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UniProtKB - Q9ES07 (S15A2_MOUSE)

Entry version 114 (02 Dec 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Solute carrier family 15 member 2

Gene

Slc15a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:11027540). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Can also transport the aminocephalosporin antibiotic cefadroxil (By similarity). Also able to transport carnosine (By similarity). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (PubMed:29784761). Probably acts by mediating transport of bacterial peptidoglycans across the plasma membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (PubMed:29784761).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=56.6 µM for D-Phe-Ala (at pH 6.0)1 Publication

    pH dependencei

    Optimum pH is 6.0 or lower.1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • dipeptide transmembrane transporter activity Source: UniProtKB
    • high-affinity oligopeptide transmembrane transporter activity Source: MGI
    • peptide:proton symporter activity Source: MGI
    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processImmunity, Innate immunity, Peptide transport, Protein transport, Symport, Transport

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-MMU-427975, Proton/oligopeptide cotransporters

    Protein family/group databases

    Transport Classification Database

    More...    TCDBi    		2.A.17.4.4, the proton-dependent oligopeptide transporter (pot/ptr) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Solute carrier family 15 member 2Curated
    Alternative name(s):
    Kidney H(+)/peptide cotransporterBy similarity
    Oligopeptide transporter, kidney isoformBy similarity
    Peptide transporter 21 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Slc15a2Imported
    Synonyms:Pept21 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...    MGIi    		MGI:1890457, Slc15a2

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 57CytoplasmicCuratedAdd BLAST57
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
    Topological domaini79 – 87ExtracellularCurated9
    Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
    Topological domaini109 – 113CytoplasmicCurated5
    Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
    Topological domaini135 – 139ExtracellularCurated5
    Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
    Topological domaini161 – 183CytoplasmicCuratedAdd BLAST23
    Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
    Topological domaini205 – 217ExtracellularCuratedAdd BLAST13
    Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
    Topological domaini239 – 295CytoplasmicCuratedAdd BLAST57
    Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
    Topological domaini317 – 343ExtracellularCuratedAdd BLAST27
    Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
    Topological domaini365 – 380CytoplasmicCuratedAdd BLAST16
    Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
    Topological domaini402 – 611ExtracellularCuratedAdd BLAST210
    Transmembranei612 – 632HelicalSequence analysisAdd BLAST21
    Topological domaini633 – 643CytoplasmicCuratedAdd BLAST11
    Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
    Topological domaini665 – 674ExtracellularCurated10
    Transmembranei675 – 695HelicalSequence analysisAdd BLAST21
    Topological domaini696 – 729CytoplasmicCuratedAdd BLAST34

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Decreased dipeptide uptake in bone marrow (PubMed:29784761). Decreased cytokine expression in response to LPS stimulation (PubMed:29784761).1 Publication

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL2073678

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000643091 – 729Solute carrier family 15 member 2Add BLAST729

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9PhosphoserineCombined sources1
    Modified residuei12PhosphothreonineCombined sources1
    Modified residuei28PhosphoserineBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi448N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Glycosylationi472N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Glycosylationi528N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Glycosylationi587N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		Q9ES07

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		Q9ES07

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q9ES07

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q9ES07

    PTM databases

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...    GlyGeni    		Q9ES07, 4 sites

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q9ES07

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q9ES07

    SwissPalm database of S-palmitoylation events

    More...    SwissPalmi    		Q9ES07

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in kidney brush border cells (at protein level) (PubMed:11027540). Highly expressed in macrophages (PubMed:29784761).2 Publications

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts (via extracellular domain region) with trypsin.

    By similarity

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...    STRINGi    		10090.ENSMUSP00000023616

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q9ES07, protein

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni402 – 611Extracellular domain (ECD)By similarityAdd BLAST210

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The extracellular domain (ECD) region specifically binds trypsin.By similarity

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. [View classification]Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG1237, Eukaryota

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q9ES07

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q9ES07

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR029028, Alpha/beta_knot_MTases
    IPR036259, MFS_trans_sf
    IPR004768, Oligopep_transport
    IPR000109, POT_fam
    IPR018456, PTR2_symporter_CS

    The PANTHER Classification System

    More...    PANTHERi    		PTHR11654, PTHR11654, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00854, PTR2, 2 hits

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF103473, SSF103473, 1 hit
    SSF75217, SSF75217, 1 hit

    TIGRFAMs; a protein family database

    More...    TIGRFAMsi    		TIGR00926, 2A1704, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS01022, PTR2_1, 1 hit
    PS01023, PTR2_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

