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Entry version 135 (26 Feb 2020)
Sequence version 1 (01 Mar 2001)
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Protein
Submitted name:

Pkd1

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Pkd1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3055 – 3077HelicalSequence analysisAdd BLAST23
Transmembranei3263 – 3284HelicalSequence analysisAdd BLAST22
Transmembranei3304 – 3326HelicalSequence analysisAdd BLAST23
Transmembranei3536 – 3558HelicalSequence analysisAdd BLAST23
Transmembranei3651 – 3670HelicalSequence analysisAdd BLAST20
Transmembranei3877 – 3896HelicalSequence analysisAdd BLAST20
Transmembranei3917 – 3939HelicalSequence analysisAdd BLAST23
Transmembranei3959 – 3980HelicalSequence analysisAdd BLAST22
Transmembranei4006 – 4028HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1687686

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9ERV0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ERV0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ERV0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9ERV0, 1 interactor

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9ERV0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini168 – 262WSCInterPro annotationAdd BLAST95
Domaini290 – 350PKDInterPro annotationAdd BLAST61
Domaini406 – 521C-type lectinInterPro annotationAdd BLAST116
Domaini942 – 998PKDInterPro annotationAdd BLAST57
Domaini1034 – 1113PKDInterPro annotationAdd BLAST80
Domaini1137 – 1199PKDInterPro annotationAdd BLAST63
Domaini1220 – 1277PKDInterPro annotationAdd BLAST58
Domaini1302 – 1367PKDInterPro annotationAdd BLAST66
Domaini1393 – 1453PKDInterPro annotationAdd BLAST61
Domaini1471 – 1535PKDInterPro annotationAdd BLAST65
Domaini1557 – 1619PKDInterPro annotationAdd BLAST63
Domaini1705 – 1791PKDInterPro annotationAdd BLAST87
Domaini1818 – 1875PKDInterPro annotationAdd BLAST58
Domaini2059 – 2133PKDInterPro annotationAdd BLAST75
Domaini2131 – 2818REJInterPro annotationAdd BLAST688
Domaini2994 – 3043GPSInterPro annotationAdd BLAST50
Domaini3100 – 3215PLATInterPro annotationAdd BLAST116

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4140 – 4178DisorderedSequence analysisAdd BLAST39
Regioni4225 – 4283DisorderedSequence analysisAdd BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2666 – 2686Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4144 – 4178PolarSequence analysisAdd BLAST35
Compositional biasi4257 – 4283PolarSequence analysisAdd BLAST27

Keywords - Domaini

Coiled coilSequence analysis, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3599 Eukaryota
ENOG410XTGE LUCA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ERV0

