UniProtKB - Q9ERL7 (GMFG_MOUSE)
Protein
Glia maturation factor gamma
Gene
Gmfg
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- actin binding Source: InterPro
- Arp2/3 complex binding Source: MGI
- growth factor activity Source: UniProtKB-KW
GO - Biological processi
- actin filament debranching Source: MGI
- negative regulation of Arp2/3 complex-mediated actin nucleation Source: MGI
- regulation of actin cytoskeleton reorganization Source: InterPro
Keywordsi
Molecular function | Growth factor |
Enzyme and pathway databases
Reactomei | R-MMU-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Glia maturation factor gammaShort name: GMF-gamma |
Gene namesi | Name:Gmfg |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1927135, Gmfg |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000214948 | 2 – 142 | Glia maturation factor gammaAdd BLAST | 141 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9ERL7 |
MaxQBi | Q9ERL7 |
PaxDbi | Q9ERL7 |
PRIDEi | Q9ERL7 |
PTM databases
iPTMneti | Q9ERL7 |
PhosphoSitePlusi | Q9ERL7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000060791, Expressed in granulocyte and 59 other tissues |
Genevisiblei | Q9ERL7, MM |
Interactioni
GO - Molecular functioni
- actin binding Source: InterPro
- growth factor activity Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 211012, 4 interactors |
DIPi | DIP-60543N |
IntActi | Q9ERL7, 2 interactors |
STRINGi | 10090.ENSMUSP00000103927 |
Miscellaneous databases
RNActi | Q9ERL7, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q9ERL7 |
SMRi | Q9ERL7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9ERL7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 139 | ADF-HPROSITE-ProRule annotationAdd BLAST | 136 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1736, Eukaryota |
GeneTreei | ENSGT00390000008920 |
HOGENOMi | CLU_087056_1_0_1 |
InParanoidi | Q9ERL7 |
OMAi | ENCNPAS |
OrthoDBi | 1477747at2759 |
PhylomeDBi | Q9ERL7 |
TreeFami | TF315147 |
Family and domain databases
CDDi | cd11283, ADF_GMF-beta_like, 1 hit |
Gene3Di | 3.40.20.10, 1 hit |
InterProi | View protein in InterPro IPR002108, ADF-H IPR029006, ADF-H/Gelsolin-like_dom_sf IPR011171, GMF IPR030076, GMFG |
PANTHERi | PTHR11249, PTHR11249, 1 hit PTHR11249:SF4, PTHR11249:SF4, 1 hit |
Pfami | View protein in Pfam PF00241, Cofilin_ADF, 1 hit |
PIRSFi | PIRSF001788, GMF-beta, 1 hit |
SMARTi | View protein in SMART SM00102, ADF, 1 hit |
PROSITEi | View protein in PROSITE PS51263, ADF_H, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9ERL7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDSLVVCEV DPELKETLRK FRFRKETNNA AIIMKVDKDR QMVVLEDELQ
60 70 80 90 100
NISPEELKLE LPERQPRFVV YSYKYVHDDG RVSYPLCFIF SSPVGCKPEQ
110 120 130 140
QMMYAGSKNR LVQTAELTKV FEIRTTDDLT ETWLKEKLAF FR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YY16 | D3YY16_MOUSE | Glia maturation factor | Gmfg | 101 | Annotation score: | ||
