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Protein

Hemogen

Gene

Hemgn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Hemogen
Alternative name(s):
Hemopoietic gene protein
Negative differentiation regulator protein
Short name:
mNDR
Gene namesi
Name:Hemgn
Synonyms:Ndr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2136910 Hemgn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002453621 – 503HemogenAdd BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphoserineBy similarity1
Modified residuei103PhosphoserineCombined sources1
Modified residuei124PhosphoserineBy similarity1
Modified residuei153PhosphoserineCombined sources1
Modified residuei158PhosphoserineCombined sources1
Modified residuei171PhosphoserineCombined sources1
Modified residuei213PhosphoserineCombined sources1
Modified residuei223PhosphoserineCombined sources1
Modified residuei228PhosphoserineBy similarity1
Modified residuei241PhosphoserineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Modified residuei286PhosphothreonineCombined sources1
Modified residuei387PhosphoserineCombined sources1
Modified residuei394PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9ERZ0
MaxQBiQ9ERZ0
PaxDbiQ9ERZ0
PeptideAtlasiQ9ERZ0
PRIDEiQ9ERZ0

PTM databases

iPTMnetiQ9ERZ0
PhosphoSitePlusiQ9ERZ0

Expressioni

Tissue specificityi

Expressed in hematopoietic precursor cells. Highly expressed in bone marrow, the red pulp of the spleen and round spermatids. Weakly expressed in peripheral blood cells.2 Publications

Developmental stagei

Expressed at E8.5 in the blood islands of the yolk sac and in the circulating primitive blood cells. Expressed in the circulating blood cells at E9.5 and E10.5. Detected in the developing hepatic primordia at E10.5. From E11.5 to E14.5, exclusively expressed in the fetal liver.2 Publications

Gene expression databases

BgeeiENSMUSG00000028332 Expressed in 111 organ(s), highest expression level in fetal liver hematopoietic progenitor cell
CleanExiMM_HEMGN
GenevisibleiQ9ERZ0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066383

Structurei

3D structure databases

ProteinModelPortaliQ9ERZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 87Necessary for nuclear localizationBy similarityAdd BLAST81

Phylogenomic databases

eggNOGiENOG410IXJU Eukaryota
ENOG411096P LUCA
GeneTreeiENSGT00390000004522
HOGENOMiHOG000049208
HOVERGENiHBG080273
InParanoidiQ9ERZ0
OMAiEIYQETP
OrthoDBiEOG091G0D5Q
PhylomeDBiQ9ERZ0
TreeFamiTF338654

Family and domain databases

InterProiView protein in InterPro
IPR033272 Hemogen
PANTHERiPTHR15993:SF6 PTHR15993:SF6, 2 hits

Sequencei

Sequence statusi: Complete.

Q9ERZ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDMGKGRPRL KLPQMPEAHP QKSCAPDIIG SWSLRNREQL RKRKAEAQGR
60 70 80 90 100
QTSQWLLGEQ KKRKYQRTGK GNKRGRKRQG NVEQKAEPWS QTERERVQEV
110 120 130 140 150
LVSAEEETEH PGNSATEALP LVPSPTKAVP ADQCSEAHQE SIQCQERAIQ
160 170 180 190 200
NHSQTHLSPT TCQGIAVLQH SPKMCQDMAE PEVFSPNMCQ ETAVPQTYPP
210 220 230 240 250
KALEEMAAAE PLSPKMCQET TVSPNHSSKV PQDMAGPEAL SPNMCQEPTV
260 270 280 290 300
PQEHTLKMCH DVARPEVLSP KTHQEMAVPK AFPCVTPGDA AGLEGCAPKA
310 320 330 340 350
LPQSDVAEGC PLDTTPTSVT PEQTTSDPDL GMAVTEGFFS EARECTVSEG
360 370 380 390 400
VSTKTHQEAV EPEFISHETY KEFTVPIVSS QKTIQESPEP EQYSPETCQP
410 420 430 440 450
IPGPENYSLE TCHEMSGPED LSIKTCQDRE EPKHSLPEGA QKVGGAQGQD
460 470 480 490 500
ADAQDSENAG AFSQDFTEME EENKADQDPE APASPQGSQE TCPENGIYSS

ALF
Length:503
Mass (Da):55,043
Last modified:March 1, 2001 - v1
Checksum:iB1027B81B55BB08D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti472E → G in AAH50798 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269248 mRNA Translation: AAG33367.1
AY699986 mRNA Translation: AAT94243.1
AK006588 mRNA Translation: BAC25148.2
AK077692 mRNA Translation: BAC36959.1
AK156536 mRNA Translation: BAE33747.1
AK171890 mRNA Translation: BAE42722.1
AL683884 Genomic DNA No translation available.
BC050798 mRNA Translation: AAH50798.1
CCDSiCCDS18150.1
RefSeqiNP_444379.1, NM_053149.2
UniGeneiMm.25793

Genome annotation databases

EnsembliENSMUST00000071096; ENSMUSP00000066383; ENSMUSG00000028332
ENSMUST00000107764; ENSMUSP00000103393; ENSMUSG00000028332
GeneIDi93966
KEGGimmu:93966
UCSCiuc008str.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269248 mRNA Translation: AAG33367.1
AY699986 mRNA Translation: AAT94243.1
AK006588 mRNA Translation: BAC25148.2
AK077692 mRNA Translation: BAC36959.1
AK156536 mRNA Translation: BAE33747.1
AK171890 mRNA Translation: BAE42722.1
AL683884 Genomic DNA No translation available.
BC050798 mRNA Translation: AAH50798.1
CCDSiCCDS18150.1
RefSeqiNP_444379.1, NM_053149.2
UniGeneiMm.25793

3D structure databases

ProteinModelPortaliQ9ERZ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066383

PTM databases

iPTMnetiQ9ERZ0
PhosphoSitePlusiQ9ERZ0

Proteomic databases

EPDiQ9ERZ0
MaxQBiQ9ERZ0
PaxDbiQ9ERZ0
PeptideAtlasiQ9ERZ0
PRIDEiQ9ERZ0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071096; ENSMUSP00000066383; ENSMUSG00000028332
ENSMUST00000107764; ENSMUSP00000103393; ENSMUSG00000028332
GeneIDi93966
KEGGimmu:93966
UCSCiuc008str.1 mouse

Organism-specific databases

CTDi55363
MGIiMGI:2136910 Hemgn

Phylogenomic databases

eggNOGiENOG410IXJU Eukaryota
ENOG411096P LUCA
GeneTreeiENSGT00390000004522
HOGENOMiHOG000049208
HOVERGENiHBG080273
InParanoidiQ9ERZ0
OMAiEIYQETP
OrthoDBiEOG091G0D5Q
PhylomeDBiQ9ERZ0
TreeFamiTF338654

Miscellaneous databases

PROiPR:Q9ERZ0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028332 Expressed in 111 organ(s), highest expression level in fetal liver hematopoietic progenitor cell
CleanExiMM_HEMGN
GenevisibleiQ9ERZ0 MM

Family and domain databases

InterProiView protein in InterPro
IPR033272 Hemogen
PANTHERiPTHR15993:SF6 PTHR15993:SF6, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHEMGN_MOUSE
AccessioniPrimary (citable) accession number: Q9ERZ0
Secondary accession number(s): B1AVH8
, Q3TAE6, Q80YT2, Q8CF29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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