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UniProtKB - Q9ERB4 (CSPG2_RAT)

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Protein

Versican core protein

Gene

Vcan

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • axon regeneration Source: RGD
  • cell adhesion Source: InterPro
  • central nervous system development Source: GO_Central
  • response to wounding Source: RGD
  • skeletal system development Source: GO_Central
View the complete GO annotation on QuickGO ...

Keywordsi

LigandCalcium, Hyaluronic acid, Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Versican core protein
Alternative name(s):
Chondroitin sulfate proteoglycan core protein 2
Short name:
Chondroitin sulfate proteoglycan 2
Glial hyaluronate-binding protein
Short name:
GHAP
Large fibroblast proteoglycan
PG-M
Gene namesi
Name:Vcan
Synonyms:Cspg2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619940 Vcan

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001752421 – 2738Versican core proteinAdd BLAST2718

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 130By similarity
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi172 ↔ 243By similarity
Disulfide bondi196 ↔ 217By similarity
Disulfide bondi270 ↔ 345By similarity
Disulfide bondi294 ↔ 315By similarity
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi692N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi758N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi802N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi805N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1435N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1633N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1660N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1684N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1738N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1848N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1963PhosphoserineBy similarity1
Modified residuei1964PhosphoserineBy similarity1
Glycosylationi2004N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2409N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2435 ↔ 2446By similarity
Disulfide bondi2440 ↔ 2455By similarity
Disulfide bondi2457 ↔ 2466By similarity
Disulfide bondi2473 ↔ 2484By similarity
Disulfide bondi2478 ↔ 2493By similarity
Disulfide bondi2495 ↔ 2504By similarity
Disulfide bondi2511 ↔ 2522By similarity
Disulfide bondi2539 ↔ 2631By similarity
Disulfide bondi2607 ↔ 2623By similarity
Disulfide bondi2638 ↔ 2681By similarity
Disulfide bondi2667 ↔ 2694By similarity
Glycosylationi2711N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2721N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiQ9ERB4
PRIDEiQ9ERB4

PTM databases

PhosphoSitePlusiQ9ERB4

Expressioni

Tissue specificityi

In kidney is expressed in the papillary area, but not in glomeruli.

Developmental stagei

Disappears after the cartilage development.

Interactioni

Subunit structurei

Interacts with FBLN1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045935

Structurei

3D structure databases

ProteinModelPortaliQ9ERB4
SMRiQ9ERB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 146Ig-like V-typeAdd BLAST126
Domaini150 – 245Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini251 – 347Link 2PROSITE-ProRule annotationAdd BLAST97
Domaini2431 – 2467EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini2469 – 2505EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini2518 – 2632C-type lectinPROSITE-ProRule annotationAdd BLAST115
Domaini2636 – 2696SushiPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni‹349 – 695GAG-alpha (glucosaminoglycan attachment domain)Add BLAST›347
Regioni696 – 2431GAG-betaAdd BLAST1736

Sequence similaritiesi

Belongs to the aggrecan/versican proteoglycan family.Curated

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IFXS Eukaryota
ENOG410ZPDG LUCA
HOGENOMiHOG000168523
HOVERGENiHBG061970
InParanoidiQ9ERB4
KOiK06793
PhylomeDBiQ9ERB4

Family and domain databases

CDDicd00033 CCP, 1 hit
cd03588 CLECT_CSPGs, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 3 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033987 CSPG_CTLD
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008 EGF, 2 hits
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 1 hit
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SM00034 CLECT, 1 hit
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 3 hits
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS50835 IG_LIKE, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits
PS50923 SUSHI, 1 hit

