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Entry version 119 (08 May 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Sodium channel protein type 4 subunit alpha

Gene

Scn4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pore-forming subunit of a voltage-gated sodium channel complex through which Na+ ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states (PubMed:11834499). Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles, and constant muscle strength in the presence of fluctuating K+ levels (PubMed:18317596, PubMed:21881211).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Channel activity is regulated by the ancillary beta subunit SCN1B. SCN1B strongly enhances the presence of the pore-forming alpha subunit at the cell surface (By similarity). Interaction with SCN1B is required for rapid channel inactivation and rapid recovery after inactivation, and prevents decrease of channel activity in response to repetitive, high-frequency depolarizations (By similarity). The channel is inhibited by tetrodotoxin (PubMed:11834499).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei401Important for inhibition by tetrodotoxinBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channel, Voltage-gated channel
Biological processIon transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5576892 Phase 0 - rapid depolarisation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel protein type 4 subunit alpha
Alternative name(s):
Sodium channel protein skeletal muscle subunit alpha
Sodium channel protein type IV subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Scn4a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:98250 Scn4a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 131CytoplasmicCuratedAdd BLAST131
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei132 – 150Helical; Name=S1 of repeat IBy similarityAdd BLAST19
Topological domaini151 – 157ExtracellularCurated7
Transmembranei158 – 178Helical; Name=S2 of repeat IBy similarityAdd BLAST21
Topological domaini179 – 192CytoplasmicCuratedAdd BLAST14
Transmembranei193 – 210Helical; Name=S3 of repeat IBy similarityAdd BLAST18
Topological domaini211 – 216ExtracellularCurated6
Transmembranei217 – 233Helical; Name=S4 of repeat IBy similarityAdd BLAST17
Topological domaini234 – 252CytoplasmicCuratedAdd BLAST19
Transmembranei253 – 272Helical; Name=S5 of repeat IBy similarityAdd BLAST20
Topological domaini273 – 385ExtracellularCuratedAdd BLAST113
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei386 – 410Pore-formingBy similarityAdd BLAST25
Topological domaini411 – 417ExtracellularCurated7
Transmembranei418 – 438Helical; Name=S6 of repeat IBy similarityAdd BLAST21
Topological domaini439 – 572CytoplasmicCuratedAdd BLAST134
Transmembranei573 – 591Helical; Name=S1 of repeat IIBy similarityAdd BLAST19
Topological domaini592 – 602ExtracellularCuratedAdd BLAST11
Transmembranei603 – 622Helical; Name=S2 of repeat IIBy similarityAdd BLAST20
Topological domaini623 – 636CytoplasmicCuratedAdd BLAST14
Transmembranei637 – 656Helical; Name=S3 of repeat IIBy similarityAdd BLAST20
Topological domaini657 – 658ExtracellularCurated2
Transmembranei659 – 676Helical; Name=S4 of repeat IIBy similarityAdd BLAST18
Topological domaini677 – 692CytoplasmicCuratedAdd BLAST16
Transmembranei693 – 711Helical; Name=S5 of repeat IIBy similarityAdd BLAST19
Topological domaini712 – 740ExtracellularCuratedAdd BLAST29
Intramembranei741 – 761Pore-formingBy similarityAdd BLAST21
Topological domaini762 – 772ExtracellularCuratedAdd BLAST11
Transmembranei773 – 791Helical; Name=S6 of repeat IIBy similarityAdd BLAST19
Topological domaini792 – 1026CytoplasmicCuratedAdd BLAST235
Transmembranei1027 – 1044Helical; Name=S1 of repeat IIIBy similarityAdd BLAST18
Topological domaini1045 – 1057ExtracellularCuratedAdd BLAST13
Transmembranei1058 – 1076Helical; Name=S2 of repeat IIIBy similarityAdd BLAST19
Topological domaini1077 – 1090CytoplasmicCuratedAdd BLAST14
Transmembranei1091 – 1109Helical; Name=S3 of repeat IIIBy similarityAdd BLAST19
Topological domaini1110 – 1117ExtracellularCurated8
Transmembranei1118 – 1136Helical; Name=S4 of repeat IIIBy similarityAdd BLAST19
Topological domaini1137 – 1153CytoplasmicCuratedAdd BLAST17
Transmembranei1154 – 1173Helical; Name=S5 of repeat IIIBy similarityAdd BLAST20
Topological domaini1174 – 1224ExtracellularCuratedAdd BLAST51
Intramembranei1225 – 1246Pore-formingBy similarityAdd BLAST22
Topological domaini1247 – 1263ExtracellularCuratedAdd BLAST17
Transmembranei1264 – 1285Helical; Name=S6 of repeat IIIBy similarityAdd BLAST22
Topological domaini1286 – 1348CytoplasmicCuratedAdd BLAST63
Transmembranei1349 – 1366Helical; Name=S1 of repeat IVBy similarityAdd BLAST18
Topological domaini1367 – 1377ExtracellularCuratedAdd BLAST11
Transmembranei1378 – 1396Helical; Name=S2 of repeat IVBy similarityAdd BLAST19
Topological domaini1397 – 1408CytoplasmicCuratedAdd BLAST12
Transmembranei1409 – 1426Helical; Name=S3 of repeat IVBy similarityAdd BLAST18
Topological domaini1427 – 1439ExtracellularCuratedAdd BLAST13
Transmembranei1440 – 1456Helical; Name=S4 of repeat IVBy similarityAdd BLAST17
Topological domaini1457 – 1475CytoplasmicCuratedAdd BLAST19
Transmembranei1476 – 1493Helical; Name=S5 of repeat IVBy similarityAdd BLAST18
Topological domaini1494 – 1515ExtracellularCuratedAdd BLAST22
Intramembranei1516 – 1538Pore-formingBy similarityAdd BLAST23
Topological domaini1539 – 1568ExtracellularCuratedAdd BLAST30
Transmembranei1569 – 1591Helical; Name=S6 of repeat IVBy similarityAdd BLAST23
Topological domaini1592 – 1841CytoplasmicCuratedAdd BLAST250