    Q9ES07-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MNPFQKNESK ETLFSPVSTE EMLPGPPSPP KKSTPKLFGS SYPLSIAFIV 
            60         70         80         90        100
    VNEFCERFSY YGMKAVLTLY FLYFLHWNED TSTSVYHAFS SLCYFTPILG 
           110        120        130        140        150
    AAIADSWLGK FKTIIYLSLV YVLGHVFKSL GAIPILGGKM LHTILSLVGL 
           160        170        180        190        200
    SLIALGTGGI KPCVAAFGGD QFEEEHAEAR TRYFSVFYLS INAGSLISTF 
           210        220        230        240        250
    ITPMLRGDVK CFGEDCYALA FGIPGLLMVL ALVVFAMGSK MYRKPPPEGN 
           260        270        280        290        300
    IVAQVTKCIW FAICNRFRNR SEDIPKRQHW LDWAAEKYPK HLIMDVKALT 
           310        320        330        340        350
    RILFLYIPLP MFWALLDQQG SRWTLQANKM DGDLGFFVLQ PDQMQVLNPF 
           360        370        380        390        400
    LVLVFIPLFD LVIYRLISKC GVNFSSLRKM AVGMILACLA FAVAALVEIK 
           410        420        430        440        450
    INGMIHPQPA SQEIFLQVLN LADGEIEVTV QGNRNNPLLV ESISSFQNTT 
           460        470        480        490        500
    HYSKLRLETK SQDLHFHLKY NNLSVHNEYS VEEKNCYQLV VHENGESLSS 
           510        520        530        540        550
    MLVKDTGIKP ANGMTAIRFI NTLHKDMNIS LDANAPLSVG KDYGVSEYRT 
           560        570        580        590        600
    VQRGKYPAVH CETEDNVFSL NLGQLDFGTT YLFVITNITN RGLQAWKAED 
           610        620        630        640        650
    IPANKLSIAW QLPQYVLVTA AEVMFSVTGL EFSYSQAPSS MKSVLQAAWL 
           660        670        680        690        700
    LTVAVGNIIV LIVAQFSGLV QWAEFVLFSC LLLVVCLIFS VMGYYYVPLK 
           710        720 
    SEGIHEATEK QIPHIQGNMI NLETKNTRL
    Length:729
    Mass (Da):81,632
    Last modified:March 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3C9D3481B1F671C
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    E9QMN8E9QMN8_MOUSE
    Solute carrier family 15 member 2
    Slc15a2
    		740Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PYQ9E9PYQ9_MOUSE
    Solute carrier family 15 member 2
    Slc15a2
    		709Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9Q329E9Q329_MOUSE
    Solute carrier family 15 member 2
    Slc15a2
    		259Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    G3XA51G3XA51_MOUSE
    Solute carrier family 15 member 2
    Slc15a2
    		189Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9Q0L2E9Q0L2_MOUSE
    Solute carrier family 15 member 2
    Slc15a2
    		84Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AF257711 Genomic DNA Translation: AAG25926.1

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		JC7501

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AF257711 Genomic DNA Translation: AAG25926.1
    PIRiJC7501

    3D structure databases

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    SWISS-MODEL Interactive Workspace

    More...    SWISS-MODEL-Workspacei    		Submit a new modelling project...

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000023616

    Chemistry databases

    ChEMBLiCHEMBL2073678

    Protein family/group databases

    TCDBi2.A.17.4.4, the proton-dependent oligopeptide transporter (pot/ptr) family

    PTM databases

    GlyGeniQ9ES07, 4 sites
    iPTMnetiQ9ES07
    PhosphoSitePlusiQ9ES07
    SwissPalmiQ9ES07

    Proteomic databases

    jPOSTiQ9ES07
    MaxQBiQ9ES07
    PaxDbiQ9ES07
    PRIDEiQ9ES07

    Organism-specific databases

    MGIiMGI:1890457, Slc15a2

    Phylogenomic databases

    eggNOGiKOG1237, Eukaryota
    InParanoidiQ9ES07
    PhylomeDBiQ9ES07

    Enzyme and pathway databases

    ReactomeiR-MMU-427975, Proton/oligopeptide cotransporters

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		Slc15a2, mouse

    Protein Ontology

    More...    PROi    		PR:Q9ES07
    RNActiQ9ES07, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Family and domain databases

    InterProiView protein in InterPro
    IPR029028, Alpha/beta_knot_MTases
    IPR036259, MFS_trans_sf
    IPR004768, Oligopep_transport
    IPR000109, POT_fam
    IPR018456, PTR2_symporter_CS
    PANTHERiPTHR11654, PTHR11654, 1 hit
    PfamiView protein in Pfam
    PF00854, PTR2, 2 hits
    SUPFAMiSSF103473, SSF103473, 1 hit
    SSF75217, SSF75217, 1 hit
    TIGRFAMsiTIGR00926, 2A1704, 1 hit
    PROSITEiView protein in PROSITE
    PS01022, PTR2_1, 1 hit
    PS01023, PTR2_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS15A2_MOUSE
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ES07
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: March 1, 2001
    Last modified: December 2, 2020
    This is version 114 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families
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