UniProtKB - Q9ES00 (UBE4B_MOUSE)

BLAST

>sp|Q9ES00|UBE4B_MOUSE Ubiquitin conjugation factor E4 B OS=Mus musculus OX=10090 GN=Ube4b PE=1 SV=3
MEELSADEIRRRRLARLAGGQTSQPTTPLTSPQRENPPGPPIAASAPGPSQSLGLNVHNM
TPATSPIGAAGVAHRSQSSEGVSSLSSSPSNSLETQSQSLSRSQSMDIDGVSCEKSMSQV
DVDSGIENMEVDENDRREKRSLSDKEPSSGPEVSEEQALQLVCKIFRVSWKDRDRDVIFL
SSLSAQFKQNPKEVFSDFKDLIGQILMEVLMMSTQTRDENPFASLTATSQPIATAARSPD
RNLMLNTGSSSGTSPMFCNMGSFSTSSLSSLGASGGASNWDSYSDHFTIETCKETDMLNY
LIECFDRVGIEEKKAPKMCSQPAVSQLLSNIRSQCISHTALVLQGSLTQPRSLQQPSFLV
PYMLCRNLPYGFIQELVRTTHQDEEVFKQIFIPILQGLALAAKECSLESDYFKYPLMALG
ELCETKFGKTHPMCNLVASLPLWLPKSLSPGSGRELQRLSYLGAFFSFSVFAEDDAKVVE
KYFSGPAITLENTRVVSQSLQHYLELGRQELFKILHSILLNGETREAALSYMAALVNANM
KKAQMQADDRLVSTDGFMLNLLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRINA
TMEDVNERLTELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRT
VEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGL
LIQLMLRILDPAYPDVTLPLNSEVPKVFAALPEFYVEDVAEFLFFIVQYSPQVLYEPCTQ
DIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPSVQPRTQKFFEMIENHPLSTKLLVPS
LMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINM
LINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLAL
ATETVDMFHLLTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPK
KLLDQLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAE
KVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTVMDRSIILRHLLNSPTDP
FNRQMLTESMLEPVPELKEQIQAWMREKQSSDH

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History
Entry version 140 (12 Sep 2018)
Sequence version 3 (27 Jul 2011)
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Protein

Ubiquitin conjugation factor E4 B

Gene

Ube4b

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (PubMed:11435423). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (By similarity).By similarity1 Publication

Miscellaneous

Catalytic activityⁱ

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein catabolic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 16314518
granzyme-mediated apoptotic signaling pathway Source: UniProtKB
neuron projection development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16314518
proteasome-mediated ubiquitin-dependent protein catabolic process
Source: MGI
Inferred from sequence orthologyⁱ
- 23509263
protein autoubiquitination
Source: MGI
Inferred from direct assayⁱ
- 23509263
protein folding
Source: UniProtKB
Non-traceable author statementⁱ
- 12504083
protein monoubiquitination
Source: MGI
Inferred from direct assayⁱ
- 23509263
protein polyubiquitination
Source: MGI
Inferred from direct assayⁱ
- 11435423
- 23509263
protein ubiquitination
Source: MGI
Inferred from direct assayⁱ
- 15466860
response to endoplasmic reticulum stress
Source: MGI
Inferred from mutant phenotypeⁱ
- 16314518
response to UV Source: UniProtKB
ubiquitin-dependent ERAD pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ubiquitin-dependent protein catabolic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 16314518
ventricular trabecula myocardium morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 16314518

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Ubl conjugation pathway

Enzyme and pathway databases

BRENDAⁱ	2.3.2.B12 3474
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ubiquitin conjugation factor E4 BCurated (EC:2.3.2.271 Publication) Alternative name(s): RING-type E3 ubiquitin transferase E4 B Ubiquitin fusion degradation protein 21 Publication
Gene namesⁱ	Name:Ube4bImported Synonyms:Ufd2Imported, Ufd2aImported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:1927086 Ube4b

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	1140	P → A: Loss of E3 ubiquitin protein ligase activity. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000194994	1 – 1173	Ubiquitin conjugation factor E4 BAdd BLAST		1173