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi663R → F: Homozygous mice are born at the expected Mendelian rate and have no visible phenotype. Hind-limb muscles show decreased excitability and decreased force when K(+) levels are low (in vivo). Isolated soleus muscle from homozygous mice has an increased susceptibility to loss of force generation at 2 mM K(+). 1 Publication1
Mutagenesisi1586M → V: A very low percentage of homozygous mice are present at 30 days after birth, suggesting high perinatal lethality. In anesthesized heterozygous mice, electromyographs from hind-limb muscle show high background activity, indicative of myotonia. Isolated extensor digitorum longus muscle from heterozygous mice displays reduced twitch force, with a normal speed of muscle contraction, but an increased muscle relaxation half-time. Isolated skeletal muscle from heterozygous mice has strongly decreased force when the K(+) levels are increased to 10 mM. Homozygous mice display prominent hind-limb weakness and muscle atrophy. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3616353

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003713161 – 1841Sodium channel protein type 4 subunit alphaAdd BLAST1841

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi214N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi280 ↔ 354By similarity
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi363 ↔ 369By similarity
Disulfide bondi723Interchain; with SCN2B or SCN4BBy similarity
Disulfide bondi723Interchain; with the conotoxin GVIIJ (when the channel is not linked to SCN2B or SCN4B; the bond to SCN2B or SCN4B protects the channel from the inhibition by toxin)By similarity
Disulfide bondi725 ↔ 731By similarity
Disulfide bondi763 ↔ 772By similarity
Disulfide bondi1183 ↔ 1203By similarity
Glycosylationi1185N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1199N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1322Phosphoserine; by PKCBy similarity1
Disulfide bondi1547 ↔ 1562By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-1322 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9ER60

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ER60

PRoteomics IDEntifications database

More...
PRIDEi
Q9ER60

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ER60

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ER60

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in quadriceps muscle (at protein level) (PubMed:18317596). Detected in hind-limb skeletal muscles, but not in heart or brain (PubMed:18317596). Detected at low levels in the myocardium.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a voltage-sensitive sodium channel complex that consists of a pore-forming alpha subunit and one or more regulatory beta subunits. Interacts with SCN1B (By similarity). Heterooligomer with SCN2B or SCN4B; disulfide-linked (By similarity). Interacts with the PDZ domain of the syntrophins SNTA1, SNTB1 and SNTB2 (PubMed:9412493). Interacts with the conotoxin GVIIJ (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000021056

