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Entry version 131 (08 May 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Unconventional myosin-XVI

Gene

Myo16

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi497 – 504ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: RGD
  • actin filament binding Source: HGNC
  • ATP binding Source: UniProtKB-KW
  • motor activity Source: InterPro
  • protein-containing complex binding Source: RGD
  • protein phosphatase binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Unconventional myosin-XVI
Alternative name(s):
Myosin heavy chain myr 8
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3
Unconventional myosin-16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myo16By similarity
Synonyms:Myr8Imported, Nyap3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Rat genome database

More...
RGDi
621561 Myo16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002891381 – 1912Unconventional myosin-XVIAdd BLAST1912

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ERC1

PRoteomics IDEntifications database

More...
PRIDEi
Q9ERC1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ERC1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ERC1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest level of isoform 1 found in brain. Also found in bladder, kidney and lung. Very low or undetectable levels of isoform 2 in all tissues tested.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 1 is expressed at all developmental stages with highest levels during the first two weeks after birth when migration of neurons and formation of dendrites and axons is highest. Within the developing brain the highest level is found in granule neurons in the initial stages of migration. Also found in soma and dendrites of developing Purkinje cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000016483 Expressed in 7 organ(s), highest expression level in brain

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ERC1 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds PPP1CA and/or PPP1CC. Binds F-actin in an ATP-sensitive manner (PubMed:11588169).

Interacts with ACOT9, ARHGAP26 and PIK3R2.

Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity).

Interacts with KIRREL3 (By similarity).

By similarity1 Publication

GO - Molecular functioni

  • actin binding Source: RGD
  • actin filament binding Source: HGNC
  • protein phosphatase binding Source: UniProtKB

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000022741

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ERC1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati59 – 88ANK 1Sequence analysisAdd BLAST30
Repeati92 – 121ANK 2Sequence analysisAdd BLAST30
Repeati125 – 154ANK 3Sequence analysisAdd BLAST30
Repeati158 – 189ANK 4Sequence analysisAdd BLAST32
Repeati191 – 217ANK 5Sequence analysisAdd BLAST27
Repeati221 – 250ANK 6Sequence analysisAdd BLAST30
Repeati253 – 283ANK 7Sequence analysisAdd BLAST31
Repeati287 – 316ANK 8Sequence analysisAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini401 – 1144Myosin motorPROSITE-ProRule annotationAdd BLAST744
Domaini1146 – 1175IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1110 – 1365Involved in CYFIP1- and NCKAP1-bindingBy similarityAdd BLAST256

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1494 – 1725Pro-richSequence analysisAdd BLAST232

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated
In the C-terminal section; belongs to the NYAP family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIRW Eukaryota
COG0666 LUCA
COG5022 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158920

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113706

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ERC1

KEGG Orthology (KO)

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KOi
K17481

Identification of Orthologs from Complete Genome Data

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OMAi
VDNQYWT

Database of Orthologous Groups

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OrthoDBi
59940at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9ERC1

