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UniProtKB - Q9ERQ8 (CAH7_MOUSE)
Protein
Carbonic anhydrase 7
Gene
Ca7
Organism
Mus musculus (Mouse)
Status
Functioni
Reversible hydration of carbon dioxide.
Catalytic activityi
- EC:4.2.1.1
Cofactori
Zn2+By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 66 | Proton donor/acceptorBy similarity | 1 | |
Metal bindingi | 96 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 98 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 121 | Zinc; catalyticBy similarity | 1 |
GO - Molecular functioni
- carbonate dehydratase activity Source: MGI
- hydro-lyase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- one-carbon metabolic process Source: GO_Central
- positive regulation of cellular pH reduction Source: MGI
- positive regulation of synaptic transmission, GABAergic Source: MGI
- regulation of chloride transport Source: MGI
- regulation of intracellular pH Source: GO_Central
Keywordsi
Molecular function | Lyase |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-1475029, Reversible hydration of carbon dioxide |
Names & Taxonomyi
Protein namesi | Recommended name: Carbonic anhydrase 7 (EC:4.2.1.1)Alternative name(s): Carbonate dehydratase VII Carbonic anhydrase VII Short name: CA-VII |
Gene namesi | Name:Ca7 Synonyms:Car7 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103100, Car7 |
VEuPathDBi | HostDB:ENSMUSG00000031883 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Cytosol
- cytosol Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000077432 | 1 – 264 | Carbonic anhydrase 7Add BLAST | 264 |
Proteomic databases
CPTACi | non-CPTAC-3421 non-CPTAC-3693 |
PaxDbi | Q9ERQ8 |
PRIDEi | Q9ERQ8 |
ProteomicsDBi | 265502 |
PTM databases
PhosphoSitePlusi | Q9ERQ8 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000031883, Expressed in optic fissure and 170 other tissues |
ExpressionAtlasi | Q9ERQ8, baseline and differential |
Genevisiblei | Q9ERQ8, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000052136 |
Chemistry databases
BindingDBi | Q9ERQ8 |
Miscellaneous databases
RNActi | Q9ERQ8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 262 | Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST | 258 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 201 – 202 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the alpha-carbonic anhydrase family.Curated
Phylogenomic databases
eggNOGi | KOG0382, Eukaryota |
GeneTreei | ENSGT00940000159757 |
InParanoidi | Q9ERQ8 |
OMAi | GHTIQAN |
OrthoDBi | 1377476at2759 |
PhylomeDBi | Q9ERQ8 |
TreeFami | TF316425 |
Family and domain databases
CDDi | cd03149, alpha_CA_VII, 1 hit |
Gene3Di | 3.10.200.10, 1 hit |
InterProi | View protein in InterPro IPR041890, Alpha_CA_VII IPR001148, CA_dom IPR036398, CA_dom_sf IPR023561, Carbonic_anhydrase_a-class IPR018338, Carbonic_anhydrase_a-class_CS |
PANTHERi | PTHR18952, PTHR18952, 1 hit |
Pfami | View protein in Pfam PF00194, Carb_anhydrase, 1 hit |
SMARTi | View protein in SMART SM01057, Carb_anhydrase, 1 hit |
SUPFAMi | SSF51069, SSF51069, 1 hit |
PROSITEi | View protein in PROSITE PS00162, ALPHA_CA_1, 1 hit PS51144, ALPHA_CA_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9ERQ8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTGHHCWGYG QDDGPSNWHK LYPIAQGDRQ SPINIISSQA VYSPSLQPLE
60 70 80 90 100
LFYEACMSLS ITNNGHSVQV DFNDSDDRTV VSGGPLEGPY RLKQLHFHWG
