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Entry version 116 (29 Sep 2021)
Sequence version 2 (24 Nov 2009)
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Protein

Regulatory solute carrier protein family 1 member 1

Gene

Rsc1a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network (By similarity).

Regulates the expression of SLC5A1 in a tissue-specific manner and is specifically involved in its regulation in the small intestine.

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-549127, Organic cation transport
R-MMU-8981373, Intestinal hexose absorption

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulatory solute carrier protein family 1 member 1
Alternative name(s):
Regulatory subunit of SGLT1
Transporter regulator RS1
Short name:
mRS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rsc1a1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3526447, Rsc1a1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000040715
HostDB:ENSMUSG00000078515

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice show a specific phenotype: first, a post-transcriptional up-regulation of SLC5A1 in the small intestine, with an increased d-glucose absorption rate and capacity; second, an increased food intake that results in a visceral type of obesity.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003241511 – 582Regulatory solute carrier protein family 1 member 1Add BLAST582

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ER99

PRoteomics IDEntifications database

More...
PRIDEi
Q9ER99

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
260738

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ER99

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in epithelial and subepithelial cells of small intestine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040715, Expressed in multi-cellular organism and 63 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9ER99, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ER99, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with YRDC.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
213804, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000101408

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9ER99, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini536 – 576UBAPROSITE-ProRule annotationAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 32DisorderedSequence analysisAdd BLAST32
Regioni56 – 76DisorderedSequence analysisAdd BLAST21
Regioni143 – 180DisorderedSequence analysisAdd BLAST38
Regioni303 – 325DisorderedSequence analysisAdd BLAST23
Regioni363 – 384DisorderedSequence analysisAdd BLAST22
Regioni390 – 409DisorderedSequence analysisAdd BLAST20
Regioni426 – 452DisorderedSequence analysisAdd BLAST27
Regioni483 – 529DisorderedSequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi56 – 70Polar residuesSequence analysisAdd BLAST15
Compositional biasi145 – 180Polar residuesSequence analysisAdd BLAST36
Compositional biasi309 – 325Polar residuesSequence analysisAdd BLAST17
Compositional biasi436 – 450Basic and acidic residuesSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RYJA, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005744

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_032729_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ER99

Identification of Orthologs from Complete Genome Data

More...
OMAi
EQCSQVS

Database of Orthologous Groups

More...
OrthoDBi
817208at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ER99

TreeFam database of animal gene trees

More...
TreeFami
TF335675

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039222, RSC1A1
IPR015940, UBA

The PANTHER Classification System

More...
PANTHERi
PTHR15397, PTHR15397, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00165, UBA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50030, UBA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9ER99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLPTSDGF DHPAPSGQSP EVGSPTSLAR SVSASVCAIK PGDPNSIESL
60 70 80 90 100
AMEATKASAE FQTNSKKTDP PPLQVLPDLA SSAEQSLAMP FHKSSKEAVV
110 120 130 140 150
AGNLEKSVEK GTQGLRVYLH TRQDASLTLT TTGMREPQIF AEEKSWHPEN
160 170 180 190 200
QTPSPVNGLQ QHRETGSVQR EAGQQSVPQD QGCLCDAEDL ELHEEVVSLE
210 220 230 240 250
ALRKGELQRH AHLPSAEKGL PASGLCSCPC SEALMEVDTA EQSLVAMCSS
260 270 280 290 300
TGRQDAVIKS PSVAHLASDN PTMEVETLQS NPSCEPVEHS ILTRELQLPE
310 320 330 340 350
DNVDMSTMDN KDDNSSSLLS GHGQPSVESA EEFCSSVTVA LKELHELLVI
360 370 380 390 400
SCKPASEESP EHVTCQSEIG AESQPSVSDL SGRRVQSVHL TPSDQYSQGS
410 420 430 440 450
CHQATSESGK TEIVGTAPCA AVEDEASTSF EGLGDGLSPD REDVRRSTES
460 470 480 490 500
ARKSCSVAIT SAKLSEQLPC TSGVEIAPEL AASEGAHSQP SEHVHNPGPD
510 520 530 540 550
RPETSSVCPG AGLPRSGLDQ PPTQSLSTPS VLPPFIFPAA DVDRILGAGF
560 570 580
TLQEALGALH RVGGNADLAL LVLLAKNIVV PT
Length:582
Mass (Da):61,251
Last modified:November 24, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF51458B600B9E82E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti135R → H in AAI50753 (PubMed:15489334).Curated1
Sequence conflicti141A → V in AAI50753 (PubMed:15489334).Curated1
Sequence conflicti185C → G in AAI50753 (PubMed:15489334).Curated1
Sequence conflicti201A → T in AAI50753 (PubMed:15489334).Curated1
Sequence conflicti323G → S in AAI50753 (PubMed:15489334).Curated1
Sequence conflicti381S → P in AAI50753 (PubMed:15489334).Curated1
Sequence conflicti440D → G in AAI50753 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y11917 Genomic DNA Translation: CAA72676.2
AL671733 Genomic DNA No translation available.
CH466615 Genomic DNA Translation: EDL13393.1
BC031491 mRNA No translation available.
BC150752 mRNA Translation: AAI50753.1
AK006435 mRNA Translation: BAB24588.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS18879.1