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Modified residueⁱ	23	PhosphoserineBy similarity	1
Modified residueⁱ	31	PhosphoserineCombined sources	1
Modified residueⁱ	84	PhosphoserineBy similarity	1
Modified residueⁱ	88	PhosphoserineCombined sources	1
Modified residueⁱ	90	PhosphoserineCombined sources	1
Modified residueⁱ	101	PhosphoserineCombined sources	1
Modified residueⁱ	103	PhosphoserineCombined sources	1
Modified residueⁱ	105	PhosphoserineBy similarity	1
Modified residueⁱ	124	PhosphoserineBy similarity	1
Modified residueⁱ	238	PhosphoserineBy similarity	1
Modified residueⁱ	674	PhosphoserineCombined sources	1
Modified residueⁱ	840	PhosphoserineCombined sources	1
Modified residueⁱ	1136	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-7 (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	109 – 110	Cleavage; by caspase-3 and caspase-7By similarity		2
Siteⁱ	123 – 124	Cleavage; by caspase-6 and granzyme BBy similarity		2

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9ES00
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9ES00
PaxDbⁱ	Q9ES00
PeptideAtlas More...PeptideAtlasⁱ	Q9ES00
PRIDEⁱ	Q9ES00

PTM databases

iPTMnetⁱ	Q9ES00
PhosphoSitePlusⁱ	Q9ES00

Expressionⁱ

Tissue specificityⁱ

Expressed predominantly in neuronal tissues. Also detected in liver, heart, brain, kidney and testis.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000028960 Expressed in 335 organ(s), highest expression level in cumulus cell
ExpressionAtlasⁱ	Q9ES00 baseline and differential
Genevisibleⁱ	Q9ES00 MM

Interactionⁱ

Subunit structureⁱ

Interacts with VCP (PubMed:12504083). Interacts with STUB1/CHIP and UNC45B (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

ATPase binding Source: MGI
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12504083
unfolded protein binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12504083

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	211009, 8 interactors
IntActⁱ	Q9ES00, 2 interactors
STRINGⁱ	10090.ENSMUSP00000099501

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	1101 – 1103	Combined sources	3
Turnⁱ	1106 – 1108	Combined sources	3
Beta strandⁱ	1113 – 1117	Combined sources	5
Beta strandⁱ	1123 – 1125	Combined sources	3
Helixⁱ	1126 – 1135	Combined sources	10
Turnⁱ	1140 – 1142	Combined sources	3
Helixⁱ	1148 – 1150	Combined sources	3
Helixⁱ	1155 – 1170	Combined sources	16

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9ES00
SMRⁱ	Q9ES00
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1098 – 1171	U-boxAdd BLAST		74

Domainⁱ

The U-box domain is required for the ubiquitin protein ligase activity.1 Publication

Sequence similaritiesⁱ

Belongs to the ubiquitin conjugation factor E4 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2042 Eukaryota COG5113 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009300
HOVERGENⁱ	HBG058129
InParanoidⁱ	Q9ES00
KEGG Orthology (KO) More...KOⁱ	K10597
OMAⁱ	AMWNHEL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02B4
TreeFamⁱ	TF300802

