Ubiquitin conjugation factor E4 B

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication

  Manual assertion based on experiment inⁱ

  • Ref.6

    "U box proteins as a new family of ubiquitin-protein ligases."
    Hatakeyama S., Yada M., Matsumoto M., Ishida N., Nakayama K.I.
    J. Biol. Chem. 276:33111-33120(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, CATALYTIC ACTIVITY, PATHWAY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DOMAIN, MUTAGENESIS OF PRO-1140.

  EC:2.3.2.27

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATPase binding Source: MGI
• ATP binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis."
    Starita L.M., Pruneda J.N., Lo R.S., Fowler D.M., Kim H.J., Hiatt J.B., Shendure J., Brzovic P.S., Fields S., Klevit R.E.
    Proc Natl Acad Sci U S A 110:E1263-72(2013) [PubMed] [Europe PMC] [Abstract]
• enzyme binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.2

    "Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a."
    Kaneko C., Hatakeyama S., Matsumoto M., Yada M., Nakayama K., Nakayama K.
    Biochem. Biophys. Res. Commun. 300:297-304(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INTERACTION WITH VCP, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• ubiquitin protein ligase activity Source: MGIInferred from direct assayⁱ
  • Ref.6

    "U box proteins as a new family of ubiquitin-protein ligases."
    Hatakeyama S., Yada M., Matsumoto M., Ishida N., Nakayama K.I.
    J. Biol. Chem. 276:33111-33120(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, CATALYTIC ACTIVITY, PATHWAY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DOMAIN, MUTAGENESIS OF PRO-1140.
  • "Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis."
    Okumura F., Hatakeyama S., Matsumoto M., Kamura T., Nakayama K.
    J. Biol. Chem. 279:53533-53543(2004) [PubMed] [Europe PMC] [Abstract]
  • "Structural and functional characterization of the monomeric U-box domain from E4B."
    Nordquist K.A., Dimitrova Y.N., Brzovic P.S., Ridenour W.B., Munro K.A., Soss S.E., Caprioli R.M., Klevit R.E., Chazin W.J.
    Biochemistry 49:347-355(2010) [PubMed] [Europe PMC] [Abstract]
  • "Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis."
    Starita L.M., Pruneda J.N., Lo R.S., Fowler D.M., Kim H.J., Hiatt J.B., Shendure J., Brzovic P.S., Fields S., Klevit R.E.
    Proc Natl Acad Sci U S A 110:E1263-72(2013) [PubMed] [Europe PMC] [Abstract]
• ubiquitin-ubiquitin ligase activity Source: MGIInferred from direct assayⁱ
  • Ref.6

    "U box proteins as a new family of ubiquitin-protein ligases."
    Hatakeyama S., Yada M., Matsumoto M., Ishida N., Nakayama K.I.
    J. Biol. Chem. 276:33111-33120(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, CATALYTIC ACTIVITY, PATHWAY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DOMAIN, MUTAGENESIS OF PRO-1140.
  • "Structural and functional characterization of the monomeric U-box domain from E4B."
    Nordquist K.A., Dimitrova Y.N., Brzovic P.S., Ridenour W.B., Munro K.A., Soss S.E., Caprioli R.M., Klevit R.E., Chazin W.J.
    Biochemistry 49:347-355(2010) [PubMed] [Europe PMC] [Abstract]
• unfolded protein binding Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • Ref.2

    "Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a."
    Kaneko C., Hatakeyama S., Matsumoto M., Yada M., Nakayama K., Nakayama K.
    Biochem. Biophys. Res. Commun. 300:297-304(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INTERACTION WITH VCP, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