NCBI Reference Sequences

More...
RefSeqi
NP_076033.4, NM_023544.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000105782; ENSMUSP00000101408; ENSMUSG00000040715
ENSMUST00000177592; ENSMUSP00000136018; ENSMUSG00000078515

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
69994

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:69994

UCSC genome browser

More...
UCSCi
uc012dod.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11917 Genomic DNA Translation: CAA72676.2
AL671733 Genomic DNA No translation available.
CH466615 Genomic DNA Translation: EDL13393.1
BC031491 mRNA No translation available.
BC150752 mRNA Translation: AAI50753.1
AK006435 mRNA Translation: BAB24588.1
CCDSiCCDS18879.1
RefSeqiNP_076033.4, NM_023544.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi213804, 1 interactor
STRINGi10090.ENSMUSP00000101408

PTM databases

PhosphoSitePlusiQ9ER99

Proteomic databases

PaxDbiQ9ER99
PRIDEiQ9ER99
ProteomicsDBi260738

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
69994

Genome annotation databases

EnsembliENSMUST00000105782; ENSMUSP00000101408; ENSMUSG00000040715
ENSMUST00000177592; ENSMUSP00000136018; ENSMUSG00000078515
GeneIDi69994
KEGGimmu:69994
UCSCiuc012dod.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6248
MGIiMGI:3526447, Rsc1a1
VEuPathDBiHostDB:ENSMUSG00000040715
HostDB:ENSMUSG00000078515

Phylogenomic databases

eggNOGiENOG502RYJA, Eukaryota
GeneTreeiENSGT00390000005744
HOGENOMiCLU_032729_0_0_1
InParanoidiQ9ER99
OMAiEQCSQVS
OrthoDBi817208at2759
PhylomeDBiQ9ER99
TreeFamiTF335675

Enzyme and pathway databases

ReactomeiR-MMU-549127, Organic cation transport
R-MMU-8981373, Intestinal hexose absorption

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
69994, 0 hits in 29 CRISPR screens

Protein Ontology

More...
PROi
PR:Q9ER99
RNActiQ9ER99, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040715, Expressed in multi-cellular organism and 63 other tissues
ExpressionAtlasiQ9ER99, baseline and differential
GenevisibleiQ9ER99, MM

Family and domain databases

InterProiView protein in InterPro
IPR039222, RSC1A1
IPR015940, UBA
PANTHERiPTHR15397, PTHR15397, 1 hit
SMARTiView protein in SMART
SM00165, UBA, 1 hit
PROSITEiView protein in PROSITE
PS50030, UBA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRSCA1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ER99
Secondary accession number(s): B1AUM1
, B2RWX9, Q78HA0, Q9CVU8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 24, 2009
Last modified: September 29, 2021
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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