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Protein

p53-induced death domain-containing protein 1

Gene

Pidd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264). Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis. Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei449PROSITE-ProRule annotationBy similarity1
Active sitei451PROSITE-ProRule annotationBy similarity1
Active sitei591PROSITE-ProRule annotationBy similarity1
Active sitei593PROSITE-ProRule annotationBy similarity1

GO - Molecular functioni

  • volume-sensitive anion channel activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases

Names & Taxonomyi

Protein namesi
Recommended name:
p53-induced death domain-containing protein 1Curated (EC:3.4.21.-By similarity)
Alternative name(s):
Leucine-rich repeat and death domain-containing protein
Cleaved into the following 3 chains:
PIDD-NBy similarity
PIDD-CBy similarity
PIDD-CCBy similarity
Gene namesi
Name:Pidd1Imported
Synonyms:Lrdd, Pidd1 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1889507 Pidd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002452442 – 915p53-induced death domain-containing protein 1Add BLAST914
ChainiPRO_00004457182 – 450PIDD-NBy similarityAdd BLAST449
ChainiPRO_0000445719451 – 915PIDD-CBy similarityAdd BLAST465
ChainiPRO_0000445720594 – 915PIDD-CCBy similarityAdd BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei304PhosphoserineBy similarity1

Post-translational modificationi

Undergoes autoproteolytic processing whose extent either directs cells towards survival or apoptotic pathways. Autoproteolytically cleaved into two main fragments PIDD-N and PIDD-C. PIDD-C can be further processed into PIDD-CC, a processing which is enhanced by DNA damage. The cleavage producing PIDD-C is required for translocation of PIDD1 to the nucleus upon DNA damage and activation of NF-kappa-B. PIDD-CC mediates the interaction with CRADD and the cleavage producing PIDD-CC is required for the activation of CASP2. PIDD-N remains associated with PIDD-C and PIDD-CC after cleavage.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei450 – 451Cleavage; by autolysisBy similarity2
Sitei592 – 593Cleavage; by autolysisBy similarity2

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9ERV7
PaxDbiQ9ERV7
PRIDEiQ9ERV7

PTM databases

iPTMnetiQ9ERV7
PhosphoSitePlusiQ9ERV7

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Inductioni

Induced by TP53/tumor suppressor p53 AND gamma-irradiation.1 Publication

Gene expression databases

BgeeiENSMUSG00000025507 Expressed in 125 organ(s), highest expression level in nasal cavity respiratory epithelium
CleanExiMM_LRDD
ExpressionAtlasiQ9ERV7 baseline and differential
GenevisibleiQ9ERV7 MM

Interactioni

Subunit structurei

Forms a complex named the PIDDosome with CASP2 and CRADD (PubMed:22279524). Forms a complex with IKBKG and RIPK1. Interacts with FADD and MADD (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi208363, 2 interactors
STRINGi10090.ENSMUSP00000026580

Structurei

3D structure databases

ProteinModelPortaliQ9ERV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati131 – 152LRR 1Add BLAST22
Repeati154 – 176LRR 2Add BLAST23
Repeati177 – 199LRR 3Add BLAST23
Repeati200 – 221LRR 4Add BLAST22
Repeati223 – 245LRR 5Add BLAST23
Repeati246 – 268LRR 6Add BLAST23
Repeati269 – 290LRR 7Add BLAST22
Domaini327 – 459ZU5 1PROSITE-ProRule annotationAdd BLAST133
Domaini460 – 601ZU5 2PROSITE-ProRule annotationAdd BLAST142
Domaini793 – 878DeathPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni428 – 457Peptidase S68PROSITE-ProRule annotationAdd BLAST30
Regioni571 – 599Peptidase S68PROSITE-ProRule annotationAdd BLAST29
Regioni585 – 721UPA domainBy similarityAdd BLAST137

Domaini

The Death domain mediates the interaction with CRADD and the formation of a complex composed of 5 PIDD1 and 7 CRADD proteins which in turn recruit 7 CASP2 to form the PIDDosome.By similarity
The LRR repeat-containing domain has a regulatory activity, being autoinhibitory for the activation of NF-kappa-B.By similarity

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
KOG4177 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150841
HOGENOMiHOG000290659
HOVERGENiHBG066762
InParanoidiQ9ERV7
KOiK10130
OMAiLWYTTKT
OrthoDBiEOG091G01ZE
PhylomeDBiQ9ERV7
TreeFamiTF331183

