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Protein

Tumor necrosis factor receptor superfamily member 23

Gene

Tnfrsf23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis through ligand competition. Cannot induce the NF-kappa-B pathway.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 23
Alternative name(s):
Decoy TRAIL receptor 1
TNF receptor family member SOB
TNF receptor homolog 1
Tumor necrosis factor receptor p60 homolog 1
Gene namesi
Name:Tnfrsf23
Synonyms:Dctrailr1, Tnfrh1, Tnfrsf1al1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1930269 Tnfrsf23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Add BLAST29
ChainiPRO_000003460430 – 155Tumor necrosis factor receptor superfamily member 23Add BLAST126
PropeptideiPRO_0000034605156 – 176Removed in mature formSequence analysisAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 49PROSITE-ProRule annotation
Disulfide bondi50 ↔ 63PROSITE-ProRule annotation
Disulfide bondi53 ↔ 72PROSITE-ProRule annotation
Disulfide bondi75 ↔ 90PROSITE-ProRule annotation
Disulfide bondi93 ↔ 106PROSITE-ProRule annotation
Disulfide bondi96 ↔ 114PROSITE-ProRule annotation
Disulfide bondi116 ↔ 131PROSITE-ProRule annotation
Disulfide bondi134 ↔ 147PROSITE-ProRule annotation
Disulfide bondi137 ↔ 155PROSITE-ProRule annotation
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi155GPI-anchor amidated cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ9ER63
PaxDbiQ9ER63
PRIDEiQ9ER63

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000037613
ExpressionAtlasiQ9ER63 baseline and differential
GenevisibleiQ9ER63 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116742

Structurei

3D structure databases

ProteinModelPortaliQ9ER63
SMRiQ9ER63
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati37 – 72TNFR-Cys 1Add BLAST36
Repeati74 – 114TNFR-Cys 2Add BLAST41
Repeati115 – 155TNFR-Cys 3Add BLAST41

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J1NE Eukaryota
ENOG4111ZZM LUCA
GeneTreeiENSGT00920000149254
HOGENOMiHOG000213469
HOVERGENiHBG085073
InParanoidiQ9ER63
KOiK05159
OMAiHTRSECK
OrthoDBiEOG091G10PE
PhylomeDBiQ9ER63
TreeFamiTF333916

Family and domain databases

CDDicd15837 TNFRSF26, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR034062 TNFRSF26_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 3 hits
SMARTiView protein in SMART
SM00208 TNFR, 3 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 3 hits
PS50050 TNFR_NGFR_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ER63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTFSHVSSL SHWFLLLLLL NLFLPVIFAM PESYSFNCPD GEYQSNDVCC
60 70 80 90 100
KTCPSGTFVK APCKIPHTQG QCEKCHPGTF TGKDNGLHDC ELCSTCDKDQ
110 120 130 140 150
NMVADCSATS DRKCECQIGL YYYDPKFPES CRPCTKCPQG IPVLQECNST
160 170
ANTVCSSSVS NPRNWLFLLM LIVFCI
Length:176
Mass (Da):19,595
Last modified:May 27, 2002 - v2
Checksum:iEE30D617F49DDB7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278264 mRNA Translation: CAC16405.1
AJ276505 Genomic DNA Translation: CAC27352.1
AY165625 mRNA Translation: AAN87805.1
AY046550 mRNA Translation: AAL05072.1
CCDSiCCDS22044.1
RefSeqiNP_077252.2, NM_024290.4
UniGeneiMm.290780

Genome annotation databases

EnsembliENSMUST00000152703; ENSMUSP00000116742; ENSMUSG00000037613
GeneIDi79201
KEGGimmu:79201
UCSCiuc009kpu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTNR23_MOUSE
AccessioniPrimary (citable) accession number: Q9ER63
Secondary accession number(s): Q8VHC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: June 20, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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