D3Z2F6 | D3Z2F6_MOUSE | Glia maturation factor gamma | Gmfg | 86 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF297221 mRNA Translation: AAG22804.1 AB097120 Genomic DNA Translation: BAC76941.1 AK002834 mRNA Translation: BAB22392.1 AK009967 mRNA Translation: BAB26617.1 AK014214 mRNA Translation: BAB29210.1 BC011488 mRNA Translation: AAH11488.1 |
CCDSi | CCDS39859.1 CCDS39860.1 |
RefSeqi | NP_001034281.1, NM_001039192.1 NP_071307.1, NM_022024.2 |
Genome annotation databases
Ensembli | ENSMUST00000078845; ENSMUSP00000077889; ENSMUSG00000060791 ENSMUST00000108292; ENSMUSP00000103927; ENSMUSG00000060791 |
GeneIDi | 63986 |
KEGGi | mmu:63986 |
UCSCi | uc009fyx.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF297221 mRNA Translation: AAG22804.1 AB097120 Genomic DNA Translation: BAC76941.1 AK002834 mRNA Translation: BAB22392.1 AK009967 mRNA Translation: BAB26617.1 AK014214 mRNA Translation: BAB29210.1 BC011488 mRNA Translation: AAH11488.1 |
CCDSi | CCDS39859.1 CCDS39860.1 |
RefSeqi | NP_001034281.1, NM_001039192.1 NP_071307.1, NM_022024.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1VKK | X-ray | 1.35 | A | 1-142 | [»] | |
1WFS | NMR | - | A | 2-139 | [»] | |
4JD2 | X-ray | 3.08 | H | 1-142 | [»] | |
BMRBi | Q9ERL7 | |||||
SMRi | Q9ERL7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 211012, 4 interactors |
DIPi | DIP-60543N |
IntActi | Q9ERL7, 2 interactors |
STRINGi | 10090.ENSMUSP00000103927 |
PTM databases
iPTMneti | Q9ERL7 |
PhosphoSitePlusi | Q9ERL7 |
Proteomic databases
EPDi | Q9ERL7 |
MaxQBi | Q9ERL7 |
PaxDbi | Q9ERL7 |
PRIDEi | Q9ERL7 |
Protocols and materials databases
Antibodypediai | 16749, 207 antibodies |
DNASUi | 63986 |
Genome annotation databases
Ensembli | ENSMUST00000078845; ENSMUSP00000077889; ENSMUSG00000060791 ENSMUST00000108292; ENSMUSP00000103927; ENSMUSG00000060791 |
GeneIDi | 63986 |
KEGGi | mmu:63986 |
UCSCi | uc009fyx.1, mouse |
Organism-specific databases
CTDi | 9535 |
MGIi | MGI:1927135, Gmfg |
Phylogenomic databases
eggNOGi | KOG1736, Eukaryota |
GeneTreei | ENSGT00390000008920 |
HOGENOMi | CLU_087056_1_0_1 |
InParanoidi | Q9ERL7 |
OMAi | ENCNPAS |
OrthoDBi | 1477747at2759 |
PhylomeDBi | Q9ERL7 |
TreeFami | TF315147 |
Enzyme and pathway databases
Reactomei | R-MMU-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 63986, 0 hits in 17 CRISPR screens |
ChiTaRSi | Gmfg, mouse |
EvolutionaryTracei | Q9ERL7 |
PROi | PR:Q9ERL7 |
RNActi | Q9ERL7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000060791, Expressed in granulocyte and 59 other tissues |
Genevisiblei | Q9ERL7, MM |
Family and domain databases
CDDi | cd11283, ADF_GMF-beta_like, 1 hit |
Gene3Di | 3.40.20.10, 1 hit |
InterProi | View protein in InterPro IPR002108, ADF-H IPR029006, ADF-H/Gelsolin-like_dom_sf IPR011171, GMF IPR030076, GMFG |
PANTHERi | PTHR11249, PTHR11249, 1 hit PTHR11249:SF4, PTHR11249:SF4, 1 hit |
Pfami | View protein in Pfam PF00241, Cofilin_ADF, 1 hit |
PIRSFi | PIRSF001788, GMF-beta, 1 hit |
SMARTi | View protein in SMART SM00102, ADF, 1 hit |
PROSITEi | View protein in PROSITE PS51263, ADF_H, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GMFG_MOUSE | |
Accessioni | Q9ERL7Primary (citable) accession number: Q9ERL7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families