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Protein

Modulator of apoptosis 1

Gene

Moap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Modulator of apoptosis 1
Short name:
MAP-1
Gene namesi
Name:Moap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1915555 Moap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001552071 – 352Modulator of apoptosis 1Add BLAST352

Post-translational modificationi

Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM39.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ9ERH6
PaxDbiQ9ERH6
PeptideAtlasiQ9ERH6
PRIDEiQ9ERH6

PTM databases

iPTMnetiQ9ERH6
PhosphoSitePlusiQ9ERH6

Expressioni

Tissue specificityi

Widely expressed, including in the brain. High expression levels in testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000096458
CleanExiMM_MOAP1
GenevisibleiQ9ERH6 MM

Interactioni

Subunit structurei

Homodimer. Under normal circumstances, held in an inactive conformation by an intramolecular interaction. Binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction and allows further binding to BAX. Binds also to BCL2 and BCLX. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization (By similarity). Interacts with TRIM39 (By similarity). Interacts with RASSF6.By similarity1 Publication

GO - Molecular functioni

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni120 – 127BH3-like8
Regioni204 – 207RASSF1-bindingBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi335 – 340Poly-Glu6

Domaini

The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction (By similarity).By similarity

Sequence similaritiesi

Belongs to the PNMA family.Curated

Phylogenomic databases

eggNOGiENOG410IIH9 Eukaryota
ENOG410YK5I LUCA
GeneTreeiENSGT00530000062986
HOGENOMiHOG000013079
HOVERGENiHBG052488
InParanoidiQ9ERH6
OMAiIPEMWAP
OrthoDBiEOG091G0BG9
PhylomeDBiQ9ERH6
TreeFamiTF335054

Family and domain databases

InterProiView protein in InterPro
IPR026523 PNMA
PANTHERiPTHR23095 PTHR23095, 1 hit
PfamiView protein in Pfam
PF14893 PNMA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ERH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRLLEDWC RGMDMNPRKA LLVAGIPPTC GVADIEEALQ AGLAPLGEHR
60 70 80 90 100
LLGRMFRRDE NKNVALIGLT VETGSALVPK EIPAKGGVWR VIFKPPDTDS
110 120 130 140 150
DFLCRLNEFL KGEGMTMGEL TRVLGNRNDP LGLDPGIMIP EIRAPMLAQA
160 170 180 190 200
LNEALKPTLQ YLRYKKLSVF SGRDPPGPGE EEFESWMFHT SQVMKTWQVS
210 220 230 240 250
DVEKRRRLIE SLRGPAFEII RVLKINNPFI TVAECLKTLE TIFGIIDNPR
260 270 280 290 300
ALQVKYLTTY QKTDEKLSAY VLRLEPLLQK LVQKGAIEKE VVNQARLDQV
310 320 330 340 350
IAGAVHKSVR RELGLPEGSP APGLLQLLTL IKDKEAEEEE VLLQAELEGY

CT
Length:352
Mass (Da):39,404
Last modified:March 1, 2001 - v1
Checksum:i8F4630D080495D98
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57R → K in AAH55374 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305551 mRNA Translation: AAG31787.1
AK019599 mRNA Translation: BAB31810.1
BC014715 mRNA Translation: AAH14715.1
BC055374 mRNA Translation: AAH55374.1
CCDSiCCDS26122.1
RefSeqiNP_001136409.1, NM_001142937.2
NP_071718.1, NM_022323.7
UniGeneiMm.291222
Mm.489678

Genome annotation databases

EnsembliENSMUST00000173760; ENSMUSP00000133459; ENSMUSG00000096458
ENSMUST00000178384; ENSMUSP00000137010; ENSMUSG00000096458
GeneIDi64113
KEGGimmu:64113
UCSCiuc011yqo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMOAP1_MOUSE
AccessioniPrimary (citable) accession number: Q9ERH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: March 1, 2001
Last modified: July 5, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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