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Protein

Testican-2

Gene

Spock2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in diverse steps of neurogenesis. Binds calcium (By similarity).By similarity

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • collagen binding Source: GO_Central
  • extracellular matrix binding Source: MGI
  • extracellular matrix structural constituent conferring compression resistance Source: BHF-UCL
  • glycosaminoglycan binding Source: MGI

GO - Biological processi

Keywordsi

LigandCalcium

Protein family/group databases

MEROPSiI31.954

Names & Taxonomyi

Protein namesi
Recommended name:
Testican-2
Alternative name(s):
SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2
Gene namesi
Name:Spock2
Synonyms:Ticn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1891351 Spock2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002670223 – 423Testican-2Add BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72PhosphoserineBy similarity1
Disulfide bondi90 ↔ 101By similarity
Disulfide bondi95 ↔ 111By similarity
Disulfide bondi136 ↔ 166By similarity
Disulfide bondi139 ↔ 159By similarity
Disulfide bondi148 ↔ 180By similarity
Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi312 ↔ 336By similarity
Disulfide bondi347 ↔ 354By similarity
Disulfide bondi356 ↔ 375By similarity
Glycosylationi382O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi387O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1

Post-translational modificationi

O-glycosylated; contains chondroitin sulfate and heparan sulfate.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQBiQ9ER58
PaxDbiQ9ER58
PRIDEiQ9ER58

PTM databases

PhosphoSitePlusiQ9ER58

Expressioni

Tissue specificityi

Brain specific.

Gene expression databases

BgeeiENSMUSG00000058297 Expressed in 229 organ(s), highest expression level in CA1 field of hippocampus
ExpressionAtlasiQ9ER58 baseline and differential
GenevisibleiQ9ER58 MM

Interactioni

Protein-protein interaction databases

IntActiQ9ER58, 1 interactor
MINTiQ9ER58
STRINGi10090.ENSMUSP00000113115

Structurei

3D structure databases

ProteinModelPortaliQ9ER58
SMRiQ9ER58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 182Kazal-likePROSITE-ProRule annotationAdd BLAST53
Domaini309 – 375Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi392 – 415Glu-richAdd BLAST24

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3555 Eukaryota
ENOG410Y6A8 LUCA
GeneTreeiENSGT00510000046429
HOGENOMiHOG000293295
HOVERGENiHBG026595
InParanoidiQ9ER58
KOiK08136
OMAiHRIKQPA
TreeFamiTF317779

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR019577 SPARC/Testican_Ca-bd-dom
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
PF00086 Thyroglobulin_1, 1 hit
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9ER58-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAPGSGRLA LPLLLLAVVA LAEGDAKGLK EGETPGNFME DEQWLSSISQ
60 70 80 90 100
YSGKIKHWNR FRDEVEDDYI KSWEDNQQGD EALDTTKDPC QKVKCSRHKV
110 120 130 140 150
CVAQGYQRAM CISRKKLEHR IKQPSLKLHG GKDSVCKPCH MAQLASVCGS
160 170 180 190 200
DGHTYSSVCK LEQQACLSSK QLAVRCEGPC PCPTEQSTAS TTDSKSETCT
210 220 230 240 250
GQDLADLGDR LRDWFQLLRE NSKQNGSANS ATNPAGLDKS LGASCKDSIG
260 270 280 290 300
WMFSKLDTSG DLFLDQTELA AINLDKYEVC IRPFFNSCDT YKDGRVSTAE
310 320 330 340 350
WCFCFWREKP PCLAELERTQ IQEAAKKKPG VFIPSCDEDG YYRKMQCDQS
360 370 380 390 400
RGDCWCVDQL GLELTGTRMH GTPDCDDIVG FSGDFGSGVG WEDEEEKETE
410 420
EAGEEAEEEE GEAGEADDGG YIW
Length:423
Mass (Da):46,863
Last modified:March 1, 2001 - v1
Checksum:i20D73E3DB3BC1A15
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6SLR4F6SLR4_MOUSE
Testican-2
Spock2
423Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278999 mRNA Translation: CAC08507.1
BC057324 mRNA Translation: AAH57324.1
CCDSiCCDS35910.1
RefSeqiNP_443720.1, NM_052994.2
UniGeneiMm.153429

Genome annotation databases

EnsembliENSMUST00000121820; ENSMUSP00000113115; ENSMUSG00000058297
GeneIDi94214
KEGGimmu:94214
UCSCiuc007fek.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278999 mRNA Translation: CAC08507.1
BC057324 mRNA Translation: AAH57324.1
CCDSiCCDS35910.1
RefSeqiNP_443720.1, NM_052994.2
UniGeneiMm.153429

3D structure databases

ProteinModelPortaliQ9ER58
SMRiQ9ER58
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9ER58, 1 interactor
MINTiQ9ER58
STRINGi10090.ENSMUSP00000113115

Protein family/group databases

MEROPSiI31.954

PTM databases

PhosphoSitePlusiQ9ER58

Proteomic databases

MaxQBiQ9ER58
PaxDbiQ9ER58
PRIDEiQ9ER58

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000121820; ENSMUSP00000113115; ENSMUSG00000058297
GeneIDi94214
KEGGimmu:94214
UCSCiuc007fek.1 mouse

Organism-specific databases

CTDi9806
MGIiMGI:1891351 Spock2

Phylogenomic databases

eggNOGiKOG3555 Eukaryota
ENOG410Y6A8 LUCA
GeneTreeiENSGT00510000046429
HOGENOMiHOG000293295
HOVERGENiHBG026595
InParanoidiQ9ER58
KOiK08136
OMAiHRIKQPA
TreeFamiTF317779

Miscellaneous databases

PROiPR:Q9ER58
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058297 Expressed in 229 organ(s), highest expression level in CA1 field of hippocampus
ExpressionAtlasiQ9ER58 baseline and differential
GenevisibleiQ9ER58 MM

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR019577 SPARC/Testican_Ca-bd-dom
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
PF00086 Thyroglobulin_1, 1 hit
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTICN2_MOUSE
AccessioniPrimary (citable) accession number: Q9ER58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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