Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Iroquois-class homeodomain protein IRX-6

Gene

Irx6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi141 – 204Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST64

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein IRX-6
Alternative name(s):
Homeodomain protein IRXB3
Iroquois homeobox protein 6
Gene namesi
Name:Irx6
Synonyms:Irxb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1927642 Irx6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491631 – 438Iroquois-class homeodomain protein IRX-6Add BLAST438

Proteomic databases

PaxDbiQ9ER75
PRIDEiQ9ER75

PTM databases

PhosphoSitePlusiQ9ER75

Expressioni

Gene expression databases

BgeeiENSMUSG00000031738 Expressed in 61 organ(s), highest expression level in thymus
CleanExiMM_IRX6
ExpressionAtlasiQ9ER75 baseline and differential
GenevisibleiQ9ER75 MM

Interactioni

Protein-protein interaction databases

BioGridi211066, 1 interactor
STRINGi10090.ENSMUSP00000034185

Structurei

3D structure databases

ProteinModelPortaliQ9ER75
SMRiQ9ER75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi256 – 267Poly-GluAdd BLAST12

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00750000117365
HOVERGENiHBG006180
InParanoidiQ9ER75

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9ER75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFSPFGHPY GSTSQFLVSA SSSATCCETA PRPVSDVASA STSASTLCCT
60 70 80 90 100
PYDSRLLGSA RPELGAALGI YGAPYAAAQS YPGYLTYGPE PPTLCGALNP
110 120 130 140 150
QYEFKDAAGS FAPSLTQPGA YYPYETTLGQ YQYDRYGGVE LSSAGRRKNA
160 170 180 190 200
TRESTSALKA WLHEHRKNPY PTKGEKIMLA IITKMTLTQV STWFANARRR
210 220 230 240 250
LKKENKMTWA PKNKGGEERK ADSGEDSLGC LNGDTKDATA SQEARGLRLS
260 270 280 290 300
DLEDLEEEEE EEEAEEEAAV SAARRLADFQ KSTQPLPAPC AAAQERCLES
310 320 330 340 350
RECGLGLPRF SFTEAPQSGE ADFITAEPGG PTMILHYPSG HKPRIWSLAH
360 370 380 390 400
TAAASAVESA PSTPPRAQSP ECHMIPRQPS SIRRLLVPRD SEGEEDSPAA
410 420 430
KAFGNSTFTL QGLPLNCAPY PRRREPEVRF QYPSGAEG
Length:438
Mass (Da):47,352
Last modified:July 27, 2011 - v2
Checksum:i51E5421FB653A0F0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BFT1Q8BFT1_MOUSE
Iroquois-class homeodomain protein ...
Irx6
439Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33P → S in CAC10403 (PubMed:11042145).Curated1
Sequence conflicti33P → S in AAI30030 (PubMed:15489334).Curated1
Sequence conflicti296R → G in CAC10403 (PubMed:11042145).Curated1
Sequence conflicti296R → G in AAI30030 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271055 mRNA Translation: CAC10403.1
AC134337 Genomic DNA No translation available.
BC130029 mRNA Translation: AAI30030.1
CCDSiCCDS80913.1
RefSeqiNP_001288066.1, NM_001301137.1
UniGeneiMm.137247

Genome annotation databases

EnsembliENSMUST00000167261; ENSMUSP00000127446; ENSMUSG00000031738
GeneIDi64379
KEGGimmu:64379
UCSCiuc009muc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271055 mRNA Translation: CAC10403.1
AC134337 Genomic DNA No translation available.
BC130029 mRNA Translation: AAI30030.1
CCDSiCCDS80913.1
RefSeqiNP_001288066.1, NM_001301137.1
UniGeneiMm.137247

3D structure databases

ProteinModelPortaliQ9ER75
SMRiQ9ER75
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211066, 1 interactor
STRINGi10090.ENSMUSP00000034185

PTM databases

PhosphoSitePlusiQ9ER75

Proteomic databases

PaxDbiQ9ER75
PRIDEiQ9ER75

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167261; ENSMUSP00000127446; ENSMUSG00000031738
GeneIDi64379
KEGGimmu:64379
UCSCiuc009muc.2 mouse

Organism-specific databases

CTDi79190
MGIiMGI:1927642 Irx6

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00750000117365
HOVERGENiHBG006180
InParanoidiQ9ER75

Miscellaneous databases

PROiPR:Q9ER75
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031738 Expressed in 61 organ(s), highest expression level in thymus
CleanExiMM_IRX6
ExpressionAtlasiQ9ER75 baseline and differential
GenevisibleiQ9ER75 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIRX6_MOUSE
AccessioniPrimary (citable) accession number: Q9ER75
Secondary accession number(s): A1L3D2, E9Q2V2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again