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Protein

Secretory carrier-associated membrane protein 2

Gene

Scamp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Secretory carrier-associated membrane protein 2
Short name:
Secretory carrier membrane protein 2
Gene namesi
Name:Scamp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1346518 Scamp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 153CytoplasmicSequence analysisAdd BLAST153
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 181LumenalSequence analysis7
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 218CytoplasmicSequence analysisAdd BLAST16
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 262LumenalSequence analysisAdd BLAST23
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 329CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912551 – 329Secretory carrier-associated membrane protein 2Add BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei319PhosphoserineBy similarity1
Modified residuei320PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9ERN0
MaxQBiQ9ERN0
PaxDbiQ9ERN0
PRIDEiQ9ERN0

PTM databases

iPTMnetiQ9ERN0
PhosphoSitePlusiQ9ERN0
SwissPalmiQ9ERN0

Expressioni

Gene expression databases

BgeeiENSMUSG00000040188 Expressed in 287 organ(s), highest expression level in blood
CleanExiMM_SCAMP2
ExpressionAtlasiQ9ERN0 baseline and differential
GenevisibleiQ9ERN0 MM

Interactioni

Subunit structurei

Interacts with SLC6A4 and SLC9A7.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038350

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni203 – 218Interaction with SLC9A7By similarityAdd BLAST16

Sequence similaritiesi

Belongs to the SCAMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3088 Eukaryota
ENOG410XSJN LUCA
GeneTreeiENSGT00390000014393
HOGENOMiHOG000294221
HOVERGENiHBG071938
InParanoidiQ9ERN0
KOiK19995
OMAiFIFFCQI
OrthoDBiEOG091G0ID2
PhylomeDBiQ9ERN0
TreeFamiTF313797

Family and domain databases

InterProiView protein in InterPro
IPR007273 SCAMP
PANTHERiPTHR10687 PTHR10687, 1 hit
PfamiView protein in Pfam
PF04144 SCAMP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9ERN0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAFDTNPFA DPVDVNPFQD PSVTQLTNAP QSGLAEFNPF SETNAATTVP
60 70 80 90 100
ATQAPGPSQP AVLQPSVEPA QPTPQAVAAA AQAGLLRQQE ELDRKAAELE
110 120 130 140 150
RKERELQNTA ANLHVRDNNW PPLPSWCPVK PCFYQDFSTE IPADYQRICK
160 170 180 190 200
MLYYLWMLHS VTLFLNLLAC LAWFTSDAAN GTAFGLSILW FLIFTPCAFL
210 220 230 240 250
CWYRPIYKAF RSDNSFSFFV FFFVFFCQIG IYFIQLIGLP NLGTSGWLAA
260 270 280 290 300
LSTMKNGPLA VTIIMMVVAG FFTLCAGLSL FLLQRVHAFY RRTGASFQQA
310 320
QEEFSQGIFS SRTFRGAASS AARGAFQGN
Length:329
Mass (Da):36,465
Last modified:March 1, 2001 - v1
Checksum:iEAA185E68E044D80
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SUU4A0A1L1SUU4_MOUSE
Secretory carrier-associated membra...
Scamp2
200Annotation score:
A0A1L1SQD1A0A1L1SQD1_MOUSE
Secretory carrier-associated membra...
Scamp2
47Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295402 mRNA Translation: AAG22799.1
BC014751 mRNA Translation: AAH14751.1
CCDSiCCDS23224.1
RefSeqiNP_073724.1, NM_022813.3
UniGeneiMm.286069

Genome annotation databases

EnsembliENSMUST00000045791; ENSMUSP00000038350; ENSMUSG00000040188
GeneIDi24044
KEGGimmu:24044
UCSCiuc009pve.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295402 mRNA Translation: AAG22799.1
BC014751 mRNA Translation: AAH14751.1
CCDSiCCDS23224.1
RefSeqiNP_073724.1, NM_022813.3
UniGeneiMm.286069

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038350

PTM databases

iPTMnetiQ9ERN0
PhosphoSitePlusiQ9ERN0
SwissPalmiQ9ERN0

Proteomic databases

EPDiQ9ERN0
MaxQBiQ9ERN0
PaxDbiQ9ERN0
PRIDEiQ9ERN0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045791; ENSMUSP00000038350; ENSMUSG00000040188
GeneIDi24044
KEGGimmu:24044
UCSCiuc009pve.2 mouse

Organism-specific databases

CTDi10066
MGIiMGI:1346518 Scamp2

Phylogenomic databases

eggNOGiKOG3088 Eukaryota
ENOG410XSJN LUCA
GeneTreeiENSGT00390000014393
HOGENOMiHOG000294221
HOVERGENiHBG071938
InParanoidiQ9ERN0
KOiK19995
OMAiFIFFCQI
OrthoDBiEOG091G0ID2
PhylomeDBiQ9ERN0
TreeFamiTF313797

Miscellaneous databases

ChiTaRSiScamp2 mouse
PROiPR:Q9ERN0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040188 Expressed in 287 organ(s), highest expression level in blood
CleanExiMM_SCAMP2
ExpressionAtlasiQ9ERN0 baseline and differential
GenevisibleiQ9ERN0 MM

Family and domain databases

InterProiView protein in InterPro
IPR007273 SCAMP
PANTHERiPTHR10687 PTHR10687, 1 hit
PfamiView protein in Pfam
PF04144 SCAMP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCAM2_MOUSE
AccessioniPrimary (citable) accession number: Q9ERN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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