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01752 PLAT_polycystin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 10 hits
3.10.100.10, 1 hit
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000483 Cys-rich_flank_reg_C
IPR000203 GPS
IPR013783 Ig-like_fold
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR000434 PC1
IPR022409 PKD/Chitinase_dom
IPR002859 PKD/REJ-like
IPR013122 PKD1_2_channel
IPR000601 PKD_dom
IPR035986 PKD_dom_sf
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR042060 PLAT_polycystin1
IPR006228 Polycystin_cat
IPR014010 REJ_dom
IPR002889 WSC_carb-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00059 Lectin_C, 1 hit
PF13855 LRR_8, 1 hit
PF00801 PKD, 14 hits
PF08016 PKD_channel, 1 hit
PF01477 PLAT, 1 hit
PF02010 REJ, 1 hit
PF01822 WSC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00500 POLYCYSTIN1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034 CLECT, 1 hit
SM00303 GPS, 1 hit
SM00308 LH2, 1 hit
SM00369 LRR_TYP, 1 hit
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SM00089 PKD, 15 hits
SM00321 WSC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49299 SSF49299, 13 hits
SSF49723 SSF49723, 1 hit
SSF56436 SSF56436, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00864 PCC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS50221 GPS, 1 hit
PS51450 LRR, 3 hits
PS50093 PKD, 12 hits
PS50095 PLAT, 1 hit
PS51111 REJ, 1 hit
PS51212 WSC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q9ERV0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ALALGLGLWL GALAGDPGRG CGPCPLPCFC SPAPDAACRV NCSGRWLQTL
60 70 80 90 100
GPSLRIPADA TALDLSHNLL QTLDIRLLVN LSGLVELDLS NNRISTLEEG
110 120 130 140 150
VFANLFNLSE INLSGNPFEC NCGLAWLPRW AKEQQVHVVQ SEATTCRGPV
160 170 180 190 200
PLAGRPLLST PLLDNACGEE YVACLPDNSS GAVAAVPFFF AHQGPLETAA
210 220 230 240 250
CSAFCFSAGE GLAALSEQNQ CLCGAGQPSN TSAACSSWCS SILLSFNSAC
260 270 280 290 300
GGPTLLQHTF PASPGAALVG PHGPLASGQP ADFHINSPLP ISSTCWNFGD
310 320 330 340 350
GSPEVDMAGP AATHSYVLPG GYHVTVVLTL GAGSALLETE VQVEVAPTVL
360 370 380 390 400
ELVCPSFVHS DESLDLGIRH RGGSALEVTY SILALDKEPA QVVHPLCPSD
410 420 430 440 450
TEIFPGNGHC YRLVAEKAPW LQAQEQCRTW AGAALAMVDS PAIQHFLVSK
460 470 480 490 500
VTRSLDVWIG FSSVEGKEGL DPQGEAFSLE SCQNWLPGEP HPATEEHCVR
510 520 530 540 550
LGPAGQCNTD LCSAPHSYVC ELRPGGPVGD ADNFLLGVSG GGRSGPLQPL
560 570 580 590 600
AQQGTLQGPL QPVEVMVFPG LSPSREAFLT AAEFETQELE DPVQLRLQVY
610 620 630 640 650
RHSREAVAPE GSSELDNSTE PAPKCVPEEL WCPGANVCVP FDALCNSHVC
660 670 680 690 700
INGSASRLGL PRASYTLWKE FFFSVPAGPP TQYLVTLHGQ DVPMLPGDLV
710 720 730 740 750
ALQHDAGPGT FLHCPLASSC PGQALYLSTN ASDWMTNLPV HLEEAWAGPV
760 770 780 790 800
CSLQLLLVTE QLTPLLGLGS NPGLQHPGHY EVRATVGNSI SRQNLSCSFS
810 820 830 840 850
VVSPVAGLRV IHPIPLDGHI YVPTNGSILV LQVDSGANAT ATAHWFGGNV
860 870 880 890 900