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR019474 Ub_conjug_fac_E4_core IPR003613 Ubox_domain IPR013083 Znf_RING/FYVE/PHD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04564 U-box, 1 hit PF10408 Ufd2P_core, 1 hit
SMARTⁱ	View protein in SMART SM00504 Ubox, 1 hit
PROSITEⁱ	View protein in PROSITE PS51698 U_BOX, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q9ES00-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEELSADEIR RRRLARLAGG QTSQPTTPLT SPQRENPPGP PIAASAPGPS 
        60         70         80         90        100
QSLGLNVHNM TPATSPIGAA GVAHRSQSSE GVSSLSSSPS NSLETQSQSL 
       110        120        130        140        150
SRSQSMDIDG VSCEKSMSQV DVDSGIENME VDENDRREKR SLSDKEPSSG 
       160        170        180        190        200
PEVSEEQALQ LVCKIFRVSW KDRDRDVIFL SSLSAQFKQN PKEVFSDFKD 
       210        220        230        240        250
LIGQILMEVL MMSTQTRDEN PFASLTATSQ PIATAARSPD RNLMLNTGSS 
       260        270        280        290        300
SGTSPMFCNM GSFSTSSLSS LGASGGASNW DSYSDHFTIE TCKETDMLNY 
       310        320        330        340        350
LIECFDRVGI EEKKAPKMCS QPAVSQLLSN IRSQCISHTA LVLQGSLTQP 
       360        370        380        390        400
RSLQQPSFLV PYMLCRNLPY GFIQELVRTT HQDEEVFKQI FIPILQGLAL 
       410        420        430        440        450
AAKECSLESD YFKYPLMALG ELCETKFGKT HPMCNLVASL PLWLPKSLSP 
       460        470        480        490        500
GSGRELQRLS YLGAFFSFSV FAEDDAKVVE KYFSGPAITL ENTRVVSQSL 
       510        520        530        540        550
QHYLELGRQE LFKILHSILL NGETREAALS YMAALVNANM KKAQMQADDR 
       560        570        580        590        600
LVSTDGFMLN LLWVLQQLST KIKLETVDPT YIFHPRCRIT LPNDETRINA 
       610        620        630        640        650
TMEDVNERLT ELYGDQPPFS EPKFPTECFF LTLHAHHLSI LPSCRRYIRR 
       660        670        680        690        700
LRAIRELNRT VEDLKNNESQ WKDSPLATRH REMLKRCKTQ LKKLVRCKAC 
       710        720        730        740        750
ADAGLLDESF LRRCLNFYGL LIQLMLRILD PAYPDVTLPL NSEVPKVFAA 
       760        770        780        790        800
LPEFYVEDVA EFLFFIVQYS PQVLYEPCTQ DIVMFLVVML CNQNYIRNPY 
       810        820        830        840        850
LVAKLVEVMF MTNPSVQPRT QKFFEMIENH PLSTKLLVPS LMKFYTDVEH 
       860        870        880        890        900
TGATSEFYDK FTIRYHISTI FKSLWQNIAH HGTFMEEFNS GKQFVRYINM 
       910        920        930        940        950
LINDTTFLLD ESLESLKRIH EVQEEMKNKE QWDQLPRDQQ QARQSQLAQD 
       960        970        980        990       1000
ERVSRSYLAL ATETVDMFHL LTKQVQKPFL RPELGPRLAA MLNFNLQQLC 
      1010       1020       1030       1040       1050
GPKCRDLKVE NPEKYGFEPK KLLDQLTDIY LQLDCARFAK AIADDQRSYS 
      1060       1070       1080       1090       1100
KELFEEVISK MRKAGIKSTI AIEKFKLLAE KVEEIVAKNA RAEIDYSDAP 
      1110       1120       1130       1140       1150
DEFRDPLMDT LMTDPVRLPS GTVMDRSIIL RHLLNSPTDP FNRQMLTESM 
      1160       1170 
LEPVPELKEQ IQAWMREKQS SDH

Length:1,173

Mass (Da):133,318

Last modified:July 27, 2011 - v3

Checksum:ⁱFC4879E47672E983

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3UZD6	G3UZD6_MOUSE	Ubiquitin conjugation factor E4 B Ubiquitin conjugation factor E4 B	Ube4b	998	Annotation score:
H7BXC2	H7BXC2_MOUSE	Ubiquitin conjugation factor E4 B Ubiquitin conjugation factor E4 B	Ube4b	128	Annotation score:
G3UZM6	G3UZM6_MOUSE	Ubiquitin conjugation factor E4 B Ubiquitin conjugation factor E4 B	Ube4b	409	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	298	L → P in AAG17287 (PubMed:11027338).Curated	1
Sequence conflictⁱ	408	E → D in AAG17287 (PubMed:11027338).Curated	1
Sequence conflictⁱ	408	E → D in BAC56586 (PubMed:12504083).Curated	1
Sequence conflictⁱ	674	S → T in BAC26672 (PubMed:16141072).Curated	1
Sequence conflictⁱ	697	C → Y in AAG17287 (PubMed:11027338).Curated	1
Sequence conflictⁱ	753	E → K in BAC26672 (PubMed:16141072).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF260924 mRNA Translation: AAG17285.1 Different termination. AF260926 mRNA Translation: AAG17287.1 AF260927 Genomic DNA Translation: AAG38492.1 AB083274 Genomic DNA Translation: BAC56586.1 AK029914 mRNA Translation: BAC26672.1 AL606973 Genomic DNA Translation: CAM16303.1 BC075620 mRNA Translation: AAH75620.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18958.1
NCBI Reference Sequences More...RefSeqⁱ	NP_071305.2, NM_022022.3
UniGeneⁱ	Mm.415260 Mm.478205

