

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023616

Chemistry databases

ChEMBLiCHEMBL2073678

Protein family/group databases

TCDBi2.A.17.4.4, the proton-dependent oligopeptide transporter (pot/ptr) family

PTM databases

GlyGeniQ9ES07, 4 sites
iPTMnetiQ9ES07
PhosphoSitePlusiQ9ES07
SwissPalmiQ9ES07

Proteomic databases

jPOSTiQ9ES07
MaxQBiQ9ES07
PaxDbiQ9ES07
PRIDEiQ9ES07
ProteomicsDBi253352

Organism-specific databases

MGIiMGI:1890457, Slc15a2

Phylogenomic databases

eggNOGiKOG1237, Eukaryota
InParanoidiQ9ES07
PhylomeDBiQ9ES07

Enzyme and pathway databases

ReactomeiR-MMU-427975, Proton/oligopeptide cotransporters

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Slc15a2, mouse

Protein Ontology

More...PROi		PR:Q9ES07
RNActiQ9ES07, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Family and domain databases

Gene3Di1.20.1250.20, 2 hits
InterProiView protein in InterPro
IPR029028, Alpha/beta_knot_MTases
IPR036259, MFS_trans_sf
IPR004768, Oligopep_transport
IPR000109, POT_fam
IPR018456, PTR2_symporter_CS
PANTHERiPTHR11654, PTHR11654, 1 hit
PfamiView protein in Pfam
PF00854, PTR2, 2 hits
SUPFAMiSSF103473, SSF103473, 1 hit
SSF75217, SSF75217, 1 hit
TIGRFAMsiTIGR00926, 2A1704, 1 hit
PROSITEiView protein in PROSITE
PS01022, PTR2_1, 1 hit
PS01023, PTR2_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS15A2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ES07
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2001
Last modified: September 29, 2021
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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