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Protein

Gamma-parvin

Gene

Parvg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably plays a role in the regulation of cell adhesion and cytoskeleton organization.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-parvin
Gene namesi
Name:Parvg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2158329 Parvg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001215861 – 331Gamma-parvinAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9ERD8
MaxQBiQ9ERD8
PaxDbiQ9ERD8
PRIDEiQ9ERD8

PTM databases

iPTMnetiQ9ERD8
PhosphoSitePlusiQ9ERD8

Expressioni

Tissue specificityi

Expressed strongly in spleen and testis, moderately in lung and weakly in brain and heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000022439 Expressed in 75 organ(s), highest expression level in thymus
CleanExiMM_PARVG
ExpressionAtlasiQ9ERD8 baseline and differential
GenevisibleiQ9ERD8 MM

Interactioni

Subunit structurei

Interacts with integrin-linked protein kinase and actin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211027, 1 interactor
IntActiQ9ERD8, 1 interactor
STRINGi10090.ENSMUSP00000131443

Structurei

3D structure databases

ProteinModelPortaliQ9ERD8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 151Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST108
Domaini210 – 317Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Belongs to the parvin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3631 Eukaryota
ENOG410XQWH LUCA
GeneTreeiENSGT00390000009673
HOGENOMiHOG000247027
HOVERGENiHBG053517
InParanoidiQ9ERD8
KOiK06275
TreeFamiTF314025

Family and domain databases

Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR028433 Parvin
PANTHERiPTHR12114 PTHR12114, 1 hit
PfamiView protein in Pfam
PF00307 CH, 2 hits
PIRSFiPIRSF039131 Parvin, 1 hit
SUPFAMiSSF47576 SSF47576, 2 hits
PROSITEiView protein in PROSITE
PS50021 CH, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9ERD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELEFLYDLL QLPKEVAQPT EEELPRGGKK KYLSPNSKRN PKFEELQKVL
60 70 80 90 100
MEWINTTLLP EHIVVRSLEE DMFDGLILHH LFQKLASLKL EVEEISLTSA
110 120 130 140 150
SQRHKLGVIL EAVNQNLQVE EKQAKWSVET IFNKDLLATL HLLVALAKRF
160 170 180 190 200
QPDLPLPDNV QVEVIHIEST KTGLKSDKQV EQLTECKSHK DQPLQDAFDE
210 220 230 240 250
LFKLAPEKVH AVQEAIVSFV NQKLERLGLS VQSLDTQFAD GVILLLLIGQ
260 270 280 290 300
LEGFFLHLKE FYLTPSSPTE MLHNVTLALD LLKDEGLFSY PVNPEDIVNK
310 320 330
DAKSTLRILY SLFQKHSLRA EGGGAHHATP N
Length:331
Mass (Da):37,603
Last modified:July 27, 2011 - v2
Checksum:i4EEA891D144444F8
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PYG5E9PYG5_MOUSE
Gamma-parvin
Parvg
384Annotation score:
A6PW97A6PW97_MOUSE
Gamma-parvin
Parvg
122Annotation score:
A0A2I3BS32A0A2I3BS32_MOUSE
Gamma-parvin
Parvg
56Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3L → S in AAH11200 (PubMed:19468303).Curated1
Sequence conflicti40N → S in AAG29542 (PubMed:11171322).Curated1
Sequence conflicti259K → T in AAH11200 (PubMed:19468303).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312712 mRNA Translation: AAG29542.1
AK040914 mRNA Translation: BAC30741.1
AK079881 mRNA Translation: BAC37772.1
AL626769 Genomic DNA No translation available.
BC011200 mRNA Translation: AAH11200.1
CCDSiCCDS27710.1
RefSeqiNP_001155972.1, NM_001162500.1
NP_071716.3, NM_022321.4
XP_011244008.1, XM_011245706.2
UniGeneiMm.251356

Genome annotation databases

EnsembliENSMUST00000023074; ENSMUSP00000023074; ENSMUSG00000022439
GeneIDi64099
KEGGimmu:64099
UCSCiuc007xbz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312712 mRNA Translation: AAG29542.1
AK040914 mRNA Translation: BAC30741.1
AK079881 mRNA Translation: BAC37772.1
AL626769 Genomic DNA No translation available.
BC011200 mRNA Translation: AAH11200.1
CCDSiCCDS27710.1
RefSeqiNP_001155972.1, NM_001162500.1
NP_071716.3, NM_022321.4
XP_011244008.1, XM_011245706.2
UniGeneiMm.251356

3D structure databases

ProteinModelPortaliQ9ERD8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211027, 1 interactor
IntActiQ9ERD8, 1 interactor
STRINGi10090.ENSMUSP00000131443

PTM databases

iPTMnetiQ9ERD8
PhosphoSitePlusiQ9ERD8

Proteomic databases

EPDiQ9ERD8
MaxQBiQ9ERD8
PaxDbiQ9ERD8
PRIDEiQ9ERD8

Protocols and materials databases

DNASUi64099
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023074; ENSMUSP00000023074; ENSMUSG00000022439
GeneIDi64099
KEGGimmu:64099
UCSCiuc007xbz.2 mouse

Organism-specific databases

CTDi64098
MGIiMGI:2158329 Parvg

Phylogenomic databases

eggNOGiKOG3631 Eukaryota
ENOG410XQWH LUCA
GeneTreeiENSGT00390000009673
HOGENOMiHOG000247027
HOVERGENiHBG053517
InParanoidiQ9ERD8
KOiK06275
TreeFamiTF314025

Miscellaneous databases

PROiPR:Q9ERD8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022439 Expressed in 75 organ(s), highest expression level in thymus
CleanExiMM_PARVG
ExpressionAtlasiQ9ERD8 baseline and differential
GenevisibleiQ9ERD8 MM

Family and domain databases

Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR028433 Parvin
PANTHERiPTHR12114 PTHR12114, 1 hit
PfamiView protein in Pfam
PF00307 CH, 2 hits
PIRSFiPIRSF039131 Parvin, 1 hit
SUPFAMiSSF47576 SSF47576, 2 hits
PROSITEiView protein in PROSITE
PS50021 CH, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPARVG_MOUSE
AccessioniPrimary (citable) accession number: Q9ERD8
Secondary accession number(s): Q8BH45, Q91X89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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