TreeFam database of animal gene trees

More...
TreeFami
TF332267

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 2 hits
cd14878 MYSc_Myo16, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR036042 MYSc_Myo16
IPR039482 NYAP_N
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF00063 Myosin_head, 1 hit
PF15439 NYAP_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 5 hits
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 11 Publication (identifier: Q9ERC1-1) [UniParc]FASTAAdd to basket
Also known as: Myr8b1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIDQCLLES LPLGQRQRLV RRMRCEQIKA YYEREKVFQK QEGLLKRIKP
60 70 80 90 100
GKSQKVRFGL ADMIQDAIIH HHDKEVLQLL KEGADPHTLV SSGGSLLHLC
110 120 130 140 150
ARYDNVFIAE VLIDRGVNVN HQDEDFWAPM HIACACDNPD IVLLLILAGA
160 170 180 190 200
NVLLQDVNGN IPLDYAVEGT ESSAILLAYL DENGVDLNSL RQIKLQRPLS
210 220 230 240 250
MLTDVRHFLS SGGDVNEKND DGVTLLHMAC ASGYKEVVLL LLEHGGDLNG
260 270 280 290 300
MDDGYWTPLH LAAKYGQTTL VKLLLAHQAN PHLVNCNGEK PSDIAASESI
310 320 330 340 350
EEMLLKAEIA WEERMKESPS VPSLAQEELY EEILHDLPEL SSKLSPLVLP
360 370 380 390 400
IAKQDSLLEK DIMFKDTTKG LCNQESQDGP PETSMVSSSS KPEQVQLTPP
410 420 430 440 450
APSDDLATLS ELNDSSLLYE IQKRFGNDQI HTFIGDIFLL VNPFKELPIY
460 470 480 490 500
STVVSQMYLS PTGQRSPSLP PHLFSCAERA FHRLFQERRP QNIILSGERG
510 520 530 540 550
SGKTQASKQI MKHLTSRASS SCTMFDSRFK HAICILEAFG HAKTTLNNVS
560 570 580 590 600
SCLIQYWELQ FCQRRKHVTG ARISTYMLEK PRLVAQPPGQ GSFLIFSWLM
610 620 630 640 650
DGLSAEEKCG LHLSNFCAHR YVSQGMREDV STAERSLNKE RLADLKHALN
660 670 680 690 700
VIGFSALEVE NLFAILSAIL HIGDIQFTAL TEADSAFVSD LQLLEQVADM
710 720 730 740 750
LQVSTDELAS ALTTDIQYFK GDVIIRRHTT QIAAFYRDLL AKSLYSRLFG
760 770 780 790 800
FLINTVNCCL QSQDEYKSLQ TLDIGILDIF GFEEFQKNEF EQLCVNLTNE
810 820 830 840 850
KMHHYIQEVL FLQEQTECVQ EGVAMETACS PGNQAGVLDF FFQKPSGFFS
860 870 880 890 900
LLDEESQAIW SVEPNLPRKL QGLLESSNTN AVYSPMKDGN GNVAFKGQGA
910 920 930 940 950
AFTVMHYAGR VTYEIRGAVE RNKDSLSQNL LFVMKTSENV VISHLFQSKL
960 970 980 990 1000
SPTGSLISSY PSFKFGGHKS SLLSKRIASS MVGVNKNYLE LSKLLKKKGT
1010 1020 1030 1040 1050
CTFLQRLERG DPATTASQLT KSLADITAKL QKGSPHFILC VKPNTSQLPG
1060 1070 1080 1090 1100
VFDHFYVSAQ LQYLGVLGLV RLFRYGYPVR PSFEDFLSRY EPLASVLLGE
1110 1120 1130 1140 1150
KKGQPAEERC RLVLQRCKLQ GWQMGVHKVF LKYWQVDQLG DLWLQMQRKI
1160 1170 1180 1190 1200
VTCQKVIRGF LARQHLLQRM SIKQQEVTSI KSFLQSTEDM ALKTYDALVI
1210 1220 1230 1240 1250
QNASDIAREH DRLRKEVHAA YHRNRQEEGT KRAEDQGGCR HAHSNSVPVP
1260 1270 1280 1290 1300
MAVDSLAQAL AGPSSRSPSL HSVFSMDDST GLPSPRKQPP PKPKRDPNTR
1310 1320 1330 1340 1350
LSASYEAVSA CLSATKDAAS EALTRPRPHS DDYSTMKKIP PRKPKRSPHT
1360 1370 1380 1390 1400
KLSGSYEEIW GPRPSGTMGQ VGKHHAPGTL GVQWASPDSM PQCTPQLPLH
1410 1420 1430 1440 1450
LPLPQGDYDD DGEPVYIEMV GNAARAGGSE TDSPDQGESV YEEMKYVLPE
1460 1470 1480 1490 1500
EGCGPGMLTF LPASPPLFLE TRKAIILEAG EGSCQPLKDT CDIPPPFPNL
1510 1520 1530 1540 1550
LPHRPPLLVF PPTPVTCSPA SDESPLTPLE VKKLPVLETN LKYPVQSEGS
1560 1570 1580 1590 1600
SPLSPQYSKA QKGENDQLTS PGFPVFNGPS RISPPATPPP PPGPPPAPCG
1610 1620 1630 1640 1650
PPSAPCGPPP APCGPPPVPC GPPPAPCGPP PAPCGAAPAP CRPPTHFAFP
1660 1670 1680 1690 1700
PDSVLVTAAK ALTNSDLPRT QPKPSSAPVL GPCSPFVKAP YSPGRTARAD
1710 1720 1730 1740 1750
LRKASSTFSP PSPYSPPNSR PLSSPLDELA SLFNSGRSVL RRSAVGRRIR
1760 1770 1780 1790 1800
EAEGFETNMN LSSRDEPSSS EMASETQDRN ANNHGTQLSS SLSSVVAAEN
1810 1820 1830 1840 1850
GNPVTNGLAE DDGCSRLCLS GMGTSSFQRH RESHTTQVIH QLRLSENESV
1860 1870 1880 1890 1900
ALQELLDWRR KLCESREGWQ EAMQHPEPRA PPPPPCKKPT LLKKPEGGSC
1910
TRLSSQLWDS SI
Length:1,912
Mass (Da):210,691
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C15014A1A83C9C3
GO
Isoform 21 Publication (identifier: Q9ERC1-2) [UniParc]FASTAAdd to basket
Also known as: Myr8a1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1322-1322: A → G
     1323-1912: Missing.

Show »
Length:1,322
Mass (Da):147,842
Checksum:i2554F7AAC222DB66
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0524441322A → G in isoform 2. 1 Publication1
Alternative sequenceiVSP_0524451323 – 1912Missing in isoform 2. 1 PublicationAdd BLAST590

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF209114 mRNA Translation: AAF20150.1
AY004215 mRNA Translation: AAG23288.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A59288

NCBI Reference Sequences

More...
RefSeqi
NP_620248.1, NM_138893.1 [Q9ERC1-1]
XP_017455479.1, XM_017599990.1 [Q9ERC1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000022742; ENSRNOP00000022741; ENSRNOG00000016483 [Q9ERC1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
192253

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:192253

UCSC genome browser

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UCSCi
RGD:621561 rat [Q9ERC1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF209114 mRNA Translation: AAF20150.1
AY004215 mRNA Translation: AAG23288.1
PIRiA59288
RefSeqiNP_620248.1, NM_138893.1 [Q9ERC1-1]
XP_017455479.1, XM_017599990.1 [Q9ERC1-1]

3D structure databases

SMRiQ9ERC1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022741

PTM databases

iPTMnetiQ9ERC1
PhosphoSitePlusiQ9ERC1

Proteomic databases

PaxDbiQ9ERC1
PRIDEiQ9ERC1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022742; ENSRNOP00000022741; ENSRNOG00000016483 [Q9ERC1-1]
GeneIDi192253
KEGGirno:192253
UCSCiRGD:621561 rat [Q9ERC1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23026
RGDi621561 Myo16

Phylogenomic databases

eggNOGiENOG410IIRW Eukaryota
COG0666 LUCA
COG5022 LUCA
GeneTreeiENSGT00940000158920
HOGENOMiHOG000113706
InParanoidiQ9ERC1
KOiK17481
OMAiVDNQYWT
OrthoDBi59940at2759
PhylomeDBiQ9ERC1
TreeFamiTF332267

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9ERC1

Gene expression databases

BgeeiENSRNOG00000016483 Expressed in 7 organ(s), highest expression level in brain
GenevisibleiQ9ERC1 RN

Family and domain databases

CDDicd00204 ANK, 2 hits
cd14878 MYSc_Myo16, 1 hit
Gene3Di1.25.40.20, 2 hits
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR036042 MYSc_Myo16
IPR039482 NYAP_N
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF00063 Myosin_head, 1 hit
PF15439 NYAP_N, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYO16_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ERC1
Secondary accession number(s): Q9QXI0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2001
Last modified: May 8, 2019
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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