SAPFEDACPP EVDFLKQDCT EEANATLFSV LVLPRLKEGD HTVEIVAQNG
910 920 930 940 950
ASQANLSLRV TAEEPICGLR AVPSPEARVL QGILVRYSPM VEAGSDVAFR
960 970 980 990 1000
WTIDDKQSLT FHNTVFNVIY QTAAVFKLSL TASNHVSNIT VNYNVTVERM
1010 1020 1030 1040 1050
NKMHGLWVSA VPAVLPPNAT LALTGGVLVD SAVEVAFLWN FGDGEQVLRQ
1060 1070 1080 1090 1100
FKPPYDESFQ VPDPTVAQVL VEHNTTHIYN TPGEYNLTVT VSNTYENLTQ
1110 1120 1130 1140 1150
QVPVSVRTVL PNVTIGMSSN VLLAGQPITF FPYPLPSADG VLYTWDFGDG
1160 1170 1180 1190 1200
SPVLIQSQPV LNHTYSMTGT YRISLEVNNT VSSVAAHVDI CVFQELHGLT
1210 1220 1230 1240 1250
VYLNQSVEQG APMVVNASVE SGDNITWTFD MGDGTVFTGP EATVEHVYLR
1260 1270 1280 1290 1300
AQNFTVTVGA TSPAGHLSQS LHVQVFVLEV LRIEPSTCIP TQPSAQIMAH
1310 1320 1330 1340 1350
VTGDPAHYLF DWTFGDGSSN VTVHGHPSVT HNFTRSGIFP LALVLSSHVN
1360 1370 1380 1390 1400
KAHYFTSICV EPEICNVTLQ PERQVVKLGD EAWLVAYPWP PFPYRYTWDF
1410 1420 1430 1440 1450
GTEDSIHTQT GGSEVTFIYR EPGSYLVIVT VSNNISSTND SAFVDVQEPV
1460 1470 1480 1490 1500
SVTGIRINGS HVLELQQPYL FSAMGNGSPA AYLWELGDGS QHEGPEVTHI
1510 1520 1530 1540 1550
YSSTGDFTVR VSGWNEVSRS EAQLNITVKQ RVRGLTINAS PTVVPLNGSV
1560 1570 1580 1590 1600
SFSTLLEVGS DVHYSWVLCD RCTPIPGGPT ISYTFRSVGT FNIIVTAENE
1610 1620 1630 1640 1650
VGSAQDSIFI YVLQLIEGLQ VVGGDGGCCF PTNYTLQLQA AVRDGTNISY
1660 1670 1680 1690 1700
SWTAQQDGGP TLISSGKSFS LTALKASTYY VHLRATNMLG SASANRTIDF
1710 1720 1730 1740 1750
VEPVESLILS ASPNPAAVNT SLTLGAELAG GSGVVYTWYL EEGLSRETSM
1760 1770 1780 1790 1800
PSTTHTFAAP GLHLVRVTAE NQLGSVNATI EVAVHGPVGG LSIRTSEPDS
1810 1820 1830 1840 1850
IFVAAGSTVP FWGQLAEGTN VTWCWTLPGG SKYSQYIDVR FPAAGHFSLW
1860 1870 1880 1890 1900
LNASNAVSWV SAVYNLTVEE PIMNLVLWAS SKVVAPGQPV HFQILLAAGS
1910 1920 1930 1940 1950
AVTFRLQVGG SIPEVLPSLH FSHSFFRVGD HMVSVQAENH VSRAQAQVRI
1960 1970 1980 1990 2000
LVLEAIVGLQ VPNCCEPGMA TGTEKNFTAR VQRGSRVAYA WYFSLQKVQG
2010 2020 2030 2040 2050
DSLVILSGRD VTYTPVAAGI LEIHVRAFNE LGGVNLTLVV EVQDIIQYVT
2060 2070 2080 2090 2100
LQSGRCFTNR SARFEAATSP SPRRVTYHWD FGDGTPVQET EESWTDHYYL
2110 2120 2130 2140 2150
HPGDYRVEVN ATNLVSFFVA QAQVTVQVLA CREPEVEVAL PLQVLMRRSQ
2160 2170 2180 2190 2200
RNYLEAHVDL RNCVSYQTEY RWEVYRTTSC QRAGRMTQMV LPGVDVSRPQ
2210 2220 2230 2240 2250
LVVPRLALPV GHYCFVFVVS FGDTPLARSI QANVTVAAER LVPIIEGGSY
2260 2270 2280 2290 2300
RVWSDTQDLV LDGSKSYDPN LEDGDQTPLN FHWACVASTQ SETGGCVLKL
2310 2320 2330 2340 2350
WARGSSVVTI PLERLEAGVE YTFNLIVWKA GRKEEATNQT VLIRSGRVPI
2360 2370 2380 2390 2400
VSLECVSCKA QAVYEVSRSS YVYLEGHCHN CSSGSKQGRW AARTFSNKTL
2410 2420 2430 2440 2450
MLNENTTSTG STGMHLVVRP GALHDGEGYI FTLTVLGHSG EEEGCRSIRL
2460 2470 2480 2490 2500
LPNRPPLGGS CRLFPLESVR GLTTKVHFEC TGWRDAEDGG APLVYALRLK
2510 2520 2530 2540 2550
RCHQNYCEDF CIYKGSLSTY GAVLPPGFQP LFVVSLTVVV EDQLGASVVA
2560 2570 2580 2590 2600
LNRSLTIVLP EPSGNPADLI PWLHSLTASV LPGLLRQADP QHVIEYSLAL
2610 2620 2630 2640 2650
ITVLNEYEQA PDMVSEPNLE QQLRAQMRKN ITETLISLRV NTVDDIQQIT
