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Protein

Interleukin-1 receptor-like 2

Gene

Il1rl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.2 Publications

GO - Molecular functioni

  • cytokine receptor activity Source: MGI
  • interleukin-1, type I, activating receptor activity Source: InterPro

GO - Biological processi

  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • positive regulation of interleukin-6 production Source: MGI
  • positive regulation of T cell differentiation Source: MGI
  • regulation of inflammatory response Source: MGI

Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-9007892 Interleukin-38 signaling
R-MMU-9014826 Interleukin-36 pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-like 2
Alternative name(s):
IL-36 receptor
Interleukin-1 receptor-related protein 2
Short name:
IL-1Rrp2
Short name:
IL1R-rp2
Gene namesi
Name:Il1rl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1913107 Il1rl2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 338ExtracellularSequence analysisAdd BLAST317
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 574CytoplasmicSequence analysisAdd BLAST215

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Complete protection from imiquimodum (IMQ)-induced skin pathology observed in wild-type mice, including hyperkeratosis, acanthosis, neutrophil recruitment, and expansion of IL-17-producing T-cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001544622 – 574Interleukin-1 receptor-like 2Add BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi44 ↔ 97PROSITE-ProRule annotation
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi149 ↔ 199PROSITE-ProRule annotation
Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi237N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi252 ↔ 319PROSITE-ProRule annotation
Glycosylationi253N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ERS7
PRIDEiQ9ERS7

PTM databases

iPTMnetiQ9ERS7
PhosphoSitePlusiQ9ERS7

Expressioni

Tissue specificityi

Expressed in bone marrow-derived dendritic cells, splenic CD4+ T-cells, bone marrow-derived macrophages and bone marrow-derived neutrophils.1 Publication

Gene expression databases

BgeeiENSMUSG00000070942 Expressed in 134 organ(s), highest expression level in ear
CleanExiMM_IL1RL2
ExpressionAtlasiQ9ERS7 baseline and differential
GenevisibleiQ9ERS7 MM

Interactioni

Subunit structurei

Interacts with IL1RAP; the association is enhanced by IL36B indicative for an functional signaling complex and inhibited by IL36RN.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092630

Structurei

3D structure databases

ProteinModelPortaliQ9ERS7
SMRiQ9ERS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 113Ig-like C2-type 1Add BLAST89
Domaini132 – 215Ig-like C2-type 2Add BLAST84
Domaini225 – 321Ig-like C2-type 3Add BLAST97
Domaini384 – 542TIRPROSITE-ProRule annotationAdd BLAST159

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQBC Eukaryota
ENOG410Z3W1 LUCA
GeneTreeiENSGT00760000119071
HOGENOMiHOG000253916
HOVERGENiHBG052103
InParanoidiQ9ERS7
KOiK05172
OMAiCHRIHVN
OrthoDBiEOG091G03IT
PhylomeDBiQ9ERS7
TreeFamiTF325519