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9ER60

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati113 – 448ICuratedAdd BLAST336
Repeati554 – 826IICuratedAdd BLAST273
Repeati1007 – 1320IIICuratedAdd BLAST314
Repeati1329 – 1627IVCuratedAdd BLAST299
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1721 – 1750IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1304 – 1306Important for rapid channel inactivationBy similarity3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410INF8 Eukaryota
COG1226 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231755

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9ER60

KEGG Orthology (KO)

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KOi
K04837

Database of Orthologous Groups

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OrthoDBi
56920at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9ER60

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR000048 IQ_motif_EF-hand-BS
IPR008052 Na_channel_a4su_mammal
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR027359 Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00170 NACHANNEL
PR01665 NACHANNEL4

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9ER60-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSSLPTLV PPGPHCLRPF TPESLAAIEQ RAMEEEARLQ RNKQMEIEEP
60 70 80 90 100
ERKPRSDLEA GKNLPLIYGD PPPEVIGVPL EDLDPYYSDK KTFIVLNKGK
110 120 130 140 150
AIFRFSATPA LYMLSPFSIV RRVAIKVLIH ALFSMFIMIT ILTNCVFMTM
160 170 180 190 200
SNPPSWSKDV EYTFTGIYTF ESLIKMLARG FCIDDFTFLR DPWNWLDFSV
210 220 230 240 250
ITMAYVTEFV DLGNISALRT FRVLRALKTI TVIPGLKTIV GALIQSVKKL
260 270 280 290 300
SDVMILTVFC LSVFALVGLQ LFMGNLRQKC VRWPPPMNDT NTTWYGNDTW
310 320 330 340 350
YGNDTWYGND TWYGNDTWNS QESWVSNSTF DWEAYINDEG NFYFLEGSND
360 370 380 390 400
ALLCGNSSDA GHCPEGYECM KAGRNPNYGY TSYDTFSWAF LALFRLMTQD
410 420 430 440 450
YWENLFQLTL RAAGKTYMIF FVVIIFLGSF YLINLILAVV AMAYAEQNEA
460 470 480 490 500
TLAEDQEKEE EFQQMLEKFK KHQEELEKAK AAQALEGGEE ADGDPTHSKD
510 520 530 540 550
CNGSLDTSGE KGPPRPSCSA ESAISDAMEE LEEAHQKCPP WWYKCAHKVL
560 570 580 590 600
IWNCCAPWVK FKHIILLIVM DPFVDLGITI CIVLNTLFMA MEHYPMTEHF
610 620 630 640 650
DNVLSVGNLV FTGIFTAEMV LKLIAMDPYE YFQQGWNIFD SFIVTLSLVE
660 670 680 690 700
LGLANVQGLS VLRSFRLLRV FKLAKSWPTL NMLIKIIGNS VGALGNLTLV
710 720 730 740 750
LAIIVFIFAV VGMQLFGKSY KECVCKIASD CSLPRWHMHD FFHSFLIVFR
760 770 780 790 800
ILCGEWIETM WDCMEVAGQA MCLTVFLMVM VIGNLVVLNL FLALLLSSFS
810 820 830 840 850
ADSLAASDED GEMNNLQIAI GRIKWGIAFA KTFLLGLLHG KILSLKDIML
860 870 880 890 900
SLGEPGGAGE NGESPPEDEK KEPPPEDGNK ELKDNHILNH VGLTDGPRSS
910 920 930 940 950
IEMDHLNFIN NPYLTIHVPI ASEESDLEMP TEEETDTFSE PEDIKKPLQP
960 970 980 990 1000
LYDGNSSVCS TADYKPPEED PEEQAEENPE GELPEECFTE ACVKRCPCLY
1010 1020 1030 1040 1050
VDISQGRGKM WWTLRRACFK IVEHNWFETF IVFMILLSSG ALAFEDIYIE
1060 1070 1080 1090 1100
QRRVIRTILE YADKVFTYIF ILEMLLKWVA YGFKVYFTNA WCWLDFLIVD
1110 1120 1130 1140 1150
VSIISLVANW LGYSELGPIK SLRTLRALRP LRALSRFEGM RVVVNALLGA
1160 1170 1180 1190 1200
IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF YYCINTTTSE RFDISVVNNK
1210 1220 1230 1240 1250
SECESLMYTG QVRWMNVKVN YDNVGLGYLS LLQVATFKGW MDIMYAAVDS
1260 1270 1280 1290 1300
REKEEQPDYE VNLYMYLYFV IFIIFGSFFT LNLFIGVIID NFNQQKKKFG
1310 1320 1330 1340 1350
GKDIFMTEEQ KKYYNAMKKL GSKKPQKPIP RPQNKIQGMV YDFVTKQVFD
1360 1370 1380 1390 1400
ISIMILICLN MVTMMVETDD QSQLKVDILY NINMVFIIVF TGECVLKMFA
1410 1420 1430 1440 1450
LRHYYFTIGW NIFDFVVVIL SIVGLALSDL IQKYFVSPTL FRVIRLARIG
1460 1470 1480 1490 1500
RVLRLIRGAK GIRTLLFALM MSLPALFNIG LLLFLVMFIY SIFGMSNFAY
1510 1520 1530 1540 1550
VKKESGIDDM FNFETFGNSI ICLFEITTSA GWDGLLNPIL NSGPPDCDPT
1560 1570 1580 1590 1600
LENPGTNIKG DCGNPSIGIC FFCSYIIISF LIVVNMYIAI ILENFNVATE
1610 1620 1630 1640 1650
ESSEPLCEDD FEMFYETWEK FDPDATQFID YSRLSDFVDT LQEPLKIAKP
1660 1670 1680 1690 1700
NKIKLITLDL PMVPGDKIHC LDILFALTKE VLGDSGEMDA LKQTMEEKFM
1710 1720 1730 1740 1750
AANPSKVSYE PITTTLKRKQ EEVCAIKIQR AYRRHLLQRS VKQASYMYRH
1760 1770 1780 1790 1800
SQEGNGDGAP EKEGLLANTM NKMYGSEKED NGVQSQGEKE KDSTEDAGPT
1810 1820 1830 1840
TEVTAPSSSD TALTPPPPSP PPPSSPPQGQ TVRPGVKESL V
Length:1,841
Mass (Da):208,798
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0766DFD33A9E0E55
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X8T7G3X8T7_MOUSE
Sodium channel protein
Scn4a mCG_2873
1,841Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti131A → T in CAM23795 (PubMed:19468303).Curated1
Sequence conflicti1056R → Q in CAM23795 (PubMed:19468303).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ278787 mRNA Translation: CAC17146.1
AL604045 Genomic DNA Translation: CAM23795.1
BC129805 mRNA Translation: AAI29806.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS48961.1