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR019502 Peptidase_S68_pidd
IPR000906 ZU5_dom
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF13855 LRR_8, 2 hits
PF10461 Peptidase_S68, 1 hit
PF00791 ZU5, 2 hits
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00369 LRR_TYP, 7 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS51450 LRR, 7 hits
PS51145 ZU5, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9ERV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVLEGQEP EETAAAAEDA ATSTLEAVDA GPGAPFLPAG NQLNLDLRPG
60 70 80 90 100
GCHRLQYLCS QQPPQLLQVE FLRLSTHEDP QLLDDTLAKV PWSLLRLRSL
110 120 130 140 150
VLKGGQSRGA LGACLHGTLT TLPAGLSDLA CLAHLDLSFN RLETLPTCVP
160 170 180 190 200
ELHGLDALLL SHNHLSELPE ALGALPALTF LTVTHNRLER LPLTLGSLST
210 220 230 240 250
LQRLDLSENL LDTIPSEIGN LRSLSELNLA SNRLQSLPAS LAGLRSLRLL
260 270 280 290 300
VLHSNLLTSV PTGLVHLPLI TRLDLRDNRL RDLPAELLDA PFVRLQGNPL
310 320 330 340 350
GEASPAPPSP PDISQVPEMP RLLLTSDLDS FLVTPHGCSV TLACGVRLQF
360 370 380 390 400
PAGATTTPVT IHYRLWLPEP GLVSLGPHDF LLSSVLELQP HGVAFQQDVS
410 420 430 440 450
LWLLFVPPRV RRCREVVVRT RSNNTWNDLE TQLEEEAPKR LWARCQVPHF
460 470 480 490 500
SWFLVVLRPV SNTCLLPPEG ALLCSSGHPG VRVTFPPGVT EEPRQVSMQV
510 520 530 540 550
VHMAGLELRT LLEESEASVS PLLCLSQSGP PSFLQPVTVQ LPLPPGVTGF
560 570 580 590 600
SLDRSHLHLL YRTPLTTTWD DITTQVALEF THLYARFQVT HFSWYWLWYT
610 620 630 640 650
TKTCVGGLAR KAWERLRLHR VNLIALQRRR DPEQVLLQCL PRNKVDATLS
660 670 680 690 700
RLLVRYRGPE PSETVEMFEG EKFFAAFERG IDVDADRPDC VDGRICFVFY
710 720 730 740 750
SHLKNVKEVY ITTALDREAQ DVRGQVSFYR GSLPVEVPAE AEAARQRKGT
760 770 780 790 800
DALWMATLPI KLPRLRGAQG SGQGTDFSLM PLNLGDAETG FLTQSNLLSV
810 820 830 840 850
ASRLGPDWPA VALHLGMPYH KLQRIRHEFR DDLDGQVRHM LFSWAERQTG
860 870 880 890 900
QPGAVGHLVQ ALEQSDRRDV AEEVRAILEL GRHKYQDSIR RTGLAPEDST
910
LPGTSASQTP ESAQA
Length:915
Mass (Da):101,141
Last modified:March 1, 2001 - v1
Checksum:i49FAA7B91D08E135
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WPI0A0A087WPI0_MOUSE
p53-induced death domain-containing...
Pidd1
244Annotation score:
A0A087WNT6A0A087WNT6_MOUSE
p53-induced death domain-containing...
Pidd1
379Annotation score:
A0A087WPX5A0A087WPX5_MOUSE
p53-induced death domain-containing...
Pidd1
244Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF274973 mRNA Translation: AAG13462.1
BC145857 mRNA Translation: AAI45858.1
CCDSiCCDS22014.1
RefSeqiNP_073145.1, NM_022654.1
XP_006536281.1, XM_006536218.3
UniGeneiMm.334321

Genome annotation databases

EnsembliENSMUST00000026580; ENSMUSP00000026580; ENSMUSG00000025507
ENSMUST00000106005; ENSMUSP00000101627; ENSMUSG00000025507
GeneIDi57913
KEGGimmu:57913
UCSCiuc009klc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF274973 mRNA Translation: AAG13462.1
BC145857 mRNA Translation: AAI45858.1
CCDSiCCDS22014.1
RefSeqiNP_073145.1, NM_022654.1
XP_006536281.1, XM_006536218.3
UniGeneiMm.334321

3D structure databases

ProteinModelPortaliQ9ERV7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208363, 2 interactors
STRINGi10090.ENSMUSP00000026580

PTM databases

iPTMnetiQ9ERV7
PhosphoSitePlusiQ9ERV7

Proteomic databases

MaxQBiQ9ERV7
PaxDbiQ9ERV7
PRIDEiQ9ERV7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026580; ENSMUSP00000026580; ENSMUSG00000025507
ENSMUST00000106005; ENSMUSP00000101627; ENSMUSG00000025507
GeneIDi57913
KEGGimmu:57913
UCSCiuc009klc.1 mouse

Organism-specific databases

CTDi55367
MGIiMGI:1889507 Pidd1

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
KOG4177 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150841
HOGENOMiHOG000290659
HOVERGENiHBG066762
InParanoidiQ9ERV7
KOiK10130
OMAiLWYTTKT
OrthoDBiEOG091G01ZE
PhylomeDBiQ9ERV7
TreeFamiTF331183

Enzyme and pathway databases

ReactomeiR-MMU-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases

Miscellaneous databases

PROiPR:Q9ERV7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025507 Expressed in 125 organ(s), highest expression level in nasal cavity respiratory epithelium
CleanExiMM_LRDD
ExpressionAtlasiQ9ERV7 baseline and differential
GenevisibleiQ9ERV7 MM

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR019502 Peptidase_S68_pidd
IPR000906 ZU5_dom
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF13855 LRR_8, 2 hits
PF10461 Peptidase_S68, 1 hit
PF00791 ZU5, 2 hits
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00369 LRR_TYP, 7 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS51450 LRR, 7 hits
PS51145 ZU5, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPIDD1_MOUSE
AccessioniPrimary (citable) accession number: Q9ERV7
Secondary accession number(s): A6H6F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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