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Protein

Pleckstrin homology domain-containing family A member 2

Gene

Plekha2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.2 Publications

GO - Molecular functioni

  • fibronectin binding Source: MGI
  • laminin binding Source: MGI
  • PDZ domain binding Source: UniProtKB
  • phosphatidylinositol-3,4-bisphosphate binding Source: MGI

GO - Biological processi

Keywordsi

LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family A member 2
Short name:
PH domain-containing family A member 2
Alternative name(s):
PH domain-containing adaptor PHAD47
Tandem PH domain-containing protein 2
Short name:
TAPP-2
Gene namesi
Name:Plekha2
Synonyms:Tapp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1928144 Plekha2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538771 – 425Pleckstrin homology domain-containing family A member 2Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei184PhosphoserineBy similarity1
Modified residuei314PhosphoserineBy similarity1
Modified residuei349PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9ERS5
MaxQBiQ9ERS5
PaxDbiQ9ERS5
PRIDEiQ9ERS5

PTM databases

iPTMnetiQ9ERS5
PhosphoSitePlusiQ9ERS5

Expressioni

Gene expression databases

BgeeiENSMUSG00000031557 Expressed in 256 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ9ERS5 baseline and differential
GenevisibleiQ9ERS5 MM

Interactioni

Subunit structurei

Binds MPDZ and PTPN13.

Binary interactionsi

WithEntry#Exp.IntActNotes
MPDZO759705EBI-8079166,EBI-821405From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9ERS5, 2 interactors
MINTiQ9ERS5

Structurei

Secondary structure

1425
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9ERS5
SMRiQ9ERS5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ERS5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 113PH 1PROSITE-ProRule annotationAdd BLAST107
Domaini198 – 298PH 2PROSITE-ProRule annotationAdd BLAST101

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IF2M Eukaryota
ENOG410ZQEQ LUCA
GeneTreeiENSGT00440000037398
HOGENOMiHOG000116175
HOVERGENiHBG053612
InParanoidiQ9ERS5
OMAiCLLWYMD
OrthoDBiEOG091G08U3
PhylomeDBiQ9ERS5
TreeFamiTF329516

Family and domain databases

Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 2 hits
SMARTiView protein in SMART
SM00233 PH, 2 hits
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q9ERS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPYVDRQNRI CGFLDIEDNE NSGKFLRRYF ILDTQANCLL WYMDNPQNLA
60 70 80 90 100
VGAGAVGSLQ LTYISKVSIA TPKQKPKTPF CFVINALSQR YFLQANDQKD
110 120 130 140 150
LKDWVEALNQ ASKITVPKAG TVPLATEVLK NLTAPPTLEK KPQVAYKTEI
160 170 180 190 200
IGGVVVQTPI SQNGGDGQEG CEPGTHAFLR RSQSYIPTSG CRPSTGPPLI
210 220 230 240 250
KSGYCVKQGN VRKSWKRRFF ALDDFTICYF KCEQDREPLR TIPLKDVLKT
260 270 280 290 300
HECLVKSGDL LMRDNLFEII TTSRTFYVQA DSPEDMHSWI EGIGAAVQAL
310 320 330 340 350
KCHPREPSFS RSISLTRPGS STLTSAPNSI LSRRRPPAEE KRGLCKAPSV
360 370 380 390 400
ASSWQPWTPV PQAEEKPLSV EHAPEDSLFM PNPGESTATG VLASSRVRHR
410 420
SEPQHPKEKP FVFNLDDENI RTSDV
Length:425
Mass (Da):47,380
Last modified:March 1, 2001 - v1
Checksum:i6666F5DB303B2CBA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z3L8D3Z3L8_MOUSE
Pleckstrin homology domain-containi...
Plekha2
95Annotation score:
F8WIK5F8WIK5_MOUSE
Pleckstrin homology domain-containi...
Plekha2
336Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti240R → H in BAC31224 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286161 mRNA Translation: AAG15198.1
AF418551 mRNA Translation: AAL57436.1
AK042324 mRNA Translation: BAC31224.2
AK078212 mRNA Translation: BAC37176.1
AK088395 mRNA Translation: BAC40325.1
BC010215 mRNA Translation: AAH10215.1
CCDSiCCDS22198.1
RefSeqiNP_112547.1, NM_031257.3
XP_006509290.1, XM_006509227.2
XP_006509291.1, XM_006509228.3
XP_006509293.1, XM_006509230.2
UniGeneiMm.261122

Genome annotation databases

EnsembliENSMUST00000064883; ENSMUSP00000066546; ENSMUSG00000031557
ENSMUST00000128715; ENSMUSP00000122564; ENSMUSG00000031557
GeneIDi83436
KEGGimmu:83436
UCSCiuc009lfq.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286161 mRNA Translation: AAG15198.1
AF418551 mRNA Translation: AAL57436.1
AK042324 mRNA Translation: BAC31224.2
AK078212 mRNA Translation: BAC37176.1
AK088395 mRNA Translation: BAC40325.1
BC010215 mRNA Translation: AAH10215.1
CCDSiCCDS22198.1
RefSeqiNP_112547.1, NM_031257.3
XP_006509290.1, XM_006509227.2
XP_006509291.1, XM_006509228.3
XP_006509293.1, XM_006509230.2
UniGeneiMm.261122

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V5PNMR-A1-113[»]
ProteinModelPortaliQ9ERS5
SMRiQ9ERS5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9ERS5, 2 interactors
MINTiQ9ERS5

PTM databases

iPTMnetiQ9ERS5
PhosphoSitePlusiQ9ERS5

Proteomic databases

EPDiQ9ERS5
MaxQBiQ9ERS5
PaxDbiQ9ERS5
PRIDEiQ9ERS5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064883; ENSMUSP00000066546; ENSMUSG00000031557
ENSMUST00000128715; ENSMUSP00000122564; ENSMUSG00000031557
GeneIDi83436
KEGGimmu:83436
UCSCiuc009lfq.3 mouse

Organism-specific databases

CTDi59339
MGIiMGI:1928144 Plekha2

Phylogenomic databases

eggNOGiENOG410IF2M Eukaryota
ENOG410ZQEQ LUCA
GeneTreeiENSGT00440000037398
HOGENOMiHOG000116175
HOVERGENiHBG053612
InParanoidiQ9ERS5
OMAiCLLWYMD
OrthoDBiEOG091G08U3
PhylomeDBiQ9ERS5
TreeFamiTF329516

Miscellaneous databases

ChiTaRSiPlekha2 mouse
EvolutionaryTraceiQ9ERS5
PROiPR:Q9ERS5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031557 Expressed in 256 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ9ERS5 baseline and differential
GenevisibleiQ9ERS5 MM

Family and domain databases

Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 2 hits
SMARTiView protein in SMART
SM00233 PH, 2 hits
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPKHA2_MOUSE
AccessioniPrimary (citable) accession number: Q9ERS5
Secondary accession number(s): Q8BY29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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