NCBI Reference Sequences

More...
RefSeqi
NP_573462.2, NM_133199.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
110880

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:110880

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278787 mRNA Translation: CAC17146.1
AL604045 Genomic DNA Translation: CAM23795.1
BC129805 mRNA Translation: AAI29806.1
CCDSiCCDS48961.1
RefSeqiNP_573462.2, NM_133199.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021056

Chemistry databases

BindingDBiQ9ER60
ChEMBLiCHEMBL3616353

PTM databases

iPTMnetiQ9ER60
PhosphoSitePlusiQ9ER60

Proteomic databases

MaxQBiQ9ER60
PaxDbiQ9ER60
PRIDEiQ9ER60

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi110880
KEGGimmu:110880

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6329
MGIiMGI:98250 Scn4a

Phylogenomic databases

eggNOGiENOG410INF8 Eukaryota
COG1226 LUCA
HOGENOMiHOG000231755
InParanoidiQ9ER60
KOiK04837
OrthoDBi56920at2759
PhylomeDBiQ9ER60

Enzyme and pathway databases

ReactomeiR-MMU-5576892 Phase 0 - rapid depolarisation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9ER60

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR000048 IQ_motif_EF-hand-BS
IPR008052 Na_channel_a4su_mammal
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PRINTSiPR00170 NACHANNEL
PR01665 NACHANNEL4
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCN4A_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ER60
Secondary accession number(s): A2VDE9, B1ARK0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: March 1, 2001
Last modified: May 8, 2019
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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