2660 2670 2680 2690 2700
AALAQCMVSS RELMCRSCLK KMLQKLEGMM RILQAETTEG TLTPTTIADS
2710 2720 2730 2740 2750
ILNITGDLIH LASLDMQGPQ PLELGAEPPS LMVASKAYNL SSALMCILMR
2760 2770 2780 2790 2800
SRVLNEEPLT LAGEEIVALG KRADPLSLLC YGKAWGPSCH FSIPEAFSGA
2810 2820 2830 2840 2850
LSDLSDVVQL ILLVDSNPFP FGYISNYTVS TKVASMAFQT QTGTQIPIEQ
2860 2870 2880 2890 2900
LAADGSITVK VPNNSDQAAQ SSHSPVGSTI VQPRASVSAV VTADNSNPQA
2910 2920 2930 2940 2950
GLHLRITYTV LNARYLSEER EPYLAVYLHS VSQPNEYNCS ASRRISLEVL
2960 2970 2980 2990 3000
EGADHRPYTF FIAPGTGTLG RSYYLNLTSH FHWSALEVSV GLYTSLCQYF
3010 3020 3030 3040 3050
SEEAMMWRTE GIVPLEETSP SQAVCLTRHL TAFGASLFVP PSHVQFIFPE
3060 3070 3080 3090 3100
PSVSINYIVL LTCVICLVTY VIMAMILRKL DQLDVSRVRV IPFCGKGGRF
3110 3120 3130 3140 3150
KYEILVKTGW SRGSGTTAHV GIMLYGEDNR SGHRHLDGDR AFHRNSLDIF
3160 3170 3180 3190 3200
QIATPQSLGS VWKIRVWHDN KGLSPAWFLQ HIIVRDLQSA RSTFFLVNDW
3210 3220 3230 3240 3250
LSVETEANGG LVEKEVLAAN EAALWQFQRL LVAELQRGFF DKHIWLSIWD
3260 3270 3280 3290 3300
RPPRSRFTRV QRVTCCVLLL CLFLAANAVW YGVVGDTTYS MGPVSSLMSP
3310 3320 3330 3340 3350
SVDTVAIGLV SSVVVYPVYL AVLFLFRMSR SKVSGDQNPT PTGQQALDVD
3360 3370 3380 3390 3400
SYLDPSVLDS SLLTLSGLTE AFSGQVKNDL FLEDAKSLVC WPSSEGTLSW
3410 3420 3430 3440 3450
PDLLSDPSVM SSTLQRLAQG RPGCMLGSEE DGASLVSPSL PAKYLSASDE
3460 3470 3480 3490 3500
DLIHQVLADG ANNPDPTQDA LIERDLLTSL SSAPGEKTET LILQTMGEKR
3510 3520 3530 3540 3550
PPSMGLTWEQ SPVTRLSRTG LVEGLRKRLL PTWCAPLAHG LSLLLVAVAV
3560 3570 3580 3590 3600
AVSGWIGASF PPSVSVMWLL SSSSSFLASF LGWEPLKVLL EALYFSLVAK
3610 3620 3630 3640 3650
RLHPDEDDTL VESPAVTPVS ERVPRVRPPH GFALFLAKEE ARKVKRLHDM
3660 3670 3680 3690 3700
LKSLLVYMLF LLVTLLANYG DASCHGHAYR LQSAIKQELD SQAFLAITRS
3710 3720 3730 3740 3750
DEFWPWMSHV LLPYVHGNQS SPELGPPRLR QVRLQEAFCP DPSSSEHMCS
3760 3770 3780 3790 3800
ATGSLSTSDY GIGWQSVVQN GSETWAYSAP DLLGAWYWGY CAVYDSGGYI
3810 3820 3830 3840 3850
QELGLSLEES RARLGFLQLH NWLDSRSRAV FVELTRYSPA VGLHAAVTLR
3860 3870 3880 3890 3900
LEFPVAGHAL AAFSVRPFAL RRLSTGLSLP LLTSVCLLLF ALYFSVAEVH
3910 3920 3930 3940 3950
TWRREGCART ARPDVGARWL LVMLTAATGL VRLAQLRIAD RQWTRFVHDH
3960 3970 3980 3990 4000
PHHFTSFDQV AQLGSVARGL AASLLFLLLV KAAQHVRFVR QWSVFGKTLC
4010 4020 4030 4040 4050
RALPELMGAT LGLVLLGVAY AQMAILLISS GADTLYSMAR AFLVLCPGAR
4060 4070 4080 4090 4100
VPTLCPSESW YLSPLLCVGL WALRVWGALR LGAVLLRWRY HALRGELYRP
4110 4120 4130 4140 4150
AWEPQDYEMV ELFLRRLRLW MGFTKVKEFR HKVRFEGMDP LPSRSSRGSK
4160 4170 4180 4190 4200
SSPVVPPPSA GSEASHPSTS SSQPDGLSAG LRRSALRLEP EPSRLHAVFE
4210 4220 4230 4240 4250
SLLVQFDRLN QATEDVYQLE QQLQSLRGHG HSGPPSSPSP GGFPASQPAL
4260 4270 4280
PSRLARASQG PDQTTGPSRV SLWPNNKVHP SST
Length:4,283
Mass (Da):465,420
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2EEA8AE9E29EBF65
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF277452 mRNA Translation: AAG33986.1