Genome annotation databases

Ensemblⁱ	ENSMUST00000103212; ENSMUSP00000099501; ENSMUSG00000028960
GeneIDⁱ	63958
KEGGⁱ	mmu:63958
UCSC genome browser More...UCSCⁱ	uc012dpr.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9ES00	Uncharacterized protein		FELCA		1350	UniRef90_Q9ES00
ubiquitin conjugation factor E4 B isoform X1		PHYCD		1202
MKIAA0684 protein (Fragment)		MOUSE		1186
Ubiquitination factor E4B		LOXAF		1185
Uncharacterized protein		PAPAN		1177
+170

Protein	Similar proteins		Species	Score	Length	Source
Q9ES00	Ubiquitin conjugation factor E4 B	)	HUMAN		1302	UniRef50_Q9ES00
Uncharacterized protein		FELCA		1350
ubiquitin conjugation factor E4 B isoform X1		PHYCD		1202
MKIAA0684 protein (Fragment)		MOUSE		1186
Ubiquitination factor E4B		LOXAF		1185
+579

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF260924 mRNA Translation: AAG17285.1 Different termination. AF260926 mRNA Translation: AAG17287.1 AF260927 Genomic DNA Translation: AAG38492.1 AB083274 Genomic DNA Translation: BAC56586.1 AK029914 mRNA Translation: BAC26672.1 AL606973 Genomic DNA Translation: CAM16303.1 BC075620 mRNA Translation: AAH75620.1
CCDSⁱ	CCDS18958.1
RefSeqⁱ	NP_071305.2, NM_022022.3
UniGeneⁱ	Mm.415260 Mm.478205

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2KR4	NMR	-	A	1092-1173	[»]
ProteinModelPortalⁱ	Q9ES00
SMRⁱ	Q9ES00
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	211009, 8 interactors
IntActⁱ	Q9ES00, 2 interactors
STRINGⁱ	10090.ENSMUSP00000099501

PTM databases

iPTMnetⁱ	Q9ES00
PhosphoSitePlusⁱ	Q9ES00

Proteomic databases

EPDⁱ	Q9ES00
MaxQBⁱ	Q9ES00
PaxDbⁱ	Q9ES00
PeptideAtlasⁱ	Q9ES00
PRIDEⁱ	Q9ES00

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000103212; ENSMUSP00000099501; ENSMUSG00000028960
GeneIDⁱ	63958
KEGGⁱ	mmu:63958
UCSCⁱ	uc012dpr.1 mouse

Organism-specific databases

CTDⁱ	10277
MGIⁱ	MGI:1927086 Ube4b

Phylogenomic databases

eggNOGⁱ	KOG2042 Eukaryota COG5113 LUCA
GeneTreeⁱ	ENSGT00390000009300
HOVERGENⁱ	HBG058129
InParanoidⁱ	Q9ES00
KOⁱ	K10597
OMAⁱ	AMWNHEL
OrthoDBⁱ	EOG091G02B4
TreeFamⁱ	TF300802

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
BRENDAⁱ	2.3.2.B12 3474

Miscellaneous databases

ChiTaRSⁱ	Ube4b mouse
Protein Ontology More...PROⁱ	PR:Q9ES00
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000028960 Expressed in 335 organ(s), highest expression level in cumulus cell
ExpressionAtlasⁱ	Q9ES00 baseline and differential
Genevisibleⁱ	Q9ES00 MM

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR019474 Ub_conjug_fac_E4_core IPR003613 Ubox_domain IPR013083 Znf_RING/FYVE/PHD
Pfamⁱ	View protein in Pfam PF04564 U-box, 1 hit PF10408 Ufd2P_core, 1 hit
SMARTⁱ	View protein in SMART SM00504 Ubox, 1 hit
PROSITEⁱ	View protein in PROSITE PS51698 U_BOX, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UBE4B_MOUSE
Accessionⁱ	Q9ES00Primary (citable) accession number: Q9ES00 Secondary accession number(s): Q6DID4, Q9EQE0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 4, 2003
	Last sequence update:	July 27, 2011
	Last modified:	September 12, 2018
	This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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Supporting data

UniProtKB - Q9ES00 (UBE4B_MOUSE)

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Ubiquitin conjugation factor E4 B

Ube4b

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