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR015621 IL-1_rcpt_fam
IPR004076 IL-1_rcpt_I-typ
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
PF01582 TIR, 1 hit
PRINTSiPR01538 INTRLEUKN1R1
PR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
PS50104 TIR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9ERS7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVTSLLFCG VFFLLLLFVA ADTCEDIFMH NVIISEGQPF PFNCTYPPET
60 70 80 90 100
NGAVNLTWYK TPSKSPVSNN RHLRVHQDQT WILFLPLTLE DSGIYQCVIR
110 120 130 140 150
NAHNCYQIAV NLTVLKNHWC DSSMEGSPVN SPDVYQQILP IGKSGSLNCH
160 170 180 190 200
LYFPESCALD SIKWYKGCEE IKAGKKYSPS GAKLLVNNVA VEDGGSYACS
210 220 230 240 250
ARLTHLGRHF TIRNYIAVNT KEVEYGRRIP NITYPKNNSI EVPLGSTLIV
260 270 280 290 300
NCNITDTKEN TNLRCWRVNN TLVDDYYKDS KRIQEGIETN VSLRDQIRYT
310 320 330 340 350
VNITFLKVKM EDYGRPFTCH AGVSAAYIIL IYPVPDFRAY LLGGLMAFLL
360 370 380 390 400
LVVSVLFIYN SFKIDIMLWY RSAFHTAQAP DDEKLYDAYV LYPKYPRGSQ
410 420 430 440 450
GHDVDTLVLK ILPEVLEKQC GYKLFIFGRD EFPGQAVASV IDENIKLCRR
460 470 480 490 500
LMVFVAPESS SFGFLKNLSE EQIAVYNALI QHGMKVILIE LEKVKDYSTM
510 520 530 540 550
PESIQYIRQK HGAIQWDGDF TEQSQCAKTK FWKKVRYHMP PRRYPASSPV
560 570
QLLGHIPCNC KAGKCNAATG LITP
Length:574
Mass (Da):65,108
Last modified:March 1, 2001 - v1
Checksum:iA677A77BBFA50A76
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YWD7A0A0A6YWD7_MOUSE
Interleukin-1 receptor-like 2
Il1rl2
166Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284433 mRNA Translation: AAG21367.1
CCDSiCCDS14910.1
RefSeqiNP_573456.1, NM_133193.3
XP_006495671.1, XM_006495608.3
XP_006495672.1, XM_006495609.3
XP_006495673.1, XM_006495610.3
XP_006495674.1, XM_006495611.3
UniGeneiMm.155583

Genome annotation databases

EnsembliENSMUST00000095020; ENSMUSP00000092630; ENSMUSG00000070942
ENSMUST00000194296; ENSMUSP00000142248; ENSMUSG00000070942
GeneIDi107527
KEGGimmu:107527
UCSCiuc007atx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284433 mRNA Translation: AAG21367.1
CCDSiCCDS14910.1
RefSeqiNP_573456.1, NM_133193.3
XP_006495671.1, XM_006495608.3
XP_006495672.1, XM_006495609.3
XP_006495673.1, XM_006495610.3
XP_006495674.1, XM_006495611.3
UniGeneiMm.155583

3D structure databases

ProteinModelPortaliQ9ERS7
SMRiQ9ERS7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092630

PTM databases

iPTMnetiQ9ERS7
PhosphoSitePlusiQ9ERS7

Proteomic databases

PaxDbiQ9ERS7
PRIDEiQ9ERS7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095020; ENSMUSP00000092630; ENSMUSG00000070942
ENSMUST00000194296; ENSMUSP00000142248; ENSMUSG00000070942
GeneIDi107527
KEGGimmu:107527
UCSCiuc007atx.1 mouse

Organism-specific databases

CTDi8808
MGIiMGI:1913107 Il1rl2

Phylogenomic databases

eggNOGiENOG410IQBC Eukaryota
ENOG410Z3W1 LUCA
GeneTreeiENSGT00760000119071
HOGENOMiHOG000253916
HOVERGENiHBG052103
InParanoidiQ9ERS7
KOiK05172
OMAiCHRIHVN
OrthoDBiEOG091G03IT
PhylomeDBiQ9ERS7
TreeFamiTF325519

Enzyme and pathway databases

ReactomeiR-MMU-9007892 Interleukin-38 signaling
R-MMU-9014826 Interleukin-36 pathway

Miscellaneous databases

PROiPR:Q9ERS7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070942 Expressed in 134 organ(s), highest expression level in ear
CleanExiMM_IL1RL2
ExpressionAtlasiQ9ERS7 baseline and differential
GenevisibleiQ9ERS7 MM

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR015621 IL-1_rcpt_fam
IPR004076 IL-1_rcpt_I-typ
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
PF01582 TIR, 1 hit
PRINTSiPR01538 INTRLEUKN1R1
PR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
PS50104 TIR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiILRL2_MOUSE
AccessioniPrimary (citable) accession number: Q9ERS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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