Genome annotation databases

UCSC genome browser

More...
UCSCi
RGD:3333 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277452 mRNA Translation: AAG33986.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Protein-protein interaction databases

IntActiQ9ERV0, 1 interactor

Chemistry databases

BindingDBiQ9ERV0
ChEMBLiCHEMBL1687686

PTM databases

iPTMnetiQ9ERV0
PhosphoSitePlusiQ9ERV0

Proteomic databases

PRIDEiQ9ERV0

Genome annotation databases

UCSCiRGD:3333 rat

Phylogenomic databases

eggNOGiKOG3599 Eukaryota
ENOG410XTGE LUCA
PhylomeDBiQ9ERV0

Family and domain databases

CDDicd01752 PLAT_polycystin, 1 hit
Gene3Di2.60.40.10, 10 hits
3.10.100.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000483 Cys-rich_flank_reg_C
IPR000203 GPS
IPR013783 Ig-like_fold
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR000434 PC1
IPR022409 PKD/Chitinase_dom
IPR002859 PKD/REJ-like
IPR013122 PKD1_2_channel
IPR000601 PKD_dom
IPR035986 PKD_dom_sf
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR042060 PLAT_polycystin1
IPR006228 Polycystin_cat
IPR014010 REJ_dom
IPR002889 WSC_carb-bd
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PF13855 LRR_8, 1 hit
PF00801 PKD, 14 hits
PF08016 PKD_channel, 1 hit
PF01477 PLAT, 1 hit
PF02010 REJ, 1 hit
PF01822 WSC, 1 hit
PRINTSiPR00500 POLYCYSTIN1
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00303 GPS, 1 hit
SM00308 LH2, 1 hit
SM00369 LRR_TYP, 1 hit
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SM00089 PKD, 15 hits
SM00321 WSC, 1 hit
SUPFAMiSSF49299 SSF49299, 13 hits
SSF49723 SSF49723, 1 hit
SSF56436 SSF56436, 1 hit
TIGRFAMsiTIGR00864 PCC, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS50221 GPS, 1 hit
PS51450 LRR, 3 hits
PS50093 PKD, 12 hits
PS50095 PLAT, 1 hit
PS51111 REJ, 1 hit
PS51212 WSC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9ERV0_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ERV0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: February 26, 2020
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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