110 120 130 140 150
KKRDMGSEHT VDGKSFPSEL HLVHWNAKKY STFGEAAAAP DGLAVVGVFL
160 170 180 190 200
ETGDEHPSMN RLTDALYMVR FKDTKAQFSC FNPKCLLPTS RHYWTYPGSL
210 220 230 240 250
TTPPLSESVT WIVLREPIRI SERQMEKFRS LLFTSEDDER IHMVDNFRPP
260
QPLKGRVVKA SFQA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3XA26 | G3XA26_MOUSE | Carbonic anhydrase | Car7 | 208 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY075021 mRNA Translation: AAL78169.1 BC094913 mRNA Translation: AAH94913.1 AF291660 mRNA Translation: AAG16230.1 |
CCDSi | CCDS22581.1 |
RefSeqi | NP_001288093.1, NM_001301164.1 NP_001288094.1, NM_001301165.1 NP_444300.1, NM_053070.3 |
Genome annotation databases
Ensembli | ENSMUST00000056051; ENSMUSP00000052136; ENSMUSG00000031883 |
GeneIDi | 12354 |
KEGGi | mmu:12354 |
UCSCi | uc009nat.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY075021 mRNA Translation: AAL78169.1 BC094913 mRNA Translation: AAH94913.1 AF291660 mRNA Translation: AAG16230.1 |
CCDSi | CCDS22581.1 |
RefSeqi | NP_001288093.1, NM_001301164.1 NP_001288094.1, NM_001301165.1 NP_444300.1, NM_053070.3 |
3D structure databases
SMRi | Q9ERQ8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000052136 |
Chemistry databases
BindingDBi | Q9ERQ8 |
ChEMBLi | CHEMBL2216 |
DrugCentrali | Q9ERQ8 |
PTM databases
PhosphoSitePlusi | Q9ERQ8 |
Proteomic databases
CPTACi | non-CPTAC-3421 non-CPTAC-3693 |
PaxDbi | Q9ERQ8 |
PRIDEi | Q9ERQ8 |
ProteomicsDBi | 265502 |
Protocols and materials databases
Antibodypediai | 29327, 134 antibodies from 27 providers |
DNASUi | 12354 |
Genome annotation databases
Ensembli | ENSMUST00000056051; ENSMUSP00000052136; ENSMUSG00000031883 |
GeneIDi | 12354 |
KEGGi | mmu:12354 |
UCSCi | uc009nat.2, mouse |
Organism-specific databases
CTDi | 12354 |
MGIi | MGI:103100, Car7 |
VEuPathDBi | HostDB:ENSMUSG00000031883 |
Phylogenomic databases
eggNOGi | KOG0382, Eukaryota |
GeneTreei | ENSGT00940000159757 |
InParanoidi | Q9ERQ8 |
OMAi | GHTIQAN |
OrthoDBi | 1377476at2759 |
PhylomeDBi | Q9ERQ8 |
TreeFami | TF316425 |
Enzyme and pathway databases
Reactomei | R-MMU-1475029, Reversible hydration of carbon dioxide |
Miscellaneous databases
BioGRID-ORCSi | 12354, 2 hits in 64 CRISPR screens |
PROi | PR:Q9ERQ8 |
RNActi | Q9ERQ8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031883, Expressed in optic fissure and 170 other tissues |
ExpressionAtlasi | Q9ERQ8, baseline and differential |
Genevisiblei | Q9ERQ8, MM |
Family and domain databases
CDDi | cd03149, alpha_CA_VII, 1 hit |
Gene3Di | 3.10.200.10, 1 hit |
InterProi | View protein in InterPro IPR041890, Alpha_CA_VII IPR001148, CA_dom IPR036398, CA_dom_sf IPR023561, Carbonic_anhydrase_a-class IPR018338, Carbonic_anhydrase_a-class_CS |
PANTHERi | PTHR18952, PTHR18952, 1 hit |
Pfami | View protein in Pfam PF00194, Carb_anhydrase, 1 hit |
SMARTi | View protein in SMART SM01057, Carb_anhydrase, 1 hit |
SUPFAMi | SSF51069, SSF51069, 1 hit |
PROSITEi | View protein in PROSITE PS00162, ALPHA_CA_1, 1 hit PS51144, ALPHA_CA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CAH7_MOUSE | |
Accessioni | Q9ERQ8Primary (citable) accession number: Q9ERQ8 Secondary accession number(s): Q811X4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 9, 2003 |
Last sequence update: | August 16, 2005 | |
Last modified: | February 23, 2022 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families