GO - Biological processⁱ

• cellular protein catabolic process Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Mammalian E4 is required for cardiac development and maintenance of the nervous system."
    Kaneko-Oshikawa C., Nakagawa T., Yamada M., Yoshikawa H., Matsumoto M., Yada M., Hatakeyama S., Nakayama K., Nakayama K.I.
    Mol Cell Biol 25:10953-10964(2005) [PubMed] [Europe PMC] [Abstract]
• granzyme-mediated apoptotic signaling pathway Source: UniProtKB
• neuron projection development Source: MGIInferred from mutant phenotypeⁱ
  • "Mammalian E4 is required for cardiac development and maintenance of the nervous system."
    Kaneko-Oshikawa C., Nakagawa T., Yamada M., Yoshikawa H., Matsumoto M., Yada M., Hatakeyama S., Nakayama K., Nakayama K.I.
    Mol Cell Biol 25:10953-10964(2005) [PubMed] [Europe PMC] [Abstract]
• proteasome-mediated ubiquitin-dependent protein catabolic process Source: MGIInferred from sequence orthologyⁱ
  • "Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis."
    Starita L.M., Pruneda J.N., Lo R.S., Fowler D.M., Kim H.J., Hiatt J.B., Shendure J., Brzovic P.S., Fields S., Klevit R.E.
    Proc Natl Acad Sci U S A 110:E1263-72(2013) [PubMed] [Europe PMC] [Abstract]
• protein autoubiquitination Source: MGIInferred from direct assayⁱ
  • "Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis."
    Starita L.M., Pruneda J.N., Lo R.S., Fowler D.M., Kim H.J., Hiatt J.B., Shendure J., Brzovic P.S., Fields S., Klevit R.E.
    Proc Natl Acad Sci U S A 110:E1263-72(2013) [PubMed] [Europe PMC] [Abstract]
• protein folding Source: UniProtKBNon-traceable author statementⁱ
  • Ref.2

    "Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a."
    Kaneko C., Hatakeyama S., Matsumoto M., Yada M., Nakayama K., Nakayama K.
    Biochem. Biophys. Res. Commun. 300:297-304(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INTERACTION WITH VCP, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• protein monoubiquitination Source: MGIInferred from direct assayⁱ
  • "Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis."
    Starita L.M., Pruneda J.N., Lo R.S., Fowler D.M., Kim H.J., Hiatt J.B., Shendure J., Brzovic P.S., Fields S., Klevit R.E.
    Proc Natl Acad Sci U S A 110:E1263-72(2013) [PubMed] [Europe PMC] [Abstract]
• protein polyubiquitination Source: MGIInferred from direct assayⁱ
  • Ref.6

    "U box proteins as a new family of ubiquitin-protein ligases."
    Hatakeyama S., Yada M., Matsumoto M., Ishida N., Nakayama K.I.
    J. Biol. Chem. 276:33111-33120(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, CATALYTIC ACTIVITY, PATHWAY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DOMAIN, MUTAGENESIS OF PRO-1140.
  • "Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis."
    Starita L.M., Pruneda J.N., Lo R.S., Fowler D.M., Kim H.J., Hiatt J.B., Shendure J., Brzovic P.S., Fields S., Klevit R.E.
    Proc Natl Acad Sci U S A 110:E1263-72(2013) [PubMed] [Europe PMC] [Abstract]
• protein ubiquitination Source: MGIInferred from direct assayⁱ
  • "Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis."
    Okumura F., Hatakeyama S., Matsumoto M., Kamura T., Nakayama K.
    J. Biol. Chem. 279:53533-53543(2004) [PubMed] [Europe PMC] [Abstract]
• response to endoplasmic reticulum stress Source: MGIInferred from mutant phenotypeⁱ
  • "Mammalian E4 is required for cardiac development and maintenance of the nervous system."
    Kaneko-Oshikawa C., Nakagawa T., Yamada M., Yoshikawa H., Matsumoto M., Yada M., Hatakeyama S., Nakayama K., Nakayama K.I.
    Mol Cell Biol 25:10953-10964(2005) [PubMed] [Europe PMC] [Abstract]
• response to UV Source: UniProtKB
• ubiquitin-dependent ERAD pathway Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• ubiquitin-dependent protein catabolic process Source: MGIInferred from mutant phenotypeⁱ
  • "Mammalian E4 is required for cardiac development and maintenance of the nervous system."
    Kaneko-Oshikawa C., Nakagawa T., Yamada M., Yoshikawa H., Matsumoto M., Yada M., Hatakeyama S., Nakayama K., Nakayama K.I.
    Mol Cell Biol 25:10953-10964(2005) [PubMed] [Europe PMC] [Abstract]
• ventricular trabecula myocardium morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Mammalian E4 is required for cardiac development and maintenance of the nervous system."
    Kaneko-Oshikawa C., Nakagawa T., Yamada M., Yoshikawa H., Matsumoto M., Yada M., Hatakeyama S., Nakayama K., Nakayama K.I.
    Mol Cell Biol 25:10953-10964(2005) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Sites

