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Protein

Receptor-transporting protein 4

Gene

Rtp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (By similarity). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (PubMed:18836069).By similarity1 Publication

GO - Molecular functioni

  • olfactory receptor binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-transporting protein 4
Alternative name(s):
28 kDa interferon-responsive protein
Gene namesi
Name:Rtp4
Synonyms:Ifrg28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1915025 Rtp4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 227CytoplasmicSequence analysisAdd BLAST227
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001819961 – 249Receptor-transporting protein 4Add BLAST249

Proteomic databases

MaxQBiQ9ER80
PaxDbiQ9ER80
PeptideAtlasiQ9ER80
PRIDEiQ9ER80

PTM databases

iPTMnetiQ9ER80
PhosphoSitePlusiQ9ER80

Expressioni

Tissue specificityi

Expressed at low levels in olfactory neurons.1 Publication

Inductioni

By interferons.

Gene expression databases

BgeeiENSMUSG00000033355 Expressed in 195 organ(s), highest expression level in intestine
CleanExiMM_RTP4
ExpressionAtlasiQ9ER80 baseline and differential
GenevisibleiQ9ER80 MM

Interactioni

Subunit structurei

Interacts with TASR16 (By similarity). Interacts with OPRD1 and OPRM1; the interaction promotes cell surface localization of the OPDR1-OPRM1 heterodimer (PubMed:18836069).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Oprd1P323002EBI-15731539,EBI-2615936

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-46418N
IntActiQ9ER80, 2 interactors
STRINGi10090.ENSMUSP00000041091

Structurei

3D structure databases

ProteinModelPortaliQ9ER80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH22 Eukaryota
ENOG4111X4F LUCA
GeneTreeiENSGT00530000063222
HOGENOMiHOG000236274
HOVERGENiHBG073235
InParanoidiQ9ER80
OMAiNSHGRCA
OrthoDBiEOG091G0DS4
PhylomeDBiQ9ER80
TreeFamiTF333246

Family and domain databases

InterProiView protein in InterPro
IPR026096 R-trans_p
IPR026690 RTP4
IPR027377 Znf-3CxxC
PANTHERiPTHR14402 PTHR14402, 1 hit
PTHR14402:SF8 PTHR14402:SF8, 1 hit
PfamiView protein in Pfam
PF13695 zf-3CxxC, 1 hit
SMARTiView protein in SMART
SM01328 zf-3CxxC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9ER80-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLFPDDFSTW EQTFQELMQE EKPGAKWSLH LDKNIVPDGA ALGWRQHQQT
60 70 80 90 100
VLGRFQCSRC CRSWTSAQVM ILCHMYPDTL KSQGQARMRI FGQKCQKCFG
110 120 130 140 150
CQFETPKFST EIIKRILNNL VNYILQRYYG HRKIALTSNA SLGEKVTLDG
160 170 180 190 200
PHDTRNCEAC SLNSHGRCAL AHKVKPPRSP SPLPKSSSPS KSCPPPPQTR
210 220 230 240
NTDFGNKTFQ DFGNRTFQGC REPPQREIEP PLFLFLSIAA FALFSLFTR
Length:249
Mass (Da):28,392
Last modified:March 1, 2001 - v1
Checksum:i2C79B36ED6F042D4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GRU4A0A1B0GRU4_MOUSE
Receptor-transporting protein 4
Rtp4
143Annotation score:
A0A1B0GSV5A0A1B0GSV5_MOUSE
Receptor-transporting protein 4
Rtp4
61Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185K → N in AAT70673 (PubMed:15550249).Curated1
Sequence conflicti185K → N in BAB31041 (PubMed:16141072).Curated1
Sequence conflicti209F → L in AAT70673 (PubMed:15550249).Curated1
Sequence conflicti209F → L in BAB31041 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251364 mRNA Translation: CAC13976.1
AY562228 mRNA Translation: AAT70673.1
AK007477 mRNA Translation: BAB25057.1
AK018021 mRNA Translation: BAB31041.1
CCDSiCCDS28079.1
RefSeqiNP_075875.3, NM_023386.5
XP_006522554.1, XM_006522491.3
UniGeneiMm.475107

Genome annotation databases

EnsembliENSMUST00000038423; ENSMUSP00000041091; ENSMUSG00000033355
ENSMUST00000209422; ENSMUSP00000147521; ENSMUSG00000033355
ENSMUST00000210901; ENSMUSP00000147442; ENSMUSG00000033355
GeneIDi67775
KEGGimmu:67775
UCSCiuc007ytw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251364 mRNA Translation: CAC13976.1
AY562228 mRNA Translation: AAT70673.1
AK007477 mRNA Translation: BAB25057.1
AK018021 mRNA Translation: BAB31041.1
CCDSiCCDS28079.1
RefSeqiNP_075875.3, NM_023386.5
XP_006522554.1, XM_006522491.3
UniGeneiMm.475107

3D structure databases

ProteinModelPortaliQ9ER80
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46418N
IntActiQ9ER80, 2 interactors
STRINGi10090.ENSMUSP00000041091

PTM databases

iPTMnetiQ9ER80
PhosphoSitePlusiQ9ER80

Proteomic databases

MaxQBiQ9ER80
PaxDbiQ9ER80
PeptideAtlasiQ9ER80
PRIDEiQ9ER80

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038423; ENSMUSP00000041091; ENSMUSG00000033355
ENSMUST00000209422; ENSMUSP00000147521; ENSMUSG00000033355
ENSMUST00000210901; ENSMUSP00000147442; ENSMUSG00000033355
GeneIDi67775
KEGGimmu:67775
UCSCiuc007ytw.2 mouse

Organism-specific databases

CTDi64108
MGIiMGI:1915025 Rtp4

Phylogenomic databases

eggNOGiENOG410IH22 Eukaryota
ENOG4111X4F LUCA
GeneTreeiENSGT00530000063222
HOGENOMiHOG000236274
HOVERGENiHBG073235
InParanoidiQ9ER80
OMAiNSHGRCA
OrthoDBiEOG091G0DS4
PhylomeDBiQ9ER80
TreeFamiTF333246

Enzyme and pathway databases

ReactomeiR-MMU-381753 Olfactory Signaling Pathway

Miscellaneous databases

ChiTaRSiRtp4 mouse
PROiPR:Q9ER80
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033355 Expressed in 195 organ(s), highest expression level in intestine
CleanExiMM_RTP4
ExpressionAtlasiQ9ER80 baseline and differential
GenevisibleiQ9ER80 MM

Family and domain databases

InterProiView protein in InterPro
IPR026096 R-trans_p
IPR026690 RTP4
IPR027377 Znf-3CxxC
PANTHERiPTHR14402 PTHR14402, 1 hit
PTHR14402:SF8 PTHR14402:SF8, 1 hit
PfamiView protein in Pfam
PF13695 zf-3CxxC, 1 hit
SMARTiView protein in SMART
SM01328 zf-3CxxC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRTP4_MOUSE
AccessioniPrimary (citable) accession number: Q9ER80
Secondary accession number(s): Q9D3D6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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