Sequences (3)i

Sequence statusi: Fragments.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform V0 (identifier: Q9ERB4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLINMNGILW MCSTLLLTHA LHKAKMEENP PVKGSLSGKV ILPCHFSTLP 
        60         70         80         90        100
TLPPDYNTSE FLRIKWSKIE VDKNGKDIKE TTVLVAQDGN IKIGQDYKGR 
       110        120        130        140        150
VSVPTHPDDV GDASLTMVKL RASDAGVYRC DVMYGIEDTQ NTMSLAVDGV 
       160        170        180        190        200
VFHYRAATSR YTLNFESAQQ ACLDIGAVIA TPEQLFAAYE DGFEQCDAGW 
       210        220        230        240        250
LSDQTVRYPI RAPREGCYGD MMGKEGVRTY GFRSPQETYD VYCYVDHLDG 
       260        270        280        290        300
DVFHITAPSK FTFEEAEAEC ANRDARLATV GELHAAWRNG FDQCDYGWLS 
       310        320        330        340        350
DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTCFPLPDSR FDAYCFKRSP 
       360        370        380        390        400
LSIIPKTEWS VSETSVPLED EVLGKSDQDT LEQTHLEATM SPEALSTIEV 
       410        420        430        440        450
TQGETQEEPQ TPGIPFPALS STAVMTKETT AFEEEGEGST YTLSEDRLMT 
       460        470        480        490        500
DSEIVPSLET TPVGTSYPGG AMTQQEVEMD TMVTQMSSIR PTVVLSTEPE 
       510        520        530        540        550
VSYEAEGSSP MEFASTLKPF GTQVTQLVEE TTEEGKKTPL DYTDLGSGLF 
       560        570        580        590        600
EQPRVTELPD FSMTPSDISV FTAIDSLHRT TPLRPPSPFT EEPHIFEKEP 
       610        620        630        640        650
SEKTTGDIIL PRESVTQHPL TTLMDIIAKK TESDIDHEYH MTSKPPVMQP 
       660        670        680        690        700
TRPSVVERKT TSKPQELSTS PPPAGTKFHP DINVYIIEVR ENKTGRMSDM 
       710        720        730        740        750
VVNGHPIDSE SKEEEPCSEE TDPLHDLFAE ILPELPDSFE IDIYHSEEDE 
       760        770        780        790        800
DGEEDCVNAT DVTTTPSVQY ITGKPHVTTV PKNPEAAEAR RGLYESVAPS 
       810        820        830        840        850
QNFSNTSATD THQFIPAETE LSTTMQFTKS KEATELLEIT WKPETYPETP 
       860        870        880        890        900
EHFSSGEPDV FPTLPSHDGK TTKWSEFITE SNPNTENPEH KQPKPIPLFP 
       910        920        930        940        950
EEFSGEGAID QASQQTIFSR ATEVALGKET DQSPTISTSS IRSGSVSVHA 
       960        970        980        990       1000
LEEDPIALTG ISQTDESMST VESWVEMTPS QTVEFSGSSS APTIEGSGEV 
      1010       1020       1030       1040       1050
EEYTNKIFNT VTDLPQREPT DTLIPLDMSN IMITDHHIYT PATTAPLDSQ 
      1060       1070       1080       1090       1100
LPSTDARPTQ FGIQTTTSEW VSSTSFEGRK TEEDKERDTN AAHTGEVQPA 
      1110       1120       1130       1140       1150
TERSDRLLLT SELESSNVAA SSPLDTWEGF VPETTSTVSE KEMANTTPVF 
      1160       1170       1180       1190       1200
TETSDVANLE TQSFEHSSSS QPRVQEELTT LSGKPPLIFM DLGSGDASTD 
      1210       1220       1230       1240       1250
MEFITASSFT LDLESDTKVK KELPSTLSPS VETSSSSEPI GLAPSTVLDI 
      1260       1270       1280       1290       1300
EIVEVMNQTS KKTLISELSG KPTSQAEVRD LYPGLGEDFS GDSSEYPTVS 
      1310       1320       1330       1340       1350
STTMKEETVG MGGSENERVK DTQTLSSIPP TSDNINPVPD SKGFGSTVAS 
      1360       1370       1380       1390       1400
TTAFPWEEFM TSAEGSGEEL SSVRSSVSLV LPLGVDILPT TESPYFDQEF 
      1410       1420       1430       1440       1450
EEAAAVTEAG KQSALPIAVS GNTVDLTENR DIEVNSTMSV DLPQTMEPAK 
      1460       1470       1480       1490       1500
LWSKPEVNPE KQEIGSETVT QDKAQGQKSF ESLHSSLAPE QTTLESQSLI 
      1510       1520       1530       1540       1550
ETEVQTSYYS MLTTMKTYNT NEEVEEEGTS IAHMSTPGPG IKGLESYPTH 
      1560       1570       1580       1590       1600
PEATGKSYSF SASALVTESG PARSVVMDSS TQEEESIKLF QKDMILTHKE 
      1610       1620       1630       1640       1650
SNSDLSFSGL GSGEALPPLP TTSVSLTDMG KINSTLYPET SHMESLGTSI 
      1660       1670       1680       1690       1700
LGDNHERMKN VSNEVRTLIS ETGSISQDST EAPNTTLSDT RTEESTTSPL 
      1710       1720       1730       1740       1750
PFMKLMDTEH SPKQTLRWEE EIQTHRPQTM TGQMTNDNSS VSEAEAAATS 
      1760       1770       1780       1790       1800
APAFLPETYS VEMTKAFATS PSQTSDLFDA NSGEGSGEVD GLDLVYTSRT 
      1810       1820       1830       1840       1850
TQASSQGDSM FASHGFIEKH PEVSRTETGA TDGSPTASAM FLHQSEYNES 
      1860       1870       1880       1890       1900
SLYPTSTLPS TVTYESPSEG IADGLQDHIR FEVSTLKPSR RKATESVIID 
      1910       1920       1930       1940       1950
LDKEDSKDLG LAITESAIVE ILPELTSDRN IIIDIDHTKP VYEYIPGIQT 
      1960       1970       1980       1990       2000
DLDSDIPLGS HGSSEESLEV QEKYEATINL SPTEEAFDGS GDALPAGHTQ 
      2010       2020       2030       2040       2050
AIYNESVTPS DGKQPEDISF SFATGIPVSS TETELNTFFP TVSTLHIPSK 
      2060       2070       2080       2090       2100
LTTASPEIDK PNIEAISLDD IFESSTLSDG QAIADQSEVI STLGHLEKTQ 
      2110       2120       2130       2140       2150
EEYEEKKYGG PSFQPEFFSG VGEVFTDAPA YVSIGRTYSV AQPLTEFPNV 
      2160       2170       2180       2190       2200
VGQSDSTHYT EATSAVSSVT ELSPQTPSSP SPVYIDSGVS EFTEVPHKSA 
      2210       2220       2230       2240       2250
QPAPTAASSQ KLIEGSFKKV RANIEATIKS LGENDHGTES PSMSPSPALD 
      2260       2270       2280       2290       2300
ISEDDSKPKL LEDLETSPTK TETSQDSPNK ANDQIPGKTA GILAGIKTTE 
      2310       2320       2330       2340       2350
SGPVVTAADD MELGDATQRP HSASAPAAFR VETSMVPQPI PQEPERPTFP 
      2360       2370       2380       2390       2400
SLEINHETHT SLFEESILAT SEKQVSQRIL DYSNQATVST LDLNTEHSIP 
      2410       2420       2430       2440       2450
PFSILDNSNE TAFLIGISEE TVEGTAVYLP GPDLCKTNPC LNGGTCYPTE 
      2460       2470       2480       2490       2500
TSYVCTCAPG YSGDQCELDF DECHSNPCRN GATCVDGLNT FRCLCLPSYV 
      2510       2520       2530       2540       2550
GALCEQDTET CDYGWHKFQG QCYKYFAHRR TWDAAERECR LQGAHLTSIL 
      2560       2570       2580       2590       2600
SHEEQMFVNR VGHDYQWIGL NDKMFEHDFR WTDGSALQYE NWRPNQPDSF 
      2610       2620       2630       2640       2650
FSAGEDCVVI IWHENGQWND VPCNYHLTYT CKKGTVACGQ PPVVENAKTF 
      2660       2670       2680       2690       2700
GKMKPRYEIN SLIRYHCKDG FIQRHLPTIR CLGNGRWAMP KITCMNPSAY 
      2710       2720       2730 
QRTYSKKYLK NSSSVKDNSI NTSKHEHRWS RRWQETRR
Length:2,738
Mass (Da):300,008
Last modified:September 26, 2001 - v2
Checksum:i12CA626D58BD8C6A
GO
Isoform V3 (identifier: Q9ERB4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     349-2431: Missing.