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• ATPase binding Source: MGI
• enzyme binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.2

    "Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a."
    Kaneko C., Hatakeyama S., Matsumoto M., Yada M., Nakayama K., Nakayama K.
    Biochem. Biophys. Res. Commun. 300:297-304(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INTERACTION WITH VCP, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• unfolded protein binding Source: UniProtKBNon-traceable author statementⁱ
  • Ref.2

    "Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a."
    Kaneko C., Hatakeyama S., Matsumoto M., Yada M., Nakayama K., Nakayama K.
    Biochem. Biophys. Res. Commun. 300:297-304(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INTERACTION WITH VCP, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MEELSADEIR RRRLARLAGG QTSQPTTPLT SPQRENPPGP PIAASAPGPS 
        60         70         80         90        100
QSLGLNVHNM TPATSPIGAA GVAHRSQSSE GVSSLSSSPS NSLETQSQSL 
       110        120        130        140        150
SRSQSMDIDG VSCEKSMSQV DVDSGIENME VDENDRREKR SLSDKEPSSG 
       160        170        180        190        200
PEVSEEQALQ LVCKIFRVSW KDRDRDVIFL SSLSAQFKQN PKEVFSDFKD 
       210        220        230        240        250
LIGQILMEVL MMSTQTRDEN PFASLTATSQ PIATAARSPD RNLMLNTGSS 
       260        270        280        290        300
SGTSPMFCNM GSFSTSSLSS LGASGGASNW DSYSDHFTIE TCKETDMLNY 
       310        320        330        340        350
LIECFDRVGI EEKKAPKMCS QPAVSQLLSN IRSQCISHTA LVLQGSLTQP 
       360        370        380        390        400
RSLQQPSFLV PYMLCRNLPY GFIQELVRTT HQDEEVFKQI FIPILQGLAL 
       410        420        430        440        450
AAKECSLESD YFKYPLMALG ELCETKFGKT HPMCNLVASL PLWLPKSLSP 
       460        470        480        490        500
GSGRELQRLS YLGAFFSFSV FAEDDAKVVE KYFSGPAITL ENTRVVSQSL 
       510        520        530        540        550
QHYLELGRQE LFKILHSILL NGETREAALS YMAALVNANM KKAQMQADDR 
       560        570        580        590        600
LVSTDGFMLN LLWVLQQLST KIKLETVDPT YIFHPRCRIT LPNDETRINA 
       610        620        630        640        650
TMEDVNERLT ELYGDQPPFS EPKFPTECFF LTLHAHHLSI LPSCRRYIRR 
       660        670        680        690        700
LRAIRELNRT VEDLKNNESQ WKDSPLATRH REMLKRCKTQ LKKLVRCKAC 
       710        720        730        740        750
ADAGLLDESF LRRCLNFYGL LIQLMLRILD PAYPDVTLPL NSEVPKVFAA 
       760        770        780        790        800
LPEFYVEDVA EFLFFIVQYS PQVLYEPCTQ DIVMFLVVML CNQNYIRNPY 
       810        820        830        840        850
LVAKLVEVMF MTNPSVQPRT QKFFEMIENH PLSTKLLVPS LMKFYTDVEH 
       860        870        880        890        900
TGATSEFYDK FTIRYHISTI FKSLWQNIAH HGTFMEEFNS GKQFVRYINM 
       910        920        930        940        950
LINDTTFLLD ESLESLKRIH EVQEEMKNKE QWDQLPRDQQ QARQSQLAQD 
       960        970        980        990       1000
ERVSRSYLAL ATETVDMFHL LTKQVQKPFL RPELGPRLAA MLNFNLQQLC 
      1010       1020       1030       1040       1050
GPKCRDLKVE NPEKYGFEPK KLLDQLTDIY LQLDCARFAK AIADDQRSYS 
      1060       1070       1080       1090       1100
KELFEEVISK MRKAGIKSTI AIEKFKLLAE KVEEIVAKNA RAEIDYSDAP 
      1110       1120       1130       1140       1150
DEFRDPLMDT LMTDPVRLPS GTVMDRSIIL RHLLNSPTDP FNRQMLTESM 
      1160       1170 
LEPVPELKEQ IQAWMREKQS SDH                              

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PATHWAY comments
   Index of metabolic and biosynthesis pathways
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
4. SIMILARITY comments
   Index of protein domains and families