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Protein

Striatin-3

Gene

Strn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Striatin-3
Alternative name(s):
Cell cycle autoantigen SG2NA
S/G2 antigen
Gene namesi
Name:Strn3
Synonyms:Gs2na, Sg2na
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2151064 Strn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512371 – 796Striatin-3Add BLAST796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei150PhosphothreonineBy similarity1
Modified residuei202PhosphoserineCombined sources1
Modified residuei214PhosphoserineBy similarity1
Modified residuei229PhosphoserineCombined sources1
Modified residuei257PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9ERG2
MaxQBiQ9ERG2
PaxDbiQ9ERG2
PeptideAtlasiQ9ERG2
PRIDEiQ9ERG2

PTM databases

iPTMnetiQ9ERG2
PhosphoSitePlusiQ9ERG2

Expressioni

Tissue specificityi

Mainly expressed in the brain and muscles but is also detected at low levels in various tissues such as kidney, spleen and lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000020954 Expressed in 295 organ(s), highest expression level in hindlimb zeugopod muscle
CleanExiMM_STRN3
ExpressionAtlasiQ9ERG2 baseline and differential
GenevisibleiQ9ERG2 MM

Interactioni

Subunit structurei

Interacts with protein phosphatase 2A (PP2A). Interacts with CDC42BPB.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi220464, 44 interactors
IntActiQ9ERG2, 49 interactors
MINTiQ9ERG2
STRINGi10090.ENSMUSP00000013130

Structurei

3D structure databases

ProteinModelPortaliQ9ERG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati477 – 516WD 1Add BLAST40
Repeati530 – 569WD 2Add BLAST40
Repeati583 – 622WD 3Add BLAST40
Repeati678 – 717WD 4Add BLAST40
Repeati720 – 759WD 5Add BLAST40
Repeati766 – 795WD 6Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni71 – 79Caveolin-bindingSequence analysis9
Regioni166 – 183Calmodulin-bindingSequence analysisAdd BLAST18

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili77 – 136Sequence analysisAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 13Poly-Gly8

Sequence similaritiesi

Belongs to the WD repeat striatin family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0642 Eukaryota
ENOG410XR31 LUCA
GeneTreeiENSGT00520000055597
HOGENOMiHOG000236343
HOVERGENiHBG007117
InParanoidiQ9ERG2
KOiK17608
OrthoDBiEOG091G0509
PhylomeDBiQ9ERG2
TreeFamiTF313387

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR013258 Striatin_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08232 Striatin, 1 hit
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9ERG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDELAGGGGG GQGMAAPPRP QQGPGGNLSL PPGANGAPGG GGPPAAEAAG
60 70 80 90 100
PPAGPELSRP QQYTIPGILH YIQHEWARFE MERAHWEVER AELQARIAFL
110 120 130 140 150
QGERKGQENL KKDLVRRIKM LEYALKQERA KYHKLKYGTE LNQGDLKMPT
160 170 180 190 200
FESEETKDVE APPAPQNSQL TWKQGRQLLR QYLQEVGYTD TILDVRSQRV
210 220 230 240 250
RSLLGLSNSE PNGSVEAKNL EQILNGGESP KQKGQEIKRP PGDVLETFNF
260 270 280 290 300
LENADDSDEE ENDMIEGIPE GKDKLRIHKH KIGNEGLAAD LTDDPDTEEA
310 320 330 340 350
LKEFDFLVTA EDGEGAGEAR SSGDGTEWDK DDLSPTAEVW DVDQGLISKL
360 370 380 390 400
KEQYKKERKG KKGVKRVNRT NLCDMITDLG DDELPHIPSG IINQSRSAST
410 420 430 440 450
RMADHEGARA EEAEPITFPS GGGKSFIMGS DDVLLSVLGL GDLADLTVTN
460 470 480 490 500
DADYSYDLPA NKDAFRKTWN PKYTLRSHFD GVRALAFHPV EPVLVTASED
510 520 530 540 550
HTLKLWNLQK TVPAKKSASL DVEPIYTFRA HIGPVLSLAI SSNGEQCFSG
560 570 580 590 600
GIDATIQWWN MPSPNVDPYD TYESNVLAGT LVAHTDAVWG LAYSGIKNQL
610 620 630 640 650
LSCSADGTIR LWNPQEKLPC VCTYNGDKEH GIPTSVDFIG CDPAHMVTSF
660 670 680 690 700
NTGSAVIYDL ETSQSLVMLS SQVDSGLQSS NHINRVVSHP TLPVTITAHE
710 720 730 740 750
DRHIKFFDNK TGKMIHSMVA HLDAVTSLAV DPNGIYLMSG SHDCSIRLWN
760 770 780 790
LDSKTCVQEI TAHRKKLDES IYDVAFHPSK AYIASAGADA LAKVFV
Length:796
Mass (Da):87,150
Last modified:March 1, 2001 - v1
Checksum:i161FAF5DDEBE23DD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2RQS1B2RQS1_MOUSE
Striatin-3
Strn3
712Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF307777 mRNA Translation: AAG24454.1
CCDSiCCDS36440.1
RefSeqiNP_443205.1, NM_052973.2
UniGeneiMm.65979

Genome annotation databases

EnsembliENSMUST00000013130; ENSMUSP00000013130; ENSMUSG00000020954
GeneIDi94186
KEGGimmu:94186
UCSCiuc007nmt.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF307777 mRNA Translation: AAG24454.1
CCDSiCCDS36440.1
RefSeqiNP_443205.1, NM_052973.2
UniGeneiMm.65979

3D structure databases

ProteinModelPortaliQ9ERG2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220464, 44 interactors
IntActiQ9ERG2, 49 interactors
MINTiQ9ERG2
STRINGi10090.ENSMUSP00000013130

PTM databases

iPTMnetiQ9ERG2
PhosphoSitePlusiQ9ERG2

Proteomic databases

EPDiQ9ERG2
MaxQBiQ9ERG2
PaxDbiQ9ERG2
PeptideAtlasiQ9ERG2
PRIDEiQ9ERG2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000013130; ENSMUSP00000013130; ENSMUSG00000020954
GeneIDi94186
KEGGimmu:94186
UCSCiuc007nmt.2 mouse

Organism-specific databases

CTDi29966
MGIiMGI:2151064 Strn3

Phylogenomic databases

eggNOGiKOG0642 Eukaryota
ENOG410XR31 LUCA
GeneTreeiENSGT00520000055597
HOGENOMiHOG000236343
HOVERGENiHBG007117
InParanoidiQ9ERG2
KOiK17608
OrthoDBiEOG091G0509
PhylomeDBiQ9ERG2
TreeFamiTF313387

Miscellaneous databases

PROiPR:Q9ERG2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020954 Expressed in 295 organ(s), highest expression level in hindlimb zeugopod muscle
CleanExiMM_STRN3
ExpressionAtlasiQ9ERG2 baseline and differential
GenevisibleiQ9ERG2 MM

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR013258 Striatin_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08232 Striatin, 1 hit
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTRN3_MOUSE
AccessioniPrimary (citable) accession number: Q9ERG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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