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Protein

Oxysterol-binding protein-related protein 5

Gene

Osbpl5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. Binds 25-hydroxycholesterol and cholesterol.By similarity

Miscellaneous

Imprinted gene expressed from the maternal allele in blastocysts.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei448PhosphatidylserineBy similarity1
Binding sitei503PhosphatidylserineBy similarity1
Binding sitei669Phosphatidylinositol 4-phosphateBy similarity1
Binding sitei673Phosphatidylinositol 4-phosphateBy similarity1
Binding sitei677Phosphatidylinositol 4-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-1482801 Acyl chain remodelling of PS

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 5
Short name:
ORP-5
Short name:
OSBP-related protein 5
Alternative name(s):
Oxysterol-binding protein homolog 11 Publication
Gene namesi
Name:Osbpl5
Synonyms:Obph11 Publication, Osbp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1930265 Osbpl5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei855 – 873HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001003741 – 874Oxysterol-binding protein-related protein 5Add BLAST874

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Modified residuei746PhosphoserineCombined sources1
Modified residuei749PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9ER64
MaxQBiQ9ER64
PaxDbiQ9ER64
PRIDEiQ9ER64

PTM databases

iPTMnetiQ9ER64
PhosphoSitePlusiQ9ER64

Expressioni

Gene expression databases

BgeeiENSMUSG00000037606 Expressed in 235 organ(s), highest expression level in sciatic nerve
CleanExiMM_OSBP2
MM_OSBPL5
ExpressionAtlasiQ9ER64 baseline and differential
GenevisibleiQ9ER64 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020411

Structurei

3D structure databases

ProteinModelPortaliQ9ER64
SMRiQ9ER64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 243PHPROSITE-ProRule annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni383 – 388Phosphatidylinositol 4-phosphate bindingBy similarity6
Regioni383 – 388Phosphatidylserine bindingBy similarity6
Regioni445 – 448Phosphatidylinositol 4-phosphate bindingBy similarity4
Regioni477 – 478Phosphatidylinositol 4-phosphate bindingBy similarity2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili93 – 123Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the OSBP family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2210 Eukaryota
ENOG410XRW6 LUCA
GeneTreeiENSGT00550000074515
HOGENOMiHOG000233870
HOVERGENiHBG053375
InParanoidiQ9ER64
KOiK20464
OMAiYEEFGET
PhylomeDBiQ9ER64

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9ER64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEEAFLRRR FSLCPPASTP QKTDPRKVPR NLLLGCENEL GPITPGRDME
60 70 80 90 100
SNGPSQPRDE EPQTPGSATK VPLAEYRLCN GSDKECTSPT TRVSKKDALK
110 120 130 140 150
AQKENYRQEK KRATKQLFSA LTDPSVVIMA DSLKIRGTLK SWTKLWCVLK
160 170 180 190 200
PGVLLIYKTP KVGQWVGTVL LHCCELIERP SKKDGFCFKL FHPLDQSVWA
210 220 230 240 250
VKGPKGESVG SITQPLPSSY LIFRAASESD GRCWLDALEL ALRCSSLLRL
260 270 280 290 300
STCKQGRDGE QGSSPDASPS SLYGLPTSAT IPDQDLFPLN GSALENDAFS
310 320 330 340 350
DKSERENAED SDAETQDHSR KTNESGSDLL DSPGGPWRGT TYVEQVQEEL
360 370 380 390 400
GELDETSQVE TVSEENKSLM WVLLRQLRPG MDLSRVVLPT FVLEPRSFLG
410 420 430 440 450
KLSDYYYHGD LLSRAAAEDD PYCRMKLVLR WYLSGFYKKP KGIKKPYNPI
460 470 480 490 500
LGETFRCRWL HPQTNSHTFY IAEQVSHHPP VSAFYVSNRK DGFCMSGSIT
510 520 530 540 550
AKSKFYGNSL SALLDGKAKL TFLNRKEEYT LTMPYAHCRG ILYGTMTMEL
560 570 580 590 600
GGKVNIECEK NNLQAELDFK LKPFFGSSAN INQISGKIMS GEEVLARLTG
610 620 630 640 650
HWDRDVFIKE ESSGGTELFW TPSEEVRRQR LKRHTVLLEE QSELESERLW
660 670 680 690 700
QHVTRAIREG DQHKATQEKS VLEEAQRQRA REHQQSLTPW KPQLFLLDPL
710 720 730 740 750
TQEWRYRYED LSPWDPLKDI AQYEQDGILH TLQRETMSGQ TTFLGSPDSR
760 770 780 790 800
HKRPSSDRRL RKASDQPSGH SQVTESSGST PESCPDLSDE DFVPGGESPC
810 820 830 840 850
PRCRREVHRL KMLQEAVLSI QEAQQELHRH LSTMLSSTVR AGQAPAPSLL
860 870
QNPRSWFLLC IFLTCQLFIN YILK
Length:874
Mass (Da):98,922
Last modified:February 11, 2002 - v3
Checksum:iFBC41FA8E219F5E3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E833G5E833_MOUSE
Oxysterol-binding protein
Osbpl5 mCG_15285
898Annotation score:
D3YWU9D3YWU9_MOUSE
Oxysterol-binding protein-related p...
Osbpl5
199Annotation score:

Sequence cautioni

The sequence CAC16404 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC27351 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37 – 44ENELGPIT → MSLVPSPQ in CAC27351 (PubMed:11063728).Curated8
Sequence conflicti312D → N in BAB85687 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278263 mRNA Translation: CAC16404.2 Different initiation.
AJ276505 Genomic DNA Translation: CAC27351.1 Different initiation.
AB074008 mRNA Translation: BAB85687.1
BC079872 mRNA Translation: AAH79872.1
CCDSiCCDS57598.1
RefSeqiNP_001186156.1, NM_001199227.1
UniGeneiMm.21199

Genome annotation databases

EnsembliENSMUST00000119499; ENSMUSP00000113362; ENSMUSG00000037606
GeneIDi79196
KEGGimmu:79196
UCSCiuc009kpw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278263 mRNA Translation: CAC16404.2 Different initiation.
AJ276505 Genomic DNA Translation: CAC27351.1 Different initiation.
AB074008 mRNA Translation: BAB85687.1
BC079872 mRNA Translation: AAH79872.1
CCDSiCCDS57598.1
RefSeqiNP_001186156.1, NM_001199227.1
UniGeneiMm.21199

3D structure databases

ProteinModelPortaliQ9ER64
SMRiQ9ER64
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020411

PTM databases

iPTMnetiQ9ER64
PhosphoSitePlusiQ9ER64

Proteomic databases

EPDiQ9ER64
MaxQBiQ9ER64
PaxDbiQ9ER64
PRIDEiQ9ER64

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000119499; ENSMUSP00000113362; ENSMUSG00000037606
GeneIDi79196
KEGGimmu:79196
UCSCiuc009kpw.2 mouse

Organism-specific databases

CTDi114879
MGIiMGI:1930265 Osbpl5

Phylogenomic databases

eggNOGiKOG2210 Eukaryota
ENOG410XRW6 LUCA
GeneTreeiENSGT00550000074515
HOGENOMiHOG000233870
HOVERGENiHBG053375
InParanoidiQ9ER64
KOiK20464
OMAiYEEFGET
PhylomeDBiQ9ER64

Enzyme and pathway databases

ReactomeiR-MMU-1482801 Acyl chain remodelling of PS

Miscellaneous databases

ChiTaRSiOsbpl5 mouse
PROiPR:Q9ER64
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037606 Expressed in 235 organ(s), highest expression level in sciatic nerve
CleanExiMM_OSBP2
MM_OSBPL5
ExpressionAtlasiQ9ER64 baseline and differential
GenevisibleiQ9ER64 MM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOSBL5_MOUSE
AccessioniPrimary (citable) accession number: Q9ER64
Secondary accession number(s): Q8R510, Q99NF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: November 7, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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