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Protein

Alpha-globin transcription factor CP2

Gene

Tfcp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds a variety of cellular promoters including fibrinogen, alpha-globin promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-globin transcription factor CP2
Gene namesi
Name:Tfcp2
Synonyms:Tcfcp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:98509 Tfcp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002280021 – 502Alpha-globin transcription factor CP2Add BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei353PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9ERA0
PaxDbiQ9ERA0
PeptideAtlasiQ9ERA0
PRIDEiQ9ERA0

PTM databases

PhosphoSitePlusiQ9ERA0

Expressioni

Gene expression databases

BgeeiENSMUSG00000009733
CleanExiMM_TCFCP2
GenevisibleiQ9ERA0 MM

Interactioni

Subunit structurei

Binds to DNA as a dimer. Interacts with UBP1 and PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1. Component of the SSP (stage selector protein) complex, which appears to be a heteromer of TFCP2 and 2 copies of NFE4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204014, 3 interactors
IntActiQ9ERA0, 2 interactors
STRINGi10090.ENSMUSP00000009877

Structurei

3D structure databases

ProteinModelPortaliQ9ERA0
SMRiQ9ERA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 386DNA-bindingBy similarityAdd BLAST254

Sequence similaritiesi

Belongs to the grh/CP2 family. CP2 subfamily.Curated

Phylogenomic databases

eggNOGiKOG4091 Eukaryota
ENOG410XNZ6 LUCA
GeneTreeiENSGT00760000119235
HOGENOMiHOG000230625
HOVERGENiHBG053805
InParanoidiQ9ERA0
KOiK09275
OMAiDEVCFVL
OrthoDBiEOG091G0YV2
PhylomeDBiQ9ERA0
TreeFamiTF314132

Family and domain databases

CDDicd09589 SAM_TFCP2, 1 hit
InterProiView protein in InterPro
IPR007604 CP2
IPR013761 SAM/pointed_sf
IPR037599 TFCP2_SAM
PfamiView protein in Pfam
PF04516 CP2, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ERA0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWALKLPLA DEVIESGLVQ DFDASLSGIG QELGAGAYSM SDVLALPIFK
60 70 80 90 100
QEESSLPPDN ENEILPFQYV LCAATSPAVK LHDETLTYLN QGQSYEIRML
110 120 130 140 150
DNRKLGELPE LNGKLVKSIF RVVFHDRRLQ YTEHQQLEGW RWNRPGDRIL
160 170 180 190 200
DIDIPMSVGV IDPRANPTQL NTVEFLWDPS KRTSVFIQVH CISTEFTMRK
210 220 230 240 250
HGGEKGVPFR VQIDTFKENG NGEYTEHLHS ASCQIKVFKP KGADRKQKID
260 270 280 290 300
REKMEKRTPH EKEKYQPSYE TTILTECSPW PEITYVNNSP SPGFNSSHSS
310 320 330 340 350
FSLGEGNGSP NHQPEPPPPV TDNLLPTTTP QEAQQWLHRN RFSTFTRLFT
360 370 380 390 400
NFSGADLLKL TRDDVIQICG PADGIRLFNA LKGRMVRPRL TIYVCQESLQ
410 420 430 440 450
LREQQPQPQP QPQKQEDGDS NGTFFVYHAI YLEELTAVEL TEKIAQLFSI
460 470 480 490 500
SPHQISQIYK QGPTGIHVVI SDEMVQNFQE EACFILDTME AETSDSYHVI

LK
Length:502
Mass (Da):57,031
Last modified:March 1, 2001 - v1
Checksum:i02D43CAA95CDF495
GO
Isoform 2 (identifier: Q9ERA0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     474-502: MVQNFQEEACFILDTMEAETSDSYHVILK → VVLSCLILPGTELWSSGRTAGTLNCLALPFL

Note: No experimental confirmation available.
Show »
Length:504
Mass (Da):56,884
Checksum:iD53015C81567A103
GO
Isoform 3 (identifier: Q9ERA0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-355: Missing.

Show »
Length:500
Mass (Da):56,903
Checksum:iD323CB8CE4872858
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017649354 – 355Missing in isoform 3. 1 Publication2
Alternative sequenceiVSP_017650474 – 502MVQNF…HVILK → VVLSCLILPGTELWSSGRTA GTLNCLALPFL in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84809 mRNA Translation: AAF99390.1
AK146503 mRNA Translation: BAE27218.1
AK147898 mRNA Translation: BAE28214.1
AK158682 mRNA Translation: BAE34609.1
BC022131 mRNA Translation: AAH22131.1
CCDSiCCDS27840.1 [Q9ERA0-1]
PIRiB42030
RefSeqiNP_001276532.1, NM_001289603.1 [Q9ERA0-3]
NP_258437.1, NM_033476.3 [Q9ERA0-1]
UniGeneiMm.219040

Genome annotation databases

EnsembliENSMUST00000009877; ENSMUSP00000009877; ENSMUSG00000009733 [Q9ERA0-3]
ENSMUST00000229696; ENSMUSP00000155683; ENSMUSG00000009733 [Q9ERA0-1]
GeneIDi21422
KEGGimmu:21422
UCSCiuc007xrl.2 mouse [Q9ERA0-1]
uc007xrm.1 mouse [Q9ERA0-2]
uc011zzo.2 mouse [Q9ERA0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTFCP2_MOUSE
AccessioniPrimary (citable) accession number: Q9ERA0
Secondary accession number(s): Q3UGJ4, Q8VC13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2001
Last modified: July 18, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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