Show »
Length:655
Mass (Da):74,475
Checksum:i602F2F37E4F1ECC4
GO
Isoform Vint (identifier: Q9ERB4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2697-2738: PSAYQRTYSKKYLKNSSSVKDNSINTSKHEHRWSRRWQETRR → RKWSFRKNGQPCFNKY

Show »
Length:2,712
Mass (Da):296,869
Checksum:iCA94EDC94168EF2A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-adjacent residuesi348 – 349Curated2
Sequence conflicti2535 – 2539AEREC → NSARG (Ref. 4) Curated5

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003091349 – 2431Missing in isoform V3. 1 PublicationAdd BLAST2083
Alternative sequenceiVSP_0030922697 – 2738PSAYQ…QETRR → RKWSFRKNGQPCFNKY in isoform Vint. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062402 mRNA Translation: AAC40166.1
U75306 mRNA Translation: AAB51125.1
AF084544 mRNA Translation: AAD48544.1
AF072892 mRNA Translation: AAC26116.1
AY007691 mRNA Translation: AAG16631.1
RefSeqiNP_001164029.1, NM_001170558.1
NP_001164030.1, NM_001170559.1 [Q9ERB4-2]
NP_001164031.1, NM_001170560.1
UniGeneiRn.35666

Genome annotation databases

GeneIDi114122
KEGGirno:114122
UCSCiRGD:619940 rat [Q9ERB4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCSPG2_RAT
AccessioniPrimary (citable) accession number: Q9ERB4
Secondary accession number(s): O08592, O88564, Q9R